Kubo Yoshiaki 久保宜明

… Alternative Names

KUBO Yoshiaki 久保宜明

久保宜明クボヨシアキ

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Researcher Number	10260069
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 徳島大学, 大学院医歯薬学研究部(医学域), 教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(医学系), 教授 2015: 徳島大学, 大学院医歯薬学研究部, 教授 2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2011 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 … More 2010: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2007 – 2008: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 2006: University of Tokushima, Associate professor, 大学院ヘルスバイオサイエンス研究部, 助教授 2004 – 2005: The University of Tokushima, Health Biosciences, Dermatology, Assistant Professor, 大学院・ヘルスバイオサイエンス研究部, 講師 2001 – 2003: 徳島大学, 医学部, 講師 1998: 徳島大, 医学部, 助手 1996 – 1997: 徳島大学, 医学部, 助手 1994: 財団法人癌研究會, 癌研究所・実験病理部, 研究員 Less
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Pathobiological dentistry/Dental radiology / Laboratory animal science / Dermatology
Keywords	Principal Investigator 有棘細胞癌 / 日光角化症 / 腫瘍化 / 表皮細胞 / 脂漏性角化症 / p16^<INK4a> / SIRT1 / ボーエン病 / pRb / E-cadherin … More / 有棘細胞癌(SCC) / Cyclin D1 / CDK4 / Ras / Bowen病 / セネッセンス / 免疫染色 / FGFR3 / エピジェネティクス / 表皮角化細胞 / 皮膚腫瘍学 / 基底細胞癌 / PCR-SSCP / 腫瘍内不均一性 / リプログラミング / 腫瘍化プロセス / immunohistochemical analysis / cell cycle / seborrheic keratosis / actinic keratosis / Bowen's disease / basal cell carcinoma / squamous cell carcinoma / p27 / 細胞周期関連遺伝子 / cancer-related genes / Promoter hypermethylation / squamous cell carcinoma(SCC) / p15 / p14^<ARF> / PTEN / RIZ1 / MGMT / p16 / 癌関連遺伝子 / DNAメチル化 / Squanus cell carcinoma / Skin carcinogenesis / Keratinocyte / 皮膚発癌 / DNA損傷 / PD-L / FOXN1 / 隆起性皮膚線維肉腫 / 皮膚線維腫 / γ-H2AX / HICl / p53 / 細胞老化 / 癌細胞 / INK4a / p19^<ARF> / Loss of heterozygosity / 皮膚腫瘍 / TSC2 / 結節性硬化症 … More Except Principal Investigator RT-PCR / skin cancer / bioluminescence in vivo imaging / p16^<INK4a> gene / BAC / 可視化 / p16^<Ink4a>遺伝子 / 皮膚癌 / イメージング / p16^<INK4a>遺伝子 / 99mTc-phytate / micrometastases / lymphoscintigraphy / malignant melanoma(MM) / sentinel lymph node / チロジナーゼ / MART-1 / HMB-45 / S-100 / 免疫染色 / RT-PCR法 / 頭頚部悪性腫瘍 / Tc標識フチン酸 / 微小転移 / リンパシンチグラフィ / 悪性黒色腫 / センチネルリンパ節 / Tumor suppressor gene / Tuberous sclerosis / TSC2 gene / Renalcarcinogenesis / Animal model / Hereditary cancer / 遺伝性腎癌 / 癌抑制遺伝子 / ヒト結節性硬化症 / TSC2遺伝子 / 腎発癌 / 疾患モデル / 遺伝性癌 / 細胞培養 / アポトーシス / 癌化 / p53 / 汗孔角化症 Less

Reprogramming of epidermal keratinocytes and the process of tumorigenesisPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Genomic instabilities and tumorigenesis in epidermal keratinocytesPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytesPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
The regulation and abnormalities of the epigenetics on epidermal keratinocytesPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applicationsPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Induction of p16^<INK4a> gene expression by oncogenic stress is involved in the tumor suppression mechanism of skin cancer
- Principal Investigator
  
  OHTANI Naoko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Tokushima
The research for the classification by molecular biology and the development of a novel therapy in squamous cell carcinomas of the skinPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
A study of sentinellymph nodes for malignant tumor of Head and Neck
- Principal Investigator
  
  KUBO Michiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima
The multistep process in skin carcinogenesisPrincipal Investigator
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
表皮ケラチノサイトにおけるp16＾＜INK4a＞及びp19＾＜ARF＞の機能Principal Investigator
- Principal Investigator
  
  久保宜明
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
DNA損傷に対する汗孔角化症細胞の反応性の研究(p53発現誘導の検討)
- Principal Investigator
  
  浦野芳夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
結節性硬化症に発生した皮膚腫瘍、及び孤発性皮膚腫瘍におけるTSC2遺伝子の解析Principal Investigator
- Principal Investigator
  
  久保宜明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Cancer Institute

All 2013 2011 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans2013
- Author(s)
  Ishigami T, Hida Y, Matsudate Y, Murao K, and Kubo Y
- Journal Title
  
  J Med Invest
  
  Volume: 60 Pages: 106-113
- NAID
  130004465277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591224
[Journal Article] fibroblast growth factor receptor 3 and oncogene-nduced senescence in skin tumours2009
- Author(s)
  Hida Y, Kubo Y, Arase S
- Journal Title
  
  Br J Dermatol 160
  
  Pages: 1258-1263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591309
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RBI/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] and Arase S Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E.
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.2005
- Author(s)
  Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E
- Journal Title
  
  Journal of Cell Biology 168
  
  Pages: 552-560
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Presentation] The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans2011
- Author(s)
  Ishigami T, Hida Y, Murao K, Matsudate Y, Kubo Y
- Organizer
  第36回日本研究皮膚科学会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22591224
[Presentation] Oncogene-induced senescence in skin tumors2008
- Author(s)
  Hida Y, Kubo Y, Arase S
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19591309
[Presentation] 皮膚腫瘍における線維芽細胞増殖因子(FGF)シグナル経路について2007
- Author(s)
  飛田泰斗史、久保宜明、荒瀬誠治
- Organizer
  第32回日本研究皮膚科学会
- Place of Presentation
  横浜
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19591309

1. OHTANI Naoko (50275195)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HIDA Yasutoshi (90380039)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. ISHIGAMI Takeshi (40464359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. MATSUDATE Yoshihiro (80622729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MURAO Kazutoshi (40363171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HINO Okio (90127910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOBAYASHI Toshiyuki (40260070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MINAMI Mitsuyoshi (10322257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUBO Michiko (00234485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IWASAKI Hirokazu (30151723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HORI Ayuko (10238769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KUDO Takaharu (10263865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HARA Eiji (80263268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. 浦野芳夫 (90176743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 坂尾佳久 (50346607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 藤田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Kubo Yoshiaki 久保 宜明

KUBO Yoshiaki 久保 宜明

久保 宜明 クボ ヨシアキ

Research Projects

Research Products

Co-Researchers

Reprogramming of epidermal keratinocytes and the process of tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomic instabilities and tumorigenesis in epidermal keratinocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation and abnormalities of the epigenetics on epidermal keratinocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applicationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of p16^<INK4a> gene expression by oncogenic stress is involved in the tumor suppression mechanism of skin cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The research for the classification by molecular biology and the development of a novel therapy in squamous cell carcinomas of the skinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of sentinellymph nodes for malignant tumor of Head and Neck

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The multistep process in skin carcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

表皮ケラチノサイトにおけるp16＾＜INK4a＞及びp19＾＜ARF＞の機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA損傷に対する汗孔角化症細胞の反応性の研究(p53発現誘導の検討)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

結節性硬化症に発生した皮膚腫瘍、及び孤発性皮膚腫瘍におけるTSC2遺伝子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma

Principal Investigator

Kubo Yoshiaki 久保宜明

KUBO Yoshiaki 久保宜明

久保宜明クボヨシアキ