Sahara Hiroeki 佐原弘益

… Alternative Names

佐原弘益サハラヒロエキ

SAHARA Hiroeki 佐原弘益

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Researcher Number	10260762
Other IDs
Affiliation (Current)	2025: 麻布大学, 獣医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 麻布大学, 獣医学部, 教授 2008: Azabu University, 獣医学部, 教授 2007: Sapporo Medical University, 医学部, 講師 2004 – 2006: 札幌医科大学, 臨海医学研究所, 講師 2005: 札幌医科大学, 臨海研究所, 講師 2000: 札幌医科大学, 臨海研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Experimental pathology / Biological Sciences Except Principal Investigator Biological Sciences / Human pathology
Keywords	Principal Investigator CD44バリアントフォーム / 癌幹細胞 / イヌ乳癌細胞 / 腫瘍幹細胞 / イヌ乳癌 / 酸化ストレス耐性 / CD44バリアントアイソフォーム / イヌ / xCT / 放射線治療 … More / 癌 / CD44 / Hsp90 / FK506 / antigen processing / antigen presentation / MHC class II / FKBP51 / 炎症 / alpha-enolase / 腫瘍抗原 / mass spectrum解析 / CD4陽性T細胞 / 口腔扁平上皮癌 / HLA-DR8 … More Except Principal Investigator SYT-SSX / HSP90 / 抗原ペプチド / survivin / サバイビン / CTL / 分子シャペロン / HAD inhibitor / epigenetics / immune escape / HLA class I down regulation / cancer vaccine / 病理標本 / CIITA / II / MHC I / 癌抗原ペプチドワクチン / mAb / 免疫治療 / β2ミクログロブリン / 腫瘍抗原 / HDAC / HLAクラス1 / ヒト癌免疫治療 / エスケープ / HDAC阻害剤 / エピジェネティクス / 免疫エスケープ / HLAクラスI / 癌ペプチドワクチン / Bioinformatics / autologous tumor / clinical trials / peptide vaccines / tumor antigens / HLA-DR8 / リカバリン / ヒト癌抗原 / hsc 70 / 癌抗原処理提示 / 癌免疫 / 臨床試験 / 肉腫 / PBF / HLA-A24 / 骨肉腫抗原遺伝子 / 胃癌抗原遺伝子 / 癌抗原ペプチド / 癌ワクチン / バイオインフォマティクス / 自家癌 / 第1相臨床試験 / ペプチドワクチン / 癌抗原 / HSP70 / ストレス蛋白質 / ポリグルタミン病 / 脊髄小脳変性症 / 樹状細胞 / MHC class 1抗原 / 抗原提示 Less

Elucidation of the role of CD44 variant molecule in radiation resistance ability in canine cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Sahara Hiroeki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Azabu University
MHC class II提示内在性抗原のFKBP51依存性新規抗原提示機構の解析Principal Investigator
- Principal Investigator
  
  SAHARA Hiroeki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Azabu University
  Sapporo Medical University
蛋白質品質管理システムによる生体防御制御の分子メカニズム
- Principal Investigator
  
  TORIGOE Toshihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Immune response and escape in human cancers
- Principal Investigator
  
  SATO Noriyuki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
MHC class IIに提示されるヒト癌抗原の分子クローニングとそのワクチン効果Principal Investigator
- Principal Investigator
  
  佐原弘益
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Human cancer vaccines
- Principal Investigator
  
  SATO Noriyuki
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University

All 2021 2020 2019 2018 2009 2008 2007 2004

All Journal Article Presentation Patent

[Journal Article] Functional analysis of CD44 variants and xCT in canine tumours2021
- Author(s)
  Tanabe Atsushi、Kimura Kento、Tazawa Hana、Maruo Takuya、Taguchi Masayuki、Sahara Hiroeki
- Journal Title
  
  Veterinary Medicine and Science
  
  Volume: 7 Issue: 2 Pages: 577-585
- DOI
  10.1002/vms3.397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06006
[Journal Article] The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells2020
- Author(s)
  Tanabe Atsushi、Sahara Hiroeki
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 10 Pages: 2780-2780
- DOI
  10.3390/cancers12102780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06006
[Journal Article] Angiogenesis-related gene expression profile in clinical cases of canine cancer2019
- Author(s)
  Tanabe A, Kobayashi D, Maeda H, Taguchi M, Sahara H.
- Journal Title
  
  Veterinary Medical Science
  
  Volume: 5 Issue: 1 Pages: 19-29
- DOI
  10.1002/vms3.127
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06006
[Journal Article] Immunosuppressive effect on T cell activation by interleukin-16-and interleukin-10-cDNA-double-transfected human squamous cell line2009
- Author(s)
  Matsumoto Y, Fujita T, Hirai I, Sahara H, Torigoe T, Ezoe K, Saito T, Cruikshank WW, Yotsuyanagi T, Sato N.
- Journal Title
  
  Burns 35
  
  Pages: 383-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Molecular pathologic approaches to human tumor immunology2009
- Author(s)
  Sato N, Hirohashi Y, Tsukahara T, Kikuchi T, Sahara H, Ichimiya S, Tamura Y and Torigoe T.
- Journal Title
  
  Pathol. Int. 59
  
  Pages: 205-217
- NAID
  10027379604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Distruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum2008
- Author(s)
  Kamiguchi, K., Torigoe, T., Fujiwara, O., Ohshima, S., Hirohashi, Y., Sahara, H., Hirai, I., Kohgo, Y., Sato, N.
- Journal Title
  
  Microbiol Immunol. 52
  
  Pages: 94-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol (SQMG), targeting angiogenesis2008
- Author(s)
  Mori, Y., Sahara, H., Matsumoto, K., Takahashi, N., Yamazaki, T., Ohta, K., Aoki, S., Miura, M., Sugawara, F., Sakaguchi, K., and Sato, N.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 1063-1070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Biological heterogeneity of the peptide binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis2007
- Author(s)
  Maeda, H., Sahara, H., Mori, Y., Torigoe, T., Kamiguchi, K., Tamura, Y., Tamura, Y., Hirata, K., and Sato, N.
- Journal Title
  
  J.Biol. Chem. 282
  
  Pages: 26956-26962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Inhibition of endogenous MHC class II-restricted antigen presentation by tacrolimus (FK506) via FKBP512007
- Author(s)
  Imai. A., Sahara, H., Tamura, Y., Jimbow, K., Saito, T., Ezoe, K., Yotsuyanagi, T., and Sato, N.
- Journal Title
  
  Eur. J.Immunol. 37
  
  Pages: 1730-1738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Effects of a new immunosuppressive agent, b-SQAG9, in swine kidney transplantation2007
- Author(s)
  Tanaka, T., Kitamura, H., Sahara, H., Imai, A., Itoh, Y., Honma, I., Ohta, K., Sugawara, F., Sakaguchi, K., Ando, A., Inoko, H., Sato, N., and Tsukamoto, T.
- Journal Title
  
  Transplant Immunol. 18
  
  Pages: 67-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Efficient cross-presentation by heat shock protein 90 peptide complex-loaded dendritic cells via an endosomal pathway2007
- Author(s)
  Kurotaki, T., Tamura, Y., Ueda, G., Oura, J., Kutomi, G., Hirohashi, Y., Sahara, H., Torigoe, T., Hiratsuka, H., Sunakawa, H., Hirata, K., and Sato, N.
- Journal Title
  
  J.Immunol. 179(3)
  
  Pages: 1803-1813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590399
[Journal Article] Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A^*2402 anchor substitute.2004
- Author(s)
  Ida, K., Kawaguchi, S., Sato, Y., Tsukahara, T., Nabeta, Y., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Kamiguchi, K., Wada, T., Nagoya, S., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Ozaki, T., Yoshikawa, H., Yamashita, T., Sato, N.
- Journal Title
  
  J.Immunol. 173
  
  Pages: 1436-1443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213116
[Patent] シクロスポリンA結合タンパク質2008
- Inventor(s)
  佐原弘益、森陽子、高橋延昭、佐藤昇志、菅原二三男、坂口謙吾、諸橋賢吾、岩端一樹、渡士幸一、下遠野邦忠、菊地浩吉、傳亘、宮下広樹
- Industrial Property Rights Holder
  佐原弘益、森陽子、高橋延昭、佐藤昇志、菅原二三男、坂口謙吾、諸橋賢吾、岩端一樹、渡士幸一、下遠野邦忠、菊地浩吉、傳亘、宮下広樹
- Filing Date
  2008-08-21
- Overseas
- Data Source
  KAKENHI-PROJECT-19590399
[Patent] シクロスポリンA結合タンパク質2007
- Inventor(s)
  佐原弘益、森陽子、高橋延昭、佐藤昇志、菅原二三男、坂口謙吾、諸橋賢吾、岩端一樹、渡士幸一、下遠野邦忠、菊地浩吉、傳亘、宮下広樹
- Industrial Property Rights Holder
  佐原弘益、森陽子、高橋延昭、佐藤昇志、菅原二三男、坂口謙吾、諸橋賢吾、岩端一樹、渡士幸一、下遠野邦忠、菊地浩吉、傳亘、宮下広樹
- Industrial Property Number
  2007-217755
- Filing Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-19590399
[Presentation] The role of CD44 variant and xCT in therapy resistance of canine tumors.2019
- Author(s)
  Tanabe A, Ichige J, Kawanami A, Yamaga H, Sahara H.
- Organizer
  78th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-18K06006
[Presentation] Functional analysis of CD44 variants and xCT in canine cancer cells2018
- Author(s)
  Tanabe A, Tazawa H, Furuya A, Ichige J, Kawanami K, Yamaga H, Sahara H
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18K06006
[Presentation] イヌ癌細胞におけるCD44バリアントとxCTの機能解析2018
- Author(s)
  佐原弘益、田辺敦、古屋綾乃、田澤花菜、田口正行
- Organizer
  日本獣医学会
- Data Source
  KAKENHI-PROJECT-18K06006
[Presentation] Presentation pathway of endogenous MHC class II-restricted antigen via immunophilin FKBP512008
- Author(s)
  Kamobayashi, K., Makishima, N., Suzuki, T., Suzuki, Y., Sahara,H.
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590399
[Presentation] Identification of new binding motif of HSP70 in the interaction with HLA-B*27-7-derived peptide by surface Plasmon resonance (SPR) analysis2007
- Author(s)
  Sahara, H., et.al.
- Organizer
  日本免疫学会
- Place of Presentation
  東京・品川
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590399
[Presentation] Identification of cyclosporin A binding protein CSBP that plays a critical role in hepatitis C virus genome replication2007
- Author(s)
  Sahara, H., et.al.
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19590399

1. TORIGOE Toshihiko (20301400)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SATO Noriyuki (50158937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. TAMURA Yasuaki (80322329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ICHIMIYA Shingo (30305221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAMIGUCHI Kenjiro (70363695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 池田英之 (40301494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sahara Hiroeki 佐原 弘益

佐原 弘益 サハラ ヒロエキ

SAHARA Hiroeki 佐原 弘益

Research Projects

Research Products

Co-Researchers

Elucidation of the role of CD44 variant molecule in radiation resistance ability in canine cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MHC class II提示内在性抗原のFKBP51依存性新規抗原提示機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛋白質品質管理システムによる生体防御制御の分子メカニズム

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune response and escape in human cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MHC class IIに提示されるヒト癌抗原の分子クローニングとそのワクチン効果Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Human cancer vaccines

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Functional analysis of CD44 variants and xCT in canine tumours2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiogenesis-related gene expression profile in clinical cases of canine cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunosuppressive effect on T cell activation by interleukin-16-and interleukin-10-cDNA-double-transfected human squamous cell line2009

Author(s)

Journal Title

Data Source

[Journal Article] Molecular pathologic approaches to human tumor immunology2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Distruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum2008

Author(s)

Journal Title

Data Source

[Journal Article] Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol (SQMG), targeting angiogenesis2008

Author(s)

Journal Title

Data Source

[Journal Article] Biological heterogeneity of the peptide binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis2007

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of endogenous MHC class II-restricted antigen presentation by tacrolimus (FK506) via FKBP512007

Author(s)

Sahara Hiroeki 佐原弘益

佐原弘益サハラヒロエキ

SAHARA Hiroeki 佐原弘益