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Kuwahara Kazuhiko  桑原 一彦

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… Alternative Names

KUWAHARA Kazuhiko  桑原 一彦

梃原 一彦  クワハラ カズヒコ

桑原 一彦  クワハラ カズヒコ

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Researcher Number 10263469
Other IDs
Affiliation (Current) 2025: 近畿大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 近畿大学, 大学病院, 講師
2021: 藤田医科大学, 医学部, 講師
2020: 藤田医科大学, 医学部, 助教
2018: 愛知県がんセンター(研究所), その他部局等, 客員研究員
2017: 新潟大学, 医歯学系, 講師 … More
2017: 新潟大学, 医歯学総合研究科, 助教
2016: 新潟大学, 医歯学系, 助教
2016: 愛知県がんセンター(研究所), 医歯学系医歯学総合研究科, 助教
2015: 愛知県がんセンター(研究所), 腫瘍免疫学部, 客員研究員
2014: 愛知県がんセンター(研究所), 腫瘍免疫学部, 室長
2012 – 2013: 熊本大学, 大学院生命科学研究部, 准教授
2009 – 2011: Kumamoto University, 大学院・生命科学研究部, 准教授
2007 – 2008: Kumamoto University, 大学院・医学薬学研究部, 准教授
2005 – 2006: 熊本大学, 大学院医学薬学研究部, 助教授
2005: 熊本大学, 大学院・医学薬学研究部, 助教授
2003: Kumamoto Univ, Graduate Sch of Med & Pharm, Immunology, Lecturer, 大学院・医学薬学研究部, 講師
2002: 熊本大学, 医学部, 講師
2001: 熊本大学, 医学部, 助手
1995: 鳥取大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Biological Sciences / Immunology / Basic Section 49020:Human pathology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / General surgery
Except Principal Investigator
Basic Section 49020:Human pathology-related / General surgery / General anatomy (including Histology/Embryology)
Keywords
Principal Investigator
乳癌 / 非遺伝性散発性乳癌 / ゲノム不安定性 / 中心体複製 / 転写共役型DNA傷害 / mRNA核外輸送 / 非遺伝性乳癌 / 発癌 / 腫瘍発生 / トランスジェニックマウス … More / 遺伝子欠損マウス / ヒストンアセチル化酵素 / BRCA / 転写共役型DNA傷害 / PARP阻害剤 / BRCA2 / 転写共役型DNA傷害 / 乳癌発症機構 / transgenic mice / knock-out mice / tumorigenesis / genome instability / centrosome duplication / ノックアウトマウス / マウスモデル / エストロゲン / DNA傷害 / DNA傷害 / p53 / 微小相同組換え / クラススイッチ / 非相同末端接合 / 相同組換え / DNA損傷 / 遺伝子矢損マウス / MCM3 / 親和性の成熟 / B細胞特異的遺伝子欠損マウス / 免疫応答 / CD40 / DNAプライマーゼ / 胚中心 / チロシンキナーゼ / シグナル伝達 / B細胞 … More
Except Principal Investigator
乳癌 / 中心体複製 / 転写共役型DNA傷害 / 核異型度 / 中心体 / SAC3D1 / 医療 / 薬剤感受性 / TREX2 / DSS1 / 薬剤抵抗性 / Lymhangiogenesis / Lectin Receptor / Cell Adhesion / Lymphocyte Recirculation / Monoclonal Antibody / Endothelial Cell / Lymphatic Vessel / Microcirculation / リンパ管転位 / 微小循環系 / リンパ球 / リンパ管新生 / レクチン受容体 / 細胞接着 / リンパ球再循環 / モノクロナール抗体 / 内皮細胞 / リンパ管 / 微小循環 Less
  • Research Projects

    (14 results)
  • Research Products

    (115 results)
  • Co-Researchers

    (13 People)
  •  GANPのヒストンアセチル化活性欠損に起因する乳癌サブタイプの臨床病理学的意義Principal Investigator

    • Principal Investigator
      桑原 一彦
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Kindai University
  •  Centrosome duplication-related molecule SAC3D1: A model of breast cancer progression and prognostic markers

    • Principal Investigator
      酒井 康弘
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Hamamatsu University School of Medicine
      Fujita Health University
  •  A novel strategy by PARP inhibitors for sporadic breast cancersPrincipal Investigator

    • Principal Investigator
      Kuwahara Kazuhiko
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kindai University
      Fujita Health University
  •  Is induction of TREX2 complex dysfunction a target for anticancer drug hypersensitivity?

    • Principal Investigator
      GONDO Naomi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Functional analysis of TREX2 complex in the development and malignant progression of sporadic breast cancersPrincipal Investigator

    • Principal Investigator
      Kuwahara Kazuhiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Niigata University
      Aichi Cancer Center Research Institute
  •  A novel mechanism of breast carcinogenesis caused by transcription-coupled DNA damagePrincipal Investigator

    • Principal Investigator
      KUWAHARA Kazuhiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Aichi Cancer Center Research Institute
      Kumamoto University
  •  Functional role of a p53 mRNA export factor, GANP, in the occurrence of sporadic breast cancersPrincipal Investigator

    • Principal Investigator
      KUWAHARA Kazuhiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Molecular analysis of microhomology-mediated end-joining in DNA repairPrincipal Investigator

    • Principal Investigator
      KUWAHARA Kazuhiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  ゲノム不安定性誘導における哺乳動物Sac3相同分子の機能Principal Investigator

    • Principal Investigator
      桑原 一彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  ゲノム不安定を誘導する中心体複製制御因子の機能解析Principal Investigator

    • Principal Investigator
      桑原 一彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  Mechanism of genome instability caused by aberrant expression of SHD1, regulator of centrosome duplicationPrincipal Investigator

    • Principal Investigator
      KUWAHARA Kazuhiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Morphological and functional characterization of a specific marker for lymphatic vessels.

    • Principal Investigator
      EZAKI Taichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Tokyo Women's Medical University
  •  抗原特異的B細胞のクローン増大調節の分子メカニズムの解析Principal Investigator

    • Principal Investigator
      桑原 一彦 (梃原 一彦)
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Kumamoto University
  •  B細胞抗原レセプター関連分子p52に結合する分子の解析Principal Investigator

    • Principal Investigator
      桑原 一彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Tottori University

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 免疫・アレルギー疾患イラストレイテッド2013

    • Author(s)
      桑原一彦、阪口薫雄
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Book] 細胞死実験プロトコール2011

    • Author(s)
      桑原一彦
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Book] 細胞死実験プロトコール2011

    • Author(s)
      桑原一彦、Suchada Phimsen、阪口薫雄
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Carcinogenesis caused by transcription‐coupled DNA damage through GANP and other components of the TREX‐2 complex2024

    • Author(s)
      Sakai Yasuhiro、Kuwahara Kazuhiko
    • Journal Title

      Pathology International

      Volume: 74 Issue: 3 Pages: 103-118

    • DOI

      10.1111/pin.13415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06987
  • [Journal Article] Testicular teratomagenesis from primordial germ cells with overexpression of germinal center-associated nuclear protein2023

    • Author(s)
      Yasuhiro Sakai, Kazuya Yoshinaga, Ayaka Yoshida, Andri Rezano, Kazuya Shiogama, Yoshiaki Kawashima, Tadashi Yoshizawa, Akihiko Yoshizawa, Shingo Hatakeyama, Chikara Ohyama, Hiroyasu Ito, Masato Abe, Hiroshi Kijima, Yoshiro Otsuki, Akihiko Ito, Toyonori Tsuzuki, Motohiro Takeya, Nobuo Sakaguchi & Kazuhiko Kuwahara
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 4 Pages: 1729-1739

    • DOI

      10.1111/cas.15685

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07686, KAKENHI-PROJECT-21K15396, KAKENHI-PROJECT-20K16228, KAKENHI-PROJECT-23K06436
  • [Journal Article] DNA Damage, DNA Repair, and Cancer: Second Edition2023

    • Author(s)
      Kuwahara Kazuhiko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 23 Pages: 16835-16835

    • DOI

      10.3390/ijms242316835

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06436, KAKENHI-PROJECT-20K07686
  • [Journal Article] Histology of Cardiac Sarcoidosis with novel considerations arranged upon a pathologic basis2022

    • Author(s)
      Shu Kato, Yasuhiro Sakai, Asako Okabe, Yoshiaki Kawashima, Kazuhiko Kuwahara, Kazuya Shiogama, Masato Abe, Hiroyasu Ito & Shin'ichiro Morimoto
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 1 Pages: 251-251

    • DOI

      10.3390/jcm11010251

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07686, KAKENHI-PROJECT-20K16228
  • [Journal Article] Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas2021

    • Author(s)
      Gondo Naomi、Sakai Yasuhiro、Zhang Zhenhuan、Hato Yukari、Kuzushima Kiyotaka、Phimsen Suchada、Kawashima Yoshiaki、Kuroda Makoto、Suzuki Motoshi、Okada Seiji、Iwata Hiroji、Toyama Tatsuya、Rezano Andri、Kuwahara Kazuhiko
    • Journal Title

      Laboratory Investigation

      Volume: 101 Issue: 8 Pages: 1048-1059

    • DOI

      10.1038/s41374-021-00613-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-20K07686, KAKENHI-PROJECT-20K16228
  • [Journal Article] GANP: An Immunoactive Protein with a Key Role in Tumourigenesis2020

    • Author(s)
      Yasuhiro Sakai & Kazuhiko Kuwahara
    • Journal Title

      Scientia

      Volume: - Pages: 1-5

    • DOI

      10.33548/scientia592

    • Open Access
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Journal Article] The critical role of germinal center-associated nuclear protein in cell biology, immunohematology, and hematolymphoid oncogenesis2020

    • Author(s)
      Yasuhiro Sakai, Suchada Phimsen, Seiji Okada & Kazuhiko Kuwahara
    • Journal Title

      Experimental Hematology

      Volume: 90 Pages: 30-38

    • DOI

      10.1016/j.exphem.2020.08.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07686, KAKENHI-PROJECT-20K16228
  • [Journal Article] Classic Hodgkin lymphoma with osseous involvement mimicking Langerhans cell histiocytosis in a child.2018

    • Author(s)
      Kazuhiko Kuwahara, Ko Kudo, Akiko Yashima-Abo, Kosuke Katayama, Keiko Kojima, Kiyoshi Tone, Etsuro Ito, Atsuko Nakazawa, Hideto Iwafuchi, Akira Kurose.
    • Journal Title

      Human Pathology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Journal Article] Immunodominant SARS coronavirus epitopes in humans elicited both enhancing and neutralizing effects on infection in non-human primates.2016

    • Author(s)
      Wang Q, Zhang L, Kuwahara K, Li L, Liu Z, Li T, Zhu H, Liu J, Xu Y, Xie J, Morioka H, Sakaguchi N, Qin C, Liu G.
    • Journal Title

      ACS Infectious Diseases

      Volume: in press Issue: 5 Pages: 361-376

    • DOI

      10.1021/acsinfecdis.6b00006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016

    • Author(s)
      Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 4 Pages: 469-477

    • DOI

      10.1111/cas.12883

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-15K21237, KAKENHI-PROJECT-15K10083
  • [Journal Article] JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells.2015

    • Author(s)
      Kitabatake M, Soma M, Zhang T, Kuwahara K, Fukushima Y, Nojima T, Kitamura D, Sakaguchi N.
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 4 Pages: 1480-1488

    • DOI

      10.4049/jimmunol.1401127

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25111512, KAKENHI-PUBLICLY-25118730, KAKENHI-PROJECT-25293116, KAKENHI-PROJECT-25460337, KAKENHI-PROJECT-25860813, KAKENHI-PROJECT-26670239, KAKENHI-PROJECT-15K10083
  • [Journal Article] Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of Eid1 stability.2014

    • Author(s)
      Buqing Ye, Zhonghua Dai, Benyu Liu, Rui Wang, Chong Li, Guanling Huang, Shuo Wang, Pengyan Xia, Xuan Yang, Kazuhiko Kuwahara, Nobuo Sakaguchi, Zusen Fan
    • Journal Title

      Stem Cells

      Volume: 32 Pages: 623-635

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Journal Article] Efficacy of anti-CD47 antibody-mediated phagocytosis with macrophages against primary effusion lymphoma.2014

    • Author(s)
      Goto H, Kojima Y, Matsuda K, Kariya R, Taura M, Kuwahara K, Nagai H, Katano H, Okada S.
    • Journal Title

      The European Journal of Cancer

      Volume: 50(10) Issue: 10 Pages: 1836-46

    • DOI

      10.1016/j.ejca.2014.03.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25114711, KAKENHI-PROJECT-25460499
  • [Journal Article] Histopathological evaluation of the diversity of cells susceptible to H5N1 virulent avian influenza virus2013

    • Author(s)
      Ogiwara H, Yasui F, Munekata K, Takagi-Kamiya A, Munakata T, Nomura N, Shibasaki F, Kuwahara K, Sakaguchi N, Sakoda Y, Kida H, Kohara M
    • Journal Title

      Am. J. Pathol

      Volume: 184 Issue: 1 Pages: 171-183

    • DOI

      10.1016/j.ajpath.2013.10.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23659314, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24590565, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25670224, KAKENHI-PROJECT-25670281
  • [Journal Article] Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival2013

    • Author(s)
      Rezano A, Kuwahara K, Yamamoto-Ibusuki M, Kitabatake M, Moolthiya P, Phimsen S, Suda T, Tone S, Yamamoto Y, Iwase H, Sakaguchi N
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 562-562

    • DOI

      10.1186/1471-2407-13-562

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23570083, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25860813
  • [Journal Article] CA-S27 : a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma2013

    • Author(s)
      Silsirivanit A, Araki N, Wongkham C, Vaeteewoottacharn K, Pairojkul C, Kuwahara K, Narimatsu Y, Sawaki H, Narimatsu H, Okada S, Sakaguchi N, Wongkham S
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 10 Pages: 1278-1284

    • DOI

      10.1111/cas.12222

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25293312, KAKENHI-PROJECT-25640068
  • [Journal Article] Broad-spectrum detection of h5 subtype influenza a viruses with a new fluorescent immunochromatography system2013

    • Author(s)
      Sakurai A, Takayama K, Nomura N, Munakata T, Yamamoto N, Tamura T, Yamada J, Hashimoto M, Kuwahara K, Sakoda Y, Suda Y, Kobayashi Y, Sakaguchi N, Kida H, Kohara M, Shibasaki F
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e76753-e76753

    • DOI

      10.1371/journal.pone.0076753

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23659069, KAKENHI-PROJECT-23659314, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24590565, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25670224, KAKENHI-PROJECT-25670281, KAKENHI-PROJECT-25860420
  • [Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013

    • Author(s)
      Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
    • Journal Title

      Molecule Cancer Therapeutics

      Volume: 12 Issue: 8 Pages: 1616-1628

    • DOI

      10.1158/1535-7163.mct-12-1239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25112716, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-25670263
  • [Journal Article] Lyn signaling to upregulate GANP is critical for the survival of high-affinity B cells in germinal centers of lymphoid organs.2012

    • Author(s)
      Kazuhiko Kuwahara
    • Journal Title

      Journal of Immunology

      Volume: 189 Pages: 3472-3479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Journal Article] Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR42012

    • Author(s)
      Toda, T., Kuwahara, K., Kondo, N., Matsuda, Z., Maeda, Y., Maeda, K. & Sakaguchi, N.
    • Journal Title

      Immunobiology

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP2012

    • Author(s)
      Phimsen, S., Kuwahara, K., Nakaya, T., Ohta, K., Suda, T., Kitabatake, M., Rezano, A., Vaeteewoottacharn, K., Okada, S., Tone, S. & Sakaguchi, N.
    • Journal Title

      Apoptosis

      Volume: 17 Pages: 679-690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] A novel serum carbohydrate marker on MUC5AC : values for diagnostic and prognostic indicators for cholangiocarcinoma2011

    • Author(s)
      Silsirivanit, A., Araki, N., Wongkham, C., Pairojkul, C., Narimatsu, Y., Kuwahara, K., Narimatsu, H., Wongkham, S. & Sakaguchi, N.
    • Journal Title

      Cancer

      Volume: 117 Pages: 3393-3403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B-cells2011

    • Author(s)
      Sakaguchi, N., Maeda, K. & Kuwahara, K.
    • Journal Title

      Scand. J. Immu

      Volume: 73 Pages: 523-526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo2010

    • Author(s)
      Kasama, Y., Sekiguchi, S., Saito, M., Tanaka, K., Satoh, M., Kuwahara, K., Sakaguchi, N., Takeya, M., Hiasa, Y., Kohara, M. & Tsukiyama-Kohara K.
    • Journal Title

      Blood

      Volume: 116 Pages: 4926-4933

    • NAID

      120003056509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Germinal center-associated nuclear protein(GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange2010

    • Author(s)
      Okamoto, N., Kuwahara, K., Ohta, K., Kitabatake, M., Takagi, K., Mizuta, H., Kondo, E. & Sakaguchi, N.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 471-484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression2010

    • Author(s)
      Nakaya, T., Kuwahara, K., Ohta, K., Kitabatake, M., Toda, T., Kondo, E. & Sakaguchi, N.
    • Journal Title

      J. Immunol

      Volume: 185 Pages: 5180-5187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells2009

    • Author(s)
      Hideya Igarashi, Kazuhiko Kuwahara, Mikoto Yoshida, Yan Xing, Kazuhiko Maeda, Koichi Nakajima, & Nobuo Sakaguchi
    • Journal Title

      Mol. Immunol 46

      Pages: 1031-1041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Journal Article] Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas2009

    • Author(s)
      Ohta, K., Kuwahara, K., Zhang, Z., Makino, K., Komohara, Y., Nakamura, H., Kuratsu, J. & Sakaguchi, N.
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 2069-2076

    • NAID

      10027196786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] GANP, involved in immunoglobulin V-region diversification, is co-expressed with AID in cholangiocarcinomas associated with long-term inflammation caused by liver fluke infestation2009

    • Author(s)
      Chan-on, W., Kuwahara, K., Kobayashi, N., Ohta, K., Shimasaki, T., Banchob, S., Leelayuwat, C. & Sakaguchi, N.
    • Journal Title

      Int. J. Oncol

      Volume: 35 Pages: 287-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells2009

    • Author(s)
      Igarashi, H., Kuwahara, K., Yoshida, M., Xing, Y., Maeda, K., Nakajima, K. & Sakaguchi, N.
    • Journal Title

      Mol. Immunol

      Volume: 46 Pages: 1031-1041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Generation of high affinity monoclonal antibodies for the prevention of HIV infection. Recent Pat2009

    • Author(s)
      Sakaguchi, N., Toda, T., Nakaya, T., Kitabatake, M., Maeda, K. & Kuwahara, K.
    • Journal Title

      DNA Gene Seq

      Volume: 3 Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Journal Article] Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene2008

    • Author(s)
      Satoru Fujimura, Takeshi Matsui, Kazuhiko Kuwahara, Kazuhiko Maeda, & Nobuo Sakaguchi
    • Journal Title

      Mol. Immunol 45

      Pages: 1712-1719

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Journal Article] GANP suppresses DNA recombination, measured by direct-repeat β-galactosidase gene construct, but does not suppress the type of recombination applying to immunoglobulin genes in mammalian cells2007

    • Author(s)
      Mikoto Yoshida, Kazuhiko Kuwahara, Tatsuya Shimasaki, Naomi Nakagata, Masao Matsuoka, & Nobuo Sakaguchi
    • Journal Title

      Genes Cells 12

      Pages: 1205-1213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Journal Article] Production of two novel monoclonal antibodies that distinguish mouse lymphatic and blood vascular endothelial cells.2006

    • Author(s)
      T.Ezaki, K.Kuwahara, S.Morikawa, K.Shimizu, N.Sakaguchi, K.Matsushima, K.Matsuno
    • Journal Title

      Anatomy and Embryology 211・5

      Pages: 379-393

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes.2006

    • Author(s)
      Kageshita T, Kuwahara K, Oka M, Ma D, Ono T, Sakaguchi N
    • Journal Title

      J. Dermatol. Sci. 42

      Pages: 55-63

    • NAID

      10020550048

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Production of two novel monoclonal antibodies that distinguish mouse lymphatic and blood vascular endothelial cells.2006

    • Author(s)
      T.Ezaki, K.Kuwahara, S.Morikawa, K.Shimizu, N.Sakaguchi, K.Matsushima, K.Matsuno
    • Journal Title

      Anatomy and Embryology 211・5

      Pages: 379-393

    • Data Source
      KAKENHI-PROJECT-18013041
  • [Journal Article] Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes.2006

    • Author(s)
      T.Kageshita, K.Kuwahara, M.Oka, D.Ma, T.Ono, N.Sakaguchi
    • Journal Title

      Journal of Dermatological Science 42・1

      Pages: 55-63

    • NAID

      10020550048

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes.2006

    • Author(s)
      T.Kageshita, K.Kuwahara, M.Oka, D.Ma, T.Ono, N.Sakaguchi
    • Journal Title

      Journal of Dermatological Science 42・1

      Pages: 55-63

    • NAID

      10020550048

    • Data Source
      KAKENHI-PROJECT-18013041
  • [Journal Article] Production of two novel monoclonal antibodies that distinguish mouse lymphatic and blood vascular endothelial cells.2006

    • Author(s)
      Ezaki T, Kuwahara K, Morikaw a S, Shimizu K, Sakaguchi N, Matsushima K, Matsuno K
    • Journal Title

      Anat. Embryol. 211

      Pages: 379-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Cutting Edge : Double-stranded DNA breaks in the immunoglobulin V-region gene were detected at lower frequency in affinity-maturation impeded GANP^<-1-> mice.2005

    • Author(s)
      Y.Kawatani, H.Igarashi, T.Matsui, K.Kuwahara, S.Fujimura, N.Okamoto, K.Takagi, N.Sakaguchi
    • Journal Title

      Journal of Immunology 175・9

      Pages: 5615-5618

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Generation of high-affinity antibody against T cell-dependent antigen in ganp gene-transgenic mouse.2005

    • Author(s)
      N.Sakaguchi, T.Kimura, S.Matsushita, S.Fujimura, J.Shibata, M.Araki, T.Sakamoto, C.Minoda, K.Kuwahara
    • Journal Title

      Journal of Immunology 174・8

      Pages: 4485-4494

    • Data Source
      KAKENHI-PROJECT-17014072
  • [Journal Article] Generation of high-affinity antibody against T cell- dependent antigen in ganp gene-transgenic mouse.2005

    • Author(s)
      Sakaguchi N, Kimura T, Matsushita S, Fujimura S, Shibata J, Araki M, Sakamoto T, Minoda C, Kuwahara K
    • Journal Title

      J. Immunol. 174

      Pages: 4485-4494

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Cutting Edge : Double-stranded DNA breaks in the immunoglobulin V-region gene were detected at lower frequency in affinity-maturation impeded GANP^<-/-> mice.2005

    • Author(s)
      Y.Kawatani, H.Igarashi, T.Matsui, K.Kuwahara.S.Fujimura, N.Okamoto, K.Takagi, N.Sakaguchi
    • Journal Title

      Journal of Immunology 175・9

      Pages: 5615-5618

    • Data Source
      KAKENHI-PROJECT-17014072
  • [Journal Article] Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.2005

    • Author(s)
      Fujimura S, Xing Y, Takeya M, Yamashita Y, Ohshima K, Kuwahara K, Sakaguchi N
    • Journal Title

      Cancer Res. 65

      Pages: 5925-5934

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.2005

    • Author(s)
      S.Fujimura, Y.Xing, M.Takeya, Y.Yamashita, K.Ohshima, K.Kuwahara, N.Sakaguchi
    • Journal Title

      Cancer Research 65・13

      Pages: 5925-5934

    • Data Source
      KAKENHI-PROJECT-17014072
  • [Journal Article] Double-stranded DNA breaks in the immunoglobulin V-region gene were detected at lower frequency in affinity-maturation impeded GANP+ mice.2005

    • Author(s)
      Kawatani Y, Igarashi H, Matsui T, Kuwahara K, Fujimura S, Okamoto N, Takagi K, Sakaguchi N
    • Journal Title

      J. Immunol. 175

      Pages: 5615-5618

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Generation of high-affinity antibody against T cell-dependent antigen in ganp gene-transgenic mouse.2005

    • Author(s)
      N.Sakaguchi, T.Kimura, S.matsushita, S.Fujimura, J.Shibata, M.Araki, T.Sakamoto, C.Minoda, K.Kuwahara
    • Journal Title

      Journal of Immunology 174・8

      Pages: 4485-4494

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.2005

    • Author(s)
      S.Fujimura, Y.Xing, M.Takeya, Y.Yamashita, K.Ohshima, K.Kuwahara, N.Sakaguchi
    • Journal Title

      Cancer Research 65・13

      Pages: 5925-5934

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Production of two novel monoclonal antibodies that distinguish mouse lymphatic and blood vascular endothelial cells.

    • Author(s)
      T.Ezaki, K.Kuwahara, S.Morikawa, K.Shimizu, N.Sakaguchi, K.Matsushima, K.Matsuno
    • Journal Title

      Anatomy and Embryology 印刷中

    • Data Source
      KAKENHI-PROJECT-17014072
  • [Journal Article] Increased expression of germinal center-associated nuclear protein (GANP) is associated with malignant transformation of melanocytes.

    • Author(s)
      T.Kageshita, K.Kuwahara, M.Oka, D.Ma, T.Ono, N.Sakaguchi
    • Journal Title

      Journal of Dermatological Science 印刷中

    • NAID

      10020550048

    • Data Source
      KAKENHI-PROJECT-17014072
  • [Journal Article] Increased expression of germinal center-associated nuclear protein(GANP)is associated with malignant transformation of melanocytes.

    • Author(s)
      T.Kageshita, K.Kuwahara, M.Oka, D.Ma, T.Ono, N.Sakaguchi
    • Journal Title

      Journal of Dermatological Science (印刷中)

    • NAID

      10020550048

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Journal Article] Production of two novel monoclonal antibodies that distinguish mouse lymphatic and blood vascular endothelial cells.

    • Author(s)
      T.Ezaki, K.Kuwahara, S.Morikawa, K.Shimizu, N.Sakaguchi, K.Matsushima, K.Matsuno
    • Journal Title

      Anatomy and Embryology (印刷中)

    • Data Source
      KAKENHI-PROJECT-17590271
  • [Patent] 高病原性トリインフルエンザに対する抗体2012

    • Inventor(s)
      阪口薫雄、桑原一彦、小原道法、芝崎太
    • Industrial Property Rights Holder
      熊本大学、東京都医学研究機構東京都臨床医学総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-278228
    • Filing Date
      2012-12-20
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Patent] 胆管がん特異的糖鎖エピトープを認識するモノクローナル抗体2009

    • Inventor(s)
      阪口薫雄、桑原一彦、荒木令江、坂本珠美
    • Industrial Property Rights Holder
      財団法人くまもとテクノ産業財団
    • Industrial Property Number
      2009-025607
    • Filing Date
      2009-02-02
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] GANP過剰発現に起因する精巣奇形腫発症とその病理学的意義2023

    • Author(s)
      桑原 一彦、酒井 康弘、伊藤 彰彦
    • Organizer
      第112回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-22K06987
  • [Presentation] GANP過剰発現に起因する精巣奇形腫発症とその病理学的意義2023

    • Author(s)
      桑原一彦、酒井康弘、伊藤彰彦
    • Organizer
      第112回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] 精巣胚細胞腫瘍感受性遺伝子ganpの免疫組織化学的解析とteratomagenesisの分子基盤の解明2023

    • Author(s)
      酒井 康弘、桑原 一彦、塩竃 和也、安倍 雅人、伊藤 弘康
    • Organizer
      第64回日本組織細胞化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-22K06987
  • [Presentation] Testicular teratomagenesis with overexpression of GANP2023

    • Author(s)
      Kazuhiko Kuwahara and Akihiko Ito
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K06436
  • [Presentation] GANP過剰発現に起因する精巣奇形腫発症とその病理学的意義2023

    • Author(s)
      桑原一彦、酒井康弘、伊藤彰彦
    • Organizer
      第112回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-23K06436
  • [Presentation] Testicular teratomagenesis with overexpression of GANP2023

    • Author(s)
      Kazuhiko Kuwahara and Akihiko Ito
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] Decrease of BRCA2-interacting DSS1 contributes to reducing the side effects of chemotherapy in breast carcinomas2022

    • Author(s)
      Kazuhiko Kuwahara & Akihiko Ito
    • Organizer
      第81回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] DSS1, an anti-cancer therapeutic target, and the mechanism of chemoresistance in breast cancers2022

    • Author(s)
      Kazuhiko Kuwahara & Yasuhiro Sakai
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] ヒト腫瘍発症及び悪性進展における転写共役型DNA傷害の病理学的意義 -非遺伝性散発性乳癌の解析からの知見-2022

    • Author(s)
      桑原一彦
    • Organizer
      第68回日本病理学会秋期特別総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] 中心体複製制御因子SAC3D1に着目した 非遺伝性乳癌の予後解析2021

    • Author(s)
      加藤秀、酒井康弘、上本康明、鈴木元、遠山竜也、桑原一彦
    • Organizer
      第110回日本病理学会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] 中心体複製制御因子の乳癌悪性進展における意義2020

    • Author(s)
      桑原一彦、酒井康弘、黒田誠、塚本徹哉
    • Organizer
      第109回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] ヒト精巣胚細胞感受性遺伝子ganpの奇形腫発症における病理学的意義2020

    • Author(s)
      酒井康弘、塚本徹哉、黒田誠、桑原一彦
    • Organizer
      第109回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K07686
  • [Presentation] Forced reduction of TREX2 complex highly sensitizes chemotherapy to breast cancer cells2017

    • Author(s)
      Kazuhiko Kuwahara, Eisaku Kondo
    • Organizer
      第21回日本がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] 生体内腫瘍におけるRーLoop形成亢進の特徴と意義2017

    • Author(s)
      栗田菜花、桑原一彦、近藤英作
    • Organizer
      第14回日本病理学会カンファレンス
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] Depletion of TREX2 components, which is related to R-loop accumulation, sensitizes chemotherapy to breast cancer cells2017

    • Author(s)
      Kazuhiko Kuwahara, Eisaku Kondo
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] TREX2 complex as a molecular target to sensitize anti-cancer agents2017

    • Author(s)
      Kazuhiko Kuwahara, Eisaku Kondo
    • Organizer
      第106回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] Forced reduction of DSS1, a member of TREX2 complex, highly sensitizes chemotherapy to breast cancer cells in a BRCA2-independent manner.2017

    • Author(s)
      Kazuhiko Kuwahara, Naomi Gondo, Andri Rezano, Zhenhuan Zhang, Yukari Hato, Kiyotaka Kuzushima, Hiroji Iwata, Tatsuya Toyama, and Eisaku Kondo
    • Organizer
      AACR Annual Meeting 2017
    • Place of Presentation
      Washington, DC
    • Year and Date
      2017-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15603
  • [Presentation] Molecular epidemiological studies of germinal center-associated nuclear protein (ganp) in the development of human sporadic breast cancers.2016

    • Author(s)
      Kazuhiko Kuwahara, Hidemi Ito, Kiyotaka Kuzushima, Hiroji Iwata, Hideo Tanaka, and Keitaro Matsuo
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      Ernest N. Morial Convention Center(米国・ニューオリンズ)
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] Identification of ganp SNPs affecting both the development and malignant progression in human sporadic breast cancers.2016

    • Author(s)
      Kazuhiko Kuwahara, Hidemi Ito, Haruru Kotani, Nobuyuki Tsunoda, Kiyotaka Kuzushima, Hiroji Iwata, Masato Nagino, Hideo Tanaka, and Keitaro Matsuo
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] 乳癌細胞においてTREX2複合体構成分子は薬剤感受性誘導の標的となる2016

    • Author(s)
      桑原一彦
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] Molecular epidemiological studies of ganp in the development of sporadic breast cancers.2015

    • Author(s)
      Kazuhiko Kuwahara, Hidemi Ito, Hirotaka Iwase, Kiyotaka Kuzushima, Hiroji Iwata, Hideo Tanaka, and Keitaro Matsuo
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] DSS1 depletion is a promising strategy increasing chemosensitivity possibly independent of BRCA2 expression.2015

    • Author(s)
      Naomi Gondo, Andri Rezano, Kiyotaka Kuzushima, Hiroji Iwata and Kazuhiko Kuwahara
    • Organizer
      The 38th San Antonio Breast Cancer Symposium (SABCS 2015)
    • Place of Presentation
      Henry B. Gonzalez Convention Center(米国・サンアントニオ)
    • Year and Date
      2015-12-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10083
  • [Presentation] Protein phosphatase subunit G5PR regulates the plasmablast differentiation and autoantibody production of peritoneal B-1a cells2013

    • Author(s)
      北畠正大、張田力、桑原一彦、阪口薫雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] Mammalian Leng8 carrying a Sac3/GANP homologous region upregulated in germinal center B cells is involved in regulation of BCR-mediated proliferation2013

    • Author(s)
      桑原一彦、北畠正大、北村大介、阪口薫雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] 乳癌発症におけるTREX2複合体の役割2013

    • Author(s)
      桑原一彦、岩瀬弘敬、阪口薫雄
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] 乳癌発症におけるmRNA核外輸送複合体分子GANP異常の関与2013

    • Author(s)
      桑原一彦、阪口薫雄
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] Lyn-mediated signaling to GANP upregulation is essential for persistence of high-affinity antigen-specific B-cells during immune response2012

    • Author(s)
      桑原一彦
    • Organizer
      日本免疫学会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] Ganp siRNAはp53不活性型悪性腫瘍に選択的に細胞死を誘導することができる2012

    • Author(s)
      桑原一彦
    • Organizer
      日本癌学会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] siGanpによるp53変異悪性腫瘍特異的な腫瘍増殖阻止2012

    • Author(s)
      桑原一彦
    • Organizer
      日本がん分子標的学会
    • Place of Presentation
      北九州市西日本総合展示場
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] Lynを介するシグナルターゲットであるGANPは末梢リンパ組織における高親和性抗体産生B細胞の維持に重要である2011

    • Author(s)
      桑原一彦
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] 乳腺特異的GANP欠損マウスにおける乳管形成障害と相関する高頻度乳癌発症2011

    • Author(s)
      桑原一彦
    • Organizer
      日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] 乳腺特異的GANP欠損マウスにおける乳管形成障害と相関する高頻度乳癌発症2011

    • Author(s)
      桑原一彦、阪口薫雄
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] 乳腺特異的GANP欠損マウスにおける乳癌発症機構の解析2011

    • Author(s)
      桑原一彦
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2011-06-24
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Lynを介するシグナルターゲットであるGANPは末梢リンパ組織における高親和性抗体産生B細胞の維持に重要である2011

    • Author(s)
      桑原一彦、Suchada Phimsen、竹森利忠、渡辺武、阪口薫雄
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Role of GANP in prevention of cancer development.2010

    • Author(s)
      Kuwahara K., Sakaguchi N.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Role of GANP in prevention of cancer development2010

    • Author(s)
      Kuwahara, K. and Sakaguchi, N.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] GANP plays a critical role in activation of B cell proliferation as a Lyn-mediated signaling target.2010

    • Author(s)
      Kuwahara K., et al.
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] GANPによる細胞周期制御2010

    • Author(s)
      桑原一彦、阪口薫雄
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本
    • Year and Date
      2010-07-23
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] GANP plays a critical role in activation of B cell proliferation as a Lyn-mediated signaling target2010

    • Author(s)
      Kuwahara, K., Nakaya, T., Watanabe, T. and Sakaguchi, N.
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] GANP発現低下に寄るDNA損傷応答の誘導2010

    • Author(s)
      桑原一彦、阪口薫雄
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Role of GANP-associated Thp1/Pcid2 in B-cell stage-dependent regulation of spindle assembly checkpoint.2010

    • Author(s)
      Sakaguchi N., Kuwahara K.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Role of GANP family members in the maturation of germinal center B cells2009

    • Author(s)
      Kuwahara, K. and Sakaguchi, N.
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Critical role of GANP in nuclear export of mRNA involved in mammalian cell division2009

    • Author(s)
      Kuwahara, K. and Sakaguchi, N.
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-21590339
  • [Presentation] Occurrence of sporadic breast cancer is significantly associated with the decreased expression of GANP, a mammalian homologue of Saccharomyces cerevisiae Sac32008

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      The Asia-Africa International Network Symposium of JSPS Asia and Africa Science Platform Program and The Fourth LiverCare Center Symposium
    • Place of Presentation
      Chroen Thani Princess Hotel (Khon Kaen, Thailand)
    • Year and Date
      2008-02-19
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] GANP分子発現低下による姉妹染色分体接着異常とその発癌における役割2008

    • Author(s)
      桑原一彦
    • Organizer
      第12回基盤的癌免疫研究会
    • Place of Presentation
      大宮ソニックシティー
    • Year and Date
      2008-07-02
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Functional differences between GANP and THP1 molecules in B cell activation and development2008

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Functional differences between GANP and THP1 in B cell activation and development.2008

    • Author(s)
      Kuwahara K.
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] GANP分子発現低下による姉妹染色分体接着異常とその発癌における役割2008

    • Author(s)
      桑原一彦
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      総合学術センター
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Occurrence of sporadic breast cancer is associated with decrease of GANP causing abnormal sister chromatid cohesion2008

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Characterization of ganp gene abnormality in human breast cancer.2007

    • Author(s)
      Kuwahara K.
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18013041
  • [Presentation] 非遺伝性散発性乳癌におけるGANPの発現異常2007

    • Author(s)
      桑原一彦
    • Organizer
      第11回がん分子標的治療研究会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Lack of THP1 protein associated with GANP impairs B cell maintenance2007

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Characterization of ganp gene abnormality in human breast cancer2007

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] 非遺伝性散発性乳癌における胚中心関連GANP分子の発現異常2007

    • Author(s)
      桑原一彦
    • Organizer
      第11回基盤的癌免疫研究会
    • Place of Presentation
      東京大学鉄門記念講堂
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] Lack of THP1 protein associated with GANP impairs B cell maintenance2007

    • Author(s)
      Kuwahara K.
    • Organizer
      日本免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19590311
  • [Presentation] The role of mammalian TREX2 complex in sporadic breast cancers

    • Author(s)
      Kazuhiko Kuwahara
    • Organizer
      BIBMC 2014
    • Place of Presentation
      Bandung, Indonesia
    • Year and Date
      2014-09-18 – 2014-09-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] 散発性乳癌におけるDSS1高発現はBRCA2の発現変化とは無関係に患者予後因子となる

    • Author(s)
      桑原一彦、岩瀬弘敬、葛島清隆、阪口薫雄
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24590388
  • [Presentation] BRCA2安定化因子DSS1の発現上昇は非遺伝性散発性乳癌における予後因子である

    • Author(s)
      桑原一彦、阪口薫雄
    • Organizer
      日本がん分子標的治療学会学術集会
    • Place of Presentation
      TKPガーデンシティ仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-24590388
  • 1.  酒井 康弘 (20754394)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  EZAKI Taichi (10128259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  MATSUSHIMA Kouji (50222427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MORIKAWA Shunichi (70339000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  GONDO Naomi (30743356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  葛島 清隆 (30311442)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  岩田 広治 (90295600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  櫻井 浩平 (10608756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  中潟 直己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  岩田 孝吉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  阪口 薫雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 12.  鈴木 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  藤田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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