Kokubo Tetsuro 古久保哲朗

… Alternative Names

古久保哲朗コクボテツロウ

KOKUBO Tetsuro 古久保哲朗

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Researcher Number	10271587
Other IDs
External Links
Affiliation (Current)	2025: 横浜市立大学, 生命医科学研究科, 教授
Affiliation (based on the past Project Information) *help	2023: 横浜市立大学, 生命医科学研究科, 教授 2014 – 2020: 横浜市立大学, 生命医科学研究科, 教授 2013: 横浜市立大学, その他の研究科, 教授 2009 – 2012: Yokohama City University, 生命ナノシステム科学研究科, 教授 2006 – 2008: 横浜市立大学, 国際総合科学研究科, 教授 … More 2005: 横浜市立大学, 大学院・国際総合科学研究科, 教授 2005: 横浜市立大学, 大学院国際総合科学研究科, 教授 2001 – 2004: 横浜市立大学, 総合理学研究科, 教授 2001: 奈良先端科技大, 助教授 1996 – 2000: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Molecular biology / Molecular biology / Basic Section 43010:Molecular biology-related / Biological Sciences Except Principal Investigator 応用微生物学・応用生物化学
Keywords	Principal Investigator TAF / TFIID / 転写因子 / 基本転写因子 / 転写制御 / 転写調節機構 / 出芽酵母 / 転写 / TBP / 転写調節 … More / SAGA / マイクロアレイ / transcription / 構造解析 / general transcription factor / 局所翻訳制御 / 転写開始 / transcriptional regulation / TAND / GTF / cell morphogenesis / gene regulation / mRNA / 液-液相転移 / RNA結合タンパク質 / RNA-binding protein / TATA box binding protein / budding yeast / gene expression / transcription factor / core promoter / basal transcription / yeast / tanscriptional regulation / activation / cyclin / THIID / レポーター遺伝子 / ポリリン酸 / MRI / NMR / イメージング / 遺伝子発現 / モニタリング / TAD / TPIID / TFIDD … More Except Principal Investigator Astaxanthin / Cell fusion / Micromanipulation / Laser-scanning cytometer / Cytometry / Screening / 細胞融合 / アスタキサンチン / ミクロマニピュレーター / レーザー顕微鏡 / サイトメトリー / スクリーニング Less

出芽酵母におけるプロモーターリプログラミング因子の同定とコア因子選択機構の解明Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Yokohama City University
Functional analysis of liquid droplet formed by coupling of specific RNA binding proteins and a basal transcription machineryPrincipal Investigator
- Principal Investigator
  
  Kokubo Tetsuro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Yokohama City University
Mechanism of how core transcription factors are involved in regulating transcription and post-transcriptional mRNA fatePrincipal Investigator
- Principal Investigator
  
  KOKUBO TETSURO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
基本転写因子TFIIDを介した転写調節機構の解明Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Mechanism of how core transcription factors affect the fate of mRNAPrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Mechanisms of core promoter recognition by general transcription factor TFIIDPrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
基本転写因子TFIIDの機能発現における天然変性領域の役割Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Mechanisms of transcriptional initiation and regulation mediated by general transcription factor TFIIDPrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Studies on the regulatory mechanisms of TFIID-mediated eukaryotic transcriptionPrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
標的分子であるTBPに結合した転写活性化ドメインの立体構造解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
転写調節における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
新規in vivo可視化技術を用いた真核細胞における遺伝情報発現機構の解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Yokohama City University
酵母を用いた基本転写因子TFIIDサブユニット(TAFs)の機能解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology
標的分子であるTBPに結合した転写活性化ドメインの立体構造解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
酵母も用いた基本転写因子TFIIDサブユニット(TAFs)の機能解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology
標的分子であるTBPに結合した転写活性化ドメインの立体構造解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
Functional characterization of TFIID subunits (TAFs) in Saccharomyces cerevisiaePrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
酵母を用いた基本転写因子TFIIDサブユニット(TAFs)の機能解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology
標的分子であるTBPに結合した転写活性化ドメインの立体構造解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
酵母を用いた基本転写因子TFIIDサブユニットp145の機能解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
Functional analysis of TAND (TAF N-terminal domain) that inhibits TBP : DNA interactionsPrincipal Investigator
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
酵母を用いた基本転写因子TFIIDサブユニットp145の機能解析Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
基本転写因子TFIIDのサブユニット中に存在するTBP機能阻害活性の生理的意義Principal Investigator
- Principal Investigator
  
  古久保哲朗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
Development of cell-sorting microscope
- Principal Investigator
  
  KATSURAGI Tohoru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Nara Institute of Science and Technology

[Book] Essay; Mechanisms of Transcriptional Activation and Repression (p1210-1217). Definitions; Activation Domain Shielding (p4-6), ATAC (p49-50), Chromatin Helicase DNA binding (CHD) (p402-404), INO80 (p1033-1035), ISWI (p1058-1060), Mammalian HDAC (p1173-1174), PIC Disassembly (p1715), Set3C (p1932-1933), TAND (p2121-2122), Tra1p (p2218-2219) : Encyclopedia ofSystems Biology, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.)2013
- Author(s)
  T. Kokubo
- Publisher
  Springer Science + Business Media LLC
- Data Source
  KAKENHI-PROJECT-23370077
[Book] Essay; Transcription in Eukaryote (p2239-2245). Definitions; Cofactors (p436-437), Core Promoter Elements (p502-504), General Transcription Factors (p813-814), Mediator (p1217-1218), PIC Assembly Pathways (p1714-1715), RNA Polymerase I, II and III (p1862-1863), SAGA (p1890-1891), Type 3 Promoters (p2306-2307) : Encyclopedia of Systems Biology, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.)2013
- Author(s)
  T. Kokubo
- Publisher
  Springer Science + Business Media LLC
- Data Source
  KAKENHI-PROJECT-23370077
[Book] Essay; Transcription Initiation in Eukaryote (p2245-2251). Definitions; Immobilized Template Assay (p989-990), Phosphodiester Bond Formation (p1702-1703), Stalk of RNAPII (p1982-1984), TAF Paralogs (p2120-2121), TFIIA-Like Factor (ALF) (p2163), TRF1 (p2299-2300), TRF2 (p2300-2301), TRF3 (p2301-2302) : Encyclopedia ofSystems Biology, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.)2013
- Author(s)
  T. Kokubo
- Publisher
  Springer Science + Business Media LLC
- Data Source
  KAKENHI-PROJECT-23370077
[Book] V章遺伝子発現系 5.1転写酵母のすべて◎系統, 細胞から分子まで2007
- Author(s)
  古久保哲朗
- Publisher
  シュプリンガー・ジャパン
- Data Source
  KAKENHI-PROJECT-18055028
[Book] V章遺伝子発現系 5.1 転写酵母のすべて ◎系統, 細胞から分子まで2007
- Author(s)
  古久保哲朗
- Publisher
  シュプリンガー・ジャパン
- Data Source
  KAKENHI-PROJECT-18370072
[Book] V章遺伝子発現系 5.1転写酵母のすべて◎系統, 細胞から分子まで2007
- Author(s)
  古久保哲朗
- Publisher
  シュプリンガー・ジャパン
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Book] 磁気共鳴法を利用した生細胞での遺伝子発現解析テクノトレンドバイオテクノロジージャーナルvol.6, No.52006
- Author(s)
  古久保哲朗, ら
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Taf1 N-terminal domain 2 (TAND2) of TFIID promotes formation of stable and mobile unstable TBP-TATA complexes2023
- Author(s)
  Miyasaka Shinji、Kitada Ryota、Kokubo Tetsuro
- Journal Title
  
  Gene
  
  Volume: 889 Pages: 147800-147800
- DOI
  10.1016/j.gene.2023.147800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05642
[Journal Article] TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent2023
- Author(s)
  Iwami R, Takai N, Matsutani M, Shiwa Y, Kokubo H, Kasahara K, Kokubo T.
- Journal Title
  
  PLoS One
  
  Volume: 18 Issue: 2 Pages: e0281233-e0281233
- DOI
  10.1371/journal.pone.0281233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05965, KAKENHI-PROJECT-23K05642
[Journal Article] The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription was restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains.2020
- Author(s)
  R. Iwami, N. Takai, T. Kokubo
- Journal Title
  
  Genes & Genetic Systems
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06063
[Journal Article] Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.2020
- Author(s)
  K. Kasahara, R. Nakayama, Y. Shiwa, Y. Kanesaki, T. Ishige, H. Yoshikawa, T. Kokubo
- Journal Title
  
  PLoS Genetics
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06063
[Journal Article] The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription is restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains2020
- Author(s)
 Iwami Ryo、Takai Naoki、Kokubo Tetsuro
- Journal Title
 
 Genes Genet. Syst.
 
 Volume: 95 Issue: 3 Pages: 151-163
- DOI
 10.1266/ggs.20-00004
- NAID
 130007891317
- ISSN
 1341-7568, 1880-5779
- Year and Date
 2020-06-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18K06063
[Journal Article] Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.2020
- Author(s)
  Koji Kasahara, Risa Nakayama, Yuh Shiwa, Yu Kanesaki, Taichiro Ishige, Hirofumi Yoshikawa, Tetsuro Kokubo
- Journal Title
  
  PLoS Genetics
  
  Volume: 16(6) Issue: 6 Pages: e1008865-e1008865
- DOI
  10.1371/journal.pgen.1008865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05965, KAKENHI-PROJECT-18K06063
[Journal Article] Multiple direct interactions of TBP with the MYC oncoprotein.2019
- Author(s)
  Y. Wei, D. Resetca, Z. Li, I. Johansson-Akhe, A. Ahlner, S. Helander, A. Wallenhammar,V. Morad, B. Raught, B. Wallner, T. Kokubo, Y. Tong, L. Z. Penn, M. Sunnerhagen
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 26 Issue: 11 Pages: 1035-1043
- DOI
  10.1038/s41594-019-0321-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06063
[Journal Article] Transcriptional activation is weakened when Taf1p N-terminal domain 1 is substituted with its Drosophila counterpart in yeast TFIID2019
- Author(s)
 K. Kasahara, S. Takahata, T. Kokubo
- Journal Title
 
 Genes Genet. Syst.
 
 Volume: 94 Issue: 1 Pages: 51-59
- DOI
 10.1266/ggs.19-00001
- NAID
 130007625028
- ISSN
 1341-7568, 1880-5779
- Year and Date
 2019-02-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18K06063, KAKENHI-PROJECT-17K07496
[Journal Article] SAGA mediates transcription from the TATA-like element independently of Taf1p/TFIID but dependent on core promoter structures in Saccharomyces cerevisiae2017
- Author(s)
  Watanabe Kiyoshi、Kokubo Tetsuro
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 11 Pages: e0188435-e0188435
- DOI
  10.1371/journal.pone.0188435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06953
[Journal Article] Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo.2016
- Author(s)
  K. Kasahara, A. Higashino, S. Unzai, H. Yoshikawa, T. Kokubo
- Journal Title
  
  Genes Cells
  
  Volume: 21(12) Issue: 12 Pages: 1333-1352
- DOI
  10.1111/gtc.12449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06953, KAKENHI-PROJECT-15K06980, KAKENHI-PROJECT-26440009
[Journal Article] Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo.2015
- Author(s)
  A. Higashino, Y. Shiwa, H. Yoshikawa, T. Kokubo, K. Kasahara
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 79(3) Issue: 3 Pages: 384-393
- DOI
  10.1080/09168451.2014.978258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24657119, KAKENHI-PUBLICLY-25118520, KAKENHI-PROJECT-26440009
[Journal Article] A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 Promoter of Saccharomyces cerevisiae.2015
- Author(s)
  K. Watanabe, M. Yabe, K. Kasahara, T. Kokubo
- Journal Title
  
  PLoS One
  
  Volume: 10(6) Issue: 6 Pages: e0129357-e0129357
- DOI
  10.1371/journal.pone.0129357
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06953, KAKENHI-PROJECT-26440009
[Journal Article] A Novel Quantitative Hemolytic Assay Coupled with Restriction Fragment Length Polymorphisms Analysis Enabled Early Diagnosis of Atypical Hemolytic Uremic Syndrome and Identified Unique Predisposing Mutations in Japan.2015
- Author(s)
  Yoshida Y, Miyata T, Matsumoto M, Shirotani-Ikejima H, Uchida Y, Ohyama Y, Kokubo T, Fujimura Y.
- Journal Title
  
  PLos One.
  
  Volume: 10 Issue: 5 Pages: e0124655-e0124655
- DOI
  10.1371/journal.pone.0124655
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-25461456, KAKENHI-PROJECT-15K06953
[Journal Article] The physical size of transcription factors is key to transcriptional regulation in chromatin domains.2015
- Author(s)
  Kazuhiro Maeshima, Kazunari Kaizu, Sachiko Tamura, Tadasu Nozaki, Tetsuro Kokubo, Koichi Takahashi.
- Journal Title
  
  J. Phys.: Condens. Matter
  
  Volume: 27 Issue: 6 Pages: 064116-064116
- DOI
  10.1088/0953-8984/27/6/064116
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J04821, KAKENHI-PLANNED-23115005, KAKENHI-PROJECT-24657119, KAKENHI-PUBLICLY-25118520
[Journal Article] Transcription in Eukaryote (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23370077
[Journal Article] Transcription in Eukaryote (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24657119
[Journal Article] Transcription Initiation in Eukaryote (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24657119
[Journal Article] Mechanisms of Transcriptional Activation and Repression (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23370077
[Journal Article] High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation2013
- Author(s)
  Anandapadamanaban M, Andresen C, Helander S, Ohyama Y, Siponen MI, Lundström P, Kokubo T, Ikura M, Moche M, Sunnerhagen M
- Journal Title
  
  Nat Struct Mol Biol
  
  Volume: 20(8) Issue: 8 Pages: 1008-14
- DOI
  10.1038/nsmb.2611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370077, KAKENHI-PROJECT-24657119, KAKENHI-PUBLICLY-25118520
[Journal Article] Transcription Initiation in Eukaryote (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23370077
[Journal Article] Mechanisms of Transcriptional Activation and Repression (review)2013
- Author(s)
  T. Kokubo
- Journal Title
  
  Encyclopedia of Systems Biology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24657119
[Journal Article] Identification and recombinant analysis of botrocetin-2, a snake venom cofactor for von Willebrand factor-induced platelet agglutination2012
- Author(s)
  Yamamoto-Suzuki Y, Sakurai Y, Fujimura Y, Matsumoto M, Hamako J, Kokubo T, Kitagawa H, Kawsar SM, Fujii Y, Ozeki Y, Matsushita F, Matsui T
- Journal Title
  
  Biochemistry
  
  Volume: 51(26) Pages: 5329-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370077
[Journal Article] Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation2011
- Author(s)
  Kano C, Ouchida R, Kokubo T, Wane JY
- Journal Title
  
  Molecular Immunology
  
  Volume: 48(15-16) Issue: 15-16 Pages: 1993-1999
- DOI
  10.1016/j.molimm.2011.06.218
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-23370077
[Journal Article] Hmol directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region2011
- Author(s)
  Kasahara K, Ohyama Y, Kokubo T
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 39(10) Issue: 10 Pages: 4136-4150
- DOI
  10.1093/nar/gkq1334
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517, KAKENHI-PROJECT-23370077
[Journal Article] Hmo1 directs preinitiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region.2011
- Author(s)
  K. Kasahara, Y. Ohyama, T. Kokubo
- Journal Title
  
  Nucleic Acids Res. vol.39, No.10
  
  Pages: 4136-4150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA.2011
- Author(s)
  Y. Ohyama, K. Kasahara, T. Kokubo
- Journal Title
  
  Genes to Cells vol.14, No.1
  
  Pages: 53-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae.2011
- Author(s)
  Sugihara F, Kasahara K, Kokubo T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: vol.39 Pages: 59-75
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517
[Journal Article] Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae.2011
- Author(s)
  F. Sugihara, K. Kasahara, T. Kokubo
- Journal Title
  
  Nucleic Acids Res. vol.39, No.1
  
  Pages: 59-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex2011
- Author(s)
  Kato Y, Kawasaki H, Ohyama Y, Morishita T, Iwasaki H, Kokubo T, Hirano H
- Journal Title
  
  Genetics
  
  Volume: 188(4) Issue: 4 Pages: 871-882
- DOI
  10.1534/genetics.111.128231
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517, KAKENHI-PROJECT-23370077
[Journal Article] Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.2011
- Author(s)
  K. Ohtsuki, K. Kasahara, T. Kokubo
- Journal Title
  
  Nucleic Acids Res. vol.38, No.6
  
  Pages: 1805-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Hmol directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region.2011
- Author(s)
  Kasahara K, Ohyama Y, Kokubo T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517
[Journal Article] Hmol directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region.2011
- Author(s)
  Kasahara K, Ohyama Y, Kokubo T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Highly redundant function of multiple AT-rich sequences as corepromoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae.2011
- Author(s)
  Sugihara F, Kasahara K, Kokubo T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: vol.39 Pages: 59-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA.2010
- Author(s)
  Ohyama Y, Kasahara K, Kokubo T.
- Journal Title
  
  Genes to Cells
  
  Volume: vol.15 Pages: 1169-1188
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517
[Journal Article] Genome-wide localization analysis of a complete set of Tafs revealsa specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.2010
- Author(s)
  Ohtsuki K, Kasahara K, Shirahige K, Kokubo T.
- Journal Title
  
  Nucleic Acids Research Vol.38
  
  Pages: 1805-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20052024
[Journal Article] Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA.2010
- Author(s)
  Ohyama Y, Kasahara K, Kokubo T.
- Journal Title
  
  Genes to Cells
  
  Volume: vol.15 Pages: 1169-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters2010
- Author(s)
  Ohtsuki K, Kasahara K, Shirahige K, Kokubo T.
- Journal Title
  
  Nucleic Acids Research Vol.38
  
  Pages: 1805-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation.2009
- Author(s)
  H. Takahashi, K. Kasahara, T. Kokubo
- Journal Title
  
  Genes to Cells vol.14, No.1
  
  Pages: 53-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Structure-function correlation of micro1 for micromere specification in sea urchin embryos.2009
- Author(s)
  A. Yamazaki, S. Ki, T. Kokubo, M. Yamaguchi
- Journal Title
  
  Mech.Dev. vol.126, No.8-9
  
  Pages: 611-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2.2009
- Author(s)
  Y. Tateishi, M. Ariyoshi, R. Igarashi, H. Hara, K. Mizuguchi, A. Seto, A. Nakai, T. Kokubo, H. Tochio, M. Shirakawa
- Journal Title
  
  J.Biol.Chem. vol.284, No.4
  
  Pages: 2435-2447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Structure-function correlation of microl for micromere specification insea urchin embryos.2009
- Author(s)
  Yamazaki A, Ki S, Kokubo T, Yamaguchi M.
- Journal Title
  
  Mechanisms of Development Vol.126
  
  Pages: 611-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20052024
[Journal Article] Structure-function correlation of micro1 for micromere specification in sea urchin embryos2009
- Author(s)
  Yamazaki A, Ki S, Kokubo T, Yamaguchi M.
- Journal Title
  
  Mechanisms of Development Vol.126
  
  Pages: 611-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370071
[Journal Article] Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II2008
- Author(s)
  Kasahara, K., Ki, S., Aoyama, K., Takahashi, H., Kokubo, T
- Journal Title
  
  Nucleic Acids Res 36(4)
  
  Pages: 1343-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Fluoroscopic assessment of protein leakage during Xenopus oocytes in-cell NMR experiment by co-injected EGFP2007
- Author(s)
  Sakai, T., Tochio, H., Inomata, K., Sasaki, Y., Tenno, T., Tanaka, T., Kokubo, Hiroaki H., Shirakawa, M
- Journal Title
  
  Anal Biochem 371(2)
  
  Pages: 247-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Magnetic resonance-based visualization of gene expression in mammalian cells using a bacterial polyphosphate kinase reporter gene2007
- Author(s)
  Ki S, Sugihara F, Kasahara K, Tochio H, Shirakawa M, Kokubo T.
- Journal Title
  
  Biotechniques 42・2
  
  Pages: 209-215
- Data Source
  KAKENHI-PROJECT-18055028
[Journal Article] Magnetic resonance-based visualization of gene expression in mammalian cells using a bacterial polyphosphate kinase reporter gene2007
- Author(s)
  Ki S, Sugihara F, Kasahara K, Tochio H, Shirakawa M, Kokubo T.
- Journal Title
  
  Biotechniques 42・2
  
  Pages: 209-215
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Real-time monitoring of functional interactions between upstream and core promoter sequences in living cells of sea urchin embryos2007
- Author(s)
  Kobayashi, A., Watanabe, Y., Akasaka, K., Kokubo, T
- Journal Title
  
  Nucleic Acids Res 35(14)
  
  Pages: 4882-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Magnetic resonance-based visualization of gene expression in mammalian cells using a bacterial polyphosphate kinase reporter geme2007
- Author(s)
  Ki, S., Sugihara, F., Kasahara, K., Tochio, H., Shirakawa, M., Kokubo, T
- Journal Title
  
  Biotechniques 42(2)
  
  Pages: 209-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae2007
- Author(s)
  Kasahara, K., Ohtsuki, K, Ki, S., Aoyama, K., Takahashi, H., Kobayashi, T., Shirahige K, Kokubo, T
- Journal Title
  
  Mol Cell Biol 27(19)
  
  Pages: 6686-705
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 12007
- Author(s)
  Mal, TK., Takahata, S., Ki, S., Zheng, L., Kokubo, T., Ikura, M
- Journal Title
  
  J Biol Chem 282(30)
  
  Pages: 22228-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] A novel magnetic resonance-based method to measure gene expression in living cells2006
- Author(s)
  S.Ki, F.Sugihara, K.Kasahara, H.Tochio, A.Okada-Marubayashi, S.Tomita, M.Morita, M.Ikeguchi, M.Shirakawa, T.Kokubo
- Journal Title
  
  Nucleic Acids Research (印刷中)
- Data Source
  KAKENHI-PROJECT-13GS0013
[Journal Article] In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes2006
- Author(s)
  Sakai T, Tochio H, Tenno T, Ito Y, Kokubo T, Hiroaki H, Shirakawa M.
- Journal Title
  
  J Biomol NMR 36・3
  
  Pages: 179-188
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] A novel magnetic resonance-based method to measure gene expression in living cells2006
- Author(s)
  Ki S, Sugihara F, Kasahara K, Tochio H, Okada-Marubayashi A, Tomita S, M orita M, Ikeguchi M, Shirakawa M, Kokubo T
- Journal Title
  
  Nucleic Acids Res 34・6
- Data Source
  KAKENHI-PROJECT-18055028
[Journal Article] In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes2006
- Author(s)
  Sakai T, Tochio H, Tenno T, Ito Y, Kokubo T, Hiroaki H, Shirakawa M
- Journal Title
  
  J Biomol NMR 36・3
  
  Pages: 179-188
- Data Source
  KAKENHI-PROJECT-18055028
[Journal Article] A novel magnetic resonance-based method to measure gene expression in living cells2006
- Author(s)
  Ki S, Sugihara F, Kasahara K, Tochio H, Okada-Marubayashi A, Tomita S, Morita M, Ikeguchi M, Shirakawa M, Kokubo T.
- Journal Title
  
  Nucleic Acids Res 34・6
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes2006
- Author(s)
  Sakai, T., Tochio, H., Tenno, T., Ito, Y., Kokubo, T., Hiroaki, H., Shirakawa, T
- Journal Title
  
  J Biomol NMR 36(3)
  
  Pages: 179-88
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] 磁気共鳴法を利用した生細胞での遺伝子発現解析2006
- Author(s)
  古久保哲郎, 奇世媛, 杉原文徳, 白川昌宏
- Journal Title
  
  バイオテクノロジージャーナル 6・5
  
  Pages: 605-608
- Data Source
  KAKENHI-PROJECT-18055028
[Journal Article] A novel magnetic resonance-based method to measure gene expression in living cells2006
- Author(s)
  S.Ki, F.Sugihara, K.Kasahara, H.Tochio, A.Okada-Marubayashi, S.Tomita, M.Morita, M.Ikeguchi, M.Shirakawa, T.Kokubo
- Journal Title
  
  Nucleic Acids Research (印刷中)
- Data Source
  KAKENHI-PROJECT-17054034
[Journal Article] A novel magnetic resonance-based method to measure gene expression in living cells2006
- Author(s)
  Ki, S., Sugihara, F., Kasahara, K., Tochio, H., Okada-Marubayashi, A., Tomita, S, Morita, M., Ikeguchi, M., Shirakawa, M., Kokubo, T
- Journal Title
  
  Nucleic Acids Res 34(6)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] 磁気共鳴法を利用した生細胞での遺伝子発現解析2006
- Author(s)
  古久保哲朗, 奇世媛, 杉原文徳, 白川昌宏
- Journal Title
  
  バイオテクノロジージャーナル 6・5
  
  Pages: 605-608
- Data Source
  KAKENHI-PROJECT-18370072
[Journal Article] Resonance assignments of 30 kDa complexes of TFIID subunit TAF1 with TATA-binding protein2005
- Author(s)
  TK.Mal, D.Liu, Y.Masutomi, L.Zheng, Y.Nakatani, T.Kokubo, M.Ikura
- Journal Title
  
  Journal of Biomolecular NMR 33・1
  
  Pages: 76-76
- Data Source
  KAKENHI-PROJECT-13GS0013
[Journal Article] Resonance assignments of 30 kDa complexes of TFIID subunit TAF1 with TATA-binding protein2005
- Author(s)
  TK.Mal, D.Liu, Y.Masutomi, L.Zheng, Y.Nakatani, T.Kokubo, M.Ikura
- Journal Title
  
  Journal of Biomolecular NMR 33・1
  
  Pages: 76-76
- Data Source
  KAKENHI-PROJECT-17054034
[Journal Article] Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation.2004
- Author(s)
  S.Takahata, K.Kasahara, M.Kawaichi, T.Kokubo
- Journal Title
  
  Molecular and Cellular Biology 24・8
  
  Pages: 3089-3099
- Data Source
  KAKENHI-PROJECT-13GS0013
[Journal Article] Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation.2004
- Author(s)
  S.Takahata, K.Kasahara, M.Kawaichi, T.Kokubo
- Journal Title
  
  Molecular and Cellular Biology 24・8
  
  Pages: 3089-3099
- Data Source
  KAKENHI-PROJECT-16013240
[Journal Article] In vivo synthesis of Taf1p lacking TAF N-terminal domain using alternative transcription or translation initiation sites.2004
- Author(s)
  K.Kasahara, M.Kawaichi, T.Kokubo
- Journal Title
  
  Genes to Cells 9・8
  
  Pages: 709-721
- Data Source
  KAKENHI-PROJECT-16013240
[Journal Article] In vivo synthesis of Taf1p lacking the TAF N-terminal domain using alternative transcription or translation initiation sites.2004
- Author(s)
  K.Kasahara, M.Kawaichi, T.Kokubo
- Journal Title
  
  Genes to Cells 9・8
  
  Pages: 709-721
- Data Source
  KAKENHI-PROJECT-13GS0013
[Presentation] 出芽酵母におけるリボソームタンパク質遺伝子の新規転写制御機構の解明2023
- Author(s)
  島村直希、古久保哲朗、笠原浩司
- Organizer
  第46回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-23K05642
[Presentation] 病原性真菌カンジダグラブラータにおけるリボソームタンパク質遺伝子の転写制御機構の解明2023
- Author(s)
  中村美春、島村直希、竹内建樹、中林幸佳、志波優、松谷峰之介、古久保哲朗、知花博治、笠原浩司
- Organizer
  第46回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-23K05642
[Presentation] ラパマイシンの標的分子FKBP12の出芽酵母における役割2019
- Author(s)
  笠原浩司、中山理紗、志波優、兼崎友、石毛太一郎、吉川博文、古久保哲朗
- Organizer
  第52回酵母遺伝学フォーラム研究報告会
- Data Source
  KAKENHI-PROJECT-18K06063
[Presentation] 出芽酵母のFK506/ラパマイシン結合タンパク質Fpr1は、リボソームタンパク質遺伝子の転写因子として働く2018
- Author(s)
  笠原浩司、中山理紗、志波優、兼崎友、石毛太一郎、吉川博文、古久保哲朗
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06063
[Presentation] 出芽酵母においてSpt3/SAGAの一過的な機能喪失がもたらす解糖系遺伝子プロモーターのTaf1/TFIID依存的な転写活性化2018
- Author(s)
  岩見亮、高井直樹、古久保哲朗
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06063
[Presentation] p53活性化剤とCDK8阻害剤の併用は神経芽腫に対し細胞死を誘導する2018
- Author(s)
  中島綾奈、宮崎允、日比谷優子、富山新太、古久保哲朗、市村幸一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06063
[Presentation] 基本転写因子TFIIDの構成因子TAF8の天然変性領域の機能解析2017
- Author(s)
  高井直樹, Ehmed Ekrem, 櫻井堅介, 大山良文, 古久保哲朗
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15K06953
[Presentation] 基本転写因子TFIIDのサブユニットであるTAF8における天然変性領域の機能解析2016
- Author(s)
  高井直樹, Ehmed Ekrem, 櫻井堅介, 大山良文, 古久保哲朗
- Organizer
  日本分子生物学会第39回年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-15K06953
[Presentation] ATP/ADP結合型RecAによるE. coli /T4 DNA LigaseのDNA末端結合活性促進の生化学的特性2016
- Author(s)
  此村直人, 新井直人, 古久保哲朗, 柴田武彦
- Organizer
  日本分子生物学会第39回年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-15K06953
[Presentation] 出芽酵母のRNAポリメラーゼII系遺伝子における新規コアプロモーターエレメントの同定ならびにその機能解析2015
- Author(s)
  渡邉清, 矢部誠, 古久保哲朗
- Organizer
  日本分子生物学会第38回年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06953
[Presentation] 出芽酵母においてgal2 変異とミトコンドリア機能阻害が誘起するガラクトース培地特異的な生育阻害効果2014
- Author(s)
  岩見亮, 大山良文, 高井直樹, 古久保哲朗
- Organizer
  日本分子生物学会第37回年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24657119
[Presentation] 出芽酵母においてgal2 変異とミトコンドリア機能阻害が誘起するガラクトース培地特異的な生育阻害効果2014
- Author(s)
  岩見亮, 大山良文, 高井直樹, 古久保哲朗
- Organizer
  日本分子生物学会第37回年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-25118520
[Presentation] ハイスループット型レポーターシステムを用いた出芽酵母由来の新規コアプロモーターエレメントの同定及びその機能解析2014
- Author(s)
  渡邉清, 矢部誠, 古久保哲朗
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜（横浜産貿ホール）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PUBLICLY-25118520
[Presentation] 二種類の異なる機能を持つG1サイクリンCln2pの転写段階での運命決定2014
- Author(s)
  高井直樹, 大山良文, 古久保哲朗
- Organizer
  転写研究会・転写サイクル・転写代謝システム共催「冬の若手ワークショップ2014」
- Place of Presentation
  軽井沢
- Year and Date
  2014-01-31
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] ハイスループット型レポーターシステムを用いた出芽酵母由来の新規コアプロモーターエレメントの同定及びその機能解析2014
- Author(s)
  渡邉清, 矢部誠, 古久保哲朗
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜（横浜産貿ホール）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-24657119
[Presentation] 出芽酵母におけるTFIIDを介したGAL遺伝子群の脱抑制機構2013
- Author(s)
  矢部誠, 大山良文, 高井直樹, 古久保哲朗
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA結合機構2013
- Author(s)
  東野綺子, 雲財悟, 中山理紗, 土屋奈穂, 吉川博文, 古久保哲朗, 笠原浩司
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母のTFIIDとSAGAは細胞の極成長に関わるRAMシグナル経路と遺伝学的に相互作用する2012
- Author(s)
  大山良文、和田忠士、古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原(和光純薬・湯河原研修所)
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] 出芽酵母における新規ハイスループット型プロモーター活性測定法の開発とその応用2012
- Author(s)
  渡邉清、矢部誠、古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原(和光純薬・湯河原研修所)
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] 基本転写因子TFIIDの機能発現における天然変性領域の役割2012
- Author(s)
  古久保哲朗
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  大阪(千里ライフサイエンスセンター)
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母のTFIIDとSAGAは細胞の極成長に関わるRAMシグナル経路と遺伝学的に相互作用する2012
- Author(s)
  大山良文, 和田忠士, 古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 母性mRNAの3'非翻訳領域を標的としたアンチセンスモルフォリノオリゴによるpoly(A)鎖短小化機構の解析2012
- Author(s)
  茂呂華奈子, 古久保哲朗, 和田忠士
- Organizer
  日本分子生物学会第35回年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母における新規ハイスループット型プロモーター活性測定法の開発とその応用2012
- Author(s)
  渡邉清、矢部誠、古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原(和光純薬・湯河原研修所)
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母における新規ハイスループット型プロモーター活性測定法の開発とその応用2012
- Author(s)
  渡邉清, 矢部誠, 古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 基本転写因子TFIIDの機能発現における天然変性領域の役割2012
- Author(s)
  古久保哲朗
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母のTFIIDとSAGAは細胞の極成長に関わるRAMシグナル経路と遺伝学的に相互作用する2012
- Author(s)
  大山良文、和田忠士、古久保哲朗
- Organizer
  新学術領域研究「転写代謝システム」・転写研究会共催「若手ワークショップ@湯河原」
- Place of Presentation
  湯河原(和光純薬・湯河原研修所)
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 基本転写因子TFIIDの機能発現における天然変性領域の役割2012
- Author(s)
  古久保哲朗
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  大阪(千里ライフサイエンスセンター)
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] Novel regulatory mechanism for transcriptional initiation of ribosomal protein genes in S.cerevisiae2011
- Author(s)
  笠原浩司、大山良文、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] TFIID and SAGA regulate the fate of CLN2 mRNA cooperatively with the RAM signaling network2011
- Author(s)
  大山良文、和田忠士、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] A novel high-throughput screening system to measure gene expression in Saccharomyces cerevisiae2011
- Author(s)
  渡邉清, 古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] A novel high-throughput screening system to measure gene expression in Saccharomyces cerevisiae2011
- Author(s)
  渡邉清、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] TFIID and SAGA regulate the fate of CLN2 mRNA cooperatively with the RAM signaling network2011
- Author(s)
  大山良文、和田忠士、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] TFIID and SAGA regulate the fate of CLN2 mRNA cooperatively with the RAM signaling network2011
- Author(s)
  大山良文, 和田忠士, 古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] Novel regulatory mechanism for transcriptional initiation of ribosomal protein genes in S.cerevisiae2011
- Author(s)
  笠原浩司、大山良文、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] Novel regulatory mechanism for transcriptional initiation of ribosomal protein genes in S. cerevisiae2011
- Author(s)
  笠原浩司, 大山良文, 古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] A novel high-throughput screening system to measure gene expression in Saccharomyces cerevisiae2011
- Author(s)
  渡邉清、古久保哲朗
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] Identification of novel core promoter elements within the TATA-less RPS5 promoter in Saccharomyces cerevisiae.2010
- Author(s)
  F. Sugihara, K.Kasahara, T.Kokubo
- Organizer
  Keystone Symposia "Dynamics of Eukaryotic Transcription during Development".
- Place of Presentation
  Big Sky Resort, Montana, USA
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] Identification of novel core promoter elements within the TATA-less RPS5 promoter in Saccharomyces cerevisiae2010
- Author(s)
  Sugihara F, Kasahara K, Kokubo T.
- Organizer
  Keystone Symposia "Dynamics of Eukaryotic Transcription during Development"
- Place of Presentation
  Big Sky Resort, Montana, USA
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] Identification of novel core promoter elements within the TATA-less RPS5 promoter in Saccharomyces cerevisiae2010
- Author(s)
  Sugihara F, Kasahara K, Kokubo T.
- Organizer
  Keystone Symposia "Dynamics of Eukaryotic Transcription during Development"
- Place of Presentation
  Big Sky Resort, Montana, USA
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PUBLICLY-22113517
[Presentation] Deletion of the N-terminal domain of TAF1 (taf1-△TAND) exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast2009
- Author(s)
  Ohyama Y, Kasahara K, Kokubo T.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20052024
[Presentation] Deletion of the N-terminal domain of TAF1(taf1-ΔTAND)exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast2009
- Author(s)
  Ohyama Y, Kasahara K, Kokubo T.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] Deletion of the N-terminal domain of TAF1 (taf1-ΔTAND) exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast.2009
- Author(s)
  Y. Ohyama, K.Kasahara, T.Kokubo
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] 出芽酵母BEM4に見出された転写因子としての新たな機能2008
- Author(s)
  小林晶子、大槻和重、白髭克彦、古久保哲朗
- Organizer
  BMB2008(第31回日本分子生物学会年会 & 第81回日本生化学会大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] TFIIDサブユニットのゲノムワイドなプロモーター結合解析2008
- Author(s)
  大槻和重、笠原浩司、白髭克彦、古久保哲朗
- Organizer
  BMB2008(第31回日本分子生物学会年会 & 第81回日本生化学会大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] 出芽酵母のHMGBファミリータンパク質HMO1によるリボソームタンパク質遺伝子の転写開始点決定機構2008
- Author(s)
  笠原浩司、奇世媛、青山佳世、高橋宏之、古久保哲朗
- Organizer
  BMB2008(第31回日本分子生物学会年会 & 第81回日本生化学会大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] Molecular function of HMO1 at ribosomal protein gene promoters.2008
- Author(s)
  K.Kasahara, K.Ohtsuki, S. Ki, K.Aoyama, H.Takahashi, T.Kokubo
- Organizer
  内藤コンファレンス/Nuclear Dynamics and RNA [I]
- Place of Presentation
  八ヶ岳
- Year and Date
  2008-06-25
- Data Source
  KAKENHI-PROJECT-20370071
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA 結合機構
- Author(s)
  東野綺子，雲財悟，中山理紗，土屋奈穂，吉川博文，古久保哲朗，笠原浩司
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA 結合機構
- Author(s)
  東野綺子，雲財悟，中山理紗，土屋奈穂，吉川博文，古久保哲朗，笠原浩司
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PROJECT-24657119
[Presentation] 出芽酵母におけるTFIIDを介したGAL遺伝子群の脱抑制機構
- Author(s)
  矢部誠，大山良文，高井直樹，古久保哲朗
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PUBLICLY-25118520
[Presentation] 出芽酵母におけるTFIIDを介したGAL遺伝子群の脱抑制機構
- Author(s)
  矢部誠，大山良文，高井直樹，古久保哲朗
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PROJECT-23370077
[Presentation] 出芽酵母におけるTFIIDを介したGAL遺伝子群の脱抑制機構
- Author(s)
  矢部誠，大山良文，高井直樹，古久保哲朗
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PROJECT-24657119
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA 結合機構
- Author(s)
  東野綺子，雲財悟，中山理紗，土屋奈穂，吉川博文，古久保哲朗，笠原浩司
- Organizer
  日本分子生物学会第36回年会
- Place of Presentation
  神戸（ポートピアホテル）
- Data Source
  KAKENHI-PUBLICLY-25118520

1. KASAHARA Kouji (40304159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 三宅剛司 (00283937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KATSURAGI Tohoru (80081579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YOSHIDA Nobuyuki (10273848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ONODERA Keiko Yamada (70202380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 白川昌宏 (00202119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KITAGAWA Hisao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松本雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤村吉博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 志波優

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kokubo Tetsuro 古久保 哲朗

古久保 哲朗 コクボ テツロウ

KOKUBO Tetsuro 古久保 哲朗

Research Projects

Research Products

Co-Researchers

出芽酵母におけるプロモーターリプログラミング因子の同定とコア因子選択機構の解明Principal Investigator

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Functional analysis of liquid droplet formed by coupling of specific RNA binding proteins and a basal transcription machineryPrincipal Investigator

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Mechanism of how core transcription factors are involved in regulating transcription and post-transcriptional mRNA fatePrincipal Investigator

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基本転写因子TFIIDを介した転写調節機構の解明Principal Investigator

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Mechanism of how core transcription factors affect the fate of mRNAPrincipal Investigator

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Mechanisms of core promoter recognition by general transcription factor TFIIDPrincipal Investigator

Principal Investigator

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基本転写因子TFIIDの機能発現における天然変性領域の役割Principal Investigator

Principal Investigator

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転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator

Principal Investigator

Project Period (FY)

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Mechanisms of transcriptional initiation and regulation mediated by general transcription factor TFIIDPrincipal Investigator

Principal Investigator

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転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator

Principal Investigator

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Studies on the regulatory mechanisms of TFIID-mediated eukaryotic transcriptionPrincipal Investigator

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転写制御における基本転写因子TFIIDサブユニット(TAFs)の分子機能Principal Investigator

Principal Investigator

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Research Institution

基本転写因子TFIIDに支配される標的遺伝子群の網羅的単離とそのプロモーター特性Principal Investigator

Principal Investigator

Kokubo Tetsuro 古久保哲朗

古久保哲朗コクボテツロウ

KOKUBO Tetsuro 古久保哲朗