ISHIGURO Masaji 石黒正路

Researcher Number	10280687
Affiliation (based on the past Project Information) *help	2015: 新潟薬科大学, 応用生物科学部, 教授 2013 – 2014: 新潟薬科大学, 応用生命科学部, 教授 2013: 新潟薬科大学, 応用生命化学部, 教授 2010: 新潟薬科大学, 応用生物科学部, 教授 2008 – 2010: Nigata University of Phermacy and Applied Life Sciences, 応用生命科学部, 教授 … More 2006: SUNTRY, Institute for Boiorganic Research, Chief Scientist, 部長研究員 2005 – 2006: Suntory Institute for Bioorganic Research, Director, 部長研究員 2004: SUNTORY INSTITUTE FOR BOIORGANIC RESEARCH, CHIEF SCIENTIST, 部長研究員 2003: (財)サントリー生物有機科学研究所, 部長研究員 2000 – 2001: (財)サントリー生物有機科学研究, 部長研究員 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical biology Except Principal Investigator Living organism molecular science / Functional basic dentistry / Drug development chemistry / 医薬分子機能学 / Bioproduction chemistry/Bioorganic chemistry / Functional biochemistry
Keywords	Principal Investigator 分子モデリング / 生体分子 / 癌 / ATR阻害 / ゴミシンN / チェックポイント / 抗がん活性増強 / リグナン / Phosphokinase / ATR … More / 五味子 / グミシンN / アンタゴニスト / アンドロステノン / OR7D4 / ステロイド / デヒドロエピアンドロステノン / CH-π相互作用 / フルアゴニスト / GPCR / 匂い受容体 … More Except Principal Investigator SHP-1 / Allergy preventive medicines / Blood flow monitoring / Hen-egg white lysozyme / NO / 卵白リゾチーム(HEL) / compound 48 / in vivoアッセイ系 / 血流モニタリング / 80 / 抗アレルギー / PAF / in vivo assay system / e NOS (6) COX-1 and 2 / inducible NO synthase (iNOS) / iNOS KO mouse / PGI_2 / COX-1、2 / in vivoアッセイ法 / アレルギー予防 / COX-1,2 / eNOS / 静脈微小循環 / iNOSノックアウトマウス / 血流 / evaluation for osteoclast function / agonist design / proteome analysis / 3-dimensional surface measurement / osteoclast / immunology / inflammation / 骨吸収能評価法 / 3D形状計測 / 骨吸収機能 / 骨吸収能 / 質量分析 / 骨吸収能力評価 / アゴニスト設計 / プロテオーム解析 / 3次元形状計測 / 破骨細胞 / 炎症・免疫 / nitric oxide(NO) / Anti-allergic assay system / endothelin-1(ET-1) / inducible NO synthase(iNOS) / 天然資源 / 血栓症 / 血管内皮 / iNOS / 血流量 / 一酸化窒素(NO) / エンドセリン-1(ET-1) / 誘導型NO合成酵素(iNOS) / アレルギー予防薬 / anti-allergy / Anaphylaxis / Anti-anaphylaxis assay method / Blood flow monitiring / 新規アッセイ法 / compound48 / アナフィラキシー / 抗アナフィラキシーアッセイ法 / 血流量モニタリング / ペプチドホルモン / インスリン様分子 / 線虫 / 休眠 / 寿命 / インスリン / 生理活性 / 生体分子 / 免疫学 / 糖鎖パターン認識 / コンピュータモデリング / ルイスxエピトープ / ルイスaエピトープ / マンナン結合タンパク質 / 腫瘍マーカー / がん / 臨床試料 / 動物レクチン / 先天性免疫 / 糖鎖 / 癌 Less

Studies on the interactions between ATR and its inhibitor Gomisin N and its application to a potentiator of antitumor agents.Principal Investigator
- Principal Investigator
  
  Ishiguro Masaji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
Integrated functionnal analyes of insulin-like peptides which regutate diapause and lifespan in Caenor habditis elegans
- Principal Investigator
  
  KAWANO Tsuyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tottori University
Structure and Function of MBP-ligand oligosaccharides isolated from SW1116 cells
- Principal Investigator
  
  KAWASAKI Toshisuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Ritsumeikan University
Studies on the Molecular Recognition and Design of Ligands of Olfactory ReceptorsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Masaji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION
- Principal Investigator
  
  ISHIGURO Kyoko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Mukogawa Women's University
The functional analysis of RANKL signaling in osteoclast for developing the agonist of SHP-1
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION
- Principal Investigator
  
  ISHIGURO Kyoko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  MUKOGAWA WOMEN'S UNIVERSITY
DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION
- Principal Investigator
  
  ISHIGURO Kyoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Mukogawa Women's University

[Book] 膜タンパク質構造研究２５章受容体分子とリガンドのモデリング2013
- Author(s)
  石黒　正路　（編者：岩田　想）
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-25293029
[Journal Article] Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to β-glycosides2016
- Author(s)
  Imai H, Suzuki-Hashido N, Ishimaru Y, Sakurai T, Yin W, Pan W, Ishiguro M, Masuda K, Abe K, Misaka T, and Hirai H.
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: in press
- NAID
  130005165371
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293029
[Journal Article] Structural Basis of pH Dependence of Neoculin, a Sweet Taste-Modifying Protein.2015
- Author(s)
  Ohkubo T, Tamiya M, Abe K, Ishiguro M.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293029
[Journal Article] Synthesis of the aglycon of pentalinoside2015
- Author(s)
  Isaka, N. Kawada, S.; Ishiguro, M.; Tamiya, M.
- Journal Title
  
  Heterocycles
  
  Volume: 91 Pages: 1715-1721
- Data Source
  KAKENHI-PROJECT-25293029
[Journal Article] Synthesis of the Aglycon of the Argelosides: Antiprolierative 14,15-seco-Pregnane Glycosides2014
- Author(s)
  Minoru Tamiya, Nobuhisa Isaka, Takaki Kitazawa, Masaji Ishiguro
- Journal Title
  
  Asian Journal of Organic Chemistry
  
  Volume: 3 Issue: 3 Pages: 265-268
- DOI
  10.1002/ajoc.201300219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293029
[Journal Article] Mode-of-action and evolution of methylenedioxy bridge forming P450s in plant specialized metabolism2014
- Author(s)
  Akio Noguchi, Manabu Horikawa, Jun Murata, Masayuki Tera, Yosuke Kawai, Masaji Ishiguro, Toshiaki Umezawa, Masaharu Mizutani, Eii
- Journal Title
  
  Plant Biotechnology
  
  Volume: 31 Issue: 5 Pages: 493-503
- DOI
  10.5511/plantbiotechnology.14.0828a
- NAID
  130004721162
- ISSN
  1342-4580, 1347-6114
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293029, KAKENHI-PROJECT-26750366
[Journal Article] Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin.2010
- Author(s)
  Ito, K, Sugawara, T., Koizumi, A., Nakajima, K.I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S.Kobayashi, T., Abe, K.
- Journal Title
  
  Biochim.Biophys.Acta
  
  Volume: 1800 Pages: 986-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diaziriny1 D-phenylalanine derivatives.2010
- Author(s)
  Masuda, K, Koizumi, A., Misaka, T., Hatanaka, Y., Abe, K., Tanaka, T., Ishiguro, M., Hashimoto., M.
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 1081-1083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Modification of D-ring Moiety of Steroids-A Novel Palladium Catalyzed Beayer-Villiger Type Rearrangement of Cyclic Silylenol ether Derivatives2010
- Author(s)
  Minoru Tamiya, Futa Takada, Nobuhisa Isaka, Nahoko Iimura, Masaji Ishiguro
- Journal Title
  
  Heterocycles 82巻
  
  Pages: 1119-1125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] G.Structure-activity relationships of GPR120 agonists based on a docking simulation.2010
- Author(s)
  Sun, Q., Hirasawa, A., Hara, T., Kimura, I., Adachi, T., Awaji, T., Ishiguro, M., Suzuki, T., Miyata., N, Tsujimoto
- Journal Title
  
  Mol.Pharmacol.
  
  Volume: 78 Pages: 804-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.2010
- Author(s)
  Sakurai, T., Misaka, T., Ueno, Y., Ishiguro, M., Matsuo, S., Ishimaru, Y., Asakura, T., Abe, K
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 595-601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera).2010
- Author(s)
  Ono, E., Homma, Y., Horikawa, M., Kunikane-Doi, S., Imai, H., Takahashi, S., Kawai, Y., Ishiguro, M., Fukui, Y., Nakayama, T.
- Journal Title
  
  Plant Cell
  
  Volume: 22 Pages: 2856-2871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Characterization of the β-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R162010
- Author(s)
  Sakurai, T., Misaka, T., Ishiguro, M., Masuda, K., Sugawara, T., Ito, K., Kobayashi, T., Matsuo, S., Ishimaru, Y., Asakura, T., Abe, K
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 28373-28378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Engineered mutation of some important amino acids in angiotensin II type1 (AT1) receptor increases the binding affinity of AT1-receptor antagonists.2010
- Author(s)
  Bhuiyan, M.A., Hossain, M., Ishiguro, M., Nakamura, T., Nagatomo, T.
- Journal Title
  
  J.Pharmacol.Sci.
  
  Volume: 113 Pages: 57-65
- NAID
  130000251910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas quorum-sensing autoinducer.2010
- Author(s)
  Ueda, C., Tateda, K., Horikawa, M., Kimura, S., Ishii, Y., Nomura, K., Yamada, K., Suematsu, T., Inoue, Y., Ishiguro, M., Miyairi, S., Yamaguchi, K.
- Journal Title
  
  Antimicrob.Agents Chemother
  
  Volume: 54 Pages: 683-688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Structure-activity relationship study on alphal adrenergic receptor antagonists from beer2009
- Author(s)
  Wakimoto T, Nitta M, Kasahara K, Chiba T, Ye Y, Tsuji K, Kan T, Nukaya H, Ishiguro M, Koike M, Yokoo Y, Suwa Y.
- Journal Title
  
  Bioorg Med Chem Lett. 19
  
  Pages: 5905-5908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species.2009
- Author(s)
  Kimura S, Tateda K, Ishii Y, Horikawa M, Miyairi S, Gotoh N, Ishiguro M, Yamaguchi K.
- Journal Title
  
  Microbiology 155
  
  Pages: 1934-1939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26(DPPVI)isolated from a human colorectal carcinoma cell line, SW1116.2009
- Author(s)
  Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T
- Journal Title
  
  Glycobiology 19
  
  Pages: 437-450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Characterization of chemoreceptive protein binding to an oviposition stimulant using a fluorescent micro-binding assay in a butterfly.2009
- Author(s)
  Tsuchihara K, Wazawa T, Ishii Y, Yanagida T, Nishida R, Zheng XG, Ishiguro M, Yoshihara K, Hisatomi O, Tokunaga F.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 345-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW11162009
- Author(s)
  Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T
- Journal Title
  
  Glycobiology 19
  
  Pages: 437-450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370052
[Journal Article] Local differentiation of sugar donor specificity of flavonoid glycosyltransferase in Lamiales.2009
- Author(s)
  Noguchi A, Horikawa M, Fukui Y, Fukuchi-Mizutani M, Iuchi-Okada A, Ishiguro M, Kiso Y, Nakayama T, Ono E
- Journal Title
  
  Plant Cell 21
  
  Pages: 1556-1572
- NAID
  110009757723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW11162009
- Author(s)
  Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T.
- Journal Title
  
  Glycobiology 19
  
  Pages: 437-450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370052
[Journal Article] Binding sites of valsartan, candesartan and losartan with angiotensin II receptor 1 subtype by molecular modeling.2009
- Author(s)
  Bhuiyan MA, Ishiguro M, Hossain M, Nakamura T, Ozaki M, Miura S, Nagatomo T.
- Journal Title
  
  Life Sci. 85
  
  Pages: 136-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Characterization of chemoreceptive protein binding to an oviposition stimulant using a fluorescent micro-binding assay in a butterfly.2009
- Author(s)
  Tsuchihara K, Wazawa T, Ishii Y, Yanagida T, Nishida R, Zheng XG, Ishiguro M, Yoshihara K, Hisatomi O, Tokunaga F.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 345-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.2008
- Author(s)
  Suzuki T, Igari S, Hirasawa A, Hata M, Ishiguro M, Fujieda H, Itoh Y, Hirano T, Nakagawa H, Ogura M, Makishima M, Tsujimoto G, Miyata N.
- Journal Title
  
  J Med Chem. 51
  
  Pages: 7640-7644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region.2008
- Author(s)
  Shimamura T, Hiraki K, Takahashi N, Hori T, Ago H, Masuda K, Takio K, Ishiguro M, Miyno M.
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 17753-17756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Mutation of important amino acid residue of Asp104Lys in human beta(1)-adrenergic receptor triggers functional and constitutive inactivation.2008
- Author(s)
  Hossain M, Ahmed M, Bhuiyan MA, Ishiguro M, Nakamura T, Ozaki M, Nasatomo T.
- Journal Title
  
  Biol Pharm Bull. 31
  
  Pages: 1517-1522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611018
[Journal Article] Allergy-Preventive flavonoids from Xanthorrhoea hastilis2007
- Author(s)
  Yuko Ogawa, Kyoko Ishiguro
- Journal Title
  
  Chem.Pharm.Bull. 55(4)(In press)
- NAID
  110006241840
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme (II)2007
- Author(s)
  Hisae Oku, Kyoko Ishiguro
- Journal Title
  
  Biol. Pharm. Bull. 30(7)(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Allergy-Preventive flavonoids from Xanthorrhoea hastilis2007
- Author(s)
  Yuko Ogawa, Hisae Oku, Kyoko Ishiguro, et al.
- Journal Title
  
  Chem. Pharm. Bull. 55(4)
  
  Pages: 675-678
- NAID
  110006241840
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Allergy-Preventive flavonoids from Xanthorrhoea hastilis.2007
- Author(s)
  Yuko Ogawa, Hisae Oku, Kvoko Ishiguro
- Journal Title
  
  Chem. Pharm. Bull. 55 (4)
  
  Pages: 675-678
- NAID
  110006241840
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme (II)2007
- Author(s)
  Hisae Oku, Kvoko Ishiguro
- Journal Title
  
  Biol. Pharm. Bull. 30(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Garcinone B. the first xanthone compound inhibiting LPS-induced transcriptional stimulation via NF-kB in C6 rat glioma2006
- Author(s)
  Koichi Aoki, Kyoko Ishiguro
- Journal Title
  
  FEBS Lett. 394(3)
  
  Pages: 206-210
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Garcinone B. the first xanthone compound inhibiting LPS-induced transcriptional stimulation via NF-kB in C6 rat glioma2006
- Author(s)
  Koichi Aoki, Tohru Yamakuni, Hisae Oku, Kvoko Ishiguro, et al.
- Journal Title
  
  FEBS Lett. 394(3)
  
  Pages: 206-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Garcinone B. the first xanthone compound inhibiting LPS-induced transcriptional stimulation via NF-kB in C6 rat glioma2006
- Author(s)
  Koichi Aoki, Nobuhiko Kondo, Hisae Oku, Kyoko Ishiguro
- Journal Title
  
  FEBS Lett. 394(3)
  
  Pages: 206-210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.2006
- Author(s)
  Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R.
- Journal Title
  
  The Journal of Clinical Investigation. 116(6)
  
  Pages: 1525-1534
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390530
[Journal Article] Allergy preventive Phenolic Glycoside from Populus sieboldii2006
- Author(s)
  Yuko Ogawa, Kyoko Ishiguro
- Journal Title
  
  J. Nat. Prod. 69
  
  Pages: 1213-1217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Primary Preventive Teas on Metabolic Syndrome- Kinginkacha, Kinkacha and Kudingcha-2006
- Author(s)
  Hisae Oku, Kvoko Ishiguro
- Journal Title
  
  Yakugaku Zasshi 126
  
  Pages: 1114-115
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Primary Preventive Teas on Metabolic Syndrome - Kinginkacha, Kinkacha and Kudingcha -2006
- Author(s)
  Hisae Oku, Kyoko Ishiguro
- Journal Title
  
  Yakugaku Zasshi 126
  
  Pages: 114-115
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Allergy preventive Phenolic Glycoside from Populus sieboldii2006
- Author(s)
  Yuko Ogawa, Kyoko Ishiguro
- Journal Title
  
  J.Nat.Prod. 69
  
  Pages: 1213-1217
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Primary Preventive Teas on Metabolic Syndrome -Kinginkacha, Kinkacha and Kudingcha-2006
- Author(s)
  Hisae Oku, Kyoko Ishiguro
- Journal Title
  
  Yakugaku Zasshi 126
  
  Pages: 114-115
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Effects of scutellaria flavonoids on the gene expression of cytokines2005
- Author(s)
  Hakamatsuka, T., Ishiguro, K.et al.
- Journal Title
  
  Yakugaku Zasshi 125
  
  Pages: 164-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Effects of scutellaria flavonoids on the gene expression of cytokines2005
- Author(s)
  Hakamatsuka, T., Okabe, A., Tsuji, A., Yamagishi, F., Ishiguro, K., et al.
- Journal Title
  
  YAKUGAKU ZASSHI 125
  
  Pages: 164-167
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ.2005
- Author(s)
  Ueda, Y., Oku, H., Iinuma, M., Ishiguro, K.
- Journal Title
  
  Biol. Pharm. Bull. 28
  
  Pages: 1786-1790
- NAID
  110003666514
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Inhibitory effect of xanthones from Guttiferae plant on PAF-induced hypotension in mice2005
- Author(s)
  Hisae OKU, Kyoko ISHIGURO
- Journal Title
  
  Planta Medica 71
  
  Pages: 90-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Antipruritic effects of Impatiens balsamina L.2005
- Author(s)
  Ishiguro, K.
- Journal Title
  
  KAMPO EYES 20
  
  Pages: 16-17
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Development of an in vivo Bioassay Method for Allergy-preventive Substances Using Hen-Egg White Lysozyme (HEL)-induced blood Flow Decrease.2005
- Author(s)
  Ishiguro, K., Oku, H., Ueda, Y., Iwaoka, E., Kunitomo, M.
- Journal Title
  
  Biol. Pharm. Bull. 28
  
  Pages: 1490-1945
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Development of an in vivo Bioassay Method for Allergy-preventive Substances Using Hen-Egg White Lysozyme(HEL)-induced blood Flow Decrease.2005
- Author(s)
  Ishiguro, K., Oku, H., Ueda, Y., Iwaoka, E., Kunitomo, M.
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1490-1495
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ.2005
- Author(s)
  Ueda, Y., Oku, H., Iinuma, M., Ishiguro, K.
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1786-1790
- NAID
  110003666514
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Development of an in vivo Bioassay Method for Allergy-preventive Substances Using Hen-Egg White Lysozyme (HEL)-induced blood Flow- Decrease.2005
- Author(s)
  Ishiguro, K., Oku, H., Ueda, Y., Iwaoka, E., Kunitomo, M.
- Journal Title
  
  Biol. Pharm. Bull. 28
  
  Pages: 1490-1495
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] Effects of scutellaria flavonoids on the gene expression of cytokines2005
- Author(s)
  Hakamatsuka, T.Ishiguro, K., et al.
- Journal Title
  
  Yakugaku Zasshi 125
  
  Pages: 164-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510185
[Journal Article] An approach to new anti-allergy medicines originating from Impatiens balsamina.2004
- Author(s)
  Kyoko Ishiguro
- Journal Title
  
  Foods & food ingredients journal 209
  
  Pages: 13-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590106
[Journal Article] An approach to new anti-allergy medicines originating from Impatiens balsamina2004
- Author(s)
  Kyoko Ishiguro
- Journal Title
  
  Foods & food ingredients journal of Japan 209
  
  Pages: 13-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590106
[Journal Article] Preventive effects of Impatiens balsamina on HEL(hen egg-white lysozyme)-induced decrease of blood flow.2002
- Author(s)
  Kyoko Ishiguro
- Journal Title
  
  Biol.Pharm.Bull 25
  
  Pages: 505-508
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590106
[Journal Article] Preventive effects of Impatiens balsamina on HEL (hen egg-white lysozyme)-induced decrease of blood flow.2002
- Author(s)
  Kyoko Ishiguro
- Journal Title
  
  Biol.Pharm.Bull. 25
  
  Pages: 505-508
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590106
[Journal Article] A Peptice Mimicking a TNF Receptor Loop Blocks RANKL-induced Signaling, Bone Resorption and Bone Loss.
- Author(s)
  K.Aoki, H.Saito, C.Itzstein, M.Ishiguro et al.
- Journal Title
  
  Journal of Clinical Investigation (In Press)
- Data Source
  KAKENHI-PROJECT-16390530
[Presentation] 2,6-Dideoxy-3-O-methylpyranosylillustrolの全合成2014
- Author(s)
  井坂修久, 田宮　実, 石澤和也, 池田舞由, 石黒正路
- Organizer
  有機合成化学協会関東支部　新潟シンポジウム
- Place of Presentation
  新潟大学
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-25293029
[Presentation] 味覚修飾タンパク質の酸による甘味発現機構の解析2014
- Author(s)
  大久保崇之, 中嶋健一朗, 伊藤啓祐, 三坂　巧, 阿部啓子, 田宮　実, 石黒正路
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザ
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-PROJECT-25293029
[Presentation] ATR阻害剤ゴミシンNの全合成2014
- Author(s)
  田宮　実, 眞柄良平, 近恵, 土屋裕徳, 熊倉美佳, 五十嵐久未, 中川悠貴, 石黒正路
- Organizer
  有機合成化学協会関東支部　新潟シンポジウム
- Place of Presentation
  新潟大学
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-25293029
[Presentation] DOI合成酵素変異体における変異と活性の相関解析2013
- Author(s)
  大久保崇之、佐藤雅人、田宮　実、高久洋暁、岩澤裕喜、石黒正路
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  関西学院
- Data Source
  KAKENHI-PROJECT-25293029
[Presentation] Illustrol の合成研究2013
- Author(s)
  井坂修久、池田舞由、北澤貴明、田宮　実、石黒正路
- Organizer
  第65回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  新潟薬科大学
- Data Source
  KAKENHI-PROJECT-25293029
[Presentation] GPCRの機能構造とリガンド認識2011
- Author(s)
  石黒正路
- Organizer
  岩田ヒト膜受容体構造プロジェクト研究成果報告会
- Place of Presentation
  京都大学
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Velutinol Aの合成研究2011
- Author(s)
  井坂修久、長谷川篤志、田宮実、石黒正路
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡大学
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] パラジウムを用いた新規Baeyer-Villiger型環拡大反応2010
- Author(s)
  田宮実、高田楓太、石黒正路
- Organizer
  第60回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  新潟薬科大学(口頭発表)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] 味覚および嗅覚受容体が多様な味や匂い物質を認識する分子機構2010
- Author(s)
  石黒正路
- Organizer
  第7回コンビナトリアル・バイオエンジニアリング会議
- Place of Presentation
  千里阪急ホテル(大阪)
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Baeyer-Villiger type rearrangement promoted by bivalent palladium2010
- Author(s)
  Minoru Tamiya, Futa Takada, Masaii Ishiguro
- Organizer
  International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu Hawaii
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] 生物と有機化学のインターフェースとしての創薬化学2010
- Author(s)
  石黒正路
- Organizer
  日本薬学会第130年会シンポジウム
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] パラジウムを用いた新規Baeyer-Villiger型環拡大反応2010
- Author(s)
  田宮実、高田楓太、石黒正路
- Organizer
  第60回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  新潟薬科大学
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Velutinol Aの合成研究2010
- Author(s)
  井坂修久、長谷川篤志、田宮実、石黒正路
- Organizer
  第60回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  新潟薬科大学
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] パラジウムを用いた新規Baeyer-Villiger型環拡大反応2010
- Author(s)
  高田楓太、井坂修久、田宮実、石黒正路
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大(口頭発表)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] パラジウムを用いた新規Baeyer-Villiger型環拡大反応2010
- Author(s)
  高田楓太, 井坂修久, 田宮実, 石黒正路
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Functional Structures of GPCRs for Recognition of Various Ligand Structures2009
- Author(s)
  石黒正路
- Organizer
  日本学術振興会169委員会第29回研究会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2009-05-13
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Functional Structures of GPCRs for Recognition of Various Ligand Structures2009
- Author(s)
  石黒正路
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Velutinol Aの合成研究2009
- Author(s)
  井坂修久、田宮実、米田照代、石黒正路
- Organizer
  第58回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  長岡技術科学大学(長岡)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] 薬物受容体の構造から薬物の働きを理解する2009
- Author(s)
  石黒正路
- Organizer
  第19回日本医療薬学会年会シンポジウム
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] 化学と生物における構造活性相関研究の役割2009
- Author(s)
  石黒正路
- Organizer
  第61回生物工学会
- Place of Presentation
  名古屋大学(名古屋)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] 機能的リガンド認識のための多様なGPCRの構造2009
- Author(s)
  石黒正路
- Organizer
  構造活性相関フォーラム2009
- Place of Presentation
  北里大学(東京)
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] ブラジキニンB1およびB2受容体とリガンドの複合体モデリングによる相互作用の解析2008
- Author(s)
  井坂修久, 安達晃弘, 納富勇輔田宮実, 米田照代, 石黒正路
- Organizer
  第36回構造活性相関シンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] マンナン結合タンパク質に対して高親和性結合を示すリガンド糖鎖の構造的特徴2008
- Author(s)
  山口圭子, 川寄伸子, Kay-Hooi Khoo, 石黒正路, 澤田敏彦, 川崎ナナ, 中尾広美, Bruce Yong Ma, 川嵜敏祐
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20370052
[Presentation] マンナン結合タンパク質に対して高親和性結合を示すリガンド糖鎖の構造的特徴2008
- Author(s)
  山口圭子、川嵜伸子、Kay-Hooi Khoo、石黒正路、澤田敏彦、川崎ナナ、中尾広美、Bruce Yong Ma、川嵜敏祐
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20370052
[Presentation] Structural models for Bradykinin B1 receptor-Ligand Complexes2008
- Author(s)
  井坂修久, 安達晃弘, 納富勇輔田宮実, 米田照代, 石黒正路
- Organizer
  8^<th> China-Japan joint Symposium on drug Design and Develpoment
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20611018
[Presentation] Velutinol A及び関連天然物の合成研究
- Author(s)
  井坂修久, 田宮　実, 北澤貴明, 石澤和也, 長谷川篤志, 池田舞由, 石黒正路
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293029
[]

1. ISHIGURO Kyoko (70151363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. OKU Hisae (90281518)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAMIYA Minoru (10468960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. KAWASAKI Toshisuke (50025706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MA BRUCE (00378788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAWASAKI Nobuko (70077676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. ISHIDA Hideharu (20203002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KATO Koichi (20211849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YONEDA Teruyo (30265714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWANO Tsuyoshi (50270567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IWASAKI Takashi (30585584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIDA Hiroshi (60322541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAKU Hiroaki (70350717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. YAMAZAKI Harutake (20456776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AOKI Kazuhiro (40272603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. HARUMIYA Satoru (50301792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIMOKAWA Hitoyata (80014257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKAGAWA Atsushi (20188890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 奧尚枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
20. 米本照代

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. 川崎敏祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
22. MA BRUCE・Yong

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

ISHIGURO Masaji 石黒 正路

Research Projects

Research Products

Co-Researchers

Studies on the interactions between ATR and its inhibitor Gomisin N and its application to a potentiator of antitumor agents.Principal Investigator

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Integrated functionnal analyes of insulin-like peptides which regutate diapause and lifespan in Caenor habditis elegans

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Structure and Function of MBP-ligand oligosaccharides isolated from SW1116 cells

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Studies on the Molecular Recognition and Design of Ligands of Olfactory ReceptorsPrincipal Investigator

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DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION

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The functional analysis of RANKL signaling in osteoclast for developing the agonist of SHP-1

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DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION

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DEVELOPMENT OF NOVEL ASSAY SYSTEM FOR ANTI-ALLERGIC COMPOUNDS FROM NATURAL SOURCES AND APPLICATION

Principal Investigator

Project Period (FY)

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[Book] 膜タンパク質構造研究２５章受容体分子とリガンドのモデリング2013

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[Journal Article] Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to β-glycosides2016

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[Journal Article] Structural Basis of pH Dependence of Neoculin, a Sweet Taste-Modifying Protein.2015

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[Journal Article] Synthesis of the aglycon of pentalinoside2015

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[Journal Article] Synthesis of the Aglycon of the Argelosides: Antiprolierative 14,15-seco-Pregnane Glycosides2014

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[Journal Article] Mode-of-action and evolution of methylenedioxy bridge forming P450s in plant specialized metabolism2014

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ISHIGURO Masaji 石黒正路