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INOUE Nobutaka  井上 信孝

ORCIDConnect your ORCID iD *help
Researcher Number 10304099
Other IDs
Affiliation (based on the past Project Information) *help 2009: 循環器病センター, 研究員
2008: National Cardiovascular Center Research Institute, 脈管生理部, 室長
2001 – 2004: Kobe University, Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Assistant Professor, 大学院・医学系研究科, 助手
2000: Kobe University School of Medicine, Assistant Professor, 医学部, 助手
1999: 神戸大学, 医学部・附属病院, 助手
1991: Kobe University School of Medicine Hospital Clinical Fellow, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Respiratory organ internal medicine
Keywords
Principal Investigator
酸化ストレス / 動脈硬化 / 活性酸素 / NADPH oxidase / glutathione peroxidase / NADH / LOX-1 / 血管障害 / ズリ応力 / グルタシオンペルオキシダーゼ … More / 冠動脈 / チオレドキシン / グルタチオンペルオキシダーゼ / 酸化的ストレス / superoxide dismutase / 血管内皮細胞 / MMP / superoxide / atherosclerosis / NADH oxidase / shear stress / cytokine / gene transfer / coronary artery / NAD(P)H oxidase / 虚血性心疾患 / Superoxide dismutase / 粥腫不安定化機構 / thioredoxin / 精神的ストレス / Coronary artery disease / SOD / Unstable plaque … More
Except Principal Investigator
動脈硬化 / atherosclerosis / 活性酸素 / 冠動脈 / 内皮細胞 / endothelial cell / HDL / 酸化ストレス / 血管平滑筋 / oxidized LDL / NADH / NADPH oxidase / superoxide / リポ蛋白 / マクロファージ / 血管内皮細胞 / lipoprotein / smooth muscle cell / macrophage / 虚血性心疾患 / スーパーオキサイド / 高血圧性血管障害 / 内皮由来血管弛緩因子 / イノシト-ル燐脂質代謝回転 / 細胞内カルシウム / リゾホスファチジルコリン / 酸化低比重リポ蛋白 / 情報伝達機構 / 高比重リポ蛋白 / 酸化低比重リポ蛋白質 / endothelium-derived relaxing factor / phosphatidyl inositol tunover / cytosolic calcium / lysophosphatidylcholine / signal transduction system / 冠動脈疾患 / 酸化LDL / 免疫染色法 / NO合成酵素 / NADH oxidase / glutathione peroxidase / coronary artery disease / リパーゼ / 平滑筋細胞 / モレキュラークローニング / 免疫組織化学 / lipase / coronary artery / molecular cloning / 内皮型NO合成酵素 / テトラヒドロビオプテリン / 遺伝子操作マウス / スーパーオキシド / ジヒドロビオプテリン / GTPCH 1 / スパーオキシド / BH4 / apoE遺伝子欠損マウス / endothelial nitric oxide synthase / nitric oxide / tetrahydrobiopterin / gene-engineered mice / 炎症 / 高血圧 / ノックアウトマウス / inflammation / hypertension / スフィンゴシン1リン酸 / スフィンゴシンキナーゼ / 気管支喘息 / Sphingosine 1-phosphate / Sphingosine Kinase / Bronchial Asthma Less
  • Research Projects

    (10 results)
  • Research Products

    (3 results)
  • Co-Researchers

    (9 People)
  •  ストレス応答破綻として捉えた心血管病の分子機構と、新たな治療法開発に関する研究Principal Investigator

    • Principal Investigator
      井上 信孝
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Research of role of endothelial cell-derived lipase in atherosclerotic diseases and the development of novel therapeutics

    • Principal Investigator
      HIRATA Ken-ichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  The Study of Sphingolipid Metabolism in Airway Remodeling

    • Principal Investigator
      NISHIMURA Yoshihiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kobe University
  •  Balance-shift in the production of NO and superoxide via endothelial nitric oxide synthase in atherogenesis

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Cross talk of oxidative and chronic mental stress in pathogenesis of coronary artery disease.Principal Investigator

    • Principal Investigator
      INOUE Nobutaka
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  血管系NADH/NADPH oxidaseの分子的同定、活性化機構とその意義

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Role of Vascular NADH/NAPDH oxidase in atherogenesis

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Analysis of the functional role of endothelial cell derived lipase in atherosclerosis

    • Principal Investigator
      HIRATA Ken-ichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      Kobe University
  •  Regulation of Gene Expression of Antioxidative Enzymes in Vascular Cells and their Gene TransferPrincipal Investigator

    • Principal Investigator
      INOUE Nobutaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  An approach to understand the mechanism and pathogenesis of production and release of endothelium-derived relaxing factor by molecular and cellular biology technique.

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University

All 2008

All Journal Article

  • [Journal Article] LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice2008

    • Author(s)
      Hu C, Chen J, Dandapat A, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Li D, Hermonat PL, Sawamura T, Mehta JL
    • Journal Title

      J Mol Cell Cardiol 44

      Pages: 76-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590889
  • [Journal Article] Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells2008

    • Author(s)
      Honjo T, Otsui K, Shiraki R, Kawashima S, Sawamura T, Yokoyama M, Inoue N
    • Journal Title

      Endothelium 15

      Pages: 137-141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590889
  • [Journal Article] Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB2008

    • Author(s)
      Sato Y, Nishimichi N, Nakano A, Takikawa K, Inoue N, Matsuda H, Sawamura T
    • Journal Title

      Atherosclerosis 200

      Pages: 303-309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590889
  • 1.  YOKOYAMA Mitsuhiro (40135794)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  KAWASHIMA Seinosuke (10177678)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  HIRATA Ken-ichi (20283880)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KAWAHARA Yasuhiro (80169755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  AKITA Hozuka (60175792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ISHIKAWA Yuichi (90159707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NISHIMURA Yoshihiro (20291453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SATOUCHI Miyako (40346268)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  FUJIOKA Yoshio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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