INOUE Nobutaka 井上信孝

Researcher Number	10304099
Other IDs
Affiliation (based on the past Project Information) *help	2009: 循環器病センター, 研究員 2008: National Cardiovascular Center Research Institute, 脈管生理部, 室長 2001 – 2004: Kobe University, Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Assistant Professor, 大学院・医学系研究科, 助手 2000: Kobe University School of Medicine, Assistant Professor, 医学部, 助手 1999: 神戸大学, 医学部・附属病院, 助手 1991: Kobe University School of Medicine Hospital Clinical Fellow, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator 酸化ストレス / 動脈硬化 / 活性酸素 / NADPH oxidase / glutathione peroxidase / NADH / LOX-1 / 血管障害 / ズリ応力 / グルタシオンペルオキシダーゼ … More / 冠動脈 / チオレドキシン / グルタチオンペルオキシダーゼ / 酸化的ストレス / superoxide dismutase / 血管内皮細胞 / MMP / superoxide / atherosclerosis / NADH oxidase / shear stress / cytokine / gene transfer / coronary artery / NAD(P)H oxidase / 虚血性心疾患 / Superoxide dismutase / 粥腫不安定化機構 / thioredoxin / 精神的ストレス / Coronary artery disease / SOD / Unstable plaque … More Except Principal Investigator 動脈硬化 / atherosclerosis / 活性酸素 / 冠動脈 / 内皮細胞 / endothelial cell / HDL / 酸化ストレス / 血管平滑筋 / oxidized LDL / NADH / NADPH oxidase / superoxide / リポ蛋白 / マクロファージ / 血管内皮細胞 / lipoprotein / smooth muscle cell / macrophage / 虚血性心疾患 / スーパーオキサイド / 高血圧性血管障害 / 内皮由来血管弛緩因子 / イノシト-ル燐脂質代謝回転 / 細胞内カルシウム / リゾホスファチジルコリン / 酸化低比重リポ蛋白 / 情報伝達機構 / 高比重リポ蛋白 / 酸化低比重リポ蛋白質 / endothelium-derived relaxing factor / phosphatidyl inositol tunover / cytosolic calcium / lysophosphatidylcholine / signal transduction system / 冠動脈疾患 / 酸化LDL / 免疫染色法 / NO合成酵素 / NADH oxidase / glutathione peroxidase / coronary artery disease / リパーゼ / 平滑筋細胞 / モレキュラークローニング / 免疫組織化学 / lipase / coronary artery / molecular cloning / 内皮型NO合成酵素 / テトラヒドロビオプテリン / 遺伝子操作マウス / スーパーオキシド / ジヒドロビオプテリン / GTPCH 1 / スパーオキシド / BH4 / apoE遺伝子欠損マウス / endothelial nitric oxide synthase / nitric oxide / tetrahydrobiopterin / gene-engineered mice / 炎症 / 高血圧 / ノックアウトマウス / inflammation / hypertension / スフィンゴシン1リン酸 / スフィンゴシンキナーゼ / 気管支喘息 / Sphingosine 1-phosphate / Sphingosine Kinase / Bronchial Asthma Less

ストレス応答破綻として捉えた心血管病の分子機構と、新たな治療法開発に関する研究Principal Investigator
- Principal Investigator
  
  井上信孝
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Research of role of endothelial cell-derived lipase in atherosclerotic diseases and the development of novel therapeutics
- Principal Investigator
  
  HIRATA Ken-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
The Study of Sphingolipid Metabolism in Airway Remodeling
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
Balance-shift in the production of NO and superoxide via endothelial nitric oxide synthase in atherogenesis
- Principal Investigator
  
  YOKOYAMA Mitsuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
Cross talk of oxidative and chronic mental stress in pathogenesis of coronary artery disease.Principal Investigator
- Principal Investigator
  
  INOUE Nobutaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
血管系NADH/NADPH oxidaseの分子的同定、活性化機構とその意義
- Principal Investigator
  
  YOKOYAMA Mitsuhiro
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
Role of Vascular NADH/NAPDH oxidase in atherogenesis
- Principal Investigator
  
  YOKOYAMA Mitsuhiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
Analysis of the functional role of endothelial cell derived lipase in atherosclerosis
- Principal Investigator
  
  HIRATA Ken-ichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Kobe University
Regulation of Gene Expression of Antioxidative Enzymes in Vascular Cells and their Gene TransferPrincipal Investigator
- Principal Investigator
  
  INOUE Nobutaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
An approach to understand the mechanism and pathogenesis of production and release of endothelium-derived relaxing factor by molecular and cellular biology technique.
- Principal Investigator
  
  YOKOYAMA Mitsuhiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University

All 2008

All Journal Article

[Journal Article] LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice2008
- Author(s)
  Hu C, Chen J, Dandapat A, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Li D, Hermonat PL, Sawamura T, Mehta JL
- Journal Title
  
  J Mol Cell Cardiol 44
  
  Pages: 76-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590889
[Journal Article] Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells2008
- Author(s)
  Honjo T, Otsui K, Shiraki R, Kawashima S, Sawamura T, Yokoyama M, Inoue N
- Journal Title
  
  Endothelium 15
  
  Pages: 137-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590889
[Journal Article] Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB2008
- Author(s)
  Sato Y, Nishimichi N, Nakano A, Takikawa K, Inoue N, Matsuda H, Sawamura T
- Journal Title
  
  Atherosclerosis 200
  
  Pages: 303-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590889

1. YOKOYAMA Mitsuhiro (40135794)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. KAWASHIMA Seinosuke (10177678)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HIRATA Ken-ichi (20283880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAWAHARA Yasuhiro (80169755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AKITA Hozuka (60175792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIKAWA Yuichi (90159707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIMURA Yoshihiro (20291453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SATOUCHI Miyako (40346268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUJIOKA Yoshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

INOUE Nobutaka 井上 信孝

Research Projects

Research Products

Co-Researchers

ストレス応答破綻として捉えた心血管病の分子機構と、新たな治療法開発に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of role of endothelial cell-derived lipase in atherosclerotic diseases and the development of novel therapeutics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Study of Sphingolipid Metabolism in Airway Remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Balance-shift in the production of NO and superoxide via endothelial nitric oxide synthase in atherogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cross talk of oxidative and chronic mental stress in pathogenesis of coronary artery disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管系NADH/NADPH oxidaseの分子的同定、活性化機構とその意義

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Vascular NADH/NAPDH oxidase in atherogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the functional role of endothelial cell derived lipase in atherosclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Regulation of Gene Expression of Antioxidative Enzymes in Vascular Cells and their Gene TransferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An approach to understand the mechanism and pathogenesis of production and release of endothelium-derived relaxing factor by molecular and cellular biology technique.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice2008

Author(s)

Journal Title

Data Source

[Journal Article] Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB2008

Author(s)

Journal Title

Data Source

INOUE Nobutaka 井上信孝