KOBUCHI Hirotsugu 小渕浩嗣

… Alternative Names

小渕浩嗣コブチヒロツグ

Less

Researcher Number	10304297
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 岡山大学, 医歯薬学域, 講師 2019 – 2020: 岡山大学, 医歯薬学総合研究科, 講師 2017: 岡山大学, 大学院医歯薬学総合研究科, 講師 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 講師 2011 – 2016: 岡山大学, 医歯(薬)学総合研究科, 講師 2014: 岡山大学, 大学院医歯薬学総合研究科, 講師
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Environmental physiology (including Physical medicine and Nutritional physiology) Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Radiation science / Laboratory medicine
Keywords	Principal Investigator 抗腫瘍効果 / 情報伝達経路 / ABC輸送体 / 細胞増殖抑制 / siRNA / アポトーシス / 遺伝子発現抑制 / HIF-1 / 細胞死 / 低分子二本鎖RNA … More / がん / ABCトランスポーター / アミノレブリン酸 / 酸化還元制御 / 低分子化合物 / 生体成分 / 酸化還元レベル / 転写因子 / 活性酸素 / 機能性分子 / 筋管細胞 / 酸化ストレス / エネルギー代謝 / 機能性化合物 / ミトコンドリア … More Except Principal Investigator 破骨細胞 / ゲノム編集 / 標的医療 / PETイメージング / ノックアウトマウス / 質量分析 / 変性骨 / Dig-hereシグナル受容体 / 新規受容体 / 骨リモデリング / 骨の鮮度 / CRISPR-Cas9 / 発生工学 / マウス / PET / 核医学 / Klotho KOマウス / 光増感剤 / 深部病巣 / 光線力学療法（PDT） / Drug Delivery System / Lactosome / Cherenkov光 / Photodynamic Therapy / Theranostics / 酸化低密度リポタンパク質　(oxLDL) / PET イメージング / 酸化脂質 / 変異　β2GPI-DV / β2－グリコプロテインI　（β2GPI） / 脂質メタボローム / 分子イメージング / LC-MSMS / 酸化リポタンパク質 / 酸化資質 / 質量顕微鏡 / 変異β2GPI-DV / β2-グリコプロテインI　(β2GPI) / LC-MS/MS / リピドミクス / メタボロミクス / 抗リン脂質抗体症候群 / 血管新生 / 血栓・止血 / Beta2-glycoprotein I / 動脈硬化 / CRISPR/Cas9 system / グルタチオン / differentiation / inflammation / glutathione / osteoclast / 破骨細胞形成 / 新規因子 / ハイスループットスクリーング / 炎症性サイトカイン / 骨髄間葉系幹細胞 Less

骨変性部位の目印「dig-hereシグナル」を認識する破骨細胞特異的受容体の探索
- Principal Investigator
  
  藤田洋史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Analysis of cell death induction and antitumor effect by suppression of the expression of ABC transporterPrincipal Investigator
- Principal Investigator
  
  小渕浩嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
The role of pattern recognition receptors in osteoclast differentiation and function
- Principal Investigator
  
  Fujita Hirofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of a novel radiological-photo-therapy essential for Theranostics targeting deep lesions
- Principal Investigator
  
  MATSUURA Eiji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Okayama University
Mechanism of glutathione-induced stimulation of osteoclast differentiation
- Principal Investigator
  
  Fujita Hirofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
Establishment of Molecular Imaging and Lipidomics Technologies for Early Diagnosis of Atherosclerotic Disease
- Principal Investigator
  
  MATSUURA Eiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
Search for novel osteoclast regulatory factors produced by bone marrow mesenchymal stem cells
- Principal Investigator
  
  FUJITA Hirofumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
The search of factors to induce mitochondrial biogenesis, and the analysis of its cellular functionsPrincipal Investigator
- Principal Investigator
  
  KOBUCHI Hirotsugu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Okayama University

All 2023 2017 2016 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7.2023
- Author(s)
  Haruna Harada, Koko Moriya, Hirotsugu Kobuchi, Naotada Ishihara, Toshihiko Utsumi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 (1) Issue: 1 Pages: 22991-22991
- DOI
  10.1038/s41598-023-50390-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05827, KAKENHI-PROJECT-21K07124
[Journal Article] Phytoestrogen Suppresses Efflux of the Diagnostic Marker Protoporphyrin IX in Lung Carcinoma.2016
- Author(s)
  Fujita H, Nagakawa K, Kobuchi H, Ogino T, Kondo Y, Inoue K, Shuin T, Utsumi T, Utsumi K, Sasaki J, Ohuchi H.
- Journal Title
  
  Cancer Res
  
  Volume: 76 Issue: 7 Pages: 1837-1846
- DOI
  10.1158/0008-5472.can-15-1484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10475, KAKENHI-PROJECT-26450125, KAKENHI-PROJECT-16K10915
[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine.2014
- Author(s)
  Ogino T, Kobuchi H, Fujita H, Matsukawa A, Utsumi K.
- Journal Title
  
  Free Radical Research
  
  Volume: 48(3) Pages: 292-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659122
[Journal Article] Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.2014
- Author(s)
  Fujita H, Yamamoto M, Ogino T, Kobuchi H, Ohmoto N, Aoyama E, Oka T, Nakanishi T, Inoue K, Sasaki J
- Journal Title
  
  Cell Biochemistry & Function
  
  Volume: 32(1) Issue: 1 Pages: 77-86
- DOI
  10.1002/cbf.2974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659122, KAKENHI-PROJECT-24592263, KAKENHI-PROJECT-25460437
[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine2014
- Author(s)
  Ogino T, Kobuchi H, Fujita H, Matsukawa A, and Utsumi K
- Journal Title
  
  Free Radical Research
  
  Volume: vol.48(3) Pages: 292-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659122
[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine.2014
- Author(s)
  Ogino T, Kobuchi H, Fujita H, Matsukawa A, Utsumi K.
- Journal Title
  
  Free Radic Res.
  
  Volume: 48 Issue: 3 Pages: 292-302
- DOI
  10.3109/10715762.2013.865840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592263
[Journal Article] Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation.2012
- Author(s)
  Kobuchi H, Moriya K, Ogino T, Fujita H, Inoue K, Shuin T, Yasuda T, Utsumi K, Utsumi T
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 11 Pages: e50082-e50082
- DOI
  10.1371/journal.pone.0050082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580136, KAKENHI-PROJECT-23659122, KAKENHI-PROJECT-24592263
[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.2011
- Author(s)
  Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, Utsumi K.
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 358 Issue: 1-2 Pages: 297-307
- DOI
  10.1007/s11010-011-0980-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580136, KAKENHI-PROJECT-23659122
[Presentation] ABCG2 siRNA導入によるがん細胞のアポトーシス誘導2017
- Author(s)
  小渕浩嗣、藤田洋史
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K10475
[Presentation] 植物性エストロゲンはガン診断マーカープロトポルフィリンIXの排出を抑制する2017
- Author(s)
  藤田洋史, 永川恵介, 小渕浩嗣, 荻野哲也, 近藤洋一, 井上啓史, 執印太郎, 内海俊彦, 内海耕慥, 佐々木順造, 大内淑代
- Organizer
  第114回岡山医学会総会
- Data Source
  KAKENHI-PROJECT-15K10475
[Presentation] ヘム代謝制御に基づく光感受性物質protoporphyrin IX蓄積機構の研究2016
- Author(s)
  藤田洋史, 永川恵介, 小渕浩嗣, 荻野哲也, 近藤洋一, 井上啓史, 執印太郎, 内海俊彦, 内海耕慥, 佐々木順造, 大内淑代
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-15K10475
[Presentation] Oxidative stress and cell differentiation: monochloramine affects differentiation of K562 erythroleukemia cell line.2014
- Author(s)
  Tetsuya Ogino, Hirotsugu Kobuchi, Hirofumi Fujita.
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24592263
[Presentation] Effects of bone marrow mesenchymal stem cells on TNF-alpha-induced osteoclast formation and ROS generation in bone marrow macrophages.2014
- Author(s)
  Hirofumi Fujita, Tetsuya Ogino, Kobuchi Hirotsugu, Hideyo Ohuchi.
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24592263
[Presentation] アセチル-L-カルニチンによる無尾両生類幼生尾部短縮の抑制2013
- Author(s)
  花田秀樹, 小渕浩嗣, 柏木啓子, 内海俊彦, 井上正康, 佐々木順造, 勝賢二郎, 佐藤英介, 内海耕慥, 柏木昭彦
- Organizer
  84回日本動物学
- Place of Presentation
  岡山
- Year and Date
  2013-09-26
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] 骨芽細胞分化培養に伴う石灰化と活性酸素の関与2013
- Author(s)
  藤田洋史、小渕浩嗣、内海耕慥、佐々木順造、大内淑代
- Organizer
  第30回日本骨代謝学
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24592263
[Presentation] アセチル-L-カルニチンによる無尾両生類幼生尾部短縮の抑制2013
- Author(s)
  花田秀樹、小渕浩嗣、柏木啓子、内海　俊彦、井上正康、佐々木順造、勝賢二郎、佐藤英介、内海耕慥、柏木昭彦
- Organizer
  第８４回　日本動物学会
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] マウス骨髄細胞培養系におけるTNF-a による破骨細胞形成と骨髄間様系細胞によるその抑制効果2013
- Author(s)
  藤田洋史、小渕浩嗣、内海耕慥、佐々木順造、大内淑代
- Organizer
  第８６回　日本生化学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] ALA 投与のよるプロトポルフィリンIX 蓄積における ABCトランスポーターABCG2 の役割とミトコンドリア局在2013
- Author(s)
  小渕浩嗣, 守屋康子, 荻野哲也, 藤田洋史, 井上啓史, 執印太郎, 保田立二, 内海耕慥, 内海俊彦
- Organizer
  第3回ポルフィリン- ALA 学会
- Place of Presentation
  神奈川
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] マウス骨髄細胞培養系におけるTNF-α による破骨細胞形成と骨髄間様系細胞によるその抑制効2013
- Author(s)
  藤田洋史, 小渕浩嗣, 内海耕慥, 佐々木順造, 大内淑代
- Organizer
  86回日本生化学大
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] ALA投与によるプロトポルフィリンIX蓄積におけるABCトランスポーターABCG2の役割とミトコンドリア局在2013
- Author(s)
  小渕浩嗣、守屋康子、荻野哲也、藤田洋史、井上啓史、執印太郎、保田立二、内海耕慥、内海俊彦
- Organizer
  第３回ポルフィリン－ALA学会
- Place of Presentation
  東京工業大学
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] 5-アミノレブリン酸によるプロトポルフィリンIX 蓄積における ABCG2 のミトコンドリア局在と機能2012
- Author(s)
  小渕浩嗣、守屋康子、荻野哲也、藤田洋史、井上啓史、執印太郎、保田立二、内海耕慥、内海俊彦
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] 5-アミノレブリン酸によるプロトポルフィリンIX 蓄積におけるABCG2 のミトコンドリア局在と機能2012
- Author(s)
  小渕浩嗣, 守屋康子, 荻野哲也, 藤田洋史, 井上啓史, 執印太郎, 保田立二, 内海耕慥, 内海俊彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] ABCG2 のミトコンドリア局在とプロトポルフィリンIX 蓄積の制御2012
- Author(s)
  小渕浩嗣, 内海俊彦, 荻野哲也, 保田立二, 内海耕慥
- Organizer
  第53回日本生化学会中国・四国支部例会
- Place of Presentation
  岡山
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] ABCG2のミトコンドリア局在とプロトポルフィリンIX蓄積の制御2012
- Author(s)
  小渕浩嗣、内海俊彦、荻野哲也、保田立二、内海耕慥
- Organizer
  第５３回日本生化学会中国・四国支部例会
- Place of Presentation
  岡山大学創立五十周年記念館
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] 骨髄間葉系幹細胞のosteogenic cultureによる細胞死仲介性石灰化と活性酸素の関与2012
- Author(s)
  藤田洋史、大本苗起子、永川恵介、小渕浩嗣、荻野哲也、大内淑代、佐々木順造、内海耕慥
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24592263
[Presentation] がん細胞のポルフィリン蓄積におけるABCG2 の役割2011
- Author(s)
  小渕浩嗣, 内海俊彦, 内海耕慥, 保田立二
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659122
[Presentation] がん細胞のポルフィリン蓄積におけるABCG2の役割2011
- Author(s)
  小渕浩嗣、内海俊彦、内海耕慥、保田立二
- Organizer
  第８４回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23659122

1. FUJITA Hirofumi (20423288)

# of Collaborated Projects: 6 results

# of Collaborated Products: 18 results
2. MATSUURA Eiji (20181688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TAKENAKA Fumiaki (10642522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OHMOTO Naoko (70598565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SASAKI Takanori (10461253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOBAYASHI Kazuko (20304298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OZEKI Eiichi (30192529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJIWAKE Hideshi (50395696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AKEHI Masaru (50786738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 保田晋助 (00374231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 内海俊彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

KOBUCHI Hirotsugu 小渕 浩嗣

小渕 浩嗣 コブチ ヒロツグ

Research Projects

Research Products

Co-Researchers

骨変性部位の目印「dig-hereシグナル」を認識する破骨細胞特異的受容体の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cell death induction and antitumor effect by suppression of the expression of ABC transporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of pattern recognition receptors in osteoclast differentiation and function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel radiological-photo-therapy essential for Theranostics targeting deep lesions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of glutathione-induced stimulation of osteoclast differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of Molecular Imaging and Lipidomics Technologies for Early Diagnosis of Atherosclerotic Disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for novel osteoclast regulatory factors produced by bone marrow mesenchymal stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The search of factors to induce mitochondrial biogenesis, and the analysis of its cellular functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phytoestrogen Suppresses Efflux of the Diagnostic Marker Protoporphyrin IX in Lung Carcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine.2014

Author(s)

Journal Title

Data Source

[Journal Article] Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine2014

Author(s)

Journal Title

Data Source

[Journal Article] Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine.2014

Author(s)

Journal Title

DOI

KOBUCHI Hirotsugu 小渕浩嗣

小渕浩嗣コブチヒロツグ