Tomiyama Takami 富山貴美

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TOMIYAMA Takami 富山貴美

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Researcher Number	10305633
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 特任教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 大阪市立大学, 大学院医学研究科, 准教授 2012 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 准教授 2007 – 2011: Osaka City University, Medical School, Neuroscience, Associate Professor 2006: 大阪市立大学, 大学院医学研究科, 講師 2001 – 2005: 大阪市立大学, 大学院・医学研究科, 講師 2004: Osaka City University, Graduate School of Medical Sciences, Lecturer, 大学院医学研究科, 講師 1999 – 2000: 大阪市立大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Natural medicines / Neurology / Biological Sciences / Neurochemistry/Neuropharmacology / Biological Sciences Except Principal Investigator Biological Sciences / Nerve anatomy/Neuropathology / Neurology / Neurology / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator Aβ / アルツハイマー病 / タウ / トランスジェニックマウス / 生薬 / 生薬抽出物 / 腸内フローラ / 認知症 / Memory / Model mouse … More / Herb extract / Fecal transplantation / Antibiotic / Alzheimer's dsease / Dementia / Gut microbiota / 病理伝播 / アミロイドβ / マイクロダイアリシス / モデルマウス / 細胞障害 / シナプス障害 / tau / シナプス機能 / 認知機能 / スパイン / 細胞内Aβオリゴマー / 危険因子 / アポリポ蛋白質 / ABCA1 / HDL / コレステロール / E693Δ変異 / APP / オリゴマー / ニューロン消失 / アストロサイト / ミクログリア / 異常リン酸化タウ / APP E693Δ変異 / Aβオリゴマー … More Except Principal Investigator APP / 脳神経疾患 / FTDP-17 / 認知症 / RNA editing / tau / splicing / 脳・神経 / エクソン10 / タウ / スプライシング / 神経科学 / presenilin / プレセニリン / アミロイド / 老化 / 痴呆 / タウ蛋白 / アルツハイマー病 / PIB / senile placate / imagin / Alzheimer / Amyloid / PET / 画像化 / dementia / exon 17 / 細胞毒性 / TUNEL / カスパーゼ3 / アポトーシス / 細胞死 / アミロイド蛋白 / nicastrin / sporadic Alzheimer's disease / 弧発性アルツハイマー病 / ニカストリン / 孤発性アルツハイマー病 / tauopachy / exon 10 / neurodegeneration / Dementia / Neuroscience / タウオパチー / neurotoxicity / model / transgenic mouse / Abeta, senile plaque / Alzheimer's disease / マルツハイマー病 / 神経毒性 / モデル / トランスジェニックマウス / 老人斑 / オリゴマー / アイソフォーム / 神経原線維変化 / 痴呆症 Less

Dementia and gut microbiotaPrincipal Investigator
- Principal Investigator
  
  TOMIYAMA Takami
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Osaka City University
The molecular action of Abeta oligomer on Alzheimer's disease.
- Principal Investigator
  
  MORI HIROSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka City University
Transmission study of Alzheimer pathology using brain microdialysisPrincipal Investigator
- Principal Investigator
  
  TOMIYAMA Takami
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
細胞内Ａβオリゴマーによるシナプス・細胞障害とｔａｕとの相互作用Principal Investigator
- Principal Investigator
  
  富山貴美
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Physiological function of Aβ in regulation of brain cholesterolPrincipal Investigator
- Principal Investigator
  
  TOMIYAMA Takami
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka City University
Aβオリゴマー仮説を検証する新しいアルツハイマー病モデルマウスの作製Principal Investigator
- Principal Investigator
  
  富山貴美
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Molecular imaging ofAlzheimer amyloid
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka City University
Alternated splicing of tau in development and neurodegenerating disorders with dementia.
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
Fundamental study on the molecular mechanism for neuropathological changes of dementia
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
A study for the contribution of RNA editing abnormality in sporadic Alzheimer's disease.
- Principal Investigator
  
  TAKUMA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
神経細胞内の分子移動障害による痴呆発症機構の解明
- Principal Investigator
  
  MORI HIROSHI
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Neuropathological study on Abeta toxicity using transgenic mice with human APP
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka City University

[Journal Article] Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.2015
- Author(s)
  Umeda T., Ramser E.M., Yamashita M., Nakajima K., Mori H., Silverman M.A., Tomiyama T
- Journal Title
  
  Acta Neuropathol. Commun
  
  Volume: 3 Issue: 1 Pages: 51-51
- DOI
  10.1186/s40478-016-0273-z
- NAID
  120006371272
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290018
[Journal Article] Increased GADD34 in oligodendrocytes in Alzheimer's disease.2015
- Author(s)
  Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 602 Pages: 50-55
- DOI
  10.1016/j.neulet.2015.06.052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-23111002
[Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.2014
- Author(s)
  Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 127(5) Issue: 5 Pages: 685-98
- DOI
  10.1007/s00401-014-1259-1
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-26117004
[Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice2014
- Author(s)
  Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Acta Neuropathol
  
  Volume: 127 Pages: 684-698
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Neurodegenerative disorder FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] The E693D (Osaka) Mutation in Amyloid Precursor Protein Potentiates Cholesterol-Mediated Intracellular Amyloid b Toxicity Via Its Impaired Cholesterol Efflux2013
- Author(s)
  Nomura S , Umeda T, Tomiyama T, Mori H.
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Issue: 12 Pages: 1541-1550
- DOI
  10.1002/jnr.23278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290018
[Journal Article] Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis2013
- Author(s)
  Takano M., Yamashita T., Nagano K., Otani M., Maekura K., Kamada H., Tsunoda S., Tsutsumi Y., Tomiyama T., Mori H., Matsuura K., Matsuyama S
- Journal Title
  
  Neuroscience Letters
  
  Volume: 534 Pages: 85-9
- DOI
  10.1016/j.neulet.2012.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650641, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25860196
[Journal Article] Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol.
  
  Volume: 183(1) Issue: 1 Pages: 211-25
- DOI
  10.1016/j.ajpath.2013.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25461266
[Journal Article] Neurodegenerative disorder FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol
  
  Volume: 183 Pages: 211-225
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Hypercholesterolemia accelerates intraneuronal accumulation of Aboligomers resulting in memory impairment in Alzheimer's disease model mice2012
- Author(s)
  Umeda T, Tomiyama T, KitajimaE, Idomoto T, Nomura S, Lambert M.P, Klein W.L, Mori H
- Journal Title
  
  Life Science
  
  Volume: 90(in Press) Issue: 23-24 Pages: 90-90
- DOI
  10.1016/j.lfs.2011.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390271, KAKENHI-PROJECT-21500352
[Journal Article] Aβオリゴマーを標的とするアルツハイマー病治療薬の展望2012
- Author(s)
  富山貴美
- Journal Title
  
  Dementia Japan
  
  Volume: 26 Pages: 300-310
- Data Source
  KAKENHI-PUBLICLY-23110514
[Journal Article] 細胞内Aβオリゴマーによるアルツハイマー病発症機構2012
- Author(s)
  富山貴美
- Journal Title
  
  Dementia Japan
  
  Volume: 26 Pages: 225-241
- Data Source
  KAKENHI-PUBLICLY-23110514
[Journal Article] 細胞内Aβオリゴマーによるアルツハイマー病発症機構2012
- Author(s)
  富山貴美
- Journal Title
  
  Dementia　Japan
  
  Volume: 26 Pages: 225-241
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Aβオリゴマーを標的とするアルツハイマー病治療薬の展望2012
- Author(s)
  富山貴美
- Journal Title
  
  Dementia　Japan
  
  Volume: 26 Pages: 300-310
- Data Source
  KAKENHI-PROJECT-24659434
[Journal Article] Aβオリゴマー仮説-アルツハイマー病の新しい考え方-2010
- Author(s)
  富山貴美
- Journal Title
  
  Dementia Japan 24
  
  Pages: 37-45
- Data Source
  KAKENHI-PROJECT-20023026
[Journal Article] Regulation of cholesterol efflux by amyloidβsecretion2010
- Author(s)
  Umeda T., Mori H., Zheng H., Tomiyama T
- Journal Title
  
  J. Neurosci. Res.
  
  Volume: 88 Pages: 1985-1994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500352
[Journal Article] 病因分子としてのβアミロイド2010
- Author(s)
  富山貴美
- Journal Title
  
  Brain and Nerve 62(in press)
- Data Source
  KAKENHI-PROJECT-20023026
[Journal Article] A mouse model of amyloid β oligomers : Their contribution to synapticalteration, abnormal tau phophorylation, glial activation, and neuronalloss in vivo2010
- Author(s)
  Takami Tomiyama
- Journal Title
  
  Journal of Neuroscience 30(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023026
[Journal Article] βアミロイドオリゴマーとシナプス機能障害2009
- Author(s)
  富山貴美
- Journal Title
  
  Cognition and Dementia 8
  
  Pages: 209-215
- Data Source
  KAKENHI-PROJECT-20023026
[Journal Article] A new amyloid βvariant favoring oligomerization in Alzheimer-typedementia.2008
- Author(s)
  Tomiyama,T.,Nagata,T.,Shimada,H.,Teraoka,T.,Fukushima,A.,Kanemitsu,H,Takuma,H.,Kuwano,R.,Imagawa,M.,Ataka,S.,Wada,Y.,Yoshioka,E.,Nishizaki,T.,Watanabe,Y.,and Mori,H.
- Journal Title
  
  Ann.Neurol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia.2008
- Author(s)
  Tomiyama, T., Nagata, T., Shimada, H., Teraoka, T., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., Wada, Y., Yoshioka, E., Nishizaki, T., Watanabe, Y, and Mori, H.
- Journal Title
  
  Ann. Neurol. (In press)(In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Cerebral vascular accumulation of Dutch-type Aβ42,but not wild-type Aβ42,in hereditary cerebral hemorrhage with amyloidosis,Dutch type.2007
- Author(s)
  Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C., Iwai, K., and Mori, H.
- Journal Title
  
  J.Neurosci.Res. 85
  
  Pages: 2917-2923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Inverse correlation between APP and synaptic plasticity in trallsgenic mice.2007
- Author(s)
  Matsuvama. S., Tbraoka, R., Mori H., and Tomiyama, T.
- Journal Title
  
  NeuroReport 18
  
  Pages: 1083-1087
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Inverse correlation between APP and synaptic plasticity in transgenic mice.2007
- Author(s)
  Matsuyama, S., Teraoka, R., Mori H., and Tomiyama, T.
- Journal Title
  
  NeuroReport 18
  
  Pages: 1083-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Cerebral vascular accumulation of Dutch-type A1342, but not wild-type A1342, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.2007
- Author(s)
  Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C.Iwai, K., Mori, H
- Journal Title
  
  J. Neurosci. Res 85
  
  Pages: 2917-2923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Cerebral vascular accumulation of Dutch-type Af342, but not wild-type Af342, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.2007
- Author(s)
  Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C., Iwai, K., Mori, H
- Journal Title
  
  J. Neurosci. Res 85
  
  Pages: 2917-2923
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Structure-activity relationship of chalcones and relatedderivatives as ligands for detecthlg of β-alnyloid plaques in the brain.2007
- Author(s)
  Ono, M., Hori, M., Haratake, M., Tomiyama, T, Mori, H., and Nakayama, M.
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 6388-6396
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Cerebral vascular accumulation of Dutch-type Aβ42, but not wild-type Aβ42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type2007
- Author(s)
  Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Sclueman, M.L., Roos, R.A.C., Iwai, K., and Mori, H.
- Journal Title
  
  J. Neurosci. Res. 85
  
  Pages: 2917-2923
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Longitudinal,quantitative assessment of amyloid,neuroinflammation and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by PET.2007
- Author(s)
  Maeda,J.,Ji,B.,Irie,T.,Tomiyama,T.,Maruyama,M.,Okauchi,T.,Staufenbiel,M.,Iwata,N.,Ono,M.,Saido,T.C.,Suzuki,K.,Mori,H.,Higuchi,M.,and Suhara,T.
- Journal Title
  
  J.Neurosci. 27
  
  Pages: 10957-10968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Structure-activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain.2007
- Author(s)
  Ono, M., Hori, M., Haratake, M., Tomiyama, T., Mori, H., and Nakayama, M.
- Journal Title
  
  Bioorg.Med.Chem 15
  
  Pages: 6388-6396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Inverse correlation between APP and synaptic plasticity in transgenic mice2007
- Author(s)
  Matsuyama, S., Teraoka, R., Mori H., Tomiyama, T
- Journal Title
  
  NeuroReport 18
  
  Pages: 1083-1087
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Structure-activity relationship of chalcones and related derivatives as ligands for detecting of f3-amyloid plaques in the brain2007
- Author(s)
  Ono, M., Hori, M., Haratake, M., Tomiyama, T., Mori, H., and Nakayama, M
- Journal Title
  
  Bioorg. Med. Chem 15
  
  Pages: 6388-6396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Longitudinal, quantitative assessment of amyloid, neuroinflammation and anti-amyloid treatment in aliving mouse model of Alzheimer's disease enabled by PET.2007
- Author(s)
  Maeda, J., Ji, B., Irie, T., Tomiyama, T., Maruyama, M., Okauchi, T., Staufenbiel, M., Iwata, N., Ono, M., Saido, T.C., Suzuki, K., Mori, H., Hiuchi, M., and Suhara, T.
- Journal Title
  
  J. Neurosci. 27
  
  Pages: 10957-10968
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Absence of synaptophysin near cortical neurons containing oligomer Aβ in Alzheimer's disease brain.2006
- Author(s)
  Ishibashi, K., Tomiyama, T., Nishitsuji, K., Hara, M., and Mori, H.
- Journal Title
  
  J. Neurosci. Res. 84
  
  Pages: 632-636
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Improved Long-Term Potentiation and Memory in Young Tau-P301 L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy2006
- Author(s)
  Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, GJ., de Vos, K., Krugers, H., Tomiyama, T., Mori, H., Joels, M., van Leuven, F., Lucassenl, P.J
- Journal Title
  
  J. Neurosci 26
  
  Pages: 3514-3523
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Absence of synaptophysin near cortical neurons containing oligomer A(3 in Alzheimer's disease brain2006
- Author(s)
  Ishibashi, K., Tomiyama, T., Nishitsuji, K., Hara, M., Mori, H
- Journal Title
  
  J. Neurosci. Res 84
  
  Pages: 632-636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 102005
- Author(s)
  Yamashita, T., Tomiyama, T., Li, Q., Numata, H., Mori, H
- Journal Title
  
  FEBS Lett 579
  
  Pages: 241-244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Regulation of tau exon 10 splicuig by a double stein-loop structure in mouse intron 102005
- Author(s)
  Yamashita, T., Tomiyama, T., Li, Q., Numata, H., and Mori, H.
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 241-244
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10.2005
- Author(s)
  Yamashita T, Tomiyama T, Li Q, Numata H, Mori H
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 241-244
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Syntaxin 5 interacts specifically with presenilin holoprotehls and affects processing of βAPP in neuronal cells.2005
- Author(s)
  Suga, K., Saito, A., Tomiyama, T., Mori, H., and Akagawa, K.
- Journal Title
  
  J. Neurochem. 94
  
  Pages: 425-439
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of f3APP in neuronal cells2005
- Author(s)
  Suga, K., Saito, A., Tomiyama, T., Mori, H., Akagawa, K
- Journal Title
  
  J. Neurochem 94
  
  Pages: 425-439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, T sutada T, Kawabata K, Mori H, Miki T
- Journal Title
  
  Arch.Neurol. 61(11)
  
  Pages: 1773-1776
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H
- Journal Title
  
  J. Neuropathol. Exp. Neurol. 63(3)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H
- Journal Title
  
  J.Neuropathol.Exp.Neurol. 63(3)
  
  Pages: 255-2061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Presenilin holoproteins, but not their N-or C-terminal fragments, interact with syntaxin 5.2004
- Author(s)
  Suga K, Tomiyama T, Mori H, Akagawa K
- Journal Title
  
  Biochem.J. 381
  
  Pages: 619-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.2004
- Author(s)
  Takuma H, Tomiyama T, Kuida K, Mori H.
- Journal Title
  
  J. Neuropathol. Esp. Neurol. 63(3)
  
  Pages: 255-261
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Presenilin holoproteins, but not their N- or C-terminal fragments, interact with syntaxin 5.2004
- Author(s)
  Suga K, Tomiyama T, Mori H, Akagawa K
- Journal Title
  
  Biochem. J. 381
  
  Pages: 619-628
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo2004
- Author(s)
  Hiroshi Takuma, Takami Tomiyama, Keisuke Kuida, Hiroshi Mori
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 63(3)
  
  Pages: 255-261
- Data Source
  KAKENHI-PROJECT-16590841
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki H.
- Journal Title
  
  Arch. Neurol. 61(11)
  
  Pages: 1773-1776
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis.2004
- Author(s)
  Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki T
- Journal Title
  
  Arch. Neurol. 61(11)
  
  Pages: 1773-1776
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Presenilin holoproteins, but not their N- or C-terminal fragments, interact with syntaxin 5.2004
- Author(s)
  Suga K, Tomiyama T, Mori H, Akagawa K.
- Journal Title
  
  Biochem. J. 381(Pt 3)
  
  Pages: 619-628
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Dimerization of presenilin-1 in vivo : suggestion of novel regulatory mechanisms leading to higher order complexes.2003
- Author(s)
  Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G
- Journal Title
  
  Biochem.Biophys.Res.Commun. 301(1)
  
  Pages: 119-126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein (COMP) affects its early vesicle trafficking in ER and induces apoptosis.2003
- Author(s)
  Hashimoto Y, Tomiyama T, Yamano Y, Mori H
- Journal Title
  
  Am.J.Pathol. 163(1)
  
  Pages: 101-110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Human neprilysin is capable of degrading amyloid b_peptide not only in the monomeric form but also the pathological oligomeric form.2003
- Author(s)
  Kanemitsu H, Tomiyama T, Mori H
- Journal Title
  
  Neurosci. Lett. 350
  
  Pages: 113-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome.2003
- Author(s)
  Mori H, Tomiyama T, Maeda N, Ozawa K, Wakasa K
- Journal Title
  
  Neuropathology 23(1)
  
  Pages: 51-56
- NAID
  50000792247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Human neprilysin is capable of degrading amyloid b_peptide not only in the monomeric form but also the pathological oligomeric form.2003
- Author(s)
  Kanemitsu H, Tomiyama T, Mori H
- Journal Title
  
  Neurosci.Lett. 350
  
  Pages: 113-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein (COMP) affects its early vesicle trafficking in ER and induces apoptosis.2003
- Author(s)
  Hashimoto Y, Tomiyama T, Yamano Y, Mori H
- Journal Title
  
  Am. J. Pathol. 163(1)
  
  Pages: 101-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form.2003
- Author(s)
  Kanemitsu H, Tomiyama T, Mori H.
- Journal Title
  
  Neurosci. Lett. 350(2)
  
  Pages: 113-116
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Dimerization of presenilin-1 in vivo : suggestion of novel regulatory mechanisms leading to higher order complexes.2003
- Author(s)
  Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G
- Journal Title
  
  Biochem. Biophys. Res. Commun. 301(1)
  
  Pages: 119-126
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D).2002
- Author(s)
  Ozawa K, Tomiyama T, Maat-Schieman ML, Roos RA, Mori H
- Journal Title
  
  Ann. NY Acad. Sci. 977
  
  Pages: 149-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D).2002
- Author(s)
  Ozawa K, Tomiyama T, Maat-Schieman ML, Roos RA, Mori H
- Journal Title
  
  Ann.NY Acad.Sci. 977
  
  Pages: 149-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition.2001
- Author(s)
  Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Mori H, et al.
- Journal Title
  
  Neurobiol. Aging 22(3)
  
  Pages: 367-376
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition.2001
- Author(s)
  Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St. George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H
- Journal Title
  
  Neurobiol.Aging 22(3)
  
  Pages: 367-376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Missemse point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells : A novel action of R406W mutation.2000
- Author(s)
  Sahara N, Tomiyama T, Mori H
- Journal Title
  
  J.Neurosci.Res. 60(3)
  
  Pages: 380-387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] Missemse point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells : A novel action of R406W mutation.2000
- Author(s)
  Sahara N, Tomiyama T, Mori H
- Journal Title
  
  J. Neurosci. Res. 60(3)
  
  Pages: 380-387
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210119
[Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia
- Author(s)
  Tomiyama, T., Nagata, T., Shimada, H., Teraoka, T., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., Wada, Y, Yoshioka, E., Nishizaki, T., Watanabe, Y, Mori, H
- Journal Title
  
  Ann. Neurol (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300114
[Patent] ノックインマウス2014
- Inventor(s)
  森啓、富山貴美、梅田知宙、森田隆、吉田佳世
- Industrial Property Rights Holder
  公立大学法人大阪市立大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-14
- Overseas
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] PASSIVE IMMUNIZATION WITH A NEW MONOCLONAL ANTIBODY TO PHOSPHO-SER413-TAU ATTENUATES TAUOPATHY PHENOTYPES IN MICE2015
- Author(s)
  Takami Tomiyama
- Organizer
  The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders
- Place of Presentation
  Nice（France）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] 認知症治療研究の新展開2015
- Author(s)
  富山　貴美
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-25290018
[Presentation] FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Tomiyama T, Umeda T, Yamashita T, Ohnishi K, Takuma H, Mori H.
- Organizer
  International Conference on Alzheimer's & Parkinson's Diseases (AD/PD2013)
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Tomiyama T
- Organizer
  The 11th International Conference on Alzheimer’s Parkinson’s Diseases (AD/PD2013)
- Place of Presentation
  Firenze Fiera, Florence, Italy
- Year and Date
  2013-03-06
- Data Source
  KAKENHI-PUBLICLY-23110514
[Presentation] FTDP-17 related tau intron 10 +16C→T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice2013
- Author(s)
  Tomiyama T, Umeda T, Yamashita T, Ohnishi K, Takuma H, Mori H
- Organizer
  The 11th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD2013)
- Place of Presentation
  Firenze Fiera, Florence, Italy
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] Aβオリゴマーモデルマウスの解析とアルツハイマー病治療戦略2012
- Author(s)
  富山貴美
- Organizer
  Novartis NeuroScience Forum 2012
- Place of Presentation
  グランドプリンスホテル新高輪、東京都港区
- Invited
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] 細胞内Aβオリゴマーによるシナプス障害と神経細胞死2012
- Author(s)
  富山貴美
- Organizer
  第31回日本認知症学会
- Place of Presentation
  つくば国際会議場、茨城県つくば市
- Year and Date
  2012-10-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110514
[Presentation] Intron変異を有する新規FTDP-17モデルマウスの作製と解析2012
- Author(s)
  梅田知宙、山下雄也、富山貴美、詫間浩、大西紀陽久、森啓
- Organizer
  第31回日本認知症学会学
- Place of Presentation
  つくば国際会議場、茨城県つくば市
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] 細胞内Aβオリゴマーによるシナプス障害と神経細胞死2012
- Author(s)
  富山貴美
- Organizer
  第31回日本認知症学会学
- Place of Presentation
  つくば国際会議場、茨城県つくば市
- Invited
- Data Source
  KAKENHI-PROJECT-24659434
[Presentation] Aβオリゴマーモデルマウスの解析とアルツハイマー病治療戦略2012
- Author(s)
  富山貴美
- Organizer
  Novartis Neuroscience Forum 2012
- Place of Presentation
  グランドプリンスホテル新高輪、東京都港区
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110514
[Presentation] The E693Δmutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells in vitro2011
- Author(s)
  梅田知宙、野村幸子、富山貴美、森啓
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] The E693Δmutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells2011
- Author(s)
  Nomura S, Umeda T, Tomiyama T, Lambert MP, Klein WL, Mori H
- Organizer
  41st Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] The E693Δ mutation in amyloid precursor protein impairs Ass-mediated cholesterol efflux from cells in vitro2011
- Author(s)
  梅田知宙、野村幸子、富山貴美、森啓
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] The E693Δ mutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells, leading to accelerated accumulation of intraneuronal Aβ oligomers and memory disturbance in mice with hypercholesterolemia2011
- Author(s)
  Nomura S, Umeda T, Tomiyama T, Lambert MP, Klein WL, Mori H
- Organizer
  41st Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] Hypercholesterolemia accelerates memory impairment in a transgenic mouse model of Aβ oligomers2010
- Author(s)
  Kitajima E, Umeda T, Idomoto T, Lambert MP, Klein WL, Tomiyama T, Mori H
- Organizer
  International Conference on Alzheimer's disease(ICAD) 2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] Regulation of cholesterol efflux by amyloidβ secretion2010
- Author(s)
  Umeda T, Mori H, Zheng H, Tomiyama T
- Organizer
  International Conference on Alzheimer's disease(ICAD) 2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] Aβ分泌によるコレステロールeffluxの制御2009
- Author(s)
  梅田知宙、森啓、Zheng Hui、富山貴美
- Organizer
  第29回日本認知症学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21500352
[Presentation] A transgenic mouse model of amyloid β oligomers : Pathological effects of the E693△ mutation in amyloid precursor protein in vivo2009
- Author(s)
  Takami Tomiyama
- Organizer
  International Conference on Alzheimer's disease
- Place of Presentation
  Messe Wien (Vienna)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] A transgenic mouse model of amyloid β oligomers2009
- Author(s)
  富山貴美
- Organizer
  日本認知症学会
- Place of Presentation
  東北大学百周年記念館(仙台市)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] APP E693△変異とAβオリゴマー仮説2009
- Author(s)
  富山貴美
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] Oligomer Aβ as the central molecule in Alzheimer's disease2009
- Author(s)
  Takami Tomiyama
- Organizer
  The 2^<nd> International Symposium on Nanomedicine
- Place of Presentation
  岡崎
- Year and Date
  2009-02-07
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] APP E693△変異で促進されるAβオリゴマーによる細胞障害2009
- Author(s)
  富山貴美
- Organizer
  日本神経化学会
- Place of Presentation
  伊香保温泉ホテル天坊(渋川市)
- Year and Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] Fibrillar or nonfibrillar Aβ? A causal molecule for Alzheimer's disease2008
- Author(s)
  Takami Tomiyama
- Organizer
  第51回日本神経化学会・第2回アジア・太平洋生物学的精神医学会・第30回日本生物学的精神医学会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] アルツハイマー病研究のトピック-Aβオリゴマー仮説-2008
- Author(s)
  富山貴美
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20023026
[Presentation] Identification and characterization of a novel APP mutation (E693Δ) in familial Alzheimer's disease2008
- Author(s)
  Takami Tomiyama
- Organizer
  The 11^<th> International Conference on Alzheimer's disease
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20023026
[]
[]

1. MORI HIROSHI (10159189)

# of Collaborated Projects: 7 results

# of Collaborated Products: 50 results
2. UMEDA Tomohiro (70549790)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. TAKUMA Hiroshi (00326258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. SUZUKI Misao (60253720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAHARA Naruhiko (40261185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. WATANABE Yasuyoshi (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 渡辺恭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 角田慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊東秀文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 川上秀史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 綾木孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomiyama Takami 富山 貴美

TOMIYAMA Takami 富山 貴美

Research Projects

Research Products

Co-Researchers

Dementia and gut microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

The molecular action of Abeta oligomer on Alzheimer's disease.

Principal Investigator

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Transmission study of Alzheimer pathology using brain microdialysisPrincipal Investigator

Principal Investigator

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細胞内Ａβオリゴマーによるシナプス・細胞障害とｔａｕとの相互作用Principal Investigator

Principal Investigator

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Review Section

Research Institution

Physiological function of Aβ in regulation of brain cholesterolPrincipal Investigator

Principal Investigator

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Research Institution

Aβオリゴマー仮説を検証する新しいアルツハイマー病モデルマウスの作製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular imaging ofAlzheimer amyloid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Alternated splicing of tau in development and neurodegenerating disorders with dementia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fundamental study on the molecular mechanism for neuropathological changes of dementia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study for the contribution of RNA editing abnormality in sporadic Alzheimer's disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経細胞内の分子移動障害による痴呆発症機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuropathological study on Abeta toxicity using transgenic mice with human APP

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[Journal Article] Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.2015

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Tomiyama Takami 富山貴美

TOMIYAMA Takami 富山貴美