TSUCHIYA Yuichi 土屋勇一

… Alternative Names

土屋勇一ツチヤユウイチ

Less

Researcher Number	10307738
Other IDs
External Links
Affiliation (Current)	2025: 東邦大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東邦大学, 薬学部, 准教授 2017 – 2021: 東邦大学, 医学部, 講師 2005 – 2006: 東邦大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 59040:Nutrition science and health science-related / Laboratory medicine / Biological Sciences
Keywords	Principal Investigator 増殖因子 / 線維化 / 修復 / 肝線維化 / 肝再生 / 非アルコール性脂肪性肝炎 / 肝星細胞 / FGF18 / 臓器連環 / 非アルコール性脂肪肝炎 … More / 線維芽細胞増殖因子 / 肝前駆細胞 / cFLIP / 血清バイオマーカー / アポトーシス / 核外移行 / 核内膜蛋白質 / 細胞核 / 卵母細胞 / アフリカツメガエル Less

Growth factor-mediated regulation of repair and fibrosis in liver injury and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  土屋勇一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Toho University
Elucidation of growth factor-mediated repair mechanism toward non-alcoholic steatohepatitis and its application for therapeutic usePrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Toho University
Development of serum biomarkers and therapeutic strategy for non-alcoholic steatohepatitis using liver-specific apoptosis-prone micePrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yuichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Toho University
アフリカツメガエル卵母細胞単離卵核を用いた核膜トポロジーの解析Principal Investigator
- Principal Investigator
  
  土屋勇一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toho University

All 2024 2023 2022 2021 2020 2019 2018 2005

All Journal Article Presentation Patent

[Journal Article] Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis2023
- Author(s)
  Tsuchiya Y, Seki T, Kobayashi K, Komazawa-Sakon S, Shichino S, Nishina T, Fukuhara K, Ikejima K, Nagai H, Igarashi Y, Ueha S, Oikawa A, Tsurusaki S, Yamazaki S, Nishiyama C, Mikami T, Yagita H, Okumura K, Kido T, Miyajima A, Matsushima K, Imasaka M, Araki K, Imamura T, Ohmuraya M, Tanaka M, Nakano H
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 6304-6304
- DOI
  10.1038/s41467-023-42058-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20666, KAKENHI-PROJECT-22K07007, KAKENHI-PROJECT-23K06489, KAKENHI-PROJECT-21K07922, KAKENHI-PLANNED-22H05064, KAKENHI-ORGANIZER-23H03834, KAKENHI-PLANNED-23H03836, KAKENHI-PROJECT-23K21285, KAKENHI-PROJECT-21H02710, KAKENHI-PROJECT-23K26860, KAKENHI-PROJECT-23K27398
[Journal Article] A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines2023
- Author(s)
  Tsuchiya Y, Komazawa-Sakon S, Tanaka M, Kanokogi T, Moriwaki K, Akiba H, Yagita H, Okumura K, Entzminger K.C., Okumura C.J., Maruyama T, Nakano H
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 675 Pages: 71-77
- DOI
  10.1016/j.bbrc.2023.06.070
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06489, KAKENHI-PROJECT-20H03472, KAKENHI-PROJECT-23K24097, KAKENHI-PROJECT-23K27398
[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021
- Author(s)
  Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 80-80
- DOI
  10.1038/s42003-020-01603-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K11589, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20K09231, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-18H02619, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-16H06276
[Journal Article] Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis2019
- Author(s)
  Tsurusaki Shinya、Tsuchiya Yuichi、Koumura Tomoko、Nakasone Misaki、Sakamoto Taro、Matsuoka Masaki、Imai Hirotaka、Yuet-Yin Kok Cindy、Okochi Hitoshi、Nakano Hiroyasu、Miyajima Atsushi、Tanaka Minoru
- Journal Title
  
  Cell Death & Disease
  
  Volume: 10 Issue: 6 Pages: 449-449
- DOI
  10.1038/s41419-019-1678-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-18H02801, KAKENHI-PROJECT-17K08994
[Journal Article] 生殖細胞における増殖と生存維持のメカニズム2005
- Author(s)
  土屋勇一
- Journal Title
  
  東邦医学会雑誌 52巻5号
  
  Pages: 353-354
- NAID
  110004631719
- Data Source
  KAKENHI-PROJECT-17050020
[Journal Article] Apoptosis-inhibiting activities of BIR family proteins in Xenopus egg extracts2005
- Author(s)
  Tsuchiya Y., Murai S., Yamashita S.
- Journal Title
  
  The FEBS Journal 272
  
  Pages: 2237-2250
- Data Source
  KAKENHI-PROJECT-17050020
[Patent] 肝線維化モデルマウス2021
- Inventor(s)
  中野裕康、土屋勇一
- Industrial Property Rights Holder
  学校法人東邦大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-136540
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K11589
[Patent] 非アルコール性脂肪性肝炎（NASH）の検出方法2018
- Inventor(s)
  土屋勇一, 中野, 裕康, 五十嵐良典, 永井英成
- Industrial Property Rights Holder
  東邦大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-245036
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis2024
- Author(s)
  Seki T, Tsuchiya Y, Shichino S, Nishina T, Yamazaki S, Matsushima K, Yagita H, Okumura K, Tanaka M, Nakano H
- Organizer
  第52回免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06489
[Presentation] 加齢による嚢胞形成と線維化2023
- Author(s)
  土屋勇一, 関崇生, 中野裕康, 田中稔, 髙橋良哉
- Organizer
  日本薬学会　第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K11589
[Presentation] FGF18は肝星細胞を活性化して肝線維化を誘導する2022
- Author(s)
  土屋勇一、小林謙太、関崇生、仁科隆史、駒澤幸子、山﨑創、三上哲夫、西山千春、中野裕康
- Organizer
  第18回東邦大学5学部合同学術集会
- Data Source
  KAKENHI-PROJECT-20K11589
[Presentation] FGF18は肝星細胞を活性化して肝線維化を誘導する2022
- Author(s)
  土屋勇一, 関崇生, 田中稔, 中野裕康
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K11589
[Presentation] FGF18はNASH における肝線維化に関与する2021
- Author(s)
  小林謙太、土屋勇一、関崇生、駒澤幸子、西山千春、三上哲夫、今村亨、田中稔、中野裕康†
- Organizer
  第29回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11589
[Presentation] 肝細胞特異的cFLIP欠損はチオアセトアミド投与による慢性肝障害と肝線維化を亢進させる2021
- Author(s)
  土屋勇一、小林謙太、関崇生、駒澤幸子、西山千春、三上哲夫、今村亨、田中稔、中野裕康
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K11589
[Presentation] Fibroblast growth factor (FGF)18 is a biomarker of non-alcoholic steatotic hepatitis2020
- Author(s)
  Yuichi Tsuchiya, Kenta Kobayashi, Shinya Tsurusaki, Sachiko Komazawa-Sakon, Minoru Tanaka, Hiroyasu Nakano.
- Organizer
  AMED-CREST/PRIME Joint International Symposium
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] フェロトーシスによる肝細胞死が非アルコール性脂肪性肝炎の初期炎症の起点として重要である2019
- Author(s)
  鶴崎慎也, 土屋勇一, 今井浩孝, 大河内仁志, 中野裕康, 田中稔
- Organizer
  第28回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] フェロトーシスによる肝細胞死が非アルコール性脂肪性肝炎の初期炎症の起点として重要である2019
- Author(s)
  鶴崎慎也, 土屋勇一, 今井浩孝, 大河内仁志, 中野裕康, 田中稔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] cFLIPは肝細胞において非アルコール性脂肪性肝炎の増悪を防ぐ2019
- Author(s)
  土屋勇一, 鶴崎慎也, 永井英成, 及川彰, 三上哲夫, 田中稔, 中野裕康
- Organizer
  第28回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] cFLIP prevents exacerbation of non-alcoholic steatotic hepatitis by inhibiting apoptosis of hepatocytes2019
- Author(s)
  Tsuchiya Y, Komazawa-Sakon S, Oikawa A, Mikami T, Nagai H, Tanaka M, Nakano H
- Organizer
  17th TNF Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] FGF18は非アルコール性脂肪性肝炎において傷害を受けた肝細胞が産生する「ダイイングコード」である2019
- Author(s)
  土屋勇一, 鶴崎慎也, 永井英成, 及川彰, 三上哲夫, 田中稔, 中野裕康
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08994
[Presentation] 肝細胞死亢進マウスを用いた非アルコール性脂肪性肝炎のバイオマーカーと治療法の開発2019
- Author(s)
  土屋勇一
- Organizer
  Expert seminar of immunology (Vol.8)
- Invited
- Data Source
  KAKENHI-PROJECT-17K08994

1. 山崎創 (70315084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 森脇健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 中野裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUCHIYA Yuichi 土屋 勇一

土屋 勇一 ツチヤ ユウイチ

Research Projects

Research Products

Co-Researchers

Growth factor-mediated regulation of repair and fibrosis in liver injury and its therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of growth factor-mediated repair mechanism toward non-alcoholic steatohepatitis and its application for therapeutic usePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of serum biomarkers and therapeutic strategy for non-alcoholic steatohepatitis using liver-specific apoptosis-prone micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アフリカツメガエル卵母細胞単離卵核を用いた核膜トポロジーの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生殖細胞における増殖と生存維持のメカニズム2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Apoptosis-inhibiting activities of BIR family proteins in Xenopus egg extracts2005

Author(s)

Journal Title

Data Source

[Patent] 肝線維化モデルマウス2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 非アルコール性脂肪性肝炎（NASH）の検出方法2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis2024

Author(s)

Organizer

Data Source

[Presentation] 加齢による嚢胞形成と線維化2023

Author(s)

Organizer

Data Source

TSUCHIYA Yuichi 土屋勇一

土屋勇一ツチヤユウイチ