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Hashizume Hideki  橋爪 秀樹

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HASHIZUME Hideki  橋爪 秀樹

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Researcher Number 10311276
Other IDs
Affiliation (Current) 2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Affiliation (based on the past Project Information) *help 2021 – 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
2016 – 2018: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
2012 – 2013: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Review Section/Research Field
Principal Investigator
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry / Living organism molecular science
Keywords
Principal Investigator
MRSA / 感染症薬 / mode of action / synergy / 作用機序解析 / 薬剤耐性菌 / 相乗的抗菌活性 / クロプトシン / メチシリン耐性黄色ブドウ球菌 / 新規抗菌薬 … More / 動物実験 / 黄色ブドウ球菌 / 相乗性 / L-156,602 / chloptosin / 薬剤併用 / 耐性菌克服 / 医薬品探索 / reverse resistance / in vivo efficacy / beta-lactam / 感染症 / 機序解析 / 耐性克服 / βラクタム剤 / tripropeptin C / ペプチド系化合物 / 抗菌剤 / 細胞壁合成 / リポペプチド / トリプロペプチンC / バンコマイシン / トリプロペプチン / 院内感染 Less
  • Research Projects

    (3 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (1 People)
  •  MOA study and efficacy evaluation of the synergistic activity of Chloptosin and L-156,602 against MRSAPrincipal Investigator

    • Principal Investigator
      Hashizume Hideki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Microbial Chemistry Research Foundation
  •  the mechanism study of reverse beta-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin CPrincipal Investigator

    • Principal Investigator
      HASHIZUME Hideki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Microbial Chemistry Research Foundation
  •  Mode of action study of tripropeptin C, which exhibits excellent in vivo efficacy superior to vancomycinPrincipal Investigator

    • Principal Investigator
      HASHIZUME Hideki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      Microbial Chemistry Research Foundation

All 2018 2013 2012 Other

All Journal Article Presentation Patent

  • [Journal Article] In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C2018

    • Author(s)
      Hideki Hashizume, Yoshiaki Takahashi, Tohru Masuda, Shun-ichi Ohba, Tomokazu Ohishi, Manabu Kawada & Masayuki Igarashi
    • Journal Title

      The Journal of Antibiotics

      Volume: 71 Issue: 1 Pages: 79-85

    • DOI

      10.1038/ja.2017.88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08338
  • [Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びベータラクタム系抗生物質の抗菌活性増強剤2013

    • Inventor(s)
      橋爪秀樹
    • Industrial Property Rights Holder
      (公財)微生物化学研究会
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びβラクタム系抗生物質の抗菌活性増 強剤2013

    • Inventor(s)
      橋爪秀樹
    • Industrial Property Rights Holder
      公益財団法人 微生物化学研究会
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-249729
    • Filing Date
      2013-12-03
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Presentation] 新規抗 MRSA 抗生物質トリプロペプチンの作用機序解析におけるSPR を利用した低分子ー低分子間相互作用解析2013

    • Author(s)
      橋爪秀樹
    • Organizer
      第13回 日本蛋白質科学会
    • Place of Presentation
      とりぎん文化会館(鳥取)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析- SPRを利用した低分子-低分子間相互作用解析の一例-2013

    • Author(s)
      橋爪秀樹
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取市)
    • Year and Date
      2013-06-13
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012

    • Author(s)
      S. Hirosawa, H. Hashizume, Y. Kobayashi, R. Watabe, K. Inoue, Y. Takahashi, S. Harada, S. Ohba*2, T. Masuda, R. Sawa, Y. Takahashi, T. Miyake, A. Nomoto and M. Shibasaki
    • Organizer
      52nd Interscience conference of antimicrobial agents and chemotherapy
    • Place of Presentation
      Moscone Convension center, SanFrancisco, USA
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012

    • Author(s)
      Sehei Hirosawa, Hideki Hashizume, Yoshihiko Kobayashi, Ryo Watabe, Kunio Inoue, Yuko Takahashi, Shigeko Harada, Syunichi Ohba, Tohru Masuda, Ryuichi Sawa, Yoshiaki Takahashi, Toshiaki Miyake, Akio Nomoto, Masakatsu Shibasaki
    • Organizer
      52^<nd> ICAAC
    • Place of Presentation
      Moscone Convension Center (San Francisco, USA)
    • Year and Date
      2012-09-11
    • Data Source
      KAKENHI-PROJECT-24710254
  • [Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析 - SPR を利用した低分子-低分子間相互作用解析の一例 -

    • Author(s)
      橋爪秀樹
    • Organizer
      第13回 日本蛋白質科学会
    • Place of Presentation
      とりぎん文化会館(鳥取市)
    • Data Source
      KAKENHI-PROJECT-24710254
  • 1.  HARADA Shigeko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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