Mukai Shoichiro 向井尚一郎

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MUKAI Shoichiro 向井尚一郎

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Researcher Number	10315369
Affiliation (Current)	2023: 宮崎大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 宮崎大学, 医学部, 准教授 2015 – 2017: 宮崎大学, 医学部, 准教授 2014: 宮崎大学, 医学部外科学講座泌尿器科学分野, 講師 2012 – 2014: 宮崎大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56030:Urology-related / Urology
Keywords	Principal Investigator HGF / MET / HAI-2 / 腎細胞癌 / PDXモデル / 膀胱癌 / ヒト化HGF-SCIDマウス / 細胞遊走能 / 細胞増殖能 / 細胞膜結合型セリンプロテアーゼ制御因子 … More / 細胞膜結合型セリンプロテアーゼ / 肝細胞増殖因子 / ヒト化HGFマウス / 膜結合型セリンプロテアーゼ制御因子 / 膜結合型セリンプロテアーゼ / マトリプテース / 骨転移 … More Except Principal Investigator 前立腺癌 / caveolin / マウス内臓転移モデル / 転移性去勢抵抗性前立腺癌 / HGF/METパスウェイ / HGF / ゼノグラフト / 骨転移 / PDXモデル / HGFマウス / PDX / 発生 / 腎 / 腎形成不全 / 先天性腎尿路奇形 / FUBIマウス / CRPC / CRPC(去勢抵抗性前立腺癌) / caveolin2 / caveolin1 / カベオリン-2 / カベオリン-1 / 去勢抵抗性前立腺癌 / 蛋白質 / タンパク質 / 癌 / シグナル伝達 / 前立腺 Less

Development of novel treatment targeting the HGF/MET pathway in metastatic CRPC
- Principal Investigator
  
  賀本敏行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Miyazaki
ヒト化マウスを用いた腎細胞癌ＰＤＸモデルの樹立とMET阻害薬効果予測因子の同定Principal Investigator
- Principal Investigator
  
  向井尚一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Miyazaki
Development of a novel treatment for prostate cancer using humanized HGF SCID mice
- Principal Investigator
  
  寺田直樹
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Miyazaki
Analysis of transmembrane proteins activity in urological cancers using humanized SCID mousePrincipal Investigator
- Principal Investigator
  
  Mukai Shoichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Miyazaki
Exploration of genetic mechanisms for renal origin using failure of ureteral bud invasion mouse
- Principal Investigator
  
  賀本敏行
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Miyazaki
Development of new treatment strategy targeting CAVEOLIN-1 and 2 related signaling axis
- Principal Investigator
  
  Kamoto Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Miyazaki
Functional analysis of membrane-anchored proteins in RCC bone metastasis and development of new targeted treatmentPrincipal Investigator
- Principal Investigator
  
  Mukai Shoichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Miyazaki
Search for a new target therapy in the advanced prostate cancer
- Principal Investigator
  
  KAMOTO Toshiyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Miyazaki

All 2020 2018 2017 2015 2014 2013

All Journal Article Presentation

[Journal Article] Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers2020
- Author(s)
  Mukai Shoichiro、Yamasaki Koji、Fujii Masato、Nagai Takahiro、Terada Naoki、Kataoka Hiroaki、Kamoto Toshiyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 8 Pages: 2663-2663
- DOI
  10.3390/ijms21082663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05175, KAKENHI-PROJECT-19K09674
[Journal Article] Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression.2015
- Author(s)
  Sugie S., Mukai S., Yamasaki K., Kamibeppu T., Tsukino H., Kamoto T.
- Journal Title
  
  Cancer Genomics Proteomics.
  
  Volume: 12 Pages: 391-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10597
[Journal Article] Cyclooxygenase 2 Genotypes Influence Progression of Prostate Cancer Susceptibility in Japanese Men.2014
- Author(s)
  Sugie S, Tsukino H, Mukai S, Akioka T, Shibata N, Nagano M, Kamoto T
- Journal Title
  
  Tumor Biology
  
  Volume: 35(3) Issue: 3 Pages: 2717-2721
- DOI
  10.1007/s13277-013-1358-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398
[Journal Article] Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis.2014
- Author(s)
  Mukai S, Yorita K, Kawagoe Y, Katayama Y, Nakahara K, Kamibeppu T, Sugie S, Tukino H, Kamoto T, Kataoka H.
- Journal Title
  
  Hum Cell.
  
  Volume: 28(1) Issue: 1 Pages: 44-50
- DOI
  10.1007/s13577-014-0101-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398, KAKENHI-PROJECT-24390099
[Journal Article] Effect of dutasteride on microvessel density in benign prostatic hyperplasia.2014
- Author(s)
  Sugie S, Mukai S, Tsukino H, Iwamoto H, Kobayashi T, Toda Y, Kamoto T.
- Journal Title
  
  In Vivo.
  
  Volume: 28(3) Pages: 355-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398
[Journal Article] Functional Polymorphism in the CAV1 T29107A Gene and Its Association with Prostate Cancer Risk among Japanese Men.2013
- Author(s)
  Sugie S, Tsukino H, Yamauchi T, Mukai S, Fujii M, Shibata N, Kuroda Y, Kamoto T.
- Journal Title
  
  Anticancer Research
  
  Volume: 33(3) Pages: 1023-1027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398
[Journal Article] Increased Plasma Caveolin-1 Levels Are Associated with Progression of Prostate Cancer among Japanese Men.2013
- Author(s)
  Sugie S, Mukai S, Tsukino H, Toda Y, Yamauchi T, Nishikata I, Kuroda Y, Morishita K, Kamoto T
- Journal Title
  
  Anticancer Res
  
  Volume: 33（5） Pages: 1893-1897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398
[Journal Article] Analysis of multimodal treatment outcome in renal cell carcinoma patients with bone metastasis.2013
- Author(s)
  Mukai S, Tsukino H, Goto T, Sugie S, Shitamura T, Kamimura T, Kamoto T.
- Journal Title
  
  Hinyokika Kiyo
  
  Volume: 59（4） Pages: 207-212
- NAID
  120005244622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592398
[Presentation] HAI-2 regulates the growth of RCC cells in bone metastasis through suppression of matripatese2018
- Author(s)
  Shoichiro Mukai
- Organizer
  The 34th Korea∸Japan Urological Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10598
[Presentation] 腎細胞癌におけるHGF/MET pathwayを介したマトリプテース及びHAIの骨転移抑制2018
- Author(s)
  山崎浩司、永井崇敬、上別府豊治、中原梢、寺田直樹、向井尚一郎、賀本敏行
- Organizer
  第27回　泌尿器分子細胞研究会
- Data Source
  KAKENHI-PROJECT-15K10598
[Presentation] Caveolin-1および2によるE-cadherinの発現抑制を介した前立腺癌遊走能の亢進2017
- Author(s)
  山崎浩司、向井尚一郎、賀本敏行
- Organizer
  第26回泌尿器分子細胞研究会
- Place of Presentation
  大分県大分市
- Data Source
  KAKENHI-PROJECT-15K10597
[Presentation] HAI-2 regulates the invasive growth of RCC cells in bone metastasis through suppression of matriptase-induced HGF activation2017
- Author(s)
  山崎浩司、向井尚一郎、賀本敏行
- Organizer
  AUA2017　米国泌尿器科学会総会
- Place of Presentation
  米国　ボストン
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10598
[Presentation] HAI-2 regulates the invasive growth of RCC cells in bone metastasis through suppression of matriptase-induced HGF activation2017
- Author(s)
  Koji Yamasaki, Kozue Nakahara, Takahiro Nagai, Toyoharu Kamibeppu, Takayuki Goto, Noboru Shibasaki, Hiromasa Sakamoto, Naoki Terada, Hiromasa Tsukino, Shoichiro Mukai, Yoshinobu Toda, Toshiyuki Kamoto
- Organizer
  112th　AUA annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10598
[Presentation] 前立腺癌患者血漿および細胞株におけるCaveolin-1の発現とその意義に関する検討2014
- Author(s)
  杉江悟、向井尚一郎、月野浩昌、西片一朗、森下和広、賀本敏行
- Organizer
  第23回泌尿器科分子細胞研究会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24592398
[Presentation] 日本人男性における前立腺癌の発症、進展とCaveolin-1(CAV1) T29107A遺伝子多型(rs7804372)との関連2013
- Author(s)
  杉江悟、山内武紀、月野浩昌、向井尚一郎、藤井将人、柴田憲彦、黒田嘉紀、賀本敏行
- Organizer
  第22回泌尿器科分子細胞研究会
- Place of Presentation
  高知市
- Data Source
  KAKENHI-PROJECT-24592398
[Presentation] Caveolin-1 Genotypes Influence Prostate Cancer Susceptibility in Japanese Men2013
- Author(s)
  杉江悟、月野浩昌、向井尚一郎、賀本敏行
- Organizer
  第５１回日本癌治療学会学術集会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24592398

1. KAMOTO Toshiyuki (00281098)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
2. 藤井将人 (10794373)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SUGIE Satoru (50626140)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. 寺田直樹 (60636637)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 永井崇敬 (60739994)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TSUKINO Hiromasa (60433059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
7. 山崎浩司 (30777355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 片岡寛章 (10214321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 秋岡貴弘 (60816940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MORISHITA Kazuhiro (80260321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAMIBEPPU Toyoharu (90649641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 西野光一郎 (90508144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 木村翔一 (10975296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森下和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Mukai Shoichiro 向井 尚一郎

MUKAI Shoichiro 向井 尚一郎

Research Projects

Research Products

Co-Researchers

Development of novel treatment targeting the HGF/MET pathway in metastatic CRPC

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト化マウスを用いた腎細胞癌ＰＤＸモデルの樹立とMET阻害薬効果予測因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel treatment for prostate cancer using humanized HGF SCID mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of transmembrane proteins activity in urological cancers using humanized SCID mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of genetic mechanisms for renal origin using failure of ureteral bud invasion mouse

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatment strategy targeting CAVEOLIN-1 and 2 related signaling axis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of membrane-anchored proteins in RCC bone metastasis and development of new targeted treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for a new target therapy in the advanced prostate cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression.2015

Author(s)

Journal Title

Data Source

[Journal Article] Cyclooxygenase 2 Genotypes Influence Progression of Prostate Cancer Susceptibility in Japanese Men.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of dutasteride on microvessel density in benign prostatic hyperplasia.2014

Author(s)

Journal Title

Data Source

[Journal Article] Functional Polymorphism in the CAV1 T29107A Gene and Its Association with Prostate Cancer Risk among Japanese Men.2013

Author(s)

Journal Title

Data Source

Mukai Shoichiro 向井尚一郎

MUKAI Shoichiro 向井尚一郎