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Abe Yoichiro  阿部 陽一郎

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ABE Yoichiro  阿部 陽一郎

ABE Yokbiro  阿部 陽一郎

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Researcher Number 10317331
Other IDs
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 助教
Affiliation (based on the past Project Information) *help 2016 – 2018: 慶應義塾大学, 医学部(信濃町), 講師
2017: 慶應義塾大学, 医学部(信濃町), 専任講師
2010 – 2014: 慶應義塾大学, 医学部, 講師
2011: 慶應義塾大学, 医学部, 助教
2000 – 2005: 慶應義塾大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Neurology / General pharmacology / Brain sciences and related fields / Neurology / Endocrinology
Except Principal Investigator
General pharmacology / General physiology
Keywords
Principal Investigator
アクアポリン4 / アストロサイト / 動物モデル / 脳神経疾患 / アルツハイマー病 / SOD1 / アミロイドβ / 視神経脊髄炎 / 免疫学 / 疾患モデル … More / 分化誘導 / ES細胞 / 抗体製剤 / 動物 / 薬理学 / 医療・福祉 / 自己免疫疾患 / 内在化/エンドサイトーシス / 抗体医薬 / モノクローナル抗体 / 老化 / 認知症 / 遺伝子 / 神経科学 / 脳リンパ排泄機構 / 脳アミロイド血管症 / spinal motor neurons / differentiation / disease model / amyotrophic lateral sclerosis / embryonic stem cell / ALS / 運動ニューロン / 病態モデル / 筋萎縮性側索硬化症 / 遺伝子改変マウス / タウ / マウスモデル / ミクログリア / 多発性硬化症 / アクアポリン / 神経病態免疫学 / 神経細胞 / ノックイン / ソマトスタチン受容体 / 細胞死 / アンギオテンシン受容体 / ロドプシン / カスペース / エンドセリン受容体 / G蛋白質共役型受容体 … More
Except Principal Investigator
脳浮腫 / アクアポリン / グリア / コンピューターシミュレーション / 非線形光学 / 水分子 / 構造機能相関 / 蛋白複合体 Less
  • Research Projects

    (9 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (12 People)
  •  Elucidation of pathomechanism of Alzheimer's disease focusing on AQP4 function and lymphatic drainage system in the brain.Principal Investigator

    • Principal Investigator
      Abe Yoichiro
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Brain sciences and related fields
    • Research Institution
      Keio University
  •  Development of new therapy for neuromyelitis optica using its animal models and anti-AQP4 antibodies.Principal Investigator

    • Principal Investigator
      Abe Yoichiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  Development of a new therapy for brain edema: study for regulation of AQP4 as a molecular target

    • Principal Investigator
      YASUI MASATO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  Investigation of an underlying mechanism of progression from accumulation of Abeta to neurofibrillary tangle formation using Alzheimer's model micePrincipal Investigator

    • Principal Investigator
      ABE Yoichiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  Establishment and analysis of novel animal models for neuromyelitis optica using aquaporin-4 knockout micePrincipal Investigator

    • Principal Investigator
      ABE Yoichiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  Regulation of aquaporin-4 by formation of protein complex and orthogonal array

    • Principal Investigator
      YASUI Masato
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General physiology
    • Research Institution
      Keio University
  •  Establishment and analysis aria vitro model neurons lifaLEVEed from transgenic ES cells, in which a FALS-linked mutant SOD1 is introducedPrincipal Investigator

    • Principal Investigator
      ABE Yokbiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  アミロイド前駆体蛋白の変異導入ES細胞を用いたアルツハイマー病神経細胞の確立Principal Investigator

    • Principal Investigator
      阿部 陽一郎
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  三量体型G蛋白を介する細胞死誘導機構の解明Principal Investigator

    • Principal Investigator
      阿部 陽一郎
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Endocrinology
    • Research Institution
      Keio University

All 2019 2018 2017 2013 2012 2011 2009 2004

All Journal Article Presentation

  • [Journal Article] SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein.2018

    • Author(s)
      Maruyama T, Abe Y, and Niikura T.
    • Journal Title

      Heliyon

      Volume: 4 Issue: 4 Pages: e00601-e00601

    • DOI

      10.1016/j.heliyon.2018.e00601

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19637
  • [Journal Article] Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells2018

    • Author(s)
      Obata Takayuki、Kershaw Jeff、Tachibana Yasuhiko、Miyauchi Takayuki、Abe Yoichiro、Shibata Sayaka、Kawaguchi Hiroshi、Ikoma Yoko、Takuwa Hiroyuki、Aoki Ichio、Yasui Masato
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17954-17954

    • DOI

      10.1038/s41598-018-36264-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-15H04910, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-17K19637, KAKENHI-PROJECT-16H05134
  • [Journal Article] Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults.2018

    • Author(s)
      Maruyama T, Wada H, Abe Y, Niikura T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 500 Issue: 2 Pages: 470-475

    • DOI

      10.1016/j.bbrc.2018.04.104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19637
  • [Journal Article] Aquaporin-4-dependent glymphatic solute transport in the rodent brain2018

    • Author(s)
      H. Mestre*, LM. Hablitz*, ALB. Xavier*, W. Feng*, W. Zou*, T. Pu*, H. Monai*, G. Murlidharan*, RM. Castellanos Rivera*, MJ. Simon*, MM. Pike*, V. Pla*, T. Du*, BT. Kress*, X. Wang, BA. Plog, AS. Thrane, I. Lundgaard, Y. Abe, M. Yasui, JH. Thomas, M. Xiao, H. Hirase, A. Asokan, JJ. Iliff, M. Nedergaard
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.40070

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14859, KAKENHI-PUBLICLY-18H05150, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-17K19637, KAKENHI-PROJECT-16H05134
  • [Journal Article] The Dual Effects of the Astrocyte-Specific Enhancer of the AQP4 M1 Promoter.2017

    • Author(s)
      Abe Yoichiro、Goda Wakami、Ikeshima-Kataoka Hiroko、Yasui Masato
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 23 Pages: 3906-3915

    • DOI

      10.1002/1873-3468.12910

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04688, KAKENHI-PROJECT-16H05134
  • [Journal Article] Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis2017

    • Author(s)
      Watanabe-Matsumoto Saori et al.
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 48-57

    • DOI

      10.1016/j.neures.2017.11.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-17K19637
  • [Journal Article] Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.2017

    • Author(s)
      Murakami M, Nagahama M, Abe Y, Niikura T.
    • Journal Title

      Neuropeptides

      Volume: 66 Pages: 90-96

    • DOI

      10.1016/j.npep.2017.10.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19637
  • [Journal Article] Establishment of Monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP42013

    • Author(s)
      Miyazaki K, Abe Y, Iwanari H, Suzuki Y, Kikuchi T, Ito T, Kato J, Kusano-Arai O, Takahashi T, Nishiyama S, Ikeshima-Kataoka H, Tsuji S, Arimitsu T, Kato Y, Sakihama T, Toyama Y, Fujihara K, Hamakubo T and Yasui M
    • Journal Title

      J. Neuroimmunol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin2013

    • Author(s)
      Hiroko Ikeshima-Kataoka, Yoichiro Abe, Takaya Abe, and Masato Yasui.
    • Journal Title

      Mol. Cell. Neurosci.

      Volume: 56 Pages: 65-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4.2013

    • Author(s)
      Kaori Miyazaki, Yoichiro Abe, Hiroko Iwanari, Yota Suzuki, Takahiro Kikuchi, Takashi Ito, Jungo Kato, Osamu Kusano-Arai, Toshiyuki Takahashi, Shuhei Nishiyama, Hiroko Ikeshima-Kataoka
    • Journal Title

      J. Neuroimmunol.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin2013

    • Author(s)
      Ikeshima-Kataoka H, Abe Y, Abe T, and Yasui M
    • Journal Title

      Mol. Cell. Neurosci

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] A novel monoclonal antibody against the C-terminal region of aquaporin-4.2013

    • Author(s)
      Julia Ramadhanti, Ping Huang, Osamu Kusano-Arai, Hiroko Iwanari, Toshiko Sakihama, Tasturo Misu, Kazuo Fujihara, Takao Hamakubo, Masato Yasui, and Yoichiro Abe
    • Journal Title

      Monoclon. Antib. Immunodiagn. Immunother.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] An astrocyte-specific enhancer of aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements2012

    • Author(s)
      Abe Y., Ikeshima-Kataoka H., et al
    • Journal Title

      J.Neurochem.

      Volume: 120 Pages: 899-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] An astrocyte-specific enhancer of aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements2012

    • Author(s)
      Abe Y, Ikeshima-Kataoka H, Goda W, Niikura T., Yasui M
    • Journal Title

      J.Neurochem

      Volume: 120(6) Pages: 899-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] An astrocyte-specific enhancer of aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements.2012

    • Author(s)
      Yoichiro Abe, Hiroko Ikeshima-Kataoka
    • Journal Title

      J. Neurochem.

      Volume: 120 Pages: 899-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] An astrocyte-specific enhancer of aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements2012

    • Author(s)
      Abe Y, Ikeshima-Kataoka H, Goda W, Niikura T, and Yasui M
    • Journal Title

      J. Neurochem

      Volume: 120(6) Pages: 899-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] Curcumin and genistein additively potentiate G551D-CFTR2011

    • Author(s)
      Yu YC*, Miki H*, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB., Sohma Y (*co-first authors)
    • Journal Title

      Journal ot Cystic Fibrosis

      Volume: 10(4) Pages: 243-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] Curcumin and genistein additively potentiate G551D-CFTR2011

    • Author(s)
      Yu Y-C, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, et al
    • Journal Title

      J.Cyst.Fibros

      Volume: 10 Pages: 243-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Journal Article] TSHR Mutations as a Cause of Congenital Hypothyroidism in Japan : a Population-Based Genetic Epidemiology Study2009

    • Author(s)
      Narumi S, Muroya K, Abe Y, Yasui M, Asakura Y, Adachi M, Hasegawa T
    • Journal Title

      J.Clin.Endocrinol.Metab. 94

      Pages: 1317-1323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390061
  • [Journal Article] Cytotoxic mechanisms by M239V presenilin 2, a little analyzed Alzheimer's disease-causative mutant.2004

    • Author(s)
      Abe, Y.
    • Journal Title

      J. Neurosci. Res. 77

      Pages: 583-595

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590845
  • [Journal Article] Cytotoxic mechanisms by M239V presenilin 2, a little analyzed Alzheimer's disease-causative mutant.2004

    • Author(s)
      Yoichiro Abe
    • Journal Title

      Journal of Neuroscience Research 77

      Pages: 583-595

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590845
  • [Presentation] Three amino-acid sequences regulate the expression level of aquaporin-42019

    • Author(s)
      Abe Y., Suzuki R., Goda W., and Yasui M.
    • Organizer
      The 92nd Annual Meeting of the Japanese Pharmacological Society
    • Data Source
      KAKENHI-PROJECT-16H05134
  • [Presentation] Development of a new Neuromyelitis Optica model mice.2018

    • Author(s)
      Chau S.H., Abe Y., and Yasui, M.
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology/The 91st Annual Meeting of the Japanese Pharmacological Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05134
  • [Presentation] Identification of regions in the C-terminal domain of aquaporin-4 responsible for its intracellular trafficking and degradation.2018

    • Author(s)
      Abe Y., Suzuki R., Goda W., and Yasui M.
    • Organizer
      The 41st Annual Meeting of the Molecular Biology Society of Japan
    • Data Source
      KAKENHI-PROJECT-16H05134
  • [Presentation] Roles of the C-terminal domain in intracellular trafficking and degradation of AQP4.2017

    • Author(s)
      Abe, Y., Fujii, A., Goda, W., and Yasui, M.
    • Organizer
      The 40th Annual Meeting of the Molecular Biology Society of Japan
    • Data Source
      KAKENHI-PROJECT-16H05134
  • [Presentation] Development of monoclonal antibodies against the extracellular domains of mouse AQP4 and its application to elucidating the disease mechanism of neuromyelitis optica2013

    • Author(s)
      阿部陽一郎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] Transcriptional regulation of the mouse aquaporin-4 M23 promoter in astrocytes.2012

    • Author(s)
      Abe, Y., Ikeshima-Kataoka, H., Goda, W., and Yasui, M.
    • Organizer
      The 85th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] アクアポリン4 M23プロモーターのアストロサイトに置ける転写調節2012

    • Author(s)
      阿部陽一郎、池島宏子
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] Development of monoclonal antibodies that block binding of NMO-IgG to AQP4.2012

    • Author(s)
      Miyazaki, K., Abe, Y., Hamakubo, T., Fujihara, K., and Yasui, M.
    • Organizer
      The 85th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] Regulation and in vivo function of square array formation of aquaporin-4.2012

    • Author(s)
      阿部陽一郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] マウス損傷脳のグリア細胞活性化におけるアクアポリン4の機能解析2012

    • Author(s)
      池島宏子、阿部陽一郎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] A consensus sequence of POU transcription factors ins indispensable for transcriptional regulation of mouse aquaporin-4 gene in astrocytes2011

    • Author(s)
      阿部陽一郎、池島宏子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] A consensus sequence of POU transcription factors is indispensable for transcriptional regulation of mouse aquaporin-4 gene in astrocytes.2011

    • Author(s)
      Abe, Y., Ikeshima-Kataoka, H., Goda, W., and Yasui, M.
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22590940
  • [Presentation] アストロサイトにおけるマウスアクアポリン4遺伝子の転写に関与するシスーエレメントの同定2011

    • Author(s)
      阿部陽一郎、池島宏子
    • Organizer
      第84回薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-22
    • Data Source
      KAKENHI-PROJECT-22590940
  • 1.  NIIKURA Takako (10301491)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  YASUI Masato (90246637)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  NAKAO Kazuki (20217657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  YUKUTAKE Yoshinori (80449016)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  IKESHIMA Hiroko (60265783)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 6.  HIRANO Yoshinori (50360631)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  橋本 祐一 (00317330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  西本 征央 (80180652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  高井 良樹 (40725743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TAKUWA Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  Watanabe Seiji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  毛内 拡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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