ITO KENJI 伊藤健二

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Ito Kenji 伊藤健二

ITO Kenji 伊藤健二

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Researcher Number	10317779
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東海大学, 医学部, 教授 2018 – 2019: 東海大学, 医学部, 准教授 2015 – 2016: 東海大学, 医学部, 准教授 2009 – 2014: Tokai University, 医学部, 講師 2007 – 2008: Tokai University, School of Medicine, Department of Anesthesiology, Assistant Professor 2006: 東海大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology
Keywords	Principal Investigator NMDA受容体 / Dセリン / モルヒネ / グルタミン酸 / 疼痛 / 鎮痛 / セリンラセマーゼ / 脊髄 / 神経障害性疼痛 / 唾液腺 … More / シアロルフィン / D-セリン / 鎮痛耐性 / in situ hybridization / 耐性 / D体セリン / 神経障害生疼痛 / 慢性疼痛 / 興奮性アミノ酸 / アストロサイト / 頭痛 / マイクロダイアリシス / Dアミノ酸 / Benzodiazepine receptor / NMDA receptor / Descending Analgesic System / D-amino acid oxidase / Serine racemase / morphine / Midazolam / D-serine / 脳室内投与 / 下行性抑制系路 / オピオイド受容体 / 神経細胞 / ベンゾジアゼピン / 下行性痛覚抑制経路 / 鎮痛作用 / ベンゾジアゼピン受容体 / 下行性疼痛抑制経路 / Dアミノ酸オキシダーゼ / ミダゾラム / モルヒネ慢性投与 / dynorphin / 鎮痛耐性形成 / 術後痛 / Ｄアミノ酸酸化酵素 / 代謝 / 免疫組織化学 / Dアミノ酸酸化酵素 / ケタミン / 麻薬 / 疼痛管理学 Less

Effects of D-body serine on spinal dorsal horn neuron modulation associated with neuropathic painPrincipal Investigator
- Principal Investigator
  
  Ito Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokai University
Effects of activated astrocyte-derived D-serine in neuropathic painPrincipal Investigator
- Principal Investigator
  
  Ito Kenji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokai University
Effects of D-serine on tolerance to the antinociceptive effects of morphinePrincipal Investigator
- Principal Investigator
  
  ITO Kenji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokai University
Long-term treatment with morphine increases the D-serine content in the rat brain and spinal cord by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidasePrincipal Investigator
- Principal Investigator
  
  ITO Kenji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokai University
Study for interaction between D-serine synthesis and development of morphine tolerancePrincipal Investigator
- Principal Investigator
  
  ITO Kenji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokai University
Study for effects of D-serine on antinociception induced by acute administration of morphinePrincipal Investigator
- Principal Investigator
  
  ITO Kenji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokai University

All 2022 2017 2014 2013 2008 2007 Other

All Journal Article Presentation

[Journal Article] Free D-amino acids in salivary gland in rat2022
- Author(s)
  Yoshikawa M, Kan T, Shirose K, Watanabe M, Matsuda M, Ito K, Kawaguchi M
- Journal Title
  
  Biology
  
  Volume: 11 Issue: 3 Pages: 390-405
- DOI
  10.3390/biology11030390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08830, KAKENHI-PROJECT-18K08831, KAKENHI-PROJECT-18K09514, KAKENHI-PROJECT-19K09337, KAKENHI-PROJECT-21K08931, KAKENHI-PROJECT-21K08955, KAKENHI-PROJECT-21K09004
[Journal Article] Effect of Peptidase Inhibitors on Dynorphin A (1-17) or (1-13)-Induced Antinociception and Toxicity at Spinal Level2017
- Author(s)
  Mitsumasa Matsuda, Masanobu Yoshikawa, Takugi Kan, Mariko Watanabe, Junko Ajimi, Shigeru Takahashi, Masaaki Miura, Kenji Ito, Hiroyuki Kobayashi, Toshiyasu Suzuki
- Journal Title
  
  Pharmacology & Pharmacy
  
  Volume: ８ Issue: 02 Pages: 33-51
- DOI
  10.4236/pp.2017.82003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462385
[Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain2014
- Author(s)
  Ito M, Yoshikawa M, Ito K, Matsuda M, Jin X.L., Takahashi S, Kobayashi H, Suzuki T
- Journal Title
  
  J. Anesthesia
  
  Volume: 28(2) Pages: 228-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592312
[Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain.2014
- Author(s)
  Ito M, Yoshikawa M, Ito K, Matsuda M, Jin X.L., Takahashi S, Kobayashi H, Suzuki T
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 28 Pages: 228-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592312
[Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors2013
- Author(s)
  Miura, M, Yoshikawa M, Watanabe M, Takahashi S, Ajimi J, Ito K, Ito M, Kawaguchi M, Kobayashi H, Suzuki T.
- Journal Title
  
  Tokai J Exp Clin Med
  
  Volume: 38 Pages: 62-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592312
[Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors2013
- Author(s)
  Miura, M, Yoshikawa M, Watanabe M, Takahashi S, Ajimi J, Ito K, Ito M, Kawaguchi M, Kobayashi H, Suzuki T
- Journal Title
  
  Tokai J Exp Clin Med
  
  Volume: 38 (2) Pages: 62-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592312
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008
- Author(s)
  Ito K, Yoshikawa M, Maeda M, Jin XL, Takahashi S, Matsuda M, Tamaki R, Kobayashi H, Suzuki T, Hashimoto A
- Journal Title
  
  Eur J Pharmacol 856(1-3)
  
  Pages: 139-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591843
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008
- Author(s)
  Ito, Kenji, et. al.
- Journal Title
  
  Eur J Pharmacol 856(1-3)
  
  Pages: 139-144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591723
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008
- Author(s)
  Konji Ito
- Journal Title
  
  European Journal of Pharmacology 586
  
  Pages: 139-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591843
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008
- Author(s)
  Kenji Ito, et. al.
- Journal Title
  
  European Journal of Pharmacology (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591723
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008
- Author(s)
  Ito Kenji, et. al.
- Journal Title
  
  European Journal of Pharmacology 856
  
  Pages: 139-144
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591723
[Journal Article] Activation of supraspinal NMDA receptor by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail flick test of rats
- Author(s)
  Masanobu Yoshikawa, Kenji Ito, et al. (他9名)
- Journal Title
  
  European Journal of Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-18591723
[Presentation] イミプラミンは唾液腺内ノルエピネフリン、セロトニン遊離量を増加する唾液腺マイクロダイアリシス法を用いた検討2022
- Author(s)
  白勢康介姜卓義渡邊真理子松田光正伊藤健二鈴木武志小林広幸吉川正信
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K09004
[Presentation] ホルマリンテストでのD-serineの鎮痛効果2008
- Author(s)
  4.松田光正,吉川正信,前田美保,伊藤健二,鈴木利保
- Organizer
  日本麻酔科学会第55回学術集会
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-20591843
[Presentation] Midazolam decreases the effect of antinociception of D-serine and morphine2007
- Author(s)
  Ito, Kenji, et. al.
- Organizer
  The 80th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Nagoya
- Year and Date
  2007-03-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591723
[Presentation] ミダゾラムは,Dセリンとモルヒネの鎮痛効果を減弱する2007
- Author(s)
  伊藤健二, 他
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2007-03-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591723
[Presentation] The expression of serine racemase mRNA in the primary culture of neuron2007
- Author(s)
  Akahori, Kazuhito, et. al.
- Organizer
  The 80th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Nagoya
- Year and Date
  2007-03-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591723

1. YOSHIKAWA Masanobu (90276791)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results

ITO KENJI 伊藤 健二

Ito Kenji 伊藤 健二

ITO Kenji 伊藤 健二

Research Projects

Research Products

Co-Researchers

Effects of D-body serine on spinal dorsal horn neuron modulation associated with neuropathic painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of activated astrocyte-derived D-serine in neuropathic painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of D-serine on tolerance to the antinociceptive effects of morphinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Long-term treatment with morphine increases the D-serine content in the rat brain and spinal cord by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for interaction between D-serine synthesis and development of morphine tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for effects of D-serine on antinociception induced by acute administration of morphinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Free D-amino acids in salivary gland in rat2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Peptidase Inhibitors on Dynorphin A (1-17) or (1-13)-Induced Antinociception and Toxicity at Spinal Level2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain2014

Author(s)

Journal Title

Data Source

[Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain.2014

Author(s)

Journal Title

Data Source

[Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors2013

Author(s)

Journal Title

Data Source

[Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors2013

Author(s)

Journal Title

Data Source

[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008

Author(s)

Journal Title

Data Source

[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats2008

Author(s)

Journal Title

ITO KENJI 伊藤健二

Ito Kenji 伊藤健二

ITO Kenji 伊藤健二

[Presentation] イミプラミンは唾液腺内ノルエピネフリン、セロトニン遊離量を増加する唾液腺マイクロダイアリシス法を用いた検討2022