OHTSUBO Masafumi 大坪正史

… Alternative Names

大坪正史オオツボマサフミ

Less

Researcher Number	10327653
Other IDs
External Links
Affiliation (Current)	2025: 浜松医科大学, 光医学総合研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 浜松医科大学, 光尖端医学教育研究センター, 助教 2015 – 2018: 浜松医科大学, 光尖端医学教育研究センター, 助教 2011 – 2014: 浜松医科大学, メディカルフォトニクス研究センター, 助教 2011 – 2012: 浜松医科大学, 学内共同利用施設等, 助教 2007 – 2010: Hamamatsu University School of Medicine, Photon Medical Research Center, Instructor … More 2006: 浜松医科大学, 光量子医学研究センター, 助手 2004: Keio University, School of Medicine, Research Associate, 医学部, 助手 2003: 慶応義塾大学, 医学部, 助手 2002: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Ophthalmology / Basic Section 52020:Neurology-related Except Principal Investigator Ophthalmology / Biological Sciences / Basic Section 52020:Neurology-related / Basic Section 56060:Ophthalmology-related / Neurosurgery / Laboratory medicine / Psychiatric science
Keywords	Principal Investigator OPTN / ALS / 筋萎縮性側索硬化症 / 神経科学 / 遺伝子 / 緑内障 / ラマン分光法 / 凝集体 / スプライソソーム / spliceosome … More / granule / FUS / ｼｸﾞﾅﾙ伝達 / 相互作用ﾀﾝﾊﾟｸ / 異常タンパク蓄積 / オートファジー / 異常蛋白蓄積 / 生体分子 / プロテオーム / シグナル伝達 / 相互作用タンパク … More Except Principal Investigator 加齢黄斑変性 / データベース / 網膜光障害 / 遺伝子変異 / ゲノム / 遺伝子 / 遺伝学 / 遺伝性眼疾患 / 脂質イメージング / 神経筋疾患 / 脳神経内科 / サルコペニア / 脂質 / ラマン分光法 / 強制発現 / 免疫細胞染色 / 免疫沈降 / cDNAライブラリー / クローニング / ハプロタイプ / 遺伝子改変動物 / 悪性転化 / グリオブラストーマ / 低悪性度グリオーマ / Functional domain / Disease / Image / Pathway / Gene / Protein / Database / Cancer / 機能性ドメイン / 疾患 / 画像 / パスウェイ / タンパク質 / 癌 / knowledge-base / hereditary skin diseases / hereditary eve diseases / polymorphism / multifactorial disease / database / mutation / monogenic disease / オンライン / グラフィカル / 多型 / 変異 / 遺伝子疾患 / 疾患遺伝子 / 知識ベース / 遺伝性皮膚疾患 / 遺伝子多型 / 多因子疾患 / 単一遺伝子疾患 / 連続戻し交配 / 光 / 感受性遺伝子 / 網膜変性 / 次世代シーケンサー / エキソーム解析 / 責任遺伝子 / 系統差 / 戻し交配 / ラット / エクソ－ム配列解析 / エクソーム配列解析 / コピー数多型解析 / 自閉症スペクトラム / 児童・思春期精神医学 / 高眼圧症 / 重複 / 欠失 / マイクロアレイ / ゲノムワイド解析 / CNV / コピー数多型 / 正常眼圧緑内障 / 開放隅角緑内障 / 拡張候補遺伝子アプローチ / モデル動物 / 原因遺伝子 / 脳神経疾患 / 情報工学 / 緑内障 / 光関連疾患 / 拡張侯補遺伝子アプローチ / ゲノム悉皆解析法 Less

Estimation of pathological mechanism through lipid composition imaging of adipose tissue in muscle fibers from patients of neuromuscular disorders
- Principal Investigator
  
  長島優
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hamamatsu University School of Medicine
ALS発症におけるOPTNの新規核内機能：スプライソソーム異常と凝集体形成Principal Investigator
- Principal Investigator
  
  大坪正史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hamamatsu University School of Medicine
Functional analysis of PANK4 and elucidation of an onset mechanism in age-related macular degeneration
- Principal Investigator
  
  Ohishi Kentaro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hamamatsu University School of Medicine
Exome analysis of glioma malignant transformation mutation and development of differentiation method by blood secretory vesicle analysis
- Principal Investigator
  
  Minoshima Shinsei
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hamamatsu University School of Medicine
Exome Sequencing to identify novel candidate genes for autism
- Principal Investigator
  
  イスメールサンシーム
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hamamatsu University School of Medicine
Investigation of a new mechanism of age-related macular degeneration using a rat model of retinal photic injury: targeted exome analysis for a responsible genomic region
- Principal Investigator
  
  Ohishi Kentaro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hamamatsu University School of Medicine
Analysis of pathogenic mechinism of glaucoma based on commonality with Amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  Ohtsubo Masafumi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hamamatsu University School of Medicine
Investigation for the genetic factor of glaucoma in another viewpoint: an analysis of possible involvement of copy number variation (CNV) in genome
- Principal Investigator
  
  MINOSHIMA Shinsei
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hamamatsu University School of Medicine
Molecular analysis of glaucoma-developing mechanism : Investigation of an OPTN-interacting proteinPrincipal Investigator
- Principal Investigator
  
  OHTSUBO Masafumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hamamatsu University School of Medicine
The development of the image database for cancer-related protein /gene interaction pathway
- Principal Investigator
  
  MITSUYAMA Susumu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Keio University
Exploration of disease-causative and -associated genes and prospect of novel molecular/cellular phenomenon
- Principal Investigator
  
  MINOSHIMA Shinsei
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
Construction of an integrated knowledge-base for mutations in disease-responsible genes and polymorphisms in disease-related genes
- Principal Investigator
  
  MINOSHIMA Shinsei
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
  Keio University

[Book] 情報処理(46巻2号112-118頁)「遺伝子変異データベース構築のための情報収集と抽出の現状」2005
- Author(s)
  大坪正史
- Total Pages
  7
- Publisher
  社団法人情報処理学会
- Data Source
  KAKENHI-PROJECT-14013053
[Book] ゲノミクス・プロテオミクスの新展開-生物情報の解析と応用-(814-827頁)「疾患データベース」2004
- Author(s)
  大坪正史
- Total Pages
  14
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-14013053
[Book] 「疾患データベース」ゲノミクス・プロテオミクスの新展開-生物情報の解析と応用-(pp814-827)2004
- Author(s)
  大坪正史
- Total Pages
  14
- Publisher
  エヌ・ティー・エス
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013053
[Book] 「疾患遺伝子研究に有用な突然変異情報の統合データベース」生化学(75巻4号pp311-318)2003
- Author(s)
  大坪正史
- Total Pages
  8
- Publisher
  日本生化学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013053
[Book] 「ヒト疾患遺伝子変異データベースの構築」Molecular Medicine(40巻1号pp50-60)2003
- Author(s)
  大坪正史
- Total Pages
  11
- Publisher
  中山書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013053
[Book] 「疾患遺伝子の総合データを活用する」蛋白質核酸酵素(48巻6号pp762-769)2003
- Author(s)
  大坪正史
- Total Pages
  8
- Publisher
  共立出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013053
[Journal Article] Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.2014
- Author(s)
  Gao J, Ohtsubo M*, Hotta Y, Minoshima S. （*Corresponding Author）
- Journal Title
  
  PlosOne
  
  Volume: 9(7) Issue: 7 Pages: e101206-e101206
- DOI
  10.1371/journal.pone.0101206
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592622, KAKENHI-PROJECT-26462659
[Journal Article] Interaction between optineurin and the bZIP transcription factor NRL2014
- Author(s)
  Wang C, Hosono K, Ohtsubo M, Ohishi K, Gao J, Nakanishi N, Hikoya A, Sato M, Hotta Y, Minoshima S.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 38(1) Issue: 1 Pages: 16-25
- DOI
  10.1002/cbin.10174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592561, KAKENHI-PROJECT-23592562, KAKENHI-PROJECT-24592622, KAKENHI-PROJECT-25462708, KAKENHI-PROJECT-25861626
[Journal Article] Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.2012
- Author(s)
  Thanseem I
- Journal Title
  
  Biol Psychiatry
  
  Volume: 71 Issue: 5 Pages: 410-8
- DOI
  10.1016/j.biopsych.2011.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390288, KAKENHI-PROJECT-23592561, KAKENHI-PROJECT-23592562, KAKENHI-PROJECT-23791323
[Journal Article] Novel USH2A mutations in Japanese Usher syndrome type 2 patients: marked differences in the mutation spectrum between the Japanese and other populations2011
- Author(s)
  Nakanishi H, Ohtsubo M, Iwasaki S, Hotta Y, Usami S, Mizuta K, Mineta H, Minoshima S
- Journal Title
  
  J Hum Genet
  
  Volume: 56(7) Pages: 484-490
- NAID
  10030659974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592562
[Journal Article] A Graphical Database of Mutations in Genes That Cause Eye Diseases.2010
- Author(s)
  Kawamura, T., Ohtsubo, M., Mitsuyama, S., Ohno-Nakamura, S., Shimizu, N., Minoshima, S. KMeyeDB
- Journal Title
  
  Hum. Mutat. 31(6)
  
  Pages: 667-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019027
[Journal Article] Identification of 11 novel mutations in USH2A among Japanese patients with Usher syndrome type 2.2009
- Author(s)
  Nakanishi, H., Ohtsubo, M., Iwasaki, S., Hotta, Y., Mizuta, K., Mineta, H., Minoshima, S.
- Journal Title
  
  Clin. Genet. 76(4)
  
  Pages: 383-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019027
[Journal Article] Genome Information Integration Project and H-Invitational 2 (2008): The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts.2008
- Author(s)
  Minoshima, S., Ohtsubo, M.
- Journal Title
  
  Nucleic Acids Res.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019027
[Journal Article] Three novel mutations of PAX6 gene in Japanese aniridia patients.2007
- Author(s)
  Kawano, T., Wang, C., Hotta, Y., Sato, M., Iwata-Amano, E., Hikoya, A., Fujita, N., Koyama, N., Shirai, S., Azuma, N., Ohtsubo, M., Shimizu, N., Minoshima, S.
- Journal Title
  
  J. Hum. Genet. 52(7)
  
  Pages: 571-574
- NAID
  40015454165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019027
[Journal Article] MutationView/KMcamcer DB: a database for cancer gene mutations.2007
- Author(s)
  Shimizu, N., Ohtsubo, M., Minoshima, S.
- Journal Title
  
  Cancer Sci. 98(3)
  
  Pages: 259-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019027
[Journal Article] The KMDB/Mutation View : a mutation database for human disease genes.2001
- Author(s)
  Minoshima, S., Mitsuyama, S., Ohtsubo, M., Kawamura, T., Ito, S., Shibamoto, S., Ito, F., Shimizu, N.
- Journal Title
  
  Nucleic Acids Res. 29
  
  Pages: 327-328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013053
[Journal Article] Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking : Possible Relationship with Glaucoma Pathology
- Author(s)
  Gao J, Ohtsubo M, Hotta Y, Minoshima S
- Journal Title
  
  PLoS ONE
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592562
[Presentation] OPTN蛋白質の核内機能とALS原因遺伝子FUS2022
- Author(s)
  大坪正史
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07535
[Presentation] ラット網膜光障害感受性遺伝子の同定と発現解析2019
- Author(s)
  大石健太郎、大坪正史、青戸一司、尾花明、細野克博、上野真治、才津浩智、寺崎浩子、平光忠久、堀田喜裕、蓑島伸生
- Organizer
  第123回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K09401
[Presentation] Fine analysis of IKBKG in a Japanese boy and 3 girls with incontinentia pigmenti.2019
- Author(s)
  ハック・ナズムール、大坪正史、仁科幸子、中尾志郎、細野克博、倉田健太郎、大石健太郎、佐藤美保、堀田喜裕、蓑島伸生、東範行
- Organizer
  第123回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K09401
[Presentation] ラット網膜光障害感受性系統差の原因遺伝子の同定：加齢黄斑変性の発症機序解明を目指して2018
- Author(s)
  大石健太郎、大坪正史、青戸一司、尾花明、細野克博、才津浩智、平光忠久、堀田喜裕、蓑島伸生
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K09401
[Presentation] 加齢黄斑変性の新規関連遺伝子の同定：光障害動物実験モデルの活用2018
- Author(s)
  大石健太郎、大坪正史、細野克博、青戸一司、尾花明、上野真治、才津浩智、寺崎浩子、平光忠久、堀田喜裕、蓑島伸生
- Organizer
  第66回日本臨床視覚電気生理学会
- Data Source
  KAKENHI-PROJECT-18K09401
[Presentation] ラット網膜光障害感受性を支配する遺伝子多型の探索2016
- Author(s)
  大石健太郎，大坪正史，細野克博，尾花明，堀田喜裕，平光忠久，蓑島伸生
- Organizer
  第39回日本分子生物学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25462708
[Presentation] The analysis of suppressive effects of citrus peel ingredient on the abnormal protein accumulation-related phenomena induced by mutant proteins of glaucoma and amyotrophic lateral sclerosis causative genes (OPTN and TARDBP)2016
- Author(s)
  Masafumi Ohtsubo, Yoshihiro Hotta, Shinsei Minoshima
- Organizer
  ICHG2016
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] ラット網膜光障害の感受性遺伝子領域の領域限定エキソーム解析2016
- Author(s)
  大石健太郎，大坪正史，細野克博，尾花明，堀田喜裕，平光忠久，蓑島伸生
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-25462708
[Presentation] ラット網膜光障害の感受性遺伝子領域の領域限定エキソーム解析2016
- Author(s)
  大石健太郎、大坪正史、細野克博、尾花　明、堀田喜裕、蓑島伸生
- Organizer
  日本眼科学会
- Place of Presentation
  仙台
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-25462708
[Presentation] 柑橘系果皮由来成分によるTDP-43凝集体蓄積の抑制の検討2015
- Author(s)
  大坪正史、堀田喜裕、蓑島伸生
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] The analysis of an inhibitory effect of citrus peel ingredient on the formation of abnormal structure caused by amyotrophic lateral sclerosis responsible genes (OPTN and TARDBP)2015
- Author(s)
  Masafumi Ohtsubo, Yoshihiro Hotta, Shinsei Minoshima
- Organizer
  慶北・浜松合同医科学シンポジウム
- Place of Presentation
  大邱（韓国）
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] An in vitro analysis of the induction mechanism of the autophagy by a component chemical of citrus peel and its application to whole animal system2015
- Author(s)
  Ohtsubo Masafumi
- Organizer
  Asia ARVO 2015
- Place of Presentation
  パシフィコ横浜（神戸）
- Year and Date
  2015-02-16
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 筋萎縮性側索硬化症と緑内障の共通の発症分子機構に関する検討：柑橘系果皮由来成分によるTDP-43凝集体蓄積の抑制2015
- Author(s)
  大坪正史
- Organizer
  第15回浜松医科学シンポジウム
- Place of Presentation
  浜松医科大学（浜松）
- Year and Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] OPTNの緑内障原因変異による細胞内異常構造のオートファジー誘導による改善の試み2014
- Author(s)
  大坪正史
- Organizer
  第118回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2014-04-05
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] オートファジーを誘導する柑橘系果皮由来成分のmTOR阻害剤との作用機序比較検討および生体への投与における作用の検討2014
- Author(s)
  大坪正史
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神戸）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 緑内障原因遺伝子OPTN産物タンパク質３量体の構成に関する検討2014
- Author(s)
  大坪正史
- Organizer
  第59回日本人類遺伝学会・第21回日本遺伝子診療学会総会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] オプチニュリンの緑内障および筋萎縮性側索硬化症原因変異による細胞内異常構造の検討2013
- Author(s)
  大坪正史
- Organizer
  第117回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 緑内障および筋萎縮性側索硬化症の原因遺伝子オプチニュリン相互作用蛋白SLC4A2の検討2012
- Author(s)
  大坪正史
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 蛋白品質管理機構の破綻とERストレス発生の観点に基づく緑内障発症機構の分子解析:オプチニュリン相互作用蛋白SLC4A2の挙動と役割の検討2011
- Author(s)
  大坪正史
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] 蛋白品質管理機構の破綻とERストレス発生の観点に基づく緑内障発症機構の分子解析:オプチニュリン相互作用蛋白SLC4A2の挙動と役割の検討(Molecular analysis of glaucoma-developing mechanism from a novel viewpoint based on the failure of endoplasmic reticulum quality control system : Investigation of an OPTN-interacting protein SLC4A2)2011
- Author(s)
  大坪正史、高潔、堀田喜裕、蓑島伸生
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] タンパク品質管理系のOPTNによる制御とSLC4A2変異の検討2011
- Author(s)
  大坪正史
- Organizer
  第3回浜松医科学シンポジウム
- Place of Presentation
  浜松医科大学(静岡県)
- Year and Date
  2011-02-25
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] 緑内障原因遺伝子オプチニュリンによるタンパク品質管理系の制御の可能性の検討2010
- Author(s)
  大坪正史
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同大会(BMB2010)
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] 緑内障原因遺伝子オプチニュリンによるタンパク品質管理系の制御の可能性の検討(The possibility for protein maintenance by glaucoma-causative gene OPTN)2010
- Author(s)
  大坪正史、細野克博、高潔、Mary K. Wirtz、堀田喜裕、蓑島伸生
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同大会(BMB2010)
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] Interaction between optineurin and bZIP transcription factor NRL.2009
- Author(s)
  Wang, C., Hosono, K., Ohtsubo, M., Ohishi, K., Nakanishi, N., Hikoya, A., Sato, M., Hotta, Y., Minoshima, S.
- Organizer
  Association for Research in Vision and Ophthalmology
- Place of Presentation
  Florida (USA)
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] Isolation of proteins interacting with optineurin, a glaucoma-causative gene product(緑内障原因遺伝子産物オプチニュリンと相互作用するタンパクの同定)2009
- Author(s)
  大坪正史、Thanseem Ismail、細野克博、堀田喜裕、蓑島伸生
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] Isolation of proteins interacting with optineurin, a product protein of glaucoma-causative gene2009
- Author(s)
  大坪正史(Masafumi Ohtsubo), Thanseem Ismail,細野克博(Katsuhiro Hosono), Ryo Asaoka, Chunxia Wang, Hiroshi Nakanishi, Hiroyuki Mineta, Yoshihiro Hotta, Shinsei Minoshima
- Organizer
  第9回慶北-浜松合同医学シンポジウム
- Place of Presentation
  慶北医科大学(中国)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] 緑内障原因遺伝子産物オプチニュリンと相互作用するタンパクの同定.2009
- Author(s)
  大坪正史、Thanseem Ismail、細野克博、堀田喜裕、蓑島伸生
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障原因遺伝子ミオシリンの相互作用蛋白の同定:発症を修飾する因子どしての可能性2009
- Author(s)
  大坪正史, 他
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] ヒト遺伝子多様性データベースの構築の現状2009
- Author(s)
  蓑島伸生、大坪正史、清水信義
- Organizer
  第16回日本遺伝子診療学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] The new version of MutationView: Enhanced Search Function and Significant Increase in the Number of Gene Entries.2009
- Author(s)
  Ohtsubo, M., Kawaguchi, K., Adachi, K., Horisawa, T., Shimizu, N., Minoshima, S.
- Organizer
  20th International Conference on Genome Informatics (GIW2009)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] Isolation of proteins interacting with optineurin, a product protein of glaucoma-causative gene2009
- Author(s)
  Ohtsubo, M., et al.
- Organizer
  第9回慶北-浜松合同医学シンポジウム(The 9th Kyungpook-Hamamatsu Joint Medical Symposium, Hamamatsu Meeting)
- Place of Presentation
  大邸(韓国)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障原因遺伝子ミオシリンの相互作用蛋白の同定 : 発症を修飾する因子としての可能性2009
- Author(s)
  大坪正史, 他
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム (東京都)
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] Isolation of proteins interacting with optineurin, a product protein of glaucoma-causative gene2009
- Author(s)
  大坪正史, 他
- Organizer
  第9回慶北-浜松合同医学シンポジウム (The 9th Kyungpook-Hamamatsu Joint Medical Symposium, Hamamatsu Meeting)
- Place of Presentation
  慶北大学医科大学 (韓国)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] A new version of MutationView : Enhanced searching function and significant increase of the number of genes with variation data2009
- Author(s)
  Ohtsubo, M., et al.
- Organizer
  Human Genome Variation Society 2009
- Place of Presentation
  Honolulu (USA)
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障原因遺伝子産物オプチニュリンと相互作用するタンパクの同定2009
- Author(s)
  大坪正史, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障原因遺伝子ミオシリンの相互作用蛋白の同定発症を修飾する因子としての可能性2009
- Author(s)
  大坪正史、中西伸夫、Thanseem Ismail、堀田喜裕、蓑島伸生
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] The new version of MutationView : Enhanced Search Function and Significant Increase in the Number of Gene Entries2009
- Author(s)
  Ohtsubo, M., et al.
- Organizer
  20th International Conference on Genome Informatics (GIW2009)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] Isolation of proteins interacting with optineurin, a glaucoma-causative gene product (緑内障原因遺伝子産物オプチニュリンと相互作用するタンパクの同定)2009
- Author(s)
  大坪正史, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川県)
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21592223
[Presentation] 独立の疾患遺伝子変異データベース構築に利用できるMutationViewソフトウェアセットの開発と公開2008
- Author(s)
  大坪正史, 他
- Organizer
  第15回日本遺伝子診療学会大会
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 疾患遺伝子変異データベースMutation Viewのサーバーソフトウェアの公開2008
- Author(s)
  大坪正史, 他
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] Construction of independent LSDBs with smooth user-interface and real-time analysis function using MutationView softwares, MV4LSDB.2008
- Author(s)
  Ohtsubo, M., Minoshima, S., Kawaguchi, K., Adachi, K., Horisawa, T., Shimizu, N.
- Organizer
  The 2008 Annual Conference of the Japanese Society for Bioinformatics (JSBi2008)
- Place of Presentation
  Osaka (Japan)
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] オプチニューリンとNRLタンパクの相互作用の解析.2008
- Author(s)
  王春霞、細野克博、大坪正史、大石健太郎、中西伸夫、堀田喜裕、蓑島伸生
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障候補領域に座し既知原因遺伝子OPTNと相互作用するタンパク遺伝子の変異解析2008
- Author(s)
  大坪正史、細野克博、朝岡亮、王春霞、中西啓、WirtzMary K. 、峯田周幸、堀田喜裕、蓑島伸生
- Organizer
  第112回日本眼科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障発症機序の分子レベルでの解明:緑内障原因遺伝子ミオシリンの産物蛋白質が細胞外で相互作用する蛋白質の探索.2008
- Author(s)
  中西伸夫、大坪正史、大石健太郎、Ismail Thanseem、細野克博、王春霞、堀田喜裕、蓑島伸生
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障候補領域に座し既知原因遺伝子OPTNと相互作用するタンパク遺伝子の変異解析2008
- Author(s)
  大坪正史, 他
- Organizer
  第112回日本眼科学会総会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] Myocilin interacting proteins: Screening of a human retina yeast two hybrid cDNA library.2007
- Author(s)
  Ohtsubo, M., Hosono, K., Wang, C., Hotta, Y., Minoshima, S.
- Organizer
  American Society of Human Genetics (ASHG) 57th Annual Meeting
- Place of Presentation
  San Diego (USA)
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] オプチニューリンとNRLタンパク質の相互作用の解析.2007
- Author(s)
  王春霞、大坪正史、細野克博、大石健太郎、堀田喜裕、蓑島伸生
- Organizer
  第111回日本眼科学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] SYMPHONIE, a knowledge-base of symptoms exhibited in diseases with genetic factors.2007
- Author(s)
  Ohtsubo, M., Wang, CX., Hotta, Y., Nakanishi, H., Mineta, H., Moriwaki, S., Kawaguchi, K., Nakanishi, N., Adachi, K., Horisawa, T., Terao, T., Minoshima, S.
- Organizer
  The 2007 Annual Conference of the Japanese Society for Bioinformatics (JSBi2007)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 新規緑内障原因遺伝子の探索:既知原因遺伝子タンパクと相互作用し,緑内障候補領域に座するタンパク遺伝子の変異解析2007
- Author(s)
  大坪正史
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] SYMPHONIE: A knowledge-base to hierarchically classify symptoms associated with gene-related diseases.2006
- Author(s)
  Ohtsubo, M., Moriwaki, S., Wang, C.X., Hotta, Y., Horisawa, T., Shimizu, N., Terao, T., Minoshima, S.
- Organizer
  The 11th International Congress of Human Genetics
- Place of Presentation
  Brisbane (Australia)
- Data Source
  KAKENHI-PROJECT-17019027
[Presentation] 緑内障および筋萎縮性側索硬化症の原因遺伝子OPTNが関わる空胞様異常構造形成の検討
- Author(s)
  大坪正史
- Organizer
  第９回浜松医科学シンポジウム
- Place of Presentation
  浜松医科大学（浜松市）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 緑内障および筋萎縮性側索硬化症の原因遺伝子オプチニュリンが関わる異常タンパク蓄積のオートファジー惹起による改善
- Author(s)
  大坪正史
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神戸）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 緑内障およびALSの原因遺伝子OPTNが関わる空胞様異常構造形成とオートファジーの関与
- Author(s)
  大坪正史
- Organizer
  第20回日本遺伝子診療学会総会
- Place of Presentation
  アクトシティ浜松コングレスセンター（浜松）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] オプチニュリンの緑内障および筋萎縮性側索硬化症原因変異による細胞内異常構造の検討
- Author(s)
  大坪正史
- Organizer
  第117回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-24592622
[Presentation] 緑内障発症機序の追究：酸化ストレス刺激により形成されるオプチニュリン高分子複合体の検討
- Author(s)
  大坪正史
- Organizer
  第10回浜松医科学シンポジウム
- Place of Presentation
  浜松医科大学（浜松）
- Data Source
  KAKENHI-PROJECT-24592622

1. OHISHI Kentaro (80345826)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. MINOSHIMA Shinsei (90181966)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
3. HOTTA Yoshihiro (90173608)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
4. MORIWAKI Shinichi (40303565)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. ISMAIL Thanseem (60569846)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. HOSONO Katsuhiro (60402260)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. MITSUYAMA Susumu (30296727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 尾花明 (40194625)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 長島優 (20635586)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Anitha A (70377753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 清水信義 (50162706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 足立直樹 (70300853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 徳山勤 (90313957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村友彦 (00437039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 瀬藤光利 (20302664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 前田明子 (20646799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中西伸夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. 王春霞

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. 杉山将隆.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NAKANISHI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHTSUBO Masafumi 大坪 正史

大坪 正史 オオツボ マサフミ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ALS発症におけるOPTNの新規核内機能：スプライソソーム異常と凝集体形成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogenic mechinism of glaucoma based on commonality with Amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of glaucoma-developing mechanism : Investigation of an OPTN-interacting proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 情報処理(46巻2号112-118頁)「遺伝子変異データベース構築のための情報収集と抽出の現状」2005

Author(s)

Total Pages

Publisher

Data Source

[Book] ゲノミクス・プロテオミクスの新展開-生物情報の解析と応用-(814-827頁)「疾患データベース」2004

Author(s)

Total Pages

Publisher

Data Source

[Book] 「疾患データベース」ゲノミクス・プロテオミクスの新展開-生物情報の解析と応用-(pp814-827)2004

Author(s)

OHTSUBO Masafumi 大坪正史

大坪正史オオツボマサフミ