KOSAKA Taiichi 小坂泰一

Researcher Number	10328213
Affiliation (based on the past Project Information) *help	2018: 東京医科大学, 医学部, 講師 2017: 東京医科大学, 医学部, 助教 2013 – 2016: 東京医科大学, 医学部, 講師 2012: 東京医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator miRNA / APL / real time-PCR / miRNA array / 人工関節弛緩 / TWIST / miR-155 / RAFs / MH7a / MMP1 … More / POSTN / TWIST1 / miRNA155 / PLFs / 非感染性人工関節弛緩(APL) / MH7A / EP4 agonist / miR132-3p / miR-155-5p / miR-543 / (1) PLFs … More Except Principal Investigator 細胞外基質分解酵素 / 神経成長因子 / 神経侵入 / 椎間板変性 / 細胞内情報伝達 / 椎間板性腰痛 / プロスタグランジン / 椎間板変性変性 / DUSP-1 / DUSP1 / 神経進入 / MAP kinase / プロスタノイド / Prostaglandin / NGF / prostaglandin / NSAIDs / MMP / 非ステロイド性抗炎症薬 / 腰痛 Less

Role of DUSP-1 on the regulation of disc degeneration and innervation in the development of discogenic low back pain
- Principal Investigator
  
  Endo Kenji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Mechanism of the suppression of disc degeneration and innervation by prostanoid in human intervetebral disc cells.
- Principal Investigator
  
  Suzuki Hidekazu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
Molecular mechanisms of disc degeneration and innervation in human discogenic pain
- Principal Investigator
  
  ENDO Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University
miRNA expression profiling of PLFs stimulated with EP4 agonistPrincipal Investigator
- Principal Investigator
  
  KOSAKA TAIICHI
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical University

All 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] 椎間板性腰痛における神経成長因子の制御2017
- Author(s)
  澤地恭昇，鈴木秀和，遠藤健司，村田寿馬，小坂泰一，山本謙吾
- Journal Title
  
  日本運動器疼痛学会誌
  
  Volume: 9 Pages: 147-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10841
[Journal Article] PGE1 attenuates IL-1b-induced NGF expression in human intervertebral disc cells2016
- Author(s)
  Kazuma Murata, Yasunobu Sawaji, Wuqikun Alimasi, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Makiko Yorifuji, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 41 Issue: 12 Pages: E710-E716
- DOI
  10.1097/brs.0000000000001379
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460728, KAKENHI-PROJECT-25462312, KAKENHI-PROJECT-16K10841
[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid and a selective COX-2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592214
[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013
- Author(s)
  Wukikun Alimasi, Yasunobu Sawaji, Kenji Endo, Makiko Yorifuji, Hidekazu Suzuki, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
- Journal Title
  
  Spine
  
  Volume: 38 Issue: 17 Pages: 1466-1472
- DOI
  10.1097/brs.0b013e318294edb1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592214, KAKENHI-PROJECT-24790579, KAKENHI-PROJECT-25462312
[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016
- Author(s)
  Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Hirosuke Nishimura, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  Spineweek 2016
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　～ヒト椎間板細胞におけるMMP-1/-13発現に着目して～2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第45回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ　国際会議場　（千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] RA-FLS（MH7A）におけるmiR-155導入の効果に関する検討2016
- Author(s)
  小坂泰一
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016
- Author(s)
  Sawaji Y., Suzuki H., Endo K., Tanaka H., Nishimura H., Kosaka T., Yamamoto K.
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] EP4agonisおよびmiR-155のRA-FLSに対する影響2016
- Author(s)
  小坂泰一
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　ーヒト椎間板細胞におけるMMP-1/-13発現に着目してー2016
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，遠藤健司，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第45回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ国際会議場　千葉県
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K10841
[Presentation] Prosthesis Loosening Fibroblasts (PLFs)へのEP4 agonist刺激によって発現変動しうる、miRNAの検討2014
- Author(s)
  小坂泰一
- Organizer
  第４４回日本人工関節学会
- Place of Presentation
  沖縄県宜野湾市
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第28回　日本整形外科基礎学術集会
- Place of Presentation
  千葉市，千葉県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第62回　東日本整形災害外科学会
- Place of Presentation
  北佐久郡，長野県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第11回　整形外科痛みを語る会
- Place of Presentation
  郡山市，福島県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第11回　整形外科痛みを語る会
- Place of Presentation
  郡山市，福島県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第6回　日本運動器疼痛学会
- Place of Presentation
  神戸市，兵庫県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰部脊柱管狭窄症におけるPGE1のMMP/NGFの発現調節2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第62回　東日本整形災害外科学会
- Place of Presentation
  北佐久郡，長野県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 人工関節周囲組織線維芽細胞へのEP4 agonist刺激によって発現変動するmiRNAの探索2013
- Author(s)
  小坂泰一
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] 椎間板細胞における神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第6回　日本運動器疼痛学会
- Place of Presentation
  神戸市，兵庫県
- Data Source
  KAKENHI-PROJECT-25462312
[Presentation] 人工関節周囲組織線維芽細胞へのEP4 agonist刺激によって発現変動するmiRNAの探索2013
- Author(s)
  小坂泰一
- Organizer
  第２８回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] 椎間板軟骨細胞における神経成長因子発現に対するPGE1の新規薬理作用神経成長因子発現に対するPGE1の新規薬理作用2013
- Author(s)
  村田寿馬，澤地恭昇，遠藤健司，ウチクンアルマス，依藤麻紀子，西村浩輔，鈴木秀和，田中英俊，小坂泰一，山本謙吾
- Organizer
  第28回　日本整形外科基礎学術集会
- Place of Presentation
  千葉市，千葉県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] Roles of PGE2 on the intervertebral disc degeneration and nerve ingrowth in human intervertebral disc cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第41回日本脊椎脊髄病学会
- Place of Presentation
  石橋文化センター，久留米市，福岡県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] ヒト椎間板変性に対する選択的COX-2阻害剤およびPGE2の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，田中英俊，小坂泰一，山本謙吾
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 腰椎椎間板変性と神経浸潤に対する選択的COX-2阻害剤の効果2012
- Author(s)
  澤地恭昇，ウチクン・アルマス，遠藤健司，小坂泰一，山本謙吾
- Organizer
  第5回　日本運動器疼痛学会
- Place of Presentation
  TFTホール，有明，東京
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] EP2/4 receptor suppresses the expression of NGF in human IVD cells2012
- Author(s)
  Alimasi W., Sawaji Y., Kimura D., Tanaka H., Kosaka T., Endo K., Yamamoto K.
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] Roles of PGE2 on the intervertebral disk degeneration and nerve ingrowth in human intervertebral disk cells2012
- Author(s)
  Wuqikun Alimasi, Yasunobu Sawaji, Dai Kimura, Hidetoshi Tanaka, Taiichi Kosaka, Kenji Endo, Kengo Yamamoto
- Organizer
  第27回　日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋国際会議場，名古屋，愛知県
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] EP1/3 pathway suppresses exaggeration of IL-1-induced collagenases by a selective COX-2 inhibitor in human IVD cells2012
- Author(s)
  Sawaji Y., Alimasi W., Endo K., Kosaka T., Kimura D. and Yamamoto K.
- Organizer
  International Society for the Study of the Lumbar Spine
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] PGE2 negatively regulates NGF expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] PGE2 negatively regulates MMP-1 expression by inducing DUSP-1 in human intervertebral disc cells
- Author(s)
  Makiko Yorifuji, Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
- Organizer
  The International Society for the Study of Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] fibroblast-like synoviocytes（mh7a）におけるmiR-155導入効果の検討
- Author(s)
  小坂泰一
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山県富山国際会議場
- Year and Date
  2015-10-22 – 2015-10-23
- Data Source
  KAKENHI-PROJECT-24592245
[Presentation] ヒト椎間板性腰痛における神経成長因子発現調節の分子機構
- Author(s)
  村田寿馬，澤地恭昇，依藤麻紀子，鈴木秀和，遠藤健司，小坂泰一，山本謙吾
- Organizer
  第12回　整形外科痛みを語る会
- Place of Presentation
  福岡県久留米市
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-24592214
[Presentation] 椎間板性腰痛に関わる神経成長因子のプロスタグランジンによる発現制御機構
- Author(s)
  澤地恭昇，村田寿馬，鈴木秀和，依藤麻紀子，田中英俊，小坂泰一，山本謙吾
- Organizer
  第44回　日本脊椎脊髄病学会学術集会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-24592214

1. SAWAJI Yasunobu (20571152)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
2. YAMAMOTO Kengo (10246316)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
3. ENDO Kenji (90266479)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
4. SUZUKI Hidekazu (40317871)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
5. KURODA Masahiko (80251304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西村浩輔 (80516047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 松岡佑嗣 (50408126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUSAKABE Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KONISHI Takamitsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田中英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOSAKA Taiichi 小坂 泰一

Research Projects

Research Products

Co-Researchers

Role of DUSP-1 on the regulation of disc degeneration and innervation in the development of discogenic low back pain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of the suppression of disc degeneration and innervation by prostanoid in human intervetebral disc cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of disc degeneration and innervation in human discogenic pain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

miRNA expression profiling of PLFs stimulated with EP4 agonistPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 椎間板性腰痛における神経成長因子の制御2017

Author(s)

Journal Title

Data Source

[Journal Article] PGE1 attenuates IL-1b-induced NGF expression in human intervertebral disc cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid and a selective COX-2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-12013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] プロスタグランジンによる椎間板変性制御機構の検討 ～ヒト椎間板細胞におけるMMP-1/-13発現に着目して～2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] RA-FLS（MH7A）におけるmiR-155導入の効果に関する検討2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] EP4agonisおよびmiR-155のRA-FLSに対する影響2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] プロスタグランジンによる椎間板変性制御機構の検討 ーヒト椎間板細胞におけるMMP-1/-13発現に着目してー2016

Author(s)

Organizer

Place of Presentation

KOSAKA Taiichi 小坂泰一

[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　～ヒト椎間板細胞におけるMMP-1/-13発現に着目して～2016

[Presentation] プロスタグランジンによる椎間板変性制御機構の検討　ーヒト椎間板細胞におけるMMP-1/-13発現に着目してー2016