Takayama Mitsuo 高山光男

… Alternative Names

TAKAYAMA Mitsuo 高山光男

高山光男タカヤマミツオ

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Researcher Number	10328635
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 理学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 横浜市立大学, 理学部, 教授 2016 – 2017: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 2015: 横浜市立大学, 生命ナノシステム科学研究科, 教授 2013: 横浜市立大学, その他の研究科, 教授 2009 – 2013: Yokohama City University, 生命ナノシステム科学研究科, 教授 2006 – 2008: 横浜市立大学, 国際総合科学研究科, 教授 2001: 横浜市立大学, 総合理学研究科, 助教授
Review Section/Research Field	Principal Investigator Analytical chemistry / Basic Section 34020:Analytical chemistry-related Except Principal Investigator 生物形態・構造
Keywords	Principal Investigator 質量分析 / 水素ラジカル / 超音波 / タンパク質 / 酸加水分解 / タンパク質化学 / ジスルフィド結合 / 有機材料 / Water / Ultrasound … More / Mass spectrometry / Degradation reaction / Hydrogen radical / Instrumental analysis / 水 / 分解反応 / 機器分析 / 大気圧微小プラズマ / 活性化学種 / ビラジカル / オゾン / 加水分解 / 抗酸化 / 還元反応 / 分解 … More Except Principal Investigator Development and differentiation / Motor neurons / Hippocampal pyramidal cells / Neuropeptides / Auditory cortex / Facial nucleus / Transient expression / Estrogen receptor / カルレチニン / 新生仔 / 大脳皮質視覚野 / 後耳介筋 / 発達分化 / 運動ニューロン / 海馬錐体細胞 / 神経ペプチド / 大脳皮質聴覚野 / 顔面神経核 / 一過性出現 / エストロゲン受容体 Less

Novel method for indentifying disulfide-linked proteins using hydrogen radicalPrincipal Investigator
- Principal Investigator
  
  Takayama Mitsuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Yokohama City University
Molecular mechanism for the resistance and degradation of organic materials to hydrogen radicalPrincipal Investigator
- Principal Investigator
  
  Takayama Mitsuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Yokohama City University
The study of specific reactions of hydrogen radical under ambient conditionsPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Mitsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Yokohama City University
Specific degradation of peptides with hydrogen radical and its application to protein chemistryPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Mitsuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Yokohama City University
Basic Research on the Regulation of Specific Degradation Reaction due to Hydrogen RadicalPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Mitsuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Yokohama City University
Analysis of transient expression of estrogen receptor in the newborn rat brain
- Principal Investigator
  
  HAYASHI Shinji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物形態・構造
- Research Institution
  YOKOHAMA CITY UNIVERSITY

[Book] 現代質量分析学2013
- Author(s)
  高山光男, 他編
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23550101
[Book] 現代質量分析学2013
- Author(s)
  高山光男、早川滋雄、瀧浪欣彦、和田芳直
- Total Pages
  514
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23550101
[Book] 現代質量分析学2013
- Author(s)
  高山光男他編
- Total Pages
  514
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23550101
[Book] 翻訳後修飾のプロテオミクス2011
- Author(s)
  平野久・大野茂男編著　高山光男（分担）
- Total Pages
  233
- Publisher
  講談社
- Data Source
  KAKENHI-PROJECT-23550101
[Book] タンパク質入門 -その化学構造とライフサイエンスへの招待-2006
- Author(s)
  高山光男
- Total Pages
  218
- Publisher
  (株)内田老鶴圃
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Sensitive and resistant of the homologous disulfide-bridged proteins alpha-lactalbumin and lysozyme to attack of hydrogen-atoms, dithiothreitol and trifluoroacetic acid, examine by matrix-assisted laser desorption/ionization mass spectrometry2022
- Author(s)
  Mitsuo Takayama
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 29 Pages: 101212-101212
- DOI
  10.1016/j.bbrep.2022.101212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Multiple Hydrogen Loss and Radical-Directed Dissociation of Peptide in MALDI-ISD MS2021
- Author(s)
  K. Miyazawa, M. Takayama
- Journal Title
  
  J. Mass Spectrom. Soc. Jpn.
  
  Volume: 69 Pages: 1-3
- NAID
  130007986230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] MALDI-MS Analysis of Antitumor Antibiotics with Thiol Containing Matrix2021
- Author(s)
  H. Yoshikwa, M. Takayama
- Journal Title
  
  J. Mass Spectrom. Soc. Jpn.
  
  Volume: 69 Pages: 4-7
- NAID
  130007986233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Multiple Hydrogen Loss from [M + H]+ and [a]+ ions of Peptides in MALDI In-Source Decay Using a Dinitro-Substituted Matrix2020
- Author(s)
  K. Miyazawa, M. Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom.
  
  Volume: 31 Issue: 3 Pages: 547-552
- DOI
  10.1021/jasms.9b00013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Influence of hydrophilic additives on the signal intensity in electrospray ionization of flavonoid glycosides2020
- Author(s)
  A. Kegashima, A. Motoyama, M. Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrom.
  
  Volume: 34 Issue: 23 Pages: 1-10
- DOI
  10.1002/rcm.8914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Estimation of flexible and rigid residues of disulfide-bridged and phosphorylated proteins using matrix-assisted laser desorption/ionization in-source decay mass spectrometry2019
- Author(s)
  M. Takayama
- Journal Title
  
  ACS Omega
  
  Volume: 4 Issue: 23 Pages: 2030820314-2030820314
- DOI
  10.1021/acsomega.9b02814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Intramolecular hydrogen transfer from the alpha-carbon (Ca) and backbone amide nitrogen (Nb) to form c- and y-ions in negative-ion CID of peptide2019
- Author(s)
  Asaki Kagoshima, Kanako Sekimoto and Mitsuo Takayama
- Journal Title
  
  Journal of the American Society for Mass Spectrometry
  
  Volume: 30 Issue: 9 Pages: 1592-1600
- DOI
  10.1007/s13361-019-02245-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05179, KAKENHI-PROJECT-19K05530
[Journal Article] Residue specific formation of [a]+ ions initiated by the loss of hydrogen from [M+H]+ in high energy CID of peptides2019
- Author(s)
  S. Sekiya, M. Yamakoshi, S. Iwamoto, K. Tanaka, M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom.
  
  Volume: 445 Pages: 116195-116195
- DOI
  10.1016/j.ijms.2019.116195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Residue-specific radical-driven dissociation of peptides using matrix-assisted laser desorption/ionization in-source decay wit hydrogen-donating and abstracting matrices2019
- Author(s)
  K. Nagoshi and M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom.
  
  Volume: 436 Pages: 2532-2532
- DOI
  10.1016/j.ijms.2018.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05530
[Journal Article] Collision-Induced Dissociation Study of Strong Hydrogen-Bonded Cluster Ions Y−(HF)n (Y=F, O2) Using Atmospheric Pressure Corona Discharge Ionization Mass Spectrometry Combined with a HF Generator2017
- Author(s)
 K. Sakamoto, K. Sekimoto and M. Takayama
- Journal Title
 
 Mass Spectrometry
 
 Volume: 6 Issue: 1 Pages: A0063-A0063
- DOI
 10.5702/massspectrometry.A0063
- NAID
 130006091407
- ISSN
 2186-5116, 2187-137X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K05545, KAKENHI-PROJECT-15K16117
[Journal Article] Ionization Capabilities of Hydronium Ions and High Electric Fields Produced by Atmospheric Pressure Corona Discharge2017
- Author(s)
  N. Sato, K. Sekimoto, M. Takayama
- Journal Title
  
  Mass Spectrometry
  
  Volume: 5 Issue: 2 Pages: S0067-S0067
- DOI
  10.5702/massspectrometry.S0067
- NAID
  130005476003
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05545, KAKENHI-PROJECT-15K16117
[Journal Article] Oxidative radical driven cleavage of peptide backbone caused by matrix-assisted laser desorption/ionization in-source decay with low matrix-to-peptide molar ratios2017
- Author(s)
  M. Yamakoshi and M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom.
  
  Volume: 422 Pages: 56-61
- DOI
  10.1016/j.ijms.2017.08.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05545
[Journal Article] The Mechanism of c-Ion Formation2016
- Author(s)
 Mitsuo Takayama
- Journal Title
 
 Mass Spectrometry
 
 Volume: 5 Issue: 1 Pages: A0044-A0044
- DOI
 10.5702/massspectrometry.A0044
- NAID
 130005138385
- ISSN
 2186-5116, 2187-137X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K05545
[Journal Article] Formation of c- and z-ions due to preferentail cleavage at the N-C bond of Xxx-Asp/Asn residues in negative-ion CID of peptides2015
- Author(s)
  N. Sugasawa, T. Kawase, M. Oshikata, R. Iimuro, A. Motoyama, M. Takayama
- Journal Title
  
  International Journal of Mass Spectrometry
  
  Volume: 383/384 Pages: 38-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05545
[Journal Article] Analysis of Flexibility of Proteins by means of Positive and Negative Ion MALDI In-Source Decay Mass Spectrometry2014
- Author(s)
  R. Iimuro and M. Takayama
- Journal Title
  
  Mass Spectrometry
  
  Volume: 3 Issue: Special_Issue Pages: S0023-S0023
- DOI
  10.5702/massspectrometry.S0023
- NAID
  130004727167
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Ionization characteristics of amino acids in direct analysis in real time mass spectrometry2014
- Author(s)
  K. Sekimoto, M. Sakakura, T. Kawamukai, H. Hike, T. Shiota, F. Usui, Y. Bando and M. Takayama
- Journal Title
  
  Analyst
  
  Volume: 139 Pages: 2589-2599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Influence of Initial Velocity of Analytes on In-source Decay Products in MALDI Mass Spectrometry using Salicylic Acid Derivative Matrices2014
- Author(s)
  D. Asakawa, M. Sakakura, and M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom.
  
  Volume: 337 Pages: 29-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Selective and Nonselective Cleavages in Positive and Negative CID of the Fragments generated from In-Source Decay of Intact Proteins in MALDI-MS2014
- Author(s)
  M. Takayama, S. Sekiya, R. Iimuro, S. Iwamoto, and K. Tanaka
- Journal Title
  
  J. Am. Soc. Mass Spectrom (Tokyo)
  
  Volume: 25 Pages: 120-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Selective and Nonselective Cleavages in Positive and Negative CID of the Fragments generated from In-Source Decay of Intact Proteins in MALDI-MS2014
- Author(s)
  M. Takayama, S. Sekiya, R. Iimuro, S. Iwamoto, and K. Tanaka
- Journal Title
  
  J. Am. Soc. Mass Spectrom.
  
  Volume: 25 Pages: 120-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Influence of Initial Velocity of Analytes on In-source Decay Products in MALDI Mass Spectrometry using Salicylic Acid Derivative Matrices2013
- Author(s)
  D. Asakawa, M. Sakakura, and M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom
  
  Volume: 337 Pages: 29-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] 5-Amino-1-naphthol, a novel 1,5-naphthalene derivative matrix suitable for MALDI in-source decay of phosphorylated peptides2013
- Author(s)
  I. Osaka, M. Sakai and M. Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrom.
  
  Volume: 27 Pages: 103-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Collision-Induced Dissociation Study of the Adduct Ions Produced in NO3−-Free Area of Atmospheric Pressure Negative Corona Discharges under Ambient Air Conditions2013
- Author(s)
 K. Sekimoto, N. Matsuda, M. Takayama
- Journal Title
 
 Mass Spectrometry
 
 Volume: 2 Issue: 1 Pages: A0020-A0020
- DOI
 10.5702/massspectrometry.A0020
- NAID
 130003380161
- ISSN
 2186-5116, 2187-137X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23550101, KAKENHI-PROJECT-24619005
[Journal Article] The pH Dependence of Product Ion Spectra Obtained from Precursor Ions with the Same Charge Number in ESI of Carbonic Anhydrase 22013
- Author(s)
  Y. Nabuchi, K.Hirose and M.Takayama
- Journal Title
  
  Mass Spectrometry
  
  Volume: 2 Issue: 1 Pages: A0016-A0016
- DOI
  10.5702/massspectrometry.A0016
- NAID
  130003380158
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] 5-Amino-1-naphthol, a novel 1, 5-naphthalene derivative matrix suitable for MALDI in-source decay of phosphorylated peptides2013
- Author(s)
  I. Osaka, M. Sakai and M. Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrom
  
  Volume: 27 Pages: 103-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Collision-induced dissociation analysis of negative atmospheric ion adducts in atmospheric pressure corona discharge ionization mass spectrometry2013
- Author(s)
  K. Sekimoto and M. Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom.
  
  Volume: 24 Issue: 5 Pages: 780-788
- DOI
  10.1007/s13361-013-0576-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101, KAKENHI-PROJECT-24619005
[Journal Article] Collision-induced dissociation analysis of negative atmospheric ion adducts in atmospheric pressure corona discharge ionization mass spectrometry2013
- Author(s)
  K. Sekimoto and M. Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom
  
  Volume: 24 Pages: 780-788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Matrix Effect on In-Source Decay Products of Peptides in Matrix-Assisted Laser Desorption/Ionization2012
- Author(s)
  D. Asakawa, M. Sakakura, M. Takayama
- Journal Title
  
  Mass Spectrometry
  
  Volume: 1 Issue: 1 Pages: A0002-A0002
- DOI
  10.5702/massspectrometry.A0002
- NAID
  130001937210
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10272, KAKENHI-PROJECT-23550101
[Journal Article] Mass spectrometric characterization of phosphorylated peptides using MALDI in-source decay via redox reactions2012
- Author(s)
  D.Asakawa and M.Takayama
- Journal Title
  
  J. Mass Spectrom
  
  Volume: 47 Pages: 180-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Flexible Xxx–Asp/Asn and Gly–Xxx Residues of Equine Cytochrome c in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry2012
- Author(s)
 M. Takayama
- Journal Title
 
 Mass Spectrometry
 
 Volume: 1 Issue: 2 Pages: A0007-A0007
- DOI
 10.5702/massspectrometry.A0007
- NAID
 10031126344
- ISSN
 2186-5116, 2187-137X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23550101
[Journal Article] Influence of Charge State of Precursor Ions on Collision-induced Dissociation of Carbonic Anhydrase 22012
- Author(s)
  Y.Nabuchi, K.Hirose and M.Takayama
- Journal Title
  
  J. Mass Spectrom. Soc. Jpn,
  
  Volume: 60 Pages: 47-50
- NAID
  10031126335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Influence of amino acid composition and phosphorylation on the ion yields of peptides in MALDI-MS2012
- Author(s)
  D.Asakawa, S.Moriguchi and M.Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom
  
  Volume: 23 Pages: 108-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Influence of Secondary Structure on In-Source Decay of Protein in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry2012
- Author(s)
  M.Takayama, I.Osaka and M.Sakakura
- Journal Title
  
  Mass Spectrometry
  
  Volume: 1 Issue: 1 Pages: A0001-A0001
- DOI
  10.5702/massspectrometry.A0001
- NAID
  10031126337
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101, KAKENHI-PROJECT-24619006
[Journal Article] Fragmentation Processes of hydrogen-Deficient Peptide Radicals in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry2012
- Author(s)
  D.Asakawa and M.Takayama
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 116 Pages: 4016-4023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Improved sonolytic hydrolysis of peptides in aqueous solution with addition of 1,4-benzenedithiol2012
- Author(s)
  M.Sakakura and M.Takayama
- Journal Title
  
  Ultrasonics Sonochemistry
  
  Volume: 19 Pages: 615-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Surface analysis of traces stained with discharge on plane electrode in atmospheric pressure negative corona2012
- Author(s)
  K.Sekimoto and M.Takayama
- Journal Title
  
  Journal of Electrostatics
  
  Volume: 70 Pages: 363-373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Mass spectrometric characterization of phosphorylated peptides using MALDI in-source decay via redox reactions2012
- Author(s)
  D.Asakawa and M.Takayama
- Journal Title
  
  J. Mass Spectrom.
  
  Volume: 47 Pages: 180-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Specific interaction between negative atmospheric ions and organic compounds in atmospheric pressure corona discharge ionization mass spectrometry2012
- Author(s)
  K.Sekimoto, M.Sakai and M.Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom.
  
  Volume: 23 Pages: 1109-1119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Cα-C bond cleavage of the peptide backbone in MALDI in-source decay using salicylic acid derivative matrices2011
- Author(s)
  D.Asakawa and M.Takayama
- Journal Title
  
  J. Am. Soc. Mass Spectrom
  
  Volume: 22 Pages: 1224-1233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Specific cleavage at peptide backbone Cα-C and CO-N bonds during MALDI-ISD mass spectrometry with 5-nitrosalicylic acid as the matrix2011
- Author(s)
  D.Asakawa and M.Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrom.
  
  Volume: 25 Pages: 2379-2383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Observation of different core water cluster ions Y-(H2O)n (Y=O2, HOx, NOx, COx) and magic number in atmospheric pressure corona discharge mass spectrometry2011
- Author(s)
  K.Sekimoto and M.Takayama
- Journal Title
  
  J. Mass Spectrom
  
  Volume: 46 Pages: 50-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] Temperature dependence of magic number and first hydrated shell of various core water cluster ions Y-(H2O)n (Y= O2, HOx, NOx, COx) in atmospheric pressure negative corona discharge mass spectrometry2011
- Author(s)
  K.Sekimoto and M.Takayama
- Journal Title
  
  Int. J. Mass Spectrom
  
  Volume: 306 Pages: 44-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550101
[Journal Article] In-source decay and fragmentation characteristics of peptides using 5-aminosalicylic acid as a matrix in matrix-assisted laser desorption/ionization mass spectrometry Journal of the American Society for Mass Spectrometry2010
- Author(s)
  M.Sakakura, M.Takayama
- Journal Title
  
  J.Am.Soc.Mass Spectrom. Vol.21
  
  Pages: 979-988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] Influence of charge state and amino acid composition on hydrogen transfer in electron capture dissociation of peptides2010
- Author(s)
  T.Nishikaze, M.Takayama
- Journal Title
  
  Journal of the American Society for Mass Spectrometry
  
  Volume: 21 Pages: 1979-1988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] Influence of charge state and amino acid composition on hydrogen transfer in electron capture dissociation of peptides2010
- Author(s)
  T.Nishikaze, M.Takayama
- Journal Title
  
  J.Am.Soc.Mass Spectrom Vol.21
  
  Pages: 1979-1988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] In-source decay and fragmentation characteristics of peptides using 5-aminosahcylic acid as a matrix in matrix-assisted laser desorption/ionization mass spectrometry2010
- Author(s)
  M.Sakakura, M.Takayama
- Journal Title
  
  Journal of the American Society for Mass Spectrometry
  
  Volume: 21 Pages: 979-988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] In-source decay and fragmentation characteristics of peptides using 5-a minosalicylic acid as a matrix in matrix-assisted laser desorption/ionization mass spectrometry2010
- Author(s)
  M.Sakakura, M.Takayama
- Journal Title
  
  Journal of the American Society for Mass Spectrometry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] Sonolytic hydrolysis of peptides in aqueous solution upon addition of catechol2009
- Author(s)
  M.Sakakura, M.Takayama
- Journal Title
  
  Ultrasonics Sonochemistry Vol.16
  
  Pages: 367-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] Sonolytic hydrolysis of peptides in aqueous solution upon addition of catechol2009
- Author(s)
  M. Sakakura, M. Takayama
- Journal Title
  
  Ultrasonics Sonochemistry 16
  
  Pages: 367-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20550081
[Journal Article] Study of factors governing negative molecular ion yields of amino acid and peptide in FAB, MALDI and ESI mass spectrometry2007
- Author(s)
  T. Nishikaze and M. Takayama
- Journal Title
  
  International Journal of Mass Spectrometry 268
  
  Pages: 47-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Study of factors governing negative molecular ion yields of amino acid and peptide in FAB, MALDI and ESI mass spectrometry2007
- Author(s)
  T. Nishikaze, M. Takayama
- Journal Title
  
  Int. J. Mass Spectrom 268
  
  Pages: 47-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Disappearance of interfering alkali-metal adducted peaks from matrix-as sisted laser desorption/ionization mass spectra of peptides with serine a ddition to a-cyano-4-hydroxycinnamic acid matrix2007
- Author(s)
  T.Nishikaze and M.Takayama
- Journal Title
  
  Rapid Commun. Mass Spectromerty 21
  
  Pages: 3345-3351
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Disappearance of interfering alkali-metal adducted peaks from matrix-assisted laser desorption/ionization mass mass spectra of peptides with serine addition to a-cyano-4-hydroxycinnami acid matrix2007
- Author(s)
  T. Nishikaze, M. Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrom 21
  
  Pages: 334-3351
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Disappearance of interfering alkali-metal adducted peaks from matrix-assisted laser desorption/ionization mass spectra of peptides with serine a ddition to a-cyano-4-hydroxycinnamic acid matrix2007
- Author(s)
  T. Nishikaze and M. Takayama
- Journal Title
  
  Rapid Commun. Mass Spectromerty 21
  
  Pages: 3345-3351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Study of factors governing negative molecular ion yields of amino acid and peptide in FAB, MALDI and ESI mass spectrometry2007
- Author(s)
  T.Nishikaze and M.Takayama
- Journal Title
  
  International Journal of Mass Spectrometry 268
  
  Pages: 47-59
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Evidence for the presence of fullerene in diesel soot using laser desorption mass spectrometry2006
- Author(s)
  M.Takayama, M.Tachibana, et al.
- Journal Title
  
  J. Mass Spectrom. Soc. Jpn 54
  
  Pages: 39-44
- Data Source
  KAKENHI-PROJECT-18550078
[Journal Article] Cooperative effect of factors governing molecular ion yields in desorption ionization mass spectrometry2006
- Author(s)
  T.Nishikaze, M.Takayama
- Journal Title
  
  Rapid Commun. Mass Spectrometry 20
  
  Pages: 376-382
- NAID
  130006998400
- Data Source
  KAKENHI-PROJECT-18550078
[Patent] 原子状水素発生器、原子状水素の製造方法および原子状水素の発生を確認する方法2015
- Inventor(s)
  高山光男
- Industrial Property Rights Holder
  高山光男
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-111987
- Filing Date
  2015-06-02
- Data Source
  KAKENHI-PROJECT-15K05545
[Patent] 大気圧コロナ放電イオン化システム及びイオン化方法2011
- Inventor(s)
  高山光男・関本奏子
- Industrial Property Rights Holder
  高山光男・関本奏子
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23550101
[Patent] タンパク質とリン酸化ペプチドのペプチド主鎖のN-Ca結合又はCa-C結合の特異的切断方法2011
- Inventor(s)
  高山光男・大坂一生
- Industrial Property Rights Holder
  高山光男・大坂一生
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23550101
[Patent] ペプチド主鎖N-Cα結合の特異的切断方法2009
- Inventor(s)
  高山光男・坂倉幹始
- Industrial Property Rights Holder
  横浜市立大学
- Industrial Property Number
  2009-167550
- Filing Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-20550081
[Patent] チオール化合物と超音波を利用したペプチドの加水分解方法2008
- Inventor(s)
  高山光男
- Industrial Property Rights Holder
  横浜市立大学
- Industrial Property Number
  2008-316326
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] チオール含有マトリックスを用いた抗腫瘍抗生物質のMALDI-MS分析2020
- Author(s)
  吉川大、高山光男
- Organizer
  第68回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-19K05530
[Presentation] MALDI-ISDにおけるペプチドからの複数水素の脱離とラジカル誘導分解2020
- Author(s)
  宮澤慶、高山光男
- Organizer
  第68回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-19K05530
[Presentation] 複数のジスルフィド結合を持つタンパク質のMALDI-ISDによる解析2019
- Author(s)
  綛谷勇貴、名越慶士郎、高山光男
- Organizer
  第６７回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-19K05530
[Presentation] 負イオンHFクラスターの水素結合解離反応とプロトン移動反応2017
- Author(s)
  坂本賢也、高山光男
- Organizer
  日本質量分析学会　総合討論会
- Data Source
  KAKENHI-PROJECT-15K05545
[Presentation] Comprehensive Top-Down Analysis of Phosphorylated Intact Proteins using MALDI-ISD MS with 5-Amino-1-Naphthol Matrix2015
- Author(s)
  Mitsuo Takayama
- Organizer
  The 25th Australian and New Zealand Society for Mass Spectrometry Conference
- Place of Presentation
  Brisbane
- Year and Date
  2015-07-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K05545
[Presentation] ペプチド負イオンCIDにおけるcイオン生成機構－分子内プロトン引き抜き－2015
- Author(s)
  本山晃・川瀬泰司・押方基司・菅澤奈美・高山光男
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-15K05545
[Presentation] -CaseinのMALDI-ISDフラグメント観測に対するイオン滞在時間の影響2015
- Author(s)
  名越慶士郎・関谷禎則・岩本慎一・田中耕一・高山光男
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-15K05545
[Presentation] 大気圧下での負イオン付加体の生成と水素引き抜き反応2013
- Author(s)
  松田菜津季・関本奏子・高山光男
- Organizer
  質量分析総合討論会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Molecular mass determination using collision-induced dissociation of negative atmospheric ion adducts generated in ambient corona discharges2013
- Author(s)
  Kanako Sekimoto and Mitsuo Takayama
- Organizer
  American Mass Spectrometry Conference
- Place of Presentation
  Mineapollis
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] 大気圧下での負イオン付加体の生成と水素引き抜き反応2013
- Author(s)
  松田菜津季, 関本奏子, 高山光男
- Organizer
  第61回質量分析総合討論会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] 大気イオン生成に与えるオゾンの影響2013
- Author(s)
  三舩千佳, 関本奏子, 高山光男
- Organizer
  第61回質量分析総合討論会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] 大気イオン生成に与えるオゾンの影響2013
- Author(s)
  三舩千佳・関本奏子・高山光男
- Organizer
  質量分析総合討論会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Application of negative atmospheric ions formed in corona discharges to specific analyte ionization under ambient conditions2012
- Author(s)
  Kanako Sekimoto and Mitsuo Takayama
- Organizer
  the 60th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Vancouver, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Influence of Charge State of Precursor Ions on Collision-Induced Dissociation of Carbonic Anhydrase 22012
- Author(s)
  Yoshiaki Nabuchi; Kenji Hirose ; Mitsuo Takayama
- Organizer
  the 60th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Optimization of matrix preparation methods for MALDI-ISD of protein2012
- Author(s)
  Ryunosuke Iimuro, Mitsuo Takayama
- Organizer
  the 19th International Mass Spectrometry Conference
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Ion formation and evolution in atmospheric pressure corona discharges between arbitrary point-to-plane electrode conditions2011
- Author(s)
  Kanako Sekimoto and Mitsuo Takayama
- Organizer
  the 59th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Negative ion formation and evolution in atmospheric pressure corona discharges between point-to-plane electrodes with arbitrary configurations2011
- Author(s)
  Kanako Sekimoto and Mitsuo Takayama
- Organizer
  the 30th International Conference on Phenomena in Ionized Gases
- Place of Presentation
  Belfast, Northern Ireland
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] 水素引き抜き反応によるMALDIインソース分解のメカニズムおよびリン酸化プロテオームへの応用2011
- Author(s)
  浅川大樹・高山光男
- Organizer
  第59回質量分析総合討論会
- Place of Presentation
  ホテル阪急エキスポパーク・大坂
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] ハードイオン化からソフトイオン化まで-その特性と応用の実際-2011
- Author(s)
  高山光男
- Organizer
  第５回日本化学会関東支部大会(招待講演)
- Place of Presentation
  東京農工大学・小金井キャンパス
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Cα-C bond cleavage of the peptide backbone in MALDI in-source decay using salicylic acid derivative matrices2011
- Author(s)
  Daiki Asakawa; Mitsuo Takayama
- Organizer
  the 59th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Negative ion formation and evolution in atmospheric pressure corona discharges between point-to-plane electrodes with arbitrary configurations2011
- Author(s)
  Kanako Sekimoto and Mitsuo Takayama
- Organizer
  VI International Workshop on Microplasmas
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Positive and negative ion formation of amino acid and its hydrated clusters using ambient corona discharge with micro-devices2011
- Author(s)
  Mami Sakai; Mitsuo Takayama
- Organizer
  the 59th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] Radical-induced fragmentation of phosphorylated-peptides in MALDI MS2011
- Author(s)
  Mitsuo Takayama, Motoshi Sakakura, Daiki Asakawa
- Organizer
  2nd Asia and Oceanic Mass Spectrometry Conference(招待講演)
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-23550101
[Presentation] A new matrix suitable for MALDI-ISD of phosphorylated peptides2010
- Author(s)
  坂倉幹始, 高山光男
- Organizer
  the 58th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Salt lake city, Utah, USA
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] A new matrix suitable for MALDI-ISD of phosphorylated peptides2010
- Author(s)
  M.Sakakura, M.Takayama
- Organizer
  58th ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Salt lake city, Utah, USA
- Year and Date
  2010-05-25
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] 超音波を用いたペプチドの分解反応とその特性2009
- Author(s)
  坂倉幹始・高山光男
- Organizer
  第70回分析化学討論会
- Place of Presentation
  和歌山大学
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] Comparative study of hydrogen-induced cleavage of peptides with MALDI-ISD and sonolysis2009
- Author(s)
 坂倉幹始・高山光男
- Organizer
 18^<th> International Mass Spectrometry Conference
- Place of Presentation
 Bremen, Germany
- Year and Date
 2009-09-02
- Data Source
 KAKENHI-PROJECT-20550081
[Presentation] Comparative study of hydrogen-induced cleavage of peptides with MALDI-ISD and sonolysis2009
- Author(s)
  坂倉幹始, 高山光男
- Organizer
  18th International Mass Spectrometry Conference
- Place of Presentation
  Bremen, Germany
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] ペプチド用新規MALDIマトリックスとインソース分解の評価2009
- Author(s)
  坂倉幹始・高山光男
- Organizer
  日本ヒトプロテオーム機構
- Place of Presentation
  北里大学
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] 水素ラジカルと超音波を利用したペプチドの分解反応のMALDI-TOFMS解析2008
- Author(s)
  坂倉幹始, 高山光男
- Organizer
  第56回質量分析総合討論会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] 超音波によるペプチドの加水分解反応の特徴2008
- Author(s)
  坂倉幹始, 高山光男
- Organizer
  第17回ソノケミストリー討論会
- Place of Presentation
  電気通信大学,東京
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] 水素ラジカルを利用するアミノ酸配列解析2008
- Author(s)
  坂倉幹始・高山光男
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜、日本
- Year and Date
  2008-03-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Presentation] 超音波によるペプチドの加水分解反応の特徴2008
- Author(s)
  坂倉幹始, 高山光男
- Organizer
  第17回ソノケミストリー討論会
- Place of Presentation
  電気通信大学
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20550081
[Presentation] Serine enhances and improve peptide ion signals in MALDI MS2007
- Author(s)
  M., Takayama, T. Nishikaze
- Organizer
  55th ASMS Conference
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Presentation] Serine enhances and improves peptide ion signals in MALDI MS2007
- Author(s)
  M.Takayama and T.Nishikaze
- Organizer
  55th ASMS Conference
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Presentation] Amino acid sequencing using a novel hydrolysis method2007
- Author(s)
  M.Sakakura, T.Nishikaze and M. Takayama
- Organizer
  55th JHUPO Conference
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-07-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18550078
[Presentation] Amino acid sequencing using a novel hydrolysis method2007
- Author(s)
  M. Sakakura, T. Nishkaze, M. Takayama
- Organizer
  5th JHUPO Conference
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-07-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18550078

1. HAYASHI Shinji (20076996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SEKIMOTO Kanako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takayama Mitsuo 高山 光男

TAKAYAMA Mitsuo 高山 光男

高山 光男 タカヤマ ミツオ

Research Projects

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Co-Researchers

Novel method for indentifying disulfide-linked proteins using hydrogen radicalPrincipal Investigator

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Molecular mechanism for the resistance and degradation of organic materials to hydrogen radicalPrincipal Investigator

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The study of specific reactions of hydrogen radical under ambient conditionsPrincipal Investigator

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Specific degradation of peptides with hydrogen radical and its application to protein chemistryPrincipal Investigator

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Basic Research on the Regulation of Specific Degradation Reaction due to Hydrogen RadicalPrincipal Investigator

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Analysis of transient expression of estrogen receptor in the newborn rat brain

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[Book] 現代質量分析学2013

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[Book] 現代質量分析学2013

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[Book] 現代質量分析学2013

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[Book] 翻訳後修飾のプロテオミクス2011

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[Book] タンパク質入門 -その化学構造とライフサイエンスへの招待-2006

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[Journal Article] Sensitive and resistant of the homologous disulfide-bridged proteins alpha-lactalbumin and lysozyme to attack of hydrogen-atoms, dithiothreitol and trifluoroacetic acid, examine by matrix-assisted laser desorption/ionization mass spectrometry2022

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[Journal Article] Multiple Hydrogen Loss and Radical-Directed Dissociation of Peptide in MALDI-ISD MS2021

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[Journal Article] MALDI-MS Analysis of Antitumor Antibiotics with Thiol Containing Matrix2021

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Takayama Mitsuo 高山光男

TAKAYAMA Mitsuo 高山光男

高山光男タカヤマミツオ