Imai Kazushi 今井一志

… Alternative Names

IMAI Kazushi 今井一志

今井一志イマイカズシ

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Researcher Number	10328859
Other IDs
Affiliation (Current)	2025: 日本歯科大学, 生命歯学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2020: 日本歯科大学, 生命歯学部, 教授 2010 – 2012: 日本歯科大学, 生命歯学部, 教授 2007: The Nippon Dental University, School of Life Dentistry at Tokyo, Associate Professor 2006: 日本歯科大学, 生命歯学部, 助教授 2004 – 2005: 日本歯科大学, 歯学部, 助教授 2001 – 2002: 日本歯科大学, 歯学部, 講師
Review Section/Research Field	Principal Investigator Pathobiological dentistry/Dental radiology / Basic Section 57020:Oral pathobiological science-related / Functional basic dentistry
Keywords	Principal Investigator 口腔癌 / sChIP / HMGA2 / 転写因子 / プロモーター / MALT1 / 浸潤 / ドメイン / experimental tumor biology / signal transduction … More / cells and tissues / Dentistry / oral carcinoma / 癌 / 実験腫瘍学 / シグナル伝達 / 細胞・組織 / 歯学 / Transcription factor / Oral carcinomas / SChIP / Sp1 / Sp3 / サイレンサー / 口腔癌細胞 / KLF5 / KLF / 遺伝子 / 形態形成 / 発生 / 歯牙 Less

Nuclear translocation mechanism of MALT1 and oral carcinoma cell invasionPrincipal Investigator
- Principal Investigator
  
  Kazushi IMAI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The Nippon Dental University
KLF-dependent cell differentiation- and EMT-inducing factor and suppression of oral carcinoma progressionPrincipal Investigator
- Principal Investigator
  
  Imai Kazushi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The Nippon Dental University
Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cellsPrincipal Investigator
- Principal Investigator
  
  IMAI Kazushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The Nippon Dental University
Astudy on the mechanism of oral carcinoma progression upon the suppression of NF kB transcriptional activity by the nucleus-localization MALT1.Principal Investigator
- Principal Investigator
  
  IMAI Kazushi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The Nippon Dental University
A Role of HMGIC in Squamous Carcinoma Cells of The Oral CavityPrincipal Investigator
- Principal Investigator
  
  IMAI Kazushi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The Nippon Dental University
上皮間充織相互作用における遺伝子発現プログラムの時間的空間的制御機構Principal Investigator
- Principal Investigator
  
  今井一志
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The Nippon Dental University

All 2021 2020 2019 2016 2015 2014 2013 2012 2011 2007 2005 2004 Other

All Journal Article Presentation Book Patent

[Book] Chapter 7: Cadherin expression and progression of squamous cell carcinomas of the oral cavity. In Squamous Cell Carcinom2012
- Author(s)
  Imai K, Maeda G, Chiba T
- Publisher
  Li X,,ed
- Data Source
  KAKENHI-PROJECT-22592103
[Book] Ectopic activation of mesenchyme-specific genes induce the epithelial-mesenchymal transition in oral cancer, in "Research Advances in Cancer"2005
- Author(s)
  Kazushi Imai
- Publisher
  Global Research Network(未定)
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] NF-kB subunit RELA suppression of mucosa-associated lymphoi tissue lymphoma tranlocation protein 1 expression in oral carcinoma cells2021
- Author(s)
  Takaomi Nozawa, Nozomi Mihara-Tomiyama, Tadashige Chiba, Kazushi Imai
- Journal Title
  
  Biochemistry and Biophysical Research Communications
  
  Volume: 542 Pages: 24-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09542
[Journal Article] Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear translocation in oral carcinoma cells and the proliferation inhibition2020
- Author(s)
  H Hayashi, T Chiba, N Mihara-Tomiyama, T Negishi, Y Kodama, H Sakashita, K Imai
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 3 Pages: 799-804
- DOI
  10.1016/j.bbrc.2019.11.171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09542
[Journal Article] MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation.2016
- Author(s)
  Chiba T, Soeno Y, Shirako Y, Sudo H, Yagishita H, Taya Y, Kawashiri S, Okada Y, Imai K.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 95 Issue: 4 Pages: 446-452
- DOI
  10.1177/0022034515621740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670861, KAKENHI-PROJECT-15H05042, KAKENHI-PROJECT-26462859
[Journal Article] Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter2015
- Author(s)
  Yamaguchi A, Kuroyama K, Tokura A, Saito A, Arikawa H, Hasebe T, Usui D, Yamaguchi K, Chiba T, Imai K
- Journal Title
  
  BMC Oral Health
  
  Volume: 16 Pages: 13-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462859
[Journal Article] Kruppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.2015
- Author(s)
  Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462859
[Journal Article] Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015
- Author(s)
  Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K
- Journal Title
  
  Int. J. Clin. Exp. Pathol.
  
  Volume: ８ Pages: 3701-3709
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462859
[Journal Article] 口腔癌進展のメカニズムと分子標的薬2013
- Author(s)
  今井一志、須藤遥、前田元太、千葉忠成
- Journal Title
  
  歯学
  
  Volume: 100 Pages: 177-181
- Data Source
  KAKENHI-PROJECT-22592103
[Journal Article] Progression of oral squamous cell carcinoma accompanied with reducedE-cadherin expression but not cadherin switch2012
- Author(s)
  Hashimoto T., Soeno Y., Maeda H., Taya Y., Aoba T., Nasu M., Kawashiri S., Imai K
- Journal Title
  
  PLOS ONE
  
  Volume: 7 Issue: 10 Pages: 1-8
- DOI
  10.1371/journal.pone.0047899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390382, KAKENHI-PROJECT-22592103, KAKENHI-PROJECT-23592782, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-24592780
[Journal Article] Epigenetic inactivation of E-cadherin by promoter hypermethylation in oral carcinoma cells2007
- Author(s)
  Maeda G, Chiba T, Aoba T, Imai K
- Journal Title
  
  Odontology (in press)
- Data Source
  KAKENHI-PROJECT-18592073
[Journal Article] Epigenetic inactivation of IkB kinase-a in oral carcinomas and tumor progression2007
- Author(s)
  Maeda G, Chiba T, Kawashiri S, Satoh T, Imai K
- Journal Title
  
  Clinical Cancer Research (in press)
- Data Source
  KAKENHI-PROJECT-18592073
[Journal Article] Ectopic activation of mesenchyme-specific genes induce the epithelial mesenchymal transition in oral cancer.2005
- Author(s)
  Kazushi Imai
- Journal Title
  
  Res.Adv.in Cancer 5
  
  Pages: 41-47
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] Ectopic activation of mesenchyme-specific genes induce the epithelial-mesenchymal transition in oral carcinomas.2005
- Author(s)
  Kazushi Imai, et al.
- Journal Title
  
  Res.Adv.in Cancer 5
  
  Pages: 41-47
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] Ectopic activation of mesenchyme-specific genes induce the epithelial-mesenchymal transition in oral cancer.2005
- Author(s)
  Kazushi Imai
- Journal Title
  
  Res. Adv. in Cancer 5
  
  Pages: 41-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] Epithelial-mesenchymal transition and progression of oral carcinomas.2004
- Author(s)
  Kazushi Imai
- Journal Title
  
  Gene Ther. Mol. Biol. 8
  
  Pages: 195-200
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] Epithelial-mesenchymal transition and progression of oral carcinomas.2004
- Author(s)
  Kazushi Imai
- Journal Title
  
  Gene Ther.Mol.Biol. 8
  
  Pages: 195-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591898
[Journal Article] Purification of matrix metalloprotei nases by column chromatography
- Author(s)
  Kazushi, Imai, Yasunori, Okada
- Journal Title
  
  Nat Protoc (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592073
[Journal Article] Inhibition of TGF- and EGF pathway gene expression and migration of oral carcinoma cells by mucosa-associated lymphoid tissue 1.
- Author(s)
  Ohyama Y, Kawamoto Y, Chiba T, Maeda G, Sakashita H, Imai K
- Journal Title
  
  Br J Cancer
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592103
[Journal Article] Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 n oral carcinoma cells and fibroblasts.
- Author(s)
  Oyama G, Midorikawa T, Matsumoto Y, Takeyama M, Yamada K, Nozawa T, Morikawa M, Imai K.
- Journal Title
  
  Odontology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592103
[Journal Article] Proteomic identification of keratin alterations with enhanced proliferation of oral carcinoma cells by loss of mucosa-associated lymphoid tissue 1 expression.
- Author(s)
  Kawamoto Y, Ohyama Y, Chiaba T, Yagishita H, Sakashita H, Imai K.
- Journal Title
  
  Int J Oncol
  
  Volume: (in press)
- URL
  http://www.spandidos-publications.com/ijo/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592103
[Journal Article] Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.
- Author(s)
  Sasaya K, Sudo H, Maeda G, Kawashiri S, Imai K.
- Journal Title
  
  PLoS One
  
  Volume: (in press)
- URL
  http://www.plosone.org/home.action
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592103
[Journal Article] Purification of matrix metalloproteinases by column chromatography
- Author(s)
  Kazushi Imai
- Journal Title
  
  Nat Protoc (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592073
[Patent] 転写因子の標的遺伝子検出方法2005
- Inventor(s)
  今井一志, 岡崎真大
- Industrial Property Rights Holder
  今井一志
- Industrial Property Number
  2005-029285
- Filing Date
  2005-02-04
- Data Source
  KAKENHI-PROJECT-16591898
[Patent] 転写因子の標的遺伝子検出方法2005
- Inventor(s)
  今井一志, 岡崎真大
- Industrial Property Rights Holder
  今井一志
- Industrial Property Number
  2005-029285
- Filing Date
  2005-02-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591898
[Presentation] 口腔癌細胞におけるMALT1核移行ドメインの解析2019
- Author(s)
  林宏泰、千葉忠成、冨山希美、今井一志、坂下英明
- Organizer
  第73回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09542
[Presentation] 口腔癌細胞におけるKruppel-like factor 4発現とプロモーターのメチル化2015
- Author(s)
  山口光祐，千葉忠成，美原希美，須藤遥，今井一志
- Organizer
  第57回日本歯科基礎医学会学術大会・総会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] Kruppel-like factor 5遺伝子のプロモーター解析2014
- Author(s)
  美原希美、千葉忠成、須藤遥、今井一志
- Organizer
  歯科基礎医学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] 口腔癌におけるKLF4/5の発現と上皮ー間葉移行への関与2014
- Author(s)
  柴田征紀、川尻秀一、今井一志
- Organizer
  日本口腔科学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] Profiling and network analysis of MALT1-responsive gene datasets in SCC.2013
- Author(s)
  Ohyama Y, Kawamoto H, Chiba T, Maeda G, Sakashita H, Imai K.
- Organizer
  IADR/AADR/CADR General Session and Exhibition
- Place of Presentation
  Seattle,WA,USA
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] Profiling and network analysis of MALT1-responsive gene dataset in SCC2013
- Author(s)
  今井一志
- Organizer
  IADR General Session and Exhibition
- Place of Presentation
  Seatle, USA
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] MALT1-responsive keratin rearrangement and proliferation of oral carcinoma cells.2013
- Author(s)
  Kawamoto H, Ohyama Y, Chiba T, Yagishita H, Sakashita H, Imai K.
- Organizer
  IADR/AADR/CADR General Session and Exhibition
- Place of Presentation
  Seattle, WA,USA
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] MALT1-responsive keratin rearrangement and proliferation of oral carcinoma cells2013
- Author(s)
  今井一志
- Organizer
  IADR General Session and Exhibition
- Place of Presentation
  Seatle, USA
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] Progression/metastasis of xenografted oral cancer cell-lines in mouse tongue.2012
- Author(s)
  Soeno Y, Shirako Y, Fujita K, Taya Y, Shimazu Y, Nakau K, Sato K, Chiba T, ImaiK,AobaT
- Organizer
  41st Annual Meeting & Exhibition of the AADR
- Place of Presentation
  Tampa,FL,USA
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] 口腔癌におけるp120カテニンとβカテニン発現の免疫組織学的解析2012
- Author(s)
  笹谷和伸、前田元太、須藤遥、千葉忠成、今井一志
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山市
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] 口腔癌の進展にはカドヘリンスイッチではなく、E-カドヘリンの発現低下が関連する2012
- Author(s)
  橋本孝志、添野雄一、田谷雄二、青葉孝昭、那須優則、前田元太、須藤遥、千葉忠成、今井一志
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山市
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] 口腔癌の進展にはカドヘリンスイッチではなく、E-カドヘリンの発現低下が関連する2012
- Author(s)
  今井一志
- Organizer
  歯科基礎医学会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] 口腔癌におけるp120カテニンとbeta-カテニン発現の免疫組織学的解析2012
- Author(s)
  今井一志
- Organizer
  歯科基礎医学会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] 口腔扁平上皮癌細胞におけるMALT1誘導タンパク質のプロテオーム解析2011
- Author(s)
  川本幸寛、大山嘉人、千葉忠成、坂下英明、今井一志
- Organizer
  第53回歯科基礎医学会学術大会・総会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-22592103
[Presentation] Enhancement of oral carcinoma cell invasion by the loss of MALT1 expression2007
- Author(s)
  今井一志
- Organizer
  第66回日本癌学会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592073
[Presentation] Enhancement of oral carcinoma cell invasion by the loss of MALT 1 expression2007
- Author(s)
  Kazushi, Imai, et. al.
- Organizer
  66th annual conference of Japan Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592073
[Presentation] Enhancement of oral carcinoma cell invasion by the loss of MALT1 expression.2007
- Author(s)
  今井一志、他
- Organizer
  第66回日本癌学会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18592073
[Presentation] Promoter analysis of Kruppel-like factor 5 gene.
- Author(s)
  Mihara N, Chiba T, Sudo H, Imai K
- Organizer
  General Session and Exhibition of the IADR
- Place of Presentation
  ボストン（米国）
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-26462859
[Presentation] 口腔癌細胞におけるMALT1誘導性遺伝子のマイクロアレイ解析
- Author(s)
  今井一志
- Organizer
  日本生化学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22592103

1. CHIBA Tadashige (60350138)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. MIHARA Nozomi (00803264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. MORIKAWA Masako (80095265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 須藤遙 (20372980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 川尻秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Imai Kazushi 今井 一志

IMAI Kazushi 今井 一志

今井 一志 イマイ カズシ

Research Projects

Research Products

Co-Researchers

Nuclear translocation mechanism of MALT1 and oral carcinoma cell invasionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

KLF-dependent cell differentiation- and EMT-inducing factor and suppression of oral carcinoma progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Astudy on the mechanism of oral carcinoma progression upon the suppression of NF kB transcriptional activity by the nucleus-localization MALT1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Role of HMGIC in Squamous Carcinoma Cells of The Oral CavityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

上皮間充織相互作用における遺伝子発現プログラムの時間的空間的制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Chapter 7: Cadherin expression and progression of squamous cell carcinomas of the oral cavity. In Squamous Cell Carcinom2012

Author(s)

Publisher

Data Source

[Book] Ectopic activation of mesenchyme-specific genes induce the epithelial-mesenchymal transition in oral cancer, in "Research Advances in Cancer"2005

Author(s)

Publisher

Data Source

[Journal Article] NF-kB subunit RELA suppression of mucosa-associated lymphoi tissue lymphoma tranlocation protein 1 expression in oral carcinoma cells2021

Author(s)

Journal Title

Data Source

[Journal Article] Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear translocation in oral carcinoma cells and the proliferation inhibition2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kr&#252;ppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter2015

Author(s)

Journal Title

Data Source

[Journal Article] Kruppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.2015

Author(s)

Journal Title

Data Source

[Journal Article] Kr&#252;ppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015

Author(s)

Journal Title

Data Source

[Journal Article] 口腔癌進展のメカニズムと分子標的薬2013

Author(s)

Journal Title

Data Source

Imai Kazushi 今井一志

IMAI Kazushi 今井一志

今井一志イマイカズシ

[Journal Article] Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter2015

[Journal Article] Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas2015