Takeuchi Tohru 武内徹

… Alternative Names

TAKEUCHI Tohru 武内徹

TAKEUCHI Toru 武内徹

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Researcher Number	10330078
Other IDs
External Links
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪医科薬科大学, 医学部, 教授 2017 – 2018: 大阪医科大学, 医学部, 准教授 2016: 大阪医科大学, 医学部, 講師 2012 – 2014: 大阪医科大学, 医学部, 講師 2007 – 2011: 大阪医科大学, 医学部, 助教 2005 – 2006: 大阪医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Laboratory medicine / Basic Section 54020:Connective tissue disease and allergy-related / Respiratory organ internal medicine
Keywords	Principal Investigator マクロファージ / S100タンパク質 / 間質性肺疾患 / 質量分析 / 関節リウマチ / 間質性肺炎 / 膠原病 / モデルマウス / 心血管病変 / 動脈硬化 … More / immunoblotting / immunoprecipitation / electrophoresis / mass spectrometry / proteome / autoantibody / Behecet's disease / Behcet病 / 二次元電気泳動 / 免疫プロッティング / 免疫沈降 / 電気泳動 / プロテオーム / 自己抗体 / ベーチェット病 / 関節炎 / 質量イメージング / プロテオミクス / プロテオーム解析 / バイオマーカー / 皮膚筋炎 … More Except Principal Investigator 自己抗体 / Diagnosis / Biomarker / Adenocarcinoma / Proteomics / Cancer / Autoantibody / Autoantibodiomics / S100タンパク / S100蛋白 / マクロファージ / 全身性強皮症 / バイオマーカー / 間質性肺炎 / クラスター解析 / ケモカイン / サイトカイン / 間質性肺疾患 / 皮膚筋炎 / ペルオキシレドキシン-6 / α-エノラーゼ / 2D-PAGE / 肺癌バイオマーカー / 肺アデノカルシノーマ / 癌プロテオミクス / 膵臓癌特異抗原 / 核内タンパク質 / 細胞膜 / Candidate marker / Triosephosphate isomerase / Pancreatic cancer / 細胞膜/核内タンパク質 / プロテオミクス / 膵臓癌 / 患者自己抗体 / L-Plastin / プロテオーム解析 / 造血器系疾患 / 癌患者自己抗体 / 癌特異マーカー / L-plastin / 非ホジキンリンパ腫 Less

Inhibitory Mechanism of Macrophage-regulatory MIKO-1 Protein in Lung FibrosisPrincipal Investigator
- Principal Investigator
  
  武内徹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Osaka Medical and Pharmaceutical University
全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明
- Principal Investigator
  
  小谷卓矢
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Anti-inflammatory and anti-fibrotic effects of a novel macrophage-inhibitory protein in interstitial pneumoniaPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Tohru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Elucidation of mechanism and disease-specific biomarkers of atherosclerosis in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Tohru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Elucidation of pathophysiological mechanism of interstitial pneumonia in dermatomyositis and biomarker mining for its therapeutic control
- Principal Investigator
  
  MAKINO Shigeki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka Medical College
Profile analysis of disease-related markers in synovial tissues of rheumatoid arthritis using imaging mass spectrometryPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Tooru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Identifications of tentative pancreatic cancer-related antigens of expressed proteins derived from membrane and nuclei components of 4 pancreatic cancer cell lines by autoantibodiomics
- Principal Investigator
  
  MIYAMOTO Yoshiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Detection of Disease-related Proteins in Dermatomyositis Associated with Interstitial Pneumonia by Proteomics-based AnalysisPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Tooru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Identifications of non-Hodgkin's lymphoma (NHL)-specific antigens bounded with autoantibodies in plasma derived from patients with NHL by an autoantibodiomics
- Principal Investigator
  
  NAKANISHI Toyofumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Identifications of diagnostic biomarkers specific binding to soluble proteins of adenocarcinoma A 549 cell lines by an autoantibodiomics
- Principal Investigator
  
  NAKANISHI Toyofumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Proteomics-based approach identifying autoantibodies in Behcet's diseasePrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Toru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College

All 2023 2022 2017 2011 2009 2008 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Human MIKO-1, a Hybrid Protein That Regulates Macrophage Function, Suppresses Lung Fibrosis in a Mouse Model of Bleomycin-Induced Interstitial Lung Disease2022
- Author(s)
  Kotani Takuya、Ikemoto Masaki、Matsuda Shogo、Masutani Ryota、Takeuchi Tohru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 9669-9669
- DOI
  10.3390/ijms23179669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08450
[Journal Article] Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study2017
- Author(s)
  Oda Katsuhiro、Kotani Takuya、Takeuchi Tohru、Ishida Takaaki、Shoda Takeshi、Isoda Kentaro、Yoshida Shuzo、Nishimura Yasuichiro、Makino Shigeki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1635-1635
- DOI
  10.1038/s41598-017-01685-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09565
[Journal Article] Combination with corticosteroids and cyclosporin-A improves pulmonary function test results and chest HRCT findings in dermatomyositis patients with acute/subacute intestitial pneumonia2011
- Author(s)
  Kotani T, Takeuchi T, et al.
- Journal Title
  
  Clin Rheumatol
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590588
[Journal Article] 炎症性筋疾患に関する最近の知見:間質性肺炎に対する免疫抑制療法の有用性2011
- Author(s)
  武内徹, 他
- Journal Title
  
  リウマチ科
  
  Volume: 45 Pages: 164-169
- Data Source
  KAKENHI-PROJECT-20590588
[Journal Article] 炎症性筋疾患に関する最近の知見:間質性肺炎に対する免疫抑制療法の有用性2011
- Author(s)
  武内徹、小谷卓矢、永井孝治、槇野茂樹
- Journal Title
  
  リウマチ科 45巻
  
  Pages: 164-169
- Data Source
  KAKENHI-PROJECT-20590588
[Journal Article] Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis2008
- Author(s)
  Y. Tabushi, T. Nakanishi, T. Takeuchi, M. Nakajima, K. Ueda, T. Kotani, S. Makino, A. Shimizu, T. Hanafusa, T. Takubo
- Journal Title
  
  Ann Clin Biochem 45(4)
  
  Pages: 413-417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590574
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A.
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci 838(1)
  
  Pages: 15-20
- NAID
  10025784546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci 838・1
  
  Pages: 15-20
- NAID
  10025784546
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A.
- Journal Title
  
  J Chromatogr B 838
  
  Pages: 15-20
- NAID
  10025784546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, et al.
- Journal Title
  
  J Chromatogr B 838
  
  Pages: 15-15
- NAID
  10025784546
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Proteomics-based discovery of α-enolase autoantibody in sera of lung adenocarcinoma2006
- Author(s)
  Nakanishi T, Takeuchi T, et al.
- Journal Title
  
  Proceedings of 53th ASMS conference on mass spectrometry and allied topics
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Proteomics-based discovery of α-enolase autoantibody in sera of lung adenocarcinoma2005
- Author(s)
  Nakanishi T, Takeuchi T, et al.
- Journal Title
  
  Proceedings of 53th ASMS conference on mass spectrometry and allied topics 248(MP30)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Combination with corticosteroids and cyclosporin-A improves pulmonary function test results and chest HRCT findings in dermatomyositis patients with acute/subacute intestitial pneumonia.
- Author(s)
  Kotani T, Takeuchi T, Makino S, et al
- Journal Title
  
  Clin Rheumatol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590588
[Journal Article] Serum Protein Profile of Rheumatoid Arthritis Treated with Anti-TNF therapy (Infliximab).
- Author(s)
  Takeuchi T, Nakanishi T, et al.
- Journal Title
  
  J Chromatogr B (In press)
- NAID
  10025806140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Serum Protein Profile of Rheumatoid Arthritis Treated with Anti-TNF therapy (Infliximab).
- Author(s)
  Takeuchi T, Nakanishi N, Tabushi Y, Hata A, Shoda T, Kotani T, Shimizu A, Takubo T, Makino S, Hanafusa T.
- Journal Title
  
  J Chromatogr B (in press)
- NAID
  10025806140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Patent] 間質性肺疾患の治療のための医薬組成物2023
- Inventor(s)
  武内徹、小谷卓矢、池本正生
- Industrial Property Rights Holder
  学校法人大阪医科薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08450
[Patent] 間質性肺疾患の治療のための医薬組成物2023
- Inventor(s)
  武内徹、小谷卓矢、池本正生
- Industrial Property Rights Holder
  学校法人大阪医科薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08450
[Presentation] 皮膚筋炎合併間質性肺炎におけるケモカインと病態および予後との検討2017
- Author(s)
  小田勝大、小谷卓矢、武内徹、石田貴昭、庄田武司、礒田健太郎、吉田周造、槇野茂樹
- Organizer
  第61回リウマチ学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2017-04-20
- Data Source
  KAKENHI-PROJECT-16K09565
[Presentation] 皮膚筋炎に合併する間背質性肺炎に対するシクロスポリン、ステロイド併用療法における副作用の検討2009
- Author(s)
  秦健一郎, 武内徹, 他(発表済)
- Organizer
  日本リウマチ学会
- Place of Presentation
  新高輪プリンスホテル(東京)
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-20590588

1. NAKANISHI Toyofumi (10247843)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
2. KOTANI Takuya (80411362)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
3. 鈴鹿隆保 (50748225)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TABUSHI Yoko (80388256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. MAKINO Shigeki (20268204)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. TAKUBO Takayuki (60163359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SHIMIZU Akira (00028581)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 池本正生 (80144385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 松田翔悟 (00898489)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. ISHIDA takaaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. ODA katsuhiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
12. KONMA junichi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. MIYAMOTO Yoshiharu (20368096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKAORI Kyoichi (10329485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MURAO Hitoshi (00278540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. GOTO Isao (90330084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 吉田周造 (40530697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 永井孝治 (30572458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 秦健一郎 (90536921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡田光貴 (80747569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 朝井章 (30622146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takeuchi Tohru 武内 徹

TAKEUCHI Tohru 武内 徹

TAKEUCHI Toru 武内 徹

Research Projects

Research Products

Co-Researchers

Inhibitory Mechanism of Macrophage-regulatory MIKO-1 Protein in Lung FibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

全身性強皮症に対する新規生物製剤 hMIKO-1の有効性検証とその機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-inflammatory and anti-fibrotic effects of a novel macrophage-inhibitory protein in interstitial pneumoniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanism and disease-specific biomarkers of atherosclerosis in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathophysiological mechanism of interstitial pneumonia in dermatomyositis and biomarker mining for its therapeutic control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Profile analysis of disease-related markers in synovial tissues of rheumatoid arthritis using imaging mass spectrometryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identifications of tentative pancreatic cancer-related antigens of expressed proteins derived from membrane and nuclei components of 4 pancreatic cancer cell lines by autoantibodiomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of Disease-related Proteins in Dermatomyositis Associated with Interstitial Pneumonia by Proteomics-based AnalysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identifications of non-Hodgkin's lymphoma (NHL)-specific antigens bounded with autoantibodies in plasma derived from patients with NHL by an autoantibodiomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identifications of diagnostic biomarkers specific binding to soluble proteins of adenocarcinoma A 549 cell lines by an autoantibodiomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomics-based approach identifying autoantibodies in Behcet's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Human MIKO-1, a Hybrid Protein That Regulates Macrophage Function, Suppresses Lung Fibrosis in a Mouse Model of Bleomycin-Induced Interstitial Lung Disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study2017

Author(s)

Journal Title

Takeuchi Tohru 武内徹

TAKEUCHI Tohru 武内徹

TAKEUCHI Toru 武内徹