Hishiki Takako 菱木貴子

… Alternative Names

HISHIKI Takako 菱木貴子

菱木貴子ヒシキタカコ

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Researcher Number	10338022
Other IDs
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 准教授 2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2017: 慶應義塾大学, 医学部, 講師 2016: 慶應義塾大学, 医学部, 特任講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 2013: 慶應義塾大学, 医学部, 特任講師 2012: 慶應義塾大学, 医学部, 講師 2002: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Chemical biology / Chemical biology Except Principal Investigator Basic Section 55050:Anesthesiology-related / Pathological medical chemistry / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 46030:Function of nervous system-related / Basic Section 53020:Cardiology-related … More / Medium-sized Section 50:Oncology and related fields / Respiratory organ internal medicine / Genome biology / Science and Engineering / Cardiovascular medicine / Anesthesiology/Resuscitation studies / Genome biology / Biological Sciences Less
Keywords	Principal Investigator 表面増強ラマンイメージング / ポリスルフィド / チオール化合物 / 膵癌 / 薬剤耐性がん / 浸潤性乳癌 / 薬剤耐性癌 / 抗薬剤耐性癌 / 活性含硫化合物 / 硫化水素 / ガスシグナル分子 … More Except Principal Investigator … More 代謝 / 低酸素 / メタボロミクス / ミトコンドリア / エネルギー代謝 / 低酸素応答 / 神経毒性 / メタボローム解析 / PHD / HIF / 過酸化水素 / ミオグロビン / 部位特異的アミノ酸置換 / 心臓流出路発生 / iPS細胞 / 心臓前駆細胞 / 遺伝子変異 / 先天性心疾患 / 発達期 / 麻酔 / 健康長寿 / 加齢 / グルココルチコイド / 骨格筋 / cerebral ischemia / microcirculation / molecular hydrogen / metabolism / stroke / Neurovascular coupling / 質量分析イメージング / Neurovascular unit / 脳虚血 / 分子状水素 / 細胞内情報伝達 / 小児 / 全身麻酔薬 / ２型糖尿病 / 脂質代謝 / 臓器連関 / 酸化ストレス / 脂肪分化 / 肥満 / 血管内皮障害 / インスリン / 2型糖尿病 / 腎機能障害 / 活性酸素種 / 内皮依存性血管拡張 / インスリン抵抗性 / メタボリックシンドローム / 一酸化窒素 / 脂肪肝 / 血管内皮機能 / 異所性脂肪沈着 / Insulin / ERK2 / 脂肪細胞 / 固形腫瘍 / 免疫 / 腫瘍血管 / mitochondria / respiratory chain / interferon-gamma / mTORC1 / p62 / Nrf2 / がん細胞 / IFNg / 腫瘍浸潤CD8T細胞 / IFNγ / Glut-1 / NRF2 / CD8TIL / 活性酸素 / 酸化的リン酸化 / 解糖系 / インターフェロンγ / CD8T細胞 / 腫瘍微小環境 / 薬剤感受性 / 代謝因子 / トランスレーショナルリサーチ / KRAS / EML4-ALK / EGFR / ドライバーがん遺伝子 / イメージングマススペクトロメトリ / バイオバンク / ゲノミクス / AMPK / Nintedanib / Bevacizumab / 高濃度酸素暴露 / Imaging MS / 肺がん / がん代謝 / プロテオミクス / 代謝生化学 / プロリン水酸化酵素 / 阻害薬 / HIF-PH / プロリン / 水酸化 / 老化 / 細胞周期 / 癌化 / 不死化 / 細胞老化 / cell-free protein synthesis / membrane protein / proton pump / cytochrome oxidase / myoglobin / heme / gene therapy / composite biocatalyst / 亜硝酸イオン還元酵素 / ペルオキシゲナーゼ / 水素イオン供給 / オーダーメイド / シトクロムP450 / 膜タンパク質複合体 / ペルオキシダーゼ / 亜硝酸還元酵素 / ポルフィセン / 膜たんぱく質複合体 / 無細胞蛋白合成系 / 膜蛋白質 / プロトンポンプ / チトクロム酸化酵素 / ヘム / 遺伝子治療 / コンポジット生体触媒 / 内皮細胞 / 毛細血管 / 代謝リモデリング / 構造リモデリング / 心不全 / グルコース / 脂肪酸 / 分子心臓病 / 虚血再灌流障害 / 心肺蘇生 / 心停止 / Cori回路 / PHD2 / 心筋梗塞 / 虚血再灌流 / メタボローム / 虚血再灌流傷害 / iscemia / metabolomics / hypoxia / プロトン供給 / X線結晶構造解析 / 水 / アミノ酸置換 / プチダレドキシン / EPR / 水素イオン輸送 / カンファー / シトクロームP450 Less

表面増強ラマンイメージングによるポリスルフィドを標的とした新規膵癌治療法の開発Principal Investigator
- Principal Investigator
  
  菱木貴子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Keio University
骨格筋グルココルチコイド作用が個体の加齢性変化に与える影響の解明
- Principal Investigator
  
  山崎広貴
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Teikyo University
発達期の脳における全身麻酔薬の神経毒性と代謝異常
- Principal Investigator
  
  佐藤泰司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  National Defense Medical College
先天性心疾患治療開発へ向けた心臓流出路発生異常の主要原因遺伝子TMEM260の機能解明
- Principal Investigator
  
  古道一樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
発達期の脳における全身麻酔薬の神経毒性メカニズムの解明
- Principal Investigator
  
  佐藤泰司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  National Defense Medical College
表面増強ラマンイメージングを用いた薬剤耐性がんにおけるポリスルフィドの機能解明Principal Investigator
- Principal Investigator
  
  菱木貴子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Keio University
Effects of molecular hydrogen on ischemic brain injury
- Principal Investigator
  
  Kajimura Mayumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Keio University
Metabolism-based dissection of tumor microenvironment infiltrated by immune cells
- Principal Investigator
  
  UDONO Heiichiro
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
Role of ERK2 in Ectopic Fat deposition and Cardiovascular Complications of Type II Diabetes
- Principal Investigator
  
  Adachi Takeshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Defense Medical College
Functional analyses of sulfur-containing amino acid-derived thiol compounds in the ischemic reperfusion disorder by MALDI MS imagingPrincipal Investigator
- Principal Investigator
  
  HISHIKI TAKAKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Elucidation of the regulatory mechanism of metabolism in response to hypoxia by hydroxylation omics analysis
- Principal Investigator
  
  Minamishima Yoji Andrew
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Gunma University
  Kyushu University
Precision medicine based on matabolic pathways in lung cancer
- Principal Investigator
  
  Soejima Kenzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
A energy shift from fatty acid to glucose is detrimental to pressure-overloaded heart
- Principal Investigator
  
  Iso Tatsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Gunma University
Identification of the specific metabolic system for cellular senescence and tumorigenesis
- Principal Investigator
  
  Minamishima Yoji Andrew
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
  Keio University
Development of method for the determination of thiol-containing metabolites using quantitative mass spectrometryPrincipal Investigator
- Principal Investigator
  
  HISHIKI TAKAKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Elucidation of activating Cori cycle caused by inhibition of PHD2 in liver
- Principal Investigator
  
  KASAHARA Masataka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Hypoxic response as a new treatment of Post cardiac arrest syndrome
- Principal Investigator
  
  MINAMISHIMA Shizuka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Keio University
New concept for treatment of iscgemia/reperfusion injuries brought by metabolomics
- Principal Investigator
  
  MINAMISHIMA Yoji Andrew
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Keio University
カムオペロンの末端酸化酵素と電子供与体たんぱく質の複合体
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Development of heme-based highly efficient biocatalysts
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  KEIO UNIVERSITY

All 2024 2023 2022 2021 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer2024
- Author(s)
  Yamamoto T、Hayashida T、Masugi Y、Oshikawa K、Hayakawa N、Itoh M、Nishime C、Suzuki M、Nagayama A、Kawai Y、Hishiki T、Suematsu M、et al.
- Journal Title
  
  Cancer Research
  
  Volume: 84 Issue: 7 Pages: 1065-1083
- DOI
  10.1158/0008-5472.can-23-2266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-23K11851, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K06845
[Journal Article] Polysulfide Serves as a Hallmark of Desmoplastic Reaction to Differentially Diagnose Ductal Carcinoma In Situ and Invasive Breast Cancer by SERS Imaging2023
- Author(s)
  Kubo Akiko、Masugi Yohei、Hase Takeshi、Nagashima Kengo、Kawai Yuko、Takizawa Minako、Hishiki Takako、Shiota Megumi、Wakui Masatoshi、Kitagawa Yuko、Kabe Yasuaki、Sakamoto Michiie、Yachie Ayako、Hayashida Tetsu、Suematsu Makoto
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 2 Pages: 240-240
- DOI
  10.3390/antiox12020240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-21K06845
[Journal Article] Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency2023
- Author(s)
  Ogawa Eri、Hishiki Takako、Hayakawa Noriyo、Suzuki Hisato、Kosaki Kenjiro、Suematsu Makoto、Takenouchi Toshiki
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 35 Pages: 100968-100968
- DOI
  10.1016/j.ymgmr.2023.100968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-22K19494
[Journal Article] The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure2022
- Author(s)
  Mizota Takamasa、Hishiki Takako、Shinoda Masahiro、Naito Yoshiko、Hirukawa Kazuya、Masugi Yohei、Itano Osamu、Obara Hideaki、Kitago Minoru、Yagi Hiroshi、Abe Yuta、Matsubara Kentaro、Suematsu Makoto、Kitagawa Yuko
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 70 Issue: 1 Pages: 54-63
- DOI
  10.3164/jcbn.21-50
- NAID
  130008139089
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08967, KAKENHI-PROJECT-21K05294
[Journal Article] SERS imaging技術による活性硫黄分子種の検出と医学応用2022
- Author(s)
  菱木貴子
- Journal Title
  
  月刊「細胞」
  
  Volume: 54 Pages: 130-133
- Data Source
  KAKENHI-PROJECT-21K05294
[Journal Article] On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity2021
- Author(s)
  Honda Kazufumi、Hishiki Takako、Yamamoto Sohe、Naito Yoshiko、Matsuura Tomomi、Iwaisako Keiko、Masui Toshihiko、Sakuma Tomohiro、Matsubara Osamu、Huang Wilber、Ida Tomoaki、Akaike Takaaki、Masugi Yohei、Sakamoto Michiie、Kato Tomoyasu、Kabe Yasuaki、Suematsu Makoto
- Journal Title
  
  Redox Biology
  
  Volume: 41 Pages: 101926-101926
- DOI
  10.1016/j.redox.2021.101926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-20K21496, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-20K08996, KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-21K06937, KAKENHI-PROJECT-19H03856
[Journal Article] Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis2021
- Author(s)
  Mukai Kuniaki、Sugimoto Hiroshi、Kamiya Katsumasa、Suzuki Reiko、Matsuura Tomomi、Hishiki Takako、Shimada Hideo、Shiro Yoshitsugu、Suematsu Makoto、Kagawa Norio
- Journal Title
  
  Current Research in Structural Biology
  
  Volume: 3 Pages: 192-205
- DOI
  10.1016/j.crstbi.2021.08.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-20K03794, KAKENHI-PROJECT-21K05294
[Journal Article] Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid binding protein-4 and -5 knockout mice.2018
- Author(s)
  Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Cardiovasc Res.
  
  Volume: - Issue: 8 Pages: 1132-1144
- DOI
  10.1093/cvr/cvy063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16H05294, KAKENHI-PROJECT-16K15456, KAKENHI-PROJECT-16K19442
[Journal Article] Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure2018
- Author(s)
  Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Sci Rep
  
  Volume: 8(1) Issue: 1 Pages: 12035-12035
- DOI
  10.1038/s41598-018-30616-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16H05294, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-16K19442
[Journal Article] Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.2018
- Author(s)
  Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H.
- Journal Title
  
  Clin Chem
  
  Volume: 64 Issue: 10 Pages: 1463-1473
- DOI
  10.1373/clinchem.2018.291963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-16K01937
[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018
- Author(s)
  Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1561-1561
- DOI
  10.1038/s41467-018-03899-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway2018
- Author(s)
  Mashima Kyoko、Takahashi Shinichi、Minami Kazushi、Izawa Yoshikane、Abe Takato、Tsukada Naoki、Hishiki Takako、Suematsu Makoto、Kajimura Mayumi、Suzuki Norihiro
- Journal Title
  
  ASN Neuro
  
  Volume: 10 Issue: 1 Pages: 1-21
- DOI
  10.1177/1759091418775562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K07066
[Journal Article] Biochemical, metabolomic, and genetic analyses of dephospho coenzyme A kinase involved in coenzyme A biosynthesis in the human enteric parasite Entamoeba histolytica.2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Hishiki T, Naito Y, Suematsu M, Hashimoto T, Nozaki T
- Journal Title
  
  Frontiers in Microbiology, section Infectious Diseases
  
  Volume: 9 Pages: 2902-2902
- DOI
  10.3389/fmicb.2018.02902
- NAID
  120007128082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K01937
[Journal Article] Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target.2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Naito Y, Hishiki T, Mori M, Suematsu M, Shiomi K, Hashimoto T, Nozaki T
- Journal Title
  
  Int J Parasitol Drugs Drug Resist.
  
  Volume: 8 Issue: 1 Pages: 125-136
- DOI
  10.1016/j.ijpddr.2018.02.004
- NAID
  120007134287
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-17K19614
[Journal Article] Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.2017
- Author(s)
  Umbarawan Y, Syamsunarno MR, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Metabolism, clinical and experimental.
  
  Volume: - Pages: 47-57
- DOI
  10.1016/j.metabol.2017.09.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16K19442, KAKENHI-PROJECT-16H05294
[Journal Article] Targeting oxygen sensing prolyl hydroxylase (PHD) for metformin-associated lactic acidosis treatment.2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 37 (16) Issue: 16
- DOI
  10.1128/mcb.00248-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16H04723, KAKENHI-PROJECT-16K07203
[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
- Author(s)
  Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 39752-39752
- DOI
  10.1038/srep39752
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-16H05330, KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-26461375, KAKENHI-PROJECT-15K12695, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15K15313, KAKENHI-PROJECT-16K15599, KAKENHI-PROJECT-15K19396, KAKENHI-PROJECT-15KK0332
[Journal Article] Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.2016
- Author(s)
  Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K.
- Journal Title
  
  Cell Metab
  
  Volume: 23 Issue: 4 Pages: 663-74
- DOI
  10.1016/j.cmet.2016.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01521, KAKENHI-PROJECT-13J30005, KAKENHI-PROJECT-25505004, KAKENHI-PROJECT-26670408, KAKENHI-PROJECT-26670410, KAKENHI-PROJECT-15K09098, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K15415, KAKENHI-PROJECT-16H05304
[Journal Article] A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.2016
- Author(s)
  Iizumi T, Takahashi S, Mashima K, Minami K, Izawa Y, Abe T, Hishiki T, Suematsu M, Kajimura M, Suzuki N
- Journal Title
  
  Neuoinflammation.
  
  Volume: １３ Pages: 99-99
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937
[Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.2015
- Author(s)
  Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H, Suematsu M.
- Journal Title
  
  Nitric Oxide.
  
  Volume: 30 (46) Pages: 102-13
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia.2015
- Author(s)
  Takenouchi T, Sugiura Y, Morikawa T, Nakanishi T, Nagahata Y, Sugioka T, Honda K, Kubo A, Hishiki T, Matsuura T, Hoshino T, Takahashi T, Suematsu M, Kajimura M.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 1 Pages: 1-12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.2015
- Author(s)
  Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 82 Pages: 116-124
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart2015
- Author(s)
  Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 82 Pages: 116-124
- DOI
  10.1016/j.yjmcc.2015.02.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461123
[Journal Article] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle2015
- Author(s)
  Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr., Suematsu M, Minamishima YA§. (§Corresponding author)
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112 Issue: 37 Pages: 11642-7
- DOI
  10.1073/pnas.1515872112
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163, KAKENHI-PLANNED-26111006, KAKENHI-PROJECT-25513008
[Journal Article] Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays oftransparent boehmite,2015
- Author(s)
  1.Yamazoe S, Naya M, Shiota M, Morikawa M, Kubo A, Tani T, Hishiki T, Horiuchi T, Suematsu M, and Kajimura M
- Journal Title
  
  ACS Nano
  
  Volume: 8 Issue: 6 Pages: 5622-5632
- DOI
  10.1021/nn4065692
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.2014
- Author(s)
  Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 306(12) Issue: 12 Pages: F1462-F1476
- DOI
  10.1152/ajprenal.00623.2013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460960
[Journal Article] Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.2014
- Author(s)
  Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, Takako Hishiki, and Makoto Suematsu.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 3480-3480
- DOI
  10.1038/ncomms4480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Distinct Metabolic Flow Enable Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes.2013
- Author(s)
  Tohyama S, Hattori F, Sano M, et al.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 1 Pages: 127-37
- DOI
  10.1016/j.stem.2012.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05269, KAKENHI-PROJECT-11J30002, KAKENHI-PROJECT-22689027, KAKENHI-PROJECT-23390072, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25461117, KAKENHI-PUBLICLY-24117716
[Journal Article] ガス分子を量る：チオールプローブを用いたH2Sの定量2013
- Author(s)
  菱木貴子
- Journal Title
  
  実験医学　別冊
  
  Volume: 36 Pages: 132-143
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting2013
- Author(s)
  Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
- Journal Title
  
  PLoS One
  
  Volume: 14;8 Issue: 11 Pages: e79386-e79386
- DOI
  10.1371/journal.pone.0079386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390146, KAKENHI-PROJECT-23790656, KAKENHI-PROJECT-24592730, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25461101, KAKENHI-PROJECT-25504002
[Journal Article] Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo.2013
- Author(s)
  Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 11 Issue: 9 Pages: 973-985
- DOI
  10.1158/1541-7786.mcr-12-0669-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310136, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle2013
- Author(s)
  Iso Tatsuya, Kurabayashi Masahiko
- Journal Title
  
  Arteriosclerosi Thrombosis and Vascular Biology
  
  Volume: vol.33 Issue: 11 Pages: 2549-2557
- DOI
  10.1161/atvbaha.113.301588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590661, KAKENHI-PROJECT-23790656, KAKENHI-PROJECT-24592730, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-24659573, KAKENHI-PROJECT-25504002
[Journal Article] Mitochondrial dysfunction associated with increased oxidative stress and -synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.2012
- Author(s)
  Imaizumi Y
- Journal Title
  
  Mol Brain
  
  Volume: 5 Issue: 1 Pages: 35-35
- DOI
  10.1186/1756-6606-5-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390041, KAKENHI-PROJECT-23591254, KAKENHI-PROJECT-23618010, KAKENHI-PROJECT-23650194, KAKENHI-PROJECT-23659102, KAKENHI-PROJECT-23689017, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24651265, KAKENHI-PUBLICLY-23110516, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-23111004, KAKENHI-PUBLICLY-23129506
[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria.2012
- Author(s)
  Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 52 Issue: 9 Pages: 1716-1726
- DOI
  10.1016/j.freeradbiomed.2012.02.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590292, KAKENHI-PROJECT-22790219, KAKENHI-PUBLICLY-23117703, KAKENHI-PROJECT-23650159, KAKENHI-PROJECT-24651265, KAKENHI-PUBLICLY-23117716
[Journal Article] Gas biology : Tiny molecules controlling metabolic systems2012
- Author(s)
  Kajimura M., Nakanishi T., Takenouchi T., Morikawa T., Hishiki T., Yukutake Y., and Suematsu M.
- Journal Title
  
  Respiratory Physiology & Neurobiology
  
  Volume: (in press) Issue: 2 Pages: 139-148
- DOI
  10.1016/j.resp.2012.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500353, KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-24651265
[Journal Article] がん代謝システムの顕微質量イメージングによる解析2012
- Author(s)
  末松誠、久保亜紀子、大村光代、菱木貴子、梶村眞弓、加部泰明、杉浦悠毅
- Journal Title
  
  実験医学増刊
  
  Volume: 30 Pages: 193-202
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答メカニズムを標的としたメトホルミン関連乳酸アシドーシス (MALA)の新規治療法の開発2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第60回日本糖尿病学会/第4回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 低酸素応答による細胞内エネルギー代謝制御機構2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第17回日本高気圧環境・潜水医学会関東地方会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis2016
- Author(s)
  寅丸智子*、壽原朋宏、早川典代、中村貴、南嶋しづか、菱木貴子、森崎浩、末松誠、南嶋洋司
- Organizer
  第4回低酸素研究会
- Place of Presentation
  早稲田大学　先端生命医科学センター
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発2016
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、山口京二、菱木貴子、森崎浩、末松誠、南嶋洋司*
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答を標的とした各種疾患治療法の開発～致死的乳酸アシドーシスの新規治療法～2016
- Author(s)
  小柳津-寅丸智子, 壽原朋宏, 早川典代, 中村貴, 南嶋しづか, 山口京二, 菱木貴子, 森崎浩, 末松誠, 南嶋洋司*
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 低酸素応答を標的とした各種疾患治療法の開発～致死的乳酸アシドーシスの新規治療法～2016
- Author(s)
  小柳津-寅丸智子, 壽原朋宏, 早川典代, 中村貴, 南嶋しづか, 山口京二, 菱木貴子, 森崎浩, 末松誠, 南嶋洋司*
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] マウス水晶体における新規抗酸化物質「過硫化グルタチオン」レベル維持には，Cystathionine β -synthase (CBS)が必要である2016
- Author(s)
  久保亜紀子，善岡尊文，後藤信一，石井功，菱木貴子，山本雄広，高野直治，星野岳郎，中村貴，吉田晃敏，梶村眞弓，末松誠
- Organizer
  第41回　日本医用マススペクトル学会
- Place of Presentation
  愛知県産業労働センター（愛知県名古屋市）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-16K01937
[Presentation] 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発2016
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、山口京二、菱木貴子、森崎浩、末松誠、南嶋洋司*
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis2016
- Author(s)
  寅丸智子*、壽原朋宏、早川典代、中村貴、南嶋しづか、菱木貴子、森崎浩、末松誠、南嶋洋司
- Organizer
  第4回低酸素研究会
- Place of Presentation
  早稲田大学　先端生命医科学センター
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Inactivating HIF-prolyl hydroxylase PHD2 in liver improves survival after lactic acidosis by activating Cori cycle2015
- Author(s)
  Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima*
- Organizer
  Keystone Symposia “Hypoxia: From Basic Mechanisms to Therapeutics (E3)”.
- Place of Presentation
  Royal Dublin Society (Dublin, Ireland)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 肝臓における低酸素応答はCori回路の活性化を介して血中乳酸レベルを制御している2015
- Author(s)
  壽原朋宏、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司*
- Organizer
  第13回がんとハイポキシア研究会
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答によるCori回路の制御機構の解明～肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発～2015
- Author(s)
  壽原朋宏*、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle2015
- Author(s)
  Tomohiro Suhara*, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin Jr., Makoto Suematsu, Yoji Andrew Minamishima
- Organizer
  第3回低酸素研究会
- Place of Presentation
  早稲田大学先端生命医科学センター（東京都新宿区）
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro2014
- Author(s)
  Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto, Ryo Fukuda, Hideyuki Saya, Makoto Suematsu and Yoji Andrew Minamishima
- Organizer
  Keystone Symposia "Tumor Metabolism (X6)"
- Place of Presentation
  Whistler, BC, Canada
- Data Source
  KAKENHI-PROJECT-23310136
[Presentation] アルギニンメチル化酵素PRMT1の細胞内局在を反映した糖代謝酵素の核内メチル化機構2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松誠
- Organizer
  第36回　日本分子生物学会本大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] 解糖系酵素PFKFB3のメチル化制御はがん細胞の酸化ストレス耐性獲得に重要である2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松誠
- Organizer
  第86回　日本生化学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] Sensitive detection and quantification of hydrogen sulfide as a gasotransmitter by combining monobromobimane-based derivatization to triple quadrupole LC/MS/MS2012
- Author(s)
  Takako Hishiki , Tsuyoshi Nakanishi and Makoto Suematsu
- Organizer
  American Society for Mass Spectrometry
- Place of Presentation
  Vancouver, BC, Canada
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] 低酸素応答による乳酸代謝制御機構
- Author(s)
  寿原明宏、笠原正貴、菱木貴子、早川典代、南嶋洋司、末松誠
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀県佐賀市神野東2-5-15ホテルマリターレ創世佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-23310136
[Presentation] Glucose Uptake in the Heart of FABP4/5 double knockout mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways.
- Author(s)
  Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Kosaku Goto, Mas Rizky A.A Syamsunarno, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Masashi Arai, Aiko Yamaguchi, Motoaki Sano, Makoto Suematsu, Keigo Endo, Gokhan S. Hotamisligil and Masahiko Kurabayashi.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26461123
[Presentation] 低酸素応答による乳酸代謝制御機構
- Author(s)
  寿原明宏、笠原正貴、菱木貴子、早川典代、南嶋洋司、末松誠
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀県佐賀市神野東2-5-15ホテルマリターレ創世佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26670163

1. KUBO Akiko (50455573)

# of Collaborated Projects: 7 results

# of Collaborated Products: 15 results
2. MINAMISHIMA Yoji Andrew (20593966)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
3. 佐藤泰司 (10505267)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SHIMADA Hideo (80095611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Adachi Takeshi (50231931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 江川毅 (10232935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YACHIE Ayako (10453549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KASAHARA Masataka (30328265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MINAMISHIMA Shizuka (20622088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAKOTO Suematsu (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Iso Tatsuya (10400756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. FUJII Hiroshi (80228957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HAYASHI Takashi (20222226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MUKAI Kuniaki (80229913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Yuki Sugiura (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Soejima Kenzo (30236145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. UDONO Heiichiro (50260659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Kajimura Mayumi (10327497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 堀洋 (20127294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 倉林正彦 (00215047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 小板橋紀通 (10420093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山本正道 (70423150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 浜本純子 (40570239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 安田浩之 (70365261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 城口克之 (00454059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 井戸康夫 (50814133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 遠藤昌吾 (60192514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 山崎広貴 (60784337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 古道一樹 (10338105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 芝田晋介 (70407089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 遠山周吾 (90528192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. MURAKAMI Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 山本雄広

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 大日方英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 家田真樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 石井功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 湯浅慎介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 城宜嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hishiki Takako 菱木 貴子

HISHIKI Takako 菱木 貴子

菱木 貴子 ヒシキ タカコ

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表面増強ラマンイメージングによるポリスルフィドを標的とした新規膵癌治療法の開発Principal Investigator

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表面増強ラマンイメージングを用いた薬剤耐性がんにおけるポリスルフィドの機能解明Principal Investigator

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Functional analyses of sulfur-containing amino acid-derived thiol compounds in the ischemic reperfusion disorder by MALDI MS imagingPrincipal Investigator

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Development of method for the determination of thiol-containing metabolites using quantitative mass spectrometryPrincipal Investigator

Hishiki Takako 菱木貴子

HISHIKI Takako 菱木貴子

菱木貴子ヒシキタカコ