Hishiki Takako 菱木貴子

… Alternative Names

Researcher Number	10338022
Other IDs
Affiliation (Current)	2020: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2016 – 2020: 慶應義塾大学, 医学部(信濃町), 講師 2017: 慶應義塾大学, 医学部, 講師 2016: 慶應義塾大学, 医学部, 特任講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 2013: 慶應義塾大学, 医学部, 特任講師 2012: 慶應義塾大学, 医学部, 講師 2002: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Chemical biology / Chemical biology Except Principal Investigator Pathological medical chemistry / Biological Sciences / Genome biology / Anesthesiology/Resuscitation studies / Cardiovascular medicine / Science and Engineering / Genome biology / Respiratory organ internal medicine / Medium-sized Section 50:Oncology and related fields / Basic Section 53020:Cardiology-related / Basic Section 46030:Function of nervous system-related
Keywords	Principal Investigator チオール化合物 / ガスシグナル分子 / 硫化水素 / 活性含硫化合物 Except Principal Investigator 低酸素 / 代謝 / 低酸素応答 / メタボロミクス / 部位特異的アミノ酸置換 / ミオグロビン … More

Effects of molecular hydrogen on ischemic brain injuryOngoing
- Principal Investigator
  
  梶村眞弓
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Keio University
Metabolism-based dissection of tumor microenvironment infiltrated by immune cellsOngoing
- Principal Investigator
  
  鵜殿平一郎
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
Role of ERK2 in Ectopic Fat deposition and Cardiovascular Complications of Type II DiabetesOngoing
- Principal Investigator
  
  足立健
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Defense Medical College
Functional analyses of sulfur-containing amino acid-derived thiol compounds in the ischemic reperfusion disorder by MALDI MS imagingPrincipal Investigator
- Principal Investigator
  
  HISHIKI TAKAKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
水酸化オミクス解析を駆使した低酸素応答による代謝制御機構の全貌解明Ongoing
- Principal Investigator
  
  南嶋洋司
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Gunma University
  Kyushu University
Precision medicine based on matabolic pathways in lung cancer
- Principal Investigator
  
  Soejima Kenzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
A energy shift from fatty acid to glucose is detrimental to pressure-overloaded heart
- Principal Investigator
  
  Iso Tatsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Gunma University
Identification of the specific metabolic system for cellular senescence and tumorigenesis
- Principal Investigator
  
  Minamishima Yoji Andrew
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
  Keio University
Development of method for the determination of thiol-containing metabolites using quantitative mass spectrometryPrincipal Investigator
- Principal Investigator
  
  HISHIKI TAKAKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Elucidation of activating Cori cycle caused by inhibition of PHD2 in liver
- Principal Investigator
  
  KASAHARA Masataka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Hypoxic response as a new treatment of Post cardiac arrest syndrome
- Principal Investigator
  
  MINAMISHIMA Shizuka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Keio University
New concept for treatment of iscgemia/reperfusion injuries brought by metabolomics
- Principal Investigator
  
  MINAMISHIMA Yoji Andrew
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Keio University
カムオペロンの末端酸化酵素と電子供与体たんぱく質の複合体
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Development of heme-based highly efficient biocatalysts
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  KEIO UNIVERSITY

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Biochemical, Metabolomic, and Genetic Analyses of Dephospho Coenzyme A Kinase Involved in Coenzyme A Biosynthesis in the Human Enteric Parasite Entamoeba histolytica2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Hishiki T, Naito Y, Suematsu M, Hashimoto T, Nozaki T
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 9 Pages: 2902-2902
- DOI
  10.3389/fmicb.2018.02902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K01937
[Journal Article] Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway2018
- Author(s)
  Mashima Kyoko、Takahashi Shinichi、Minami Kazushi、Izawa Yoshikane、Abe Takato、Tsukada Naoki、Hishiki Takako、Suematsu Makoto、Kajimura Mayumi、Suzuki Norihiro
- Journal Title
  
  ASN Neuro
  
  Volume: 10 Pages: 1759-1762
- DOI
  10.1177/1759091418775562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K07066
[Journal Article] Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure2018
- Author(s)
  Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Scientific Reports
  
  Volume: 8(1) Pages: 12035-12035
- DOI
  10.1038/s41598-018-30616-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16H05294, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-16K19442
[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.2018
- Author(s)
  Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
- Journal Title
  
  Nat Commun
  
  Volume: 9 Pages: 1561-1561
- DOI
  10.1038/s41467-018-03899-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K07124
[Journal Article] Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera2018
- Author(s)
  Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H.
- Journal Title
  
  Clinical Chemistry
  
  Volume: 64 Pages: 1463-1473
- DOI
  10.1373/clinchem.2018.291963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-16K01937
[Journal Article] Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice2018
- Author(s)
  Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Cardiovascular Research
  
  Volume: - Pages: 1132-1144
- DOI
  10.1093/cvr/cvy063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16H05294, KAKENHI-PROJECT-16K15456, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-16K19442
[Journal Article] Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Naito Y, Hishiki T, Mori M, Suematsu M, Shiomi K, Hashimoto T, Nozaki T
- Journal Title
  
  International Journal for Parasitology: Drugs and Drug Resistance
  
  Volume: 8 Pages: 125-136
- DOI
  10.1016/j.ijpddr.2018.02.004
- NAID
  120006469266
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-17K19614
[Journal Article] Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 37 (16)
- DOI
  10.1128/mcb.00248-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16H04723
[Journal Article] Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.2017
- Author(s)
  Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 39752-39752
- DOI
  10.1038/srep39752
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-26461375, KAKENHI-PROJECT-15K12695, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15K15313, KAKENHI-PROJECT-16K15599, KAKENHI-PROJECT-15K19396, KAKENHI-PROJECT-15KK0332, KAKENHI-PROJECT-16H05330
[Journal Article] Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice2017
- Author(s)
  Umbarawan Y, Syamsunarno MR, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
- Journal Title
  
  Metabolism
  
  Volume: - Pages: 47-57
- DOI
  10.1016/j.metabol.2017.09.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K09572, KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-16K19442, KAKENHI-PROJECT-16H05294
[Journal Article] Glutamine Oxidation is Indispensable for Survival of Human Pluripotent Stem Cells.2016
- Author(s)
  Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K.
- Journal Title
  
  Cell Metab.
  
  Volume: 23 Pages: 663-674
- DOI
  10.1016/j.cmet.2016.03.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01521, KAKENHI-PROJECT-13J30005, KAKENHI-PROJECT-25505004, KAKENHI-PROJECT-26670408, KAKENHI-PROJECT-26670410, KAKENHI-PROJECT-15K09098, KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16K15415, KAKENHI-PROJECT-16H05304
[Journal Article] A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.2016
- Author(s)
  Iizumi T, Takahashi S, Mashima K, Minami K, Izawa Y, Abe T, Hishiki T, Suematsu M, Kajimura M, Suzuki N
- Journal Title
  
  Neuoinflammation.
  
  Volume: １３ Pages: 99-99
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937
[Journal Article] Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart2015
- Author(s)
  Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 82 Pages: 116-124
- DOI
  10.1016/j.yjmcc.2015.02.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461123
[Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.2015
- Author(s)
  Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H, Suematsu M.
- Journal Title
  
  Nitric Oxide.
  
  Volume: 30 (46) Pages: 102-13
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite.2015
- Author(s)
  1.Yamazoe S, Naya M, Shiota M, Morikawa M, Kubo A, Tani T, Hishiki T, Horiuchi T, Suematsu M, and Kajimura M
- Journal Title
  
  ACS Nano.
  
  Volume: 8 Pages: 5622-32
- DOI
  10.1021/nn4065692
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia.2015
- Author(s)
  Takenouchi T, Sugiura Y, Morikawa T, Nakanishi T, Nagahata Y, Sugioka T, Honda K, Kubo A, Hishiki T, Matsuura T, Hoshino T, Takahashi T, Suematsu M, Kajimura M.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 1 Pages: 1-12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.2015
- Author(s)
  Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 82 Pages: 116-124
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.2015
- Author(s)
  Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr., Suematsu M, Minamishima YA§. (§Corresponding author)
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Pages: 11642-11647
- DOI
  10.1073/pnas.1515872112
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163, KAKENHI-PLANNED-26111006, KAKENHI-PROJECT-25513008
[Journal Article] Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.2014
- Author(s)
  Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, Takako Hishiki, and Makoto Suematsu.
- Journal Title
  
  Nature Communucations
  
  Volume: 5 Pages: 3480-3480
- DOI
  10.1038/ncomms4480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model of homocystinuria.2014
- Author(s)
  Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 306(12)
- DOI
  10.1152/ajprenal.00623.2013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460960
[Journal Article] Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo2013
- Author(s)
  Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 11 Pages: 973-985
- DOI
  10.1158/1541-7786.mcr-12-0669-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310136, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Capillary endothelial Fatty Acid binding proteins 4 and 5 play a critical role in Fatty Acid uptake in heart and skeletal muscle2013
- Author(s)
  Iso Tatsuya, Kurabayashi Masahiko
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: vol.33 Pages: 2549-2557
- DOI
  10.1161/atvbaha.113.301588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590661, KAKENHI-PROJECT-23790656, KAKENHI-PROJECT-24592730, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-24659573, KAKENHI-PROJECT-25504002
[Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.2013
- Author(s)
  Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
- Journal Title
  
  Plos One
  
  Volume: 14;8
- DOI
  10.1371/journal.pone.0079386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390146, KAKENHI-PROJECT-23790656, KAKENHI-PROJECT-24592730, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25461101, KAKENHI-PROJECT-25504002
[Journal Article] Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes.2013
- Author(s)
  Tohyama S, Hattori F, Sano M, et al.
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 12 Pages: 127-137
- DOI
  10.1016/j.stem.2012.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05269, KAKENHI-PROJECT-11J30002, KAKENHI-PROJECT-22689027, KAKENHI-PROJECT-23390072, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25461117, KAKENHI-PUBLICLY-24117716
[Journal Article] ガス分子を量る：チオールプローブを用いたH2Sの定量2013
- Author(s)
  菱木貴子
- Journal Title
  
  実験医学　別冊
  
  Volume: 36 Pages: 132-143
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] がん代謝システムの顕微質量イメージングによる解析2012
- Author(s)
  末松誠、久保亜紀子、大村光代、菱木貴子、梶村眞弓、加部泰明、杉浦悠毅
- Journal Title
  
  実験医学増刊
  
  Volume: 30 Pages: 193-202
- Data Source
  KAKENHI-PROJECT-24651265
[Journal Article] Mitochondrial dysfunction and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain2012
- Author(s)
  Imaizumi Y
- Journal Title
  
  Molecular Brain
  
  Volume: 5 Pages: 35-35
- DOI
  10.1186/1756-6606-5-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390041, KAKENHI-PROJECT-23591254, KAKENHI-PROJECT-23618010, KAKENHI-PROJECT-23650194, KAKENHI-PROJECT-23659102, KAKENHI-PROJECT-23689017, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24651265, KAKENHI-PUBLICLY-23110516, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-23111004, KAKENHI-PUBLICLY-23129506
[Journal Article] Gas biology: tiny molecules controlling metabolic systems.2012
- Author(s)
  Kajimura M., Nakanishi T., Takenouchi T., Morikawa T., Hishiki T., Yukutake Y., and Suematsu M.
- Journal Title
  
  Respir Physiol Neurobiol
  
  Volume: (in press) Pages: 139-148
- DOI
  10.1016/j.resp.2012.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500353, KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-24651265
[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria2012
- Author(s)
  Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 52 Pages: 1716-1726
- DOI
  10.1016/j.freeradbiomed.2012.02.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590292, KAKENHI-PROJECT-22790219, KAKENHI-PUBLICLY-23117703, KAKENHI-PROJECT-23650159, KAKENHI-PROJECT-24651265, KAKENHI-PUBLICLY-23117716
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答メカニズムを標的としたメトホルミン関連乳酸アシドーシス (MALA)の新規治療法の開発2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第60回日本糖尿病学会/第4回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 低酸素応答による細胞内エネルギー代謝制御機構2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第17回日本高気圧環境・潜水医学会関東地方会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis2016
- Author(s)
  寅丸智子*、壽原朋宏、早川典代、中村貴、南嶋しづか、菱木貴子、森崎浩、末松誠、南嶋洋司
- Organizer
  第4回低酸素研究会
- Place of Presentation
  早稲田大学　先端生命医科学センター
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] マウス水晶体における新規抗酸化物質「過硫化グルタチオン」レベル維持には，Cystathionine β -synthase (CBS)が必要である2016
- Author(s)
  久保亜紀子，善岡尊文，後藤信一，石井功，菱木貴子，山本雄広，高野直治，星野岳郎，中村貴，吉田晃敏，梶村眞弓，末松誠
- Organizer
  第41回　日本医用マススペクトル学会
- Place of Presentation
  愛知県産業労働センター（愛知県名古屋市）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-16K01937
[Presentation] 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発2016
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、山口京二、菱木貴子、森崎浩、末松誠、南嶋洋司*
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis2016
- Author(s)
  寅丸智子*、壽原朋宏、早川典代、中村貴、南嶋しづか、菱木貴子、森崎浩、末松誠、南嶋洋司
- Organizer
  第4回低酸素研究会
- Place of Presentation
  早稲田大学　先端生命医科学センター
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 低酸素応答を標的とした各種疾患治療法の開発～致死的乳酸アシドーシスの新規治療法～2016
- Author(s)
  小柳津-寅丸智子, 壽原朋宏, 早川典代, 中村貴, 南嶋しづか, 山口京二, 菱木貴子, 森崎浩, 末松誠, 南嶋洋司*
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答を標的とした各種疾患治療法の開発～致死的乳酸アシドーシスの新規治療法～2016
- Author(s)
  小柳津-寅丸智子, 壽原朋宏, 早川典代, 中村貴, 南嶋しづか, 山口京二, 菱木貴子, 森崎浩, 末松誠, 南嶋洋司*
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発2016
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、山口京二、菱木貴子、森崎浩、末松誠、南嶋洋司*
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Inactivating HIF-prolyl hydroxylase PHD2 in liver improves survival after lactic acidosis by activating Cori cycle2015
- Author(s)
  Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima*
- Organizer
  Keystone Symposia “Hypoxia: From Basic Mechanisms to Therapeutics (E3)”.
- Place of Presentation
  Royal Dublin Society (Dublin, Ireland)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 肝臓における低酸素応答はCori回路の活性化を介して血中乳酸レベルを制御している2015
- Author(s)
  壽原朋宏、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司*
- Organizer
  第13回がんとハイポキシア研究会
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答によるCori回路の制御機構の解明～肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発～2015
- Author(s)
  壽原朋宏*、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle2015
- Author(s)
  Tomohiro Suhara*, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin Jr., Makoto Suematsu, Yoji Andrew Minamishima
- Organizer
  第3回低酸素研究会
- Place of Presentation
  早稲田大学先端生命医科学センター（東京都新宿区）
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro2014
- Author(s)
  Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto, Ryo Fukuda, Hideyuki Saya, Makoto Suematsu and Yoji Andrew Minamishima
- Organizer
  Keystone Symposia "Tumor Metabolism (X6)"
- Place of Presentation
  Whistler, BC, Canada
- Data Source
  KAKENHI-PROJECT-23310136
[Presentation] 解糖系酵素PFKFB3のメチル化制御はがん細胞の酸化ストレス耐性獲得に重要である2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松誠
- Organizer
  第86回　日本生化学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] アルギニンメチル化酵素PRMT1の細胞内局在を反映した糖代謝酵素の核内メチル化機構2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松誠
- Organizer
  第36回　日本分子生物学会本大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] Sensitive detection and quantification of hydrogen sulfide as a gasotransmitter by combining monobromobimane-based derivatization to triple quadrupole LC/MS/MS2012
- Author(s)
  Takako Hishiki , Tsuyoshi Nakanishi and Makoto Suematsu
- Organizer
  American Society for Mass Spectrometry
- Place of Presentation
  Vancouver, BC, Canada
- Data Source
  KAKENHI-PROJECT-24651265
[Presentation] 低酸素応答による乳酸代謝制御機構
- Author(s)
  寿原明宏、笠原正貴、菱木貴子、早川典代、南嶋洋司、末松誠
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀県佐賀市神野東2-5-15ホテルマリターレ創世佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-23310136
[Presentation] 低酸素応答による乳酸代謝制御機構
- Author(s)
  寿原明宏、笠原正貴、菱木貴子、早川典代、南嶋洋司、末松誠
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  佐賀県佐賀市神野東2-5-15ホテルマリターレ創世佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Glucose Uptake in the Heart of FABP4/5 double knockout mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways.
- Author(s)
  Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Kosaku Goto, Mas Rizky A.A Syamsunarno, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Masashi Arai, Aiko Yamaguchi, Motoaki Sano, Makoto Suematsu, Keigo Endo, Gokhan S. Hotamisligil and Masahiko Kurabayashi.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26461123

1. KUBO Akiko (50455573)

# of Collaborated Projects: 7 results

# of Collaborated Products: 18 results
2. MINAMISHIMA Yoji Andrew (20593966)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
3. SHIMADA Hideo (80095611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 江川毅 (10232935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YACHIE Ayako (10453549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KASAHARA Masataka (30328265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MINAMISHIMA Shizuka (20622088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MAKOTO Suematsu (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Iso Tatsuya (10400756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. FUJII Hiroshi (80228957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HAYASHI Takashi (20222226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MUKAI Kuniaki (80229913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yuki Sugiura (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Soejima Kenzo (30236145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 堀洋 (20127294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 倉林正彦 (00215047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
17. 小板橋紀通 (10420093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 山本正道 (70423150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 浜本純子 (40570239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 安田浩之 (70365261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鵜殿平一郎 (50260659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 城口克之 (00454059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 足立健 (50231931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤泰司 (10505267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 井戸康夫 (50814133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 梶村眞弓 (10327497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
27. MATSUI Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
28. MURAKAMI Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. SAMPETREAN Oltea

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. HATTORI Fumiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. NISHIYAMA Takahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. TANAKA Hirotoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. AKAHOSHI Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 山本雄広

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
35. 遠藤啓吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 大日方英

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
37. 須永浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
38. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 関倫久

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
40. 村田光繁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 湯浅慎介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 福田恵一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 藤田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 遠山周吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 金澤英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 福田淳二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 赤松和土

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 家田真樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 中島尚美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 太田成男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 清水宣明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 半田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 峯岸直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 石井功

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hishiki Takako 菱木 貴子

HISHIKI Takako 菱木 貴子

菱木 貴子 ヒシキ タカコ

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Effects of molecular hydrogen on ischemic brain injuryOngoing

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Metabolism-based dissection of tumor microenvironment infiltrated by immune cellsOngoing

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Role of ERK2 in Ectopic Fat deposition and Cardiovascular Complications of Type II DiabetesOngoing

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Functional analyses of sulfur-containing amino acid-derived thiol compounds in the ischemic reperfusion disorder by MALDI MS imagingPrincipal Investigator

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水酸化オミクス解析を駆使した低酸素応答による代謝制御機構の全貌解明Ongoing

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Development of method for the determination of thiol-containing metabolites using quantitative mass spectrometryPrincipal Investigator

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Hishiki Takako 菱木貴子

HISHIKI Takako 菱木貴子

菱木貴子ヒシキタカコ

[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.2018