SHIMOKAWA Toshibumi 下川敏文

Researcher Number	10339327
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 日本大学, 医学部, 研究員 2012 – 2015: 日本大学, 医学部, 助教 2003 – 2004: 日本大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Immunology / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator bZIP / 好中球 / 血球分化 / 酵母ツーハイブリッド法 / C/EBPα / タンパク質-タンパク質相互作用 / RINGフィンガードメイン / RING1B / ポリコーム抑制複合体 / 好中球分化 … More / 急性骨髄性白血業 / ETS / タンパク質ータンパク質相互作用 / タンパク質–タンパク質相互作用 / GABP / 顆粒球分化 … More Except Principal Investigator FcεRI / マスト細胞 / アレルギー / reactive oxygen species / innate immunity / allergy / Toll like receptors / mast cell / 活性酸素 / 自然免疫 / Toll-like receptors / IgE / シグナル伝達 Less

好中球分化誘導因子C/EBPαとポリコーム抑制複合体のクロストークの解明Principal Investigator
- Principal Investigator
  
  下川敏文
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nihon University
Identification of RING1B as the interactor of the novel C-terminal functional domain of C/EBPalphaPrincipal Investigator
- Principal Investigator
  
  SHIMOKAWA Toshibumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nihon University
Crosstalk between C/EBPalpha and GABP in myeloid differentiation and gene expressionPrincipal Investigator
- Principal Investigator
  
  SHIMOKAWA Toshibumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nihon University
Elucidation and regulation of mast cell activation by FcεRIβ chain
- Principal Investigator
  
  RA Chisei
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nihon University
analyses of molecular mechanisms of mast cell activation in the innate immune and allergic reactions
- Principal Investigator
  
  RA Chisei
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Nihon University

All 2018 2017 2016 2015 2013 2011 2005 2003 Other

All Journal Article Presentation

[Journal Article] IgAレセプター発現と顆粒球分化の転写調節機構2015
- Author(s)
  下川敏文，布村聡，藤澤大輔，羅智靖
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 63
- NAID
  40020505093
- Data Source
  KAKENHI-PROJECT-25461462
[Journal Article] Identification of the C/EBPα C-terminal tail residues involved in the protein interaction with GABP and their potency in myeloid differentiation of K562 cells2013
- Author(s)
  Toshibumi Shimokawa, Satoshi Nunomura, Daisuke Fujisawa, and Chisei Ra
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1829 Issue: 11 Pages: 1207-1217
- DOI
  10.1016/j.bbagrm.2013.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461462
[Journal Article] Fcε RI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the Fcε RIβ chain2011
- Author(s)
  Terada T, Nunomura S, Shimokawa T, Murayama K, Era S, Kondo N, Ra C
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 744-748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390202
[Journal Article] C/EBPα functionally physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcαR, CD89) promoter2005
- Author(s)
  Shimokawa T, Ra C.
- Journal Title
  
  Blood (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Journal Article] C/EBPα functionally physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcaR, CD89) promoter2005
- Author(s)
  Shimokawa T, Ra C
- Journal Title
  
  Blood (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Journal Article] C/EBP α and Ets protein family members regulate the human myeloid IgA Fc receptor (FcαR, CD89) promoter.2003
- Author(s)
  Shimokawa T, Ra C.
- Journal Title
  
  J.Immunol. 170(5)
  
  Pages: 2564-2572
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Journal Article] Monocyte chemoattractant protein (MCP)-1 production via functionally reconstituted Fcalpha receptor (CD89) on glomerular mesangial cells.2003
- Author(s)
  Tsuge T, Suzuki Y, Shimokawa T, Horikoshi S, Okumura K, Ra C, Tomino Y.
- Journal Title
  
  Inflamm.Res. 52(10)
  
  Pages: 428-432
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Journal Article] Alternative splicing of myeloid IgA Fc receptor (FcalphaR, CD89) transcripts in inflammatory responses.2003
- Author(s)
  Togo S, Shimokawa T, Fukuchi Y, Ra C.
- Journal Title
  
  FEBS Lett. 535(1-3)
  
  Pages: 205-209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Journal Article] C/EBPα and Ets protein family members regulate the human myeloid IgA Fc receptor (FcαR, CD89) promoter.2003
- Author(s)
  Shimokawa T, Ra C.
- Journal Title
  
  J.Immunol. 170(5)
  
  Pages: 2564-2572
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390163
[Presentation] 好中球分化誘導因子C/EBPαとポリコ―ム群タンパク質RING1Bの会合様式2018
- Author(s)
  下川敏文，羅智靖
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09879
[Presentation] 好中球誘導因子C/EBPαの新規C末端機能領域とPolycomb群タンパク質RING1Bの相互作用2017
- Author(s)
  下川敏文，羅智靖
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09879
[Presentation] 好中球分化誘導因子C/EBPαの新規Ｃ末端機能領域とその会合因子2016
- Author(s)
  下川敏文，岡山吉道，羅智靖
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09879
[Presentation] C/EBPαの新規Ｃ末端機能領域を介した顆粒球系細胞分化経路2016
- Author(s)
  下川敏文，羅智靖
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K09879
[Presentation] 好中球分化におけるC/EBPαC末端の標的遺伝子特異的制御2015
- Author(s)
  下川敏文，布村聡，藤澤大輔，羅智靖
- Organizer
  第38回日本分子生物学会年会，第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 好中球分化におけるC/EBPαC末端のGABP会合領域の解析2015
- Author(s)
  下川敏文，布村聡，藤澤大輔，羅智靖
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂， ANAクラウンプラザホテル金沢，ホテル日航金沢，ホテル金沢，金沢市アートホール，もてなしドーム（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] Analysis of C/EBPα C-terminal regulatory region in granulocytic differentiation2013
- Author(s)
  Toshibumi Shimokawa, Satoshi Nunomura, Daisuke Fujisawa, Okayama Yoshimichi, and Chisei Ra
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 好中球分化誘導因子C/EBPαのC-末端領域の解析2013
- Author(s)
  下川敏文，布村聡，藤澤大輔，岡山吉道，羅智靖
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  ホテルニューオータニ（東京と千代田区）
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 好中球分化におけるC/EBPαのC 末端GABP 相互作用領域の解析2013
- Author(s)
  下川敏文，布村聡，藤澤大輔，羅智靖
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド ，神戸国際会議場 ，神戸国際展示場 ，神戸ポートピアホテル（神戸市中央区）
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 転写因子間相互作用を標的とした骨髄系細胞の分化制御に関する研究
- Author(s)
  下川敏文，布村聡，藤澤大輔，岡山吉道，羅智靖
- Organizer
  第524回日大医学会例会
- Place of Presentation
  日本大学医学部（東京都板橋区）
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 骨髄細胞分化におけるC/EBPαのC-末端領域の解析
- Author(s)
  下川敏文，布村聡，藤澤大輔，岡山吉道，羅智靖
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール（東京都港区）
- Year and Date
  2015-05-26 – 2015-05-28
- Data Source
  KAKENHI-PROJECT-25461462
[Presentation] 好中球分化におけるC/EBPαのC末端領域の解析
- Author(s)
  下川敏文，布村聡，藤澤大輔，羅智靖
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461462

1. RA Chisei (60230851)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. NUNOMURA Satoshi (70424728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. SUZUKI Yoshihiro (80206549)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. OKAYAMA Yoshimichi (80292605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKAHASHI Kyoko (70366574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUJISAWA Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

SHIMOKAWA Toshibumi 下川 敏文

Research Projects

Research Products

Co-Researchers

好中球分化誘導因子C/EBPαとポリコーム抑制複合体のクロストークの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of RING1B as the interactor of the novel C-terminal functional domain of C/EBPalphaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk between C/EBPalpha and GABP in myeloid differentiation and gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation and regulation of mast cell activation by FcεRIβ chain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

analyses of molecular mechanisms of mast cell activation in the innate immune and allergic reactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] IgAレセプター発現と顆粒球分化の転写調節機構2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Identification of the C/EBPα C-terminal tail residues involved in the protein interaction with GABP and their potency in myeloid differentiation of K562 cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fcε RI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the Fcε RIβ chain2011

Author(s)

Journal Title

Data Source

[Journal Article] C/EBPα functionally physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcαR, CD89) promoter2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] C/EBPα functionally physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcaR, CD89) promoter2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] C/EBP α and Ets protein family members regulate the human myeloid IgA Fc receptor (FcαR, CD89) promoter.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Monocyte chemoattractant protein (MCP)-1 production via functionally reconstituted Fcalpha receptor (CD89) on glomerular mesangial cells.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Alternative splicing of myeloid IgA Fc receptor (FcalphaR, CD89) transcripts in inflammatory responses.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] C/EBPα and Ets protein family members regulate the human myeloid IgA Fc receptor (FcαR, CD89) promoter.2003

Author(s)

Journal Title

Description

Data Source

[Presentation] 好中球分化誘導因子C/EBPαとポリコ―ム群タンパク質RING1Bの会合様式2018

Author(s)

SHIMOKAWA Toshibumi 下川敏文