Doi Keiko 土井佳子

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土井佳子ドイケイコ

DOI Keiko 土井佳子

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Researcher Number	10341538
Other IDs
Affiliation (Current)	2025: 福岡大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 福岡大学, 医学部, 講師 2012 – 2018: 福岡大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Experimental pathology
Keywords	Principal Investigator 赤血球 / ZFAT / 赤血球分化 / 転写因子 / T細胞

骨髄赤血球系前駆細胞における転写制御因子ＺＦＡＴの機能解析Principal Investigator
- Principal Investigator
  
  土井佳子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Fukuoka University
Elucidation of Zfat function in fetal erythropoiesis using a conditional knockout mousePrincipal Investigator
- Principal Investigator
  
  DOI Keiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Fukuoka University
Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse modelPrincipal Investigator
- Principal Investigator
  
  DOI Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fukuoka University

All 2023 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Zfat expression in ZsGreen reporter gene knoc;in mice: Implications for a novel function of Zfat in definitive erythropoiesis.2018
- Author(s)
  Tsunoda T, Doi K, Ishikura S, Luo H, Nishi K, Matsuzaki H, Koyanagi M, Tanaka Y, Okamura T, Shirasawa S
- Journal Title
  
  Int J Mol Med.
  
  Volume: 42 Pages: 2595-2603
- DOI
  10.3892/ijmm.2018.3806
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08166, KAKENHI-PROJECT-18K07215
[Journal Article] Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.2016
- Author(s)
  Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, Kawai T, Tanaka Y, Iwaihara Y, Luo H, Nishi K, Okamura T, Shirasawa S.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1859(11) Issue: 11 Pages: 1398-1410
- DOI
  10.1016/j.bbagrm.2016.08.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
[Journal Article] The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.2016
- Author(s)
  Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura　T, Tsunoda T, Shirasawa S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 291(29) Issue: 29 Pages: 15282-91
- DOI
  10.1074/jbc.m116.723734
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06847, KAKENHI-PROJECT-15K08166
[Journal Article] Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.2015
- Author(s)
  Iwaihara Y, Ishikura S, Doi K, Tsunoda T, Fujimoto T, Okamura T, Shirasawa S.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 4419-4423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08166
[Journal Article] Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.2015
- Author(s)
  Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.
- Journal Title
  
  J Cell Biochem.
  
  Volume: 16(1) Issue: 1 Pages: 149-57
- DOI
  10.1002/jcb.24954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501322, KAKENHI-PROJECT-24590465, KAKENHI-PROJECT-15K08166
[Journal Article] The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.2014
- Author(s)
  Doi K, Ishikura S, Shirasawa S.
- Journal Title
  
  Anticancer Res
  
  Volume: 34 Pages: 4489-4495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590465
[Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013
- Author(s)
  Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 10 Pages: e76254-e76254
- DOI
  10.1371/journal.pone.0076254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590465
[Journal Article] ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.2012
- Author(s)
  Doi K, Shirasawa S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 425(1) Issue: 1 Pages: 107-112
- DOI
  10.1016/j.bbrc.2012.07.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24590465, KAKENHI-PLANNED-22133009
[Presentation] Comprehensive gene expression analysis during repression of the transcriptional regulator Zfat in mouse fetal liver2023
- Author(s)
  Keiko Doi, Midori Koyanagi, Yoko Tanaka
- Organizer
  Human Genetics Asia2023合同開催 / 日本人類遺伝学会第68回大会, 第14回アジアパシフィック人類遺伝学会（APCHG）, 第22回東アジア人類遺伝学会連合（EAUHGS）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07235
[Presentation] 末梢T細胞のTCR刺激時における転写制御分子Zfatの機能メカニズムの解明2018
- Author(s)
  土井佳子、石倉周平、角田俊之、小柳緑、田中陽子、中林一彦、白澤専二
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-15K08166
[Presentation] T細胞における転写制御分子ZFATの分子機構の解明2017
- Author(s)
  土井佳子、石倉周平、角田俊之、小柳緑、田中陽子、中林一彦、白澤専二
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-15K08166
[Presentation] Identification of the genes regulated by ZFAT in T cells through ChIP-seq analysis2016
- Author(s)
  Keiko Doi, Toshiyuki Tsunoda, Midori Koyanagi, Shuhei Ishikura, Yoko Tanaka, Kazuhiko Nakabayashi, Senji Shirasawa
- Organizer
  第13回国際人類遺伝学会
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08166
[Presentation] T細胞における免疫系転写制御分子Zfatの転写制御標的分子の同定2015
- Author(s)
  土井佳子、角田俊之、小柳緑、石倉周平、田中陽子、白澤専二
- Organizer
  第１９回バイオ治療法研究会学術集会
- Place of Presentation
  東京理科大学森戸記念館(東京都新宿区)
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K08166
[Presentation] ChIP-seq解析によるT細胞におけるZFATの転写制御標的分子の同定2015
- Author(s)
  土井佳子、角田俊之、小柳緑、石倉周平、田中陽子、中林一彦、白澤専二
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-15K08166
[Presentation] ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進2014
- Author(s)
  土井佳子、石倉周平、岡村匡史、角田俊之、田中陽子、白澤専二
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  船堀
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-24590465
[Presentation] 転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明2013
- Author(s)
  土井佳子、小川雅弘、岡村匡史、石倉周平、角田俊之、田中陽子、白澤専二
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590465
[Presentation] 遺伝子改変マウスを利用した転写制御分子ZFATの機能解明2012
- Author(s)
  土井佳子
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590465

1. SHIRASAWA Senji (10253535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. TSUNODA Toshiyuki (70444817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. KOYANAGI Midori (20153687)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results

Doi Keiko 土井 佳子

土井 佳子 ドイ ケイコ

DOI Keiko 土井 佳子

Research Projects

Research Products

Co-Researchers

骨髄赤血球系前駆細胞における転写制御因子ＺＦＡＴの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Zfat function in fetal erythropoiesis using a conditional knockout mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Zfat expression in ZsGreen reporter gene knoc;in mice: Implications for a novel function of Zfat in definitive erythropoiesis.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.2015

Author(s)

Journal Title

Data Source

[Journal Article] Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.2014

Author(s)

Journal Title

Data Source

[Journal Article] Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Comprehensive gene expression analysis during repression of the transcriptional regulator Zfat in mouse fetal liver2023

Author(s)

Organizer

Data Source

[Presentation] 末梢T細胞のTCR刺激時における転写制御分子Zfatの機能メカニズムの解明2018

Author(s)

Organizer

Data Source

[Presentation] T細胞における転写制御分子ZFATの分子機構の解明2017

Author(s)

Organizer

Data Source

[Presentation] Identification of the genes regulated by ZFAT in T cells through ChIP-seq analysis2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] T細胞における免疫系転写制御分子Zfatの転写制御標的分子の同定2015

Doi Keiko 土井佳子

土井佳子ドイケイコ

DOI Keiko 土井佳子