Yamaguchi Hideki 山口英樹

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YAMAGUCHI Hideki 山口英樹

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Researcher Number	10345035
Other IDs
Affiliation (Current)	2025: 公益財団法人佐々木研究所, 附属研究所, 部長
Affiliation (based on the past Project Information) *help	2023 – 2024: 公益財団法人佐々木研究所, 附属研究所, 部長 2022: 公益財団法人佐々木研究所, 附属研究所, 副所長兼部長 2017 – 2021: 公益財団法人佐々木研究所, 附属研究所, 部長(移行) 2015 – 2016: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2014: 国立がん研究センター, 難治進行がん研究分野, ユニット長 2011 – 2014: 独立行政法人国立がん研究センター, 研究所, ユニット長 2007 – 2009: 東京薬科大学, 生命科学部, 講師
Review Section/Research Field	Principal Investigator Tumor biology / Basic Section 49010:Pathological biochemistry-related / Basic Section 50010:Tumor biology-related / Tumor biology / Biological Sciences / Functional biochemistry Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Tumor biology / Tumor biology / Functional biochemistry
Keywords	Principal Investigator スキルス胃癌 / 浸潤突起 / PLEKHA5 / 腹膜播種 / 癌 / イノシトールリン脂質 / 細胞間接着 / E-cadherin / 口唇口蓋裂 / スキルス胃がん … More / シグナル伝達 / リン酸化 / 腹膜播種性転移 / Met / 腫瘍不均一性 / 蛍光イメージング / 浸潤転移 / がん浸潤 / アクチニン / 浸潤 / 膜輸送 / 転移 / がん / 細胞内輸送 / CDCP1 / 微絨毛形成 / エンドサイトーシス / 内耳有毛細胞 / ミオシン / ホスホリパーゼC / イノシトールリン脂質代謝 / 細胞情報伝達機構 … More Except Principal Investigator がん浸潤・転移 / 光ピンセット / 細胞のメカニクス / 細胞膜の張力 / がん幹細胞性 / がん幹細胞 / 細胞膜のメカニクス / 細胞・組織 / 癌 / 微小環境 / Dasatinib / CAF / がん間質相互作用 / 細胞間接着 / 癌微小環境 / 癌間質相互作用 / ファージ抗体 / 間質線維芽細胞 / スキルス胃がん / MT1-MMP / Autophagy / ERK / Metastasis / Invasion / MMP / CDCP1 / Ras / ヘアケラチン / Foxn1 / ホスフォリパーゼ C / 毛形成 / ヌードマウス / ホスフォリパーゼC / 表皮と毛包形成 / イノシトールリン脂質 Less

細胞膜メカニクスによるがん幹細胞性の機械的制御と新規治療戦略
- Principal Investigator
  
  辻田和也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kobe University
Analysis of the molecular function of PLEKHA5 involved in the onset of scirrhous gastric carcinoma and cleft lip and palatePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hideki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Sasaki Foundation
Mechanisms of Met specific signaling for cancer malignancy mediated by a novel target molecule PLEKHA5Principal Investigator
- Principal Investigator
  
  Yamaguchi Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Sasaki Foundation
Mechanistic analysis of cooperative invasion between cancer cells and stromal fibroblasts
- Principal Investigator
  
  Sakai Ryuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Kitasato University
Analysis of tumor heterogeneity in peritoneal dissemination of scirrhous gastric carcinoma by multi-color fluorescent imagingPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hideki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Sasaki Foundation
  National Cancer Center Japan
Analysis of the regulatory mechanisms of the actin cytoskeleton in invadopodia formation by cancer cellsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hideki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Analysis of the mechanism of cancer progression that overcome the cellular senescence by activated Ras
- Principal Investigator
  
  UEKITA TAKAMASA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群)
  National Center of Neurology and Psychiatry
細胞内ロジスティクスによる癌細胞浸潤能の制御機構の解明Principal Investigator
- Principal Investigator
  
  山口英樹
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Japan
Functional analysis of phosphoinositides in invasion and metastasis of breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Hideki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Functional analysis of phospholipase Cδ3 in inner hair cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Hideki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanism of hair follicle formation regulated by Phosphoinositide metabolism
- Principal Investigator
  
  FUKAMI Kiyoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

[Journal Article] Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis.2023
- Author(s)
  Makoto Miyazaki, Ayaka Nakabo, Yoshiko Nagano, Yuko Nagamura, Kazuyoshi Yanagihara, Rieko Ohki, Yoshikazu Nakamura, KiyokoFukami, JunKawamoto, Kenji Umayahara, Masaru Sakamoto, Keiichi Iwaya, and Hideki Yamaguchi.
- Journal Title
  
  Cancer Letters
  
  Volume: 553 Pages: 215983-215983
- DOI
  10.1016/j.canlet.2022.215983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03523, KAKENHI-PROJECT-20F20414, KAKENHI-PROJECT-20K07605, KAKENHI-PROJECT-21K15518, KAKENHI-PROJECT-21K06879
[Journal Article] がん細胞のクラスター形成を介した腹膜播種機構2023
- Author(s)
  宮崎允、山口英樹
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 44-47
- Data Source
  KAKENHI-PROJECT-21K06879
[Journal Article] Receptor Tyrosine Kinases Amplified in Diffuse-Type Gastric Carcinoma: Potential Targeted Therapies and Novel Downstream Effectors2022
- Author(s)
  Yamaguchi Hideki、Nagamura Yuko、Miyazaki Makoto
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 15 Pages: 3750-3750
- DOI
  10.3390/cancers14153750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06879
[Journal Article] PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification2021
- Author(s)
  Nagamura Yuko、Miyazaki Makoto、Nagano Yoshiko、Yuki Masako、Fukami Kiyoko、Yanagihara Kazuyoshi、Sasaki Kazuki、Sakai Ryuichi、Yamaguchi Hideki
- Journal Title
  
  Oncogenesis
  
  Volume: 10 Issue: 3 Pages: 25-25
- DOI
  10.1038/s41389-021-00314-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-19K16758, KAKENHI-PROJECT-21K06879, KAKENHI-PROJECT-16H06276
[Journal Article] Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility2020
- Author(s)
  Yoneda A., Kanemaru K., Matsubara A., Takai E., Shimozawa M., Satow R., Yamaguchi H., Nakamura Y., Fukami K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: in press Issue: 4 Pages: 1050-1056
- DOI
  10.1016/j.bbrc.2020.05.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02575, KAKENHI-PROJECT-20K06563, KAKENHI-PROJECT-17H05056, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-19K16080
[Journal Article] MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane.2019
- Author(s)
  Miyagawa, T.,* Hasegawa, K.,* Aoki, Y.,* Watanabe, T.,* Otagiri, Y., Arasaki, K., Wakana, Y., Asano, K., Tanaka, M., Yamaguchi, H., Tagaya, M. and Inoue, H. (*, These authors contributed equally to this work.)
- Journal Title
  
  J. Cell Biol.
  
  Volume: 218 Issue: 10 Pages: 3355-3371
- DOI
  10.1083/jcb.201808149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06138, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-17H04052, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-17K07348, KAKENHI-PROJECT-17H04068
[Journal Article] Identification and characterization of a novel <i>adenomatous polyposis coli</i> mutation in adult pancreatoblastoma2018
- Author(s)
  Yamaguchi S, Fujii T, Izumi Y, Fukumura Y, Han M, Yamaguchi H, Akita T, Yamashita C, Kato S, Sekiya T.
- Journal Title
  
  Oncotarget
  
  Volume: 9(12) Issue: 12 Pages: 10818-10827
- DOI
  10.18632/oncotarget.24017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10035, KAKENHI-PROJECT-16K10558, KAKENHI-PROJECT-17K10652, KAKENHI-PROJECT-17H07134, KAKENHI-PROJECT-15K07901, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-26860227, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-18K14961, KAKENHI-PROJECT-16K11029
[Journal Article] Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells2018
- Author(s)
  Miyamoto Shingo、Nagamura Yuko、Nakabo Ayaka、Okabe Akira、Yanagihara Kazuyoshi、Fukami Kiyoko、Sakai Ryuichi、Yamaguchi Hideki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 2 Pages: 1942-1947
- DOI
  10.1016/j.bbrc.2017.12.067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-17H04051
[Journal Article] Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft2018
- Author(s)
  Yamamoto Yutaro、Tomiyama Arata、Sasaki Nobuyoshi、Yamaguchi Hideki、Shirakihara Takuya、Nakashima Katsuhiko、Kumagai Kosuke、Takeuchi Satoru、Toyooka Terushige、Otani Naoki、Wada Kojiro、Narita Yoshitaka、Ichimura Koichi、Sakai Ryuichi、Namba Hiroki、Mori Kentaro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 1292-1299
- DOI
  10.1016/j.bbrc.2017.11.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-18K07219
[Journal Article] Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells2017
- Author(s)
  Yamaguchi Hideki、Ito Yuumi、Miura Nami、Nagamura Yuko、Nakabo Ayaka、Fukami Kiyoko、Honda Kazufumi、Sakai Ryuichi
- Journal Title
  
  European Journal of Cell Biology
  
  Volume: 96 Issue: 7 Pages: 685-694
- DOI
  10.1016/j.ejcb.2017.07.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-17H04051, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-16H05547, KAKENHI-PROJECT-16K15833
[Journal Article] Novel small molecule inhibiting CDCP1-PKCδ pathway reduces tumor metastasis and proliferation.2017
- Author(s)
  Nakashima K, Uekita T, Yano S, Kikuchi JI, Nakanishi R, Sakamoto N, Fukumoto K, Nomoto A, Kawamoto K, Shibahara T, Yamaguchi H, Sakai R.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1049-1057
- DOI
  10.1111/cas.13218
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-16K14622
[Journal Article] Direct interaction between carcinoma cells and cancer associated fibroblasts for the regulation of cancer invasion2015
- Author(s)
  Yamaguchi H, and Sakai R
- Journal Title
  
  Cancers
  
  Volume: 7 Issue: 4 Pages: 2054-2062
- DOI
  10.3390/cancers7040876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043
[Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis2015
- Author(s)
  Ueno H, Tomiyama A, Yamaguchi H, Uekita T et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 468 Issue: 1-2 Pages: 240-247
- DOI
  10.1016/j.bbrc.2015.10.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-26290043
[Journal Article] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells.2014
- Author(s)
  Yamaguchi H, Yoshida H, Takanashi M, Ito Y, Fukami K, Yanagihara K, Yashiro M, Sakai R.
- Journal Title
  
  PlosOne
  
  Volume: 9 Issue: 1 Pages: e85485-e85485
- DOI
  10.1371/journal.pone.0085485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043
[Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.2014
- Author(s)
  Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.
- Journal Title
  
  Cancer Res.
  
  Volume: 74(14) Issue: 14 Pages: 3790-3801
- DOI
  10.1158/0008-5472.can-14-0241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-25253095, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461402, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26461603, KAKENHI-PROJECT-26670493
[Journal Article] Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and FGFR inhibitors.2014
- Author(s)
  Yamaguchi H, Takanashi M, Yoshida N, Ito Y, Kamata R, Fukami K, Yanagihara K, Sakai R.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 5 Pages: 528-536
- DOI
  10.1111/cas.12387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-26293071
[Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells.2013
- Author(s)
  Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 11(6) Issue: 6 Pages: 628-37
- DOI
  10.1158/1541-7786.mcr-12-0544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-25430126
[Journal Article] Pathological roles of invadopodia in cancer invasion and metastasis.2012
- Author(s)
  Yamaguchi H
- Journal Title
  
  Eur. J. Cell. Biol.
  
  Volume: 91 Pages: 902-907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] がん細胞による浸潤突起形成の分子機構2012
- Author(s)
  山口英樹
- Journal Title
  
  生化学.日本生化学会
  
  Volume: Vol.84
- NAID
  10030346185
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] N-WASP-mediated invadopodium formation is necessary for intravasation and lung metastasis of mammary tumors2012
- Author(s)
  Gligorijevic B, Wyckoff J, Yamaguchi H, Wang Y, Roussos E, Condeelis J
- Journal Title
  
  Journal of Cell Science
  
  Volume: 125 Issue: 3 Pages: 724-734
- DOI
  10.1242/jcs.092726
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23113729, KAKENHI-PROJECT-23701069
[Journal Article] Pathological roles of invadopodia in cancer invasion and metastasis2012
- Author(s)
  Yamaguchi H
- Journal Title
  
  Eur. J. Cell. Biol.
  
  Volume: 91 Issue: 11-12 Pages: 902-907
- DOI
  10.1016/j.ejcb.2012.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069, KAKENHI-PUBLICLY-23113729
[Journal Article] N-WASP-mediated invadopodium formation is necessary for intravasation and lung metastasis of mammary tumors.2012
- Author(s)
  Gligorijevic B, Wyckoff J, Yamaguchi H, Wang Y, Roussos E, and Condeelis J
- Journal Title
  
  J. Cell Sci.
  
  Volume: 125 Pages: 724-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] がん細胞による浸潤突起形成の分子機構2012
- Author(s)
  山口英樹
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 35-38
- NAID
  10030346185
- Data Source
  KAKENHI-PUBLICLY-23113729
[Journal Article] がん細胞による浸潤突起形成の分子機構2012
- Author(s)
  山口英樹
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 35-38
- NAID
  10030346185
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Epidermal phospholipase C δ1 regulates granulocyte counts and systemic interleukin-17 levels in mice.2012
- Author(s)
  Kaori Kanemaru
- Journal Title
  
  Nat. Commun.
  
  Volume: 3 Issue: 1 Pages: 963-963
- DOI
  10.1038/ncomms1960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J08751, KAKENHI-PROJECT-23591467, KAKENHI-PROJECT-23701069, KAKENHI-PROJECT-24790295
[Journal Article] Phosphatidylinositol 5-phosphate 4-kinase IIbeta promotes vitamin D receptor-dependent E-cadherin expression in SW480 cells.2011
- Author(s)
  Kouchi Z, Fujiwara Y, Yamaguchi H, Nakamura Y, and Fukami K
- Journal Title
  
  Biochem. Biophys. Res. Comm.
  
  Volume: 408 Pages: 523-529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Phospholipase Cδ3 regulates RhoA/Rho kinase signaling and neurite outgrowth.2011
- Author(s)
  Kouchi Z, Igarashi T, Shibayama N, Inanobe S, Sakurai K, Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, and Fukami K
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 8459-8471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Phospholipase Cd3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane.2011
- Author(s)
  Sakurai K, Hirata M, Yamaguchi H, Nakamura Y, and Fukami K
- Journal Title
  
  Advan. Enzyme Regul.
  
  Volume: 51 Pages: 171-181
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis.2011
- Author(s)
  Hirata M, Suzuki M, Ishii R, Kitazumi T, Sasaki T, Kitamura T, Yamaguchi H, Nakamura Y, and Fukami K
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 1926-1937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation2011
- Author(s)
  Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K
- Journal Title
  
  J.Cell Biol.
  
  Volume: 193 Issue: 7 Pages: 1275-1288
- DOI
  10.1083/jcb.201009126
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112524, KAKENHI-PUBLICLY-23113729, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-23701069
[Journal Article] PI3-kinase signaling pathway mediated by p110α regulates invadopodia formation.2011
- Author(s)
  Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Yoshida N, Kouchi Z, Nakamura Y, Sakai R, and Fukami K
- Journal Title
  
  J. Cell. Biol.
  
  Volume: 193 Pages: 1275-1288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] Phosphatidylinositol 4, 5-bisphosphate and PIP5-kinase Iαare required for invadopodia formation in human breast cancer cells.2010
- Author(s)
  H. Yamaguchi†, S. Yoshida, E. Muroi, M. Kawamura, Z. Kouchi, Y. Nakamura, R. Sakai, K. Fukami
- Journal Title
  
  Cancer Sci. 101
  
  Pages: 1632-1638
- NAID
  10026594611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Phospholipase C-eta2 is highly expressed in the habenula and retina.2010
- Author(s)
  K. Kanemaru, M. Nakahara, Y. Nakamura, Y. Hashiguchi, Z. Kouchi, H. Yamaguchi, N. Oshima, H. Kiyonari, K. Fukami
- Journal Title
  
  Gene Expr. Patterns 10
  
  Pages: 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.2009
- Author(s)
  V. DesMarais, H. Yamaguchi, M. Oser, L. Soon, G. Mouneimne, C. Sarmiento, R. Eddy, J. Condeelis:
- Journal Title
  
  Cell Motil. Cytoskeleton 66
  
  Pages: 303-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.2009
- Author(s)
  H. Yamaguchi†, Y. Takeo, S. Yoshida, Z. Kouchi, Y. Nakamura, K. Fukami
- Journal Title
  
  Cancer Res 69
  
  Pages: 8594-8602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Cortactin regulates cofilin and N-WASP activities to control the stages of invadopodium assembly and maturation.2009
- Author(s)
  M. Oser, H. Yamaguchi, C.C. Mader, M. Arias, V. DesMarais, J. van Rheenen, A.J. Koleske, J. Condeelis
- Journal Title
  
  J. Cell Biol. 186
  
  Pages: 571-587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Phospholipase C-d1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation2008
- Author(s)
  Nakamura, Y., Ichinohe, M., Hirata, M., Matsuura, H., Fujiwara, T., Igarashi,T., Nakahara, M., Yamaguchi, H., Yasugi, S., Takenawa, T., Fukami, K.
- Journal Title
  
  in normal hair development. FASEB J. 22
  
  Pages: 841-849
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis2008
- Author(s)
  8.Philippar, U., Roussos, E. T., Oser, M., Yamaguchi, H., Kim, H. D., Giampieri, S., Wang, Y., Goswami, S., Wyckoff, J. B., Lauffenburger, D. A., Sahai, E., Condeelis, J. S., Gertler, F. B.
- Journal Title
  
  Dev. Cell 15
  
  Pages: 813-828
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] Membrane targeting of WAVE2 is not sufficient for WAVE2 dependent actin polymerization : a role for IRSp53 in mediating the interaction between Rac and WAVE22008
- Author(s)
  Abou-Kheir, W., Issac, B., Yamaguchi, H., Cox, D.
- Journal Title
  
  J. Cell Sci. 121
  
  Pages: 379-390
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] WASP family members and Formin proteins coordinate regulation of cell protrusions in carcinoma cells2008
- Author(s)
  Sarniento, C., Wang, W., Dovas, A., Yamaguchi, H., Sidani, M., El-Sibai, M., DesMarais, V., Holman, H. A., Kitchen, S., Backer, J. M., Alberts, A., Condeelis, J.
- Journal Title
  
  J. Cell Biol. 180
  
  Pages: 1219-1232
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] Phospholipase C-δ1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development.2008
- Author(s)
  Y. Nakamura, M. Ichinohe, M. Hirata, H. Matsuura, T. Fujiwara, T. Igarashi, M. Nakahara, H. Yamaguchi, S. Yasugi, T. Takenawa, K. Fukami
- Journal Title
  
  FASEB J. 22
  
  Pages: 841-849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.2008
- Author(s)
  U. Philippar, E.T. Roussos, M. Oser, H. Yamaguchi, H.D. Kim, S. Giampieri, S. Giampieri, Y. Wang, S. Goswami, J.B. Wyckoff, D.A. Lauffenburger, E. Sahai, J.S. Condeelis, F.B. Gertler
- Journal Title
  
  Dev. Cell 15
  
  Pages: 813-828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] WASP family members and Formin proteins coordinate regulation of cell protrusions in carcinoma cells.2008
- Author(s)
  C. Sarmiento, W. Wang, A. Dovas, H. Yamaguchi, M. Sidani, M. El-Sibai, V. DesMarais, H.A. Holman, S. Kitchen, J.M. Backer, A. Alberts, J. Condeelis
- Journal Title
  
  J. Cell Biol. 180
  
  Pages: 1219-1232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Membrane targeting of WAVE2 is not sufficient for WAVE2 dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE22008
- Author(s)
  W. Abou-Kheir, B. Issac, H. Yamaguchi, D. Cox
- Journal Title
  
  J. Cell Sci. 121
  
  Pages: 379-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770108
[Journal Article] Lack of phospholipase C-d1 induces skin inflammation. Biochem2007
- Author(s)
  Ichinohe, M., Nakamura, Y., Sai, K., Nakahara, M., Yamaguchi, H., Fukami, K.
- Journal Title
  
  Biophys. Res. Comm. 356
  
  Pages: 912-8
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface2007
- Author(s)
  Mizokami, A., Kanematsu, T., Ishibashi, H., Yamaguchi, T., Tanida, I., Takenaka, K., Nakayama, K.I., Fukami, K., Takenawa, T., Kominami, E., Moss, S. J., Yamamoto, T., Nabekura, J., Hirata, M.
- Journal Title
  
  J. Neurosci 27
  
  Pages: 1692-701
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] Polarity-regulating kinase protease-activated receptor 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons2007
- Author(s)
  Terabayashi, T., Itoh, T. J., Yamaguchi, H., Yoshimura, Y., Funato, Y., Ohno, S., Miki, H.
- Journal Title
  
  J. Neurosci 27 27
  
  Pages: 13098-13107
- Data Source
  KAKENHI-PROJECT-19370057
[Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells. Mol.
- Author(s)
  Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, and Sakai R
- Journal Title
  
  Cancer Res.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701069
[Journal Article] N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells
- Author(s)
  DesMarais, V., Yamaguchi, H., Oser, M., Soon, L., Mouneimne, G., Sarmiento, C., Eddy, R., Condeelis, J.
- Journal Title
  
  Cell Motil. Cytoskeleton (in press)
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Integrinα5 mediates the direct heterocellular interaction between cancer cells and cancer-associated fibroblasts and promotes peritoneal metastasis of diffuse-type gastric carcinoma2023
- Author(s)
  Yamaguchi H, Miyamoto S, Nagano Y, Miyazaki M, and Nagamura Y
- Organizer
  American Association for Cancer Research Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] スキルス胃癌の多細胞性腹膜播種の分子機構と治療標的2023
- Author(s)
  山口英樹、永村ゆう子、宮崎允
- Organizer
  第32回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] 腹腔内におけるがん細胞クラスター形成を標的とした新規腹膜播種治療法の開発2023
- Author(s)
  宮崎允、柳原五吉、大木理恵子、山口英樹
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] インテグリンα5はがん細胞とがん関連線維芽細胞の接着を担いスキルス胃がんの浸潤と腹膜播種性転移に寄与する2023
- Author(s)
  宮本真吾、永野佳子、宮崎允、永村ゆう子、山口英樹
- Organizer
  日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] スキルス胃がん細胞と間質線維芽細胞の直接的な相互作用を担う分子機構2023
- Author(s)
  山口英樹、永村ゆう子、宮崎允
- Organizer
  第75回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] Tissue factor-induced fibrinogenesis and cancer cell clustering contribute to polyclonal peritoneal metastasis in diffuse-type gastric carcinoma2023
- Author(s)
  Miyazaki M, Nagamura Y, and Yamaguchi H
- Organizer
  American Association for Cancer Research Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] 浸潤突起依存的・非依存的ながん浸潤転移の分子機構2023
- Author(s)
  山口英樹
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] PLEKHA5はMet遺伝子増幅を持つスキルス胃癌細胞の生存及び腹膜播種を制御する2021
- Author(s)
  山口英樹、宮崎允、永野佳子、深見希代子、柳原五吉、佐々木一樹、堺隆一
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] スキルス胃癌細胞の増殖と腹膜播種におけるPLEKHA5の機能解析2021
- Author(s)
  山口英樹、永村ゆう子、宮崎允、永野佳子、結城雅子、深見希代子、柳原五吉、佐々木一樹、堺隆一
- Organizer
  第30回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] Met遺伝子増幅を持つスキルス胃癌細胞におけるPLEKHA5の機能解析2021
- Author(s)
  山口英樹、永村ゆう子、宮崎允、永野佳子、結城雅子、深見希代子、柳原五吉、佐々木一樹、堺隆一
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K06879
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌腹膜播種機構の解析2020
- Author(s)
  宮崎允、中坊彩花、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] がん細胞による浸潤突起形成を指標としたハイスループットスクリーニング系の確立と阻害剤の探索2020
- Author(s)
  結城雅子、深見希代子、山口英樹
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌腹膜播種巣の形成機構の解析2020
- Author(s)
  宮崎允、中坊彩花、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第29回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングを用いたスキルス胃癌腹膜播種機構の解析2020
- Author(s)
  宮崎允、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] スキルス胃癌と間質線維芽細胞の直接的な相互作用に関わる分子の探索2019
- Author(s)
  宮本真吾、宮崎允、柳原五吉、八代正和、堺隆一、山口英樹
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌腹膜播種機構の解析2019
- Author(s)
  宮崎允、中坊彩花、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第28回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングを用いたスキルス胃癌腹膜播種機構の解析2019
- Author(s)
  宮崎允、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] ApcMin/+マウス腸ポリープ由来上皮細胞のオルガノイド形態に着目した大腸がん悪性化機構の解明2019
- Author(s)
  宮本真吾、鱧屋隆博、小宮雅美、藤井元、武藤倫弘、山口英樹
- Organizer
  第26回日本がん予防学会総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌腹膜播種機構の解析2019
- Author(s)
  宮崎允、宮本真吾、柳原五吉、深見希代子、山口英樹
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] スキルス胃癌と間質線維芽細胞の直接的な相互作用に関わる分子の探索2019
- Author(s)
  宮本真吾、宮崎允、柳原五吉、八代正和、堺隆一、田中正人、山口英樹
- Organizer
  第28回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] びまん性胃癌におけるRhoAのスプライシング異常とそれに伴う発現および活性の低下2018
- Author(s)
  宮本真吾、中坊彩花、深見希代子、柳原五吉、堺隆一、山口英樹
- Organizer
  第77回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] スキルス胃癌と間質線維芽細胞の直接的な相互作用に関わる分子機構の解明2018
- Author(s)
  宮本真吾、堺隆一、山口英樹
- Organizer
  第27回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] スキルス胃がんと間質線維芽細胞の直接的な相互作用に関わる分子機構の解明2018
- Author(s)
  宮本真吾、堺隆一、山口英樹
- Organizer
  第27回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] びまん性胃癌細胞にみられたRhoAのスプライシング異常とそれに伴う発現および活性の消失2018
- Author(s)
  宮本真吾、中坊彩花、深見希代子、柳原五吉、堺隆一、山口英樹
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌腹膜播種機構の解析2018
- Author(s)
  中坊彩花、深見希代子、山口英樹
- Organizer
  第77回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07219
[Presentation] びまん性胃がんにおけるRhoAのスプライシング異常とそれに伴う発現及び活性の低下2018
- Author(s)
  宮本真吾、中坊彩花、深見希代子、柳原五吉、堺隆一、山口英樹
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌の腫瘍不均一性と転移機構の解析2017
- Author(s)
  中坊彩花、深見希代子、山口英樹
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] マルチカラー蛍光イメージングによるスキルス胃癌転移過程の解析2017
- Author(s)
  中坊彩花、深見希代子、山口英樹
- Organizer
  ２０１７年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃癌細胞の増殖及び浸潤転移におけるSHP2の機能解析2017
- Author(s)
  山口英樹、堺隆一
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃癌細胞におけるSHP2の機能解析2017
- Author(s)
  山口英樹、富山新太、堺隆一
- Organizer
  第７６回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] スキルス胃癌細胞におけるSHP2の機能解析2017
- Author(s)
  山口英樹、富山新太、堺隆一
- Organizer
  第76回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃癌細胞の増殖及び浸潤転移におけるSHP2の機能解析2017
- Author(s)
  山口英樹、堺隆一
- Organizer
  第２６回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] スキルス胃癌における新規チロシンリン酸化タンパク質PLEKHA5の機能解析2016
- Author(s)
  山口英樹、白木原琢也、堺隆一
- Organizer
  第75回癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃がんにおける活性化受容体型チロシンキナーゼ結合蛋白質の同定と機能解析2016
- Author(s)
  白木原琢哉、山口英樹、堺隆一
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] Interaction between carcinoma cells and stromal fibroblasts during invasion and metastasis of scirrhous gastric carcinoma2016
- Author(s)
  山口英樹、柳原五吉、八代正和、堺隆一
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] 膜輸送による腫瘍形成とがん悪性化の制御2016
- Author(s)
  山口英樹、富山新太、堺隆一
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃がんにおける新規チロシンリン酸化タンパク質PLEKHA5の機能解析2016
- Author(s)
  山口英樹、白木原琢哉、堺隆一
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] スキルス胃がん細胞におけるPLEKHA5の機能解析2016
- Author(s)
  山口英樹、白木原琢哉、堺隆一
- Organizer
  第25回日本がん転移学会学術集会・総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-16K14616
[Presentation] スキルス胃癌細胞におけるPLEKHA5の機能解析2016
- Author(s)
  山口英樹、白木原琢也、堺隆一
- Organizer
  第25回日本がん転移学会学術集会・総会
- Place of Presentation
  鳥取
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-16K14622
[Presentation] スキルス胃癌細胞におけるMet及び下流シグナル伝達分子の機能解析2015
- Author(s)
  山口英樹、白木原琢也、堺隆一
- Organizer
  第74回癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] スキルス胃癌におけるMet下流シグナル伝達分子の機能解析2015
- Author(s)
  山口英樹、白木原琢也、堺隆一
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] スキルス胃癌細胞におけるMet下流シグナル伝達分子の解析2015
- Author(s)
  山口英樹、白木原琢也、堺隆一
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  大阪
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] The role of stromal fibroblasts in invasion and metastasis of scirrhous gastric carcinoma cells2013
- Author(s)
  山口英樹、堺隆一
- Organizer
  第65回日本細胞生物学会合同大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation2013
- Author(s)
  Yamaguchi H, Yoshida N, and Sakai R
- Organizer
  AACR Special Conference of Tumor Invasion and Metastasis
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Differential sensitivities to molecular target drugs in scirrhous gastric carcinoma cell lines2013
- Author(s)
  Yamaguchi H, Yoshida N, Takanashi M, and Sakai R
- Organizer
  The 9th AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  Maui, USA
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells2013
- Author(s)
  Yamaguchi H, Yanagihara K, Yashiro M, and Sakai R
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] CDCP1はMT1-MMPの機能と浸潤突起を介したがん細胞の浸潤を制御する2013
- Author(s)
  上北尚正、山口英樹、堺隆一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501327
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation2013
- Author(s)
  Yamaguchi H
- Organizer
  AACR Special Conference of Tumor Invasion and Metastasis
- Place of Presentation
  San Diego, USA
- Year and Date
  2013-01-21
- Data Source
  KAKENHI-PUBLICLY-23113729
[Presentation] Molecular mechanisms of invadopodium formation and its role in cancer invasion and metastasis2013
- Author(s)
  山口英樹
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Invited
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells2013
- Author(s)
  Yamaguchi H and Sakai R
- Organizer
  Cell Migration and Invasion in Physiology and Pathology
- Place of Presentation
  Nijmegen, The Netherland
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells2012
- Author(s)
  山口英樹、柳原五吉、八代正和、堺隆一
- Organizer
  第45回日本発生生物学会・第64回日本細胞生物学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] スキルス胃癌細胞と間質線維芽細胞の相互作用による細胞外基質リモデリングと浸潤2012
- Author(s)
  山口英樹、吉田那智、高梨美帆、深見希代子、柳原五吉、八代正和、堺隆一
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation2012
- Author(s)
  山口英樹
- Organizer
  第102回米国がん学会大会
- Place of Presentation
  オーランド、米国
- Year and Date
  2012-04-05
- Data Source
  KAKENHI-PUBLICLY-23113729
[Presentation] スキルス胃癌細胞株におけるc-Met 受容体型チロシンキナーゼ依存性の検討2012
- Author(s)
  山口英樹、柳原五吉、堺隆一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells2012
- Author(s)
  Yamaguchi H, Yanagihara K, Yashiro M, and Sakai R
- Organizer
  103rd Annual meeting of the American Association for Cancer Research
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] スキルス胃癌細胞におけるMet シグナル伝達系の機能解析2012
- Author(s)
  山口英樹、堺隆一
- Organizer
  第21回日本がん転移学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation2011
- Author(s)
  Yamaguchi H
- Organizer
  Podosomes, Invadopodia, and Focal Adhesions in Physiology and Pathology
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Phosphoinositide 3-kinase signaling pathway mediated by p110alpha regulates invadopodia formation2011
- Author(s)
  Yamaguchi H, Fukami K, and Sakai R
- Organizer
  102nd Annual meeting of the American Association for Cancer Research
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] 細胞膜脂質による癌細胞浸潤の制御機構2011
- Author(s)
  山口英樹
- Organizer
  第６３回日本細胞生物学会大会(招待講演)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] 細胞膜脂質による癌細胞浸潤の制御機構2011
- Author(s)
  山口英樹
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  札幌(ミニシンポジウム)(招待講演)
- Year and Date
  2011-06-28
- Data Source
  KAKENHI-PUBLICLY-23113729
[Presentation] 腫瘍由来線維芽細胞との共培養によるスキルス胃癌浸潤機構の解析2011
- Author(s)
  山口英樹、柳原五吉、八代正和、堺隆一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] スキルス胃癌細胞の胃癌由来線維芽細胞を介した細胞外基質リモデリングと浸潤2011
- Author(s)
  山口英樹、堺隆一
- Organizer
  第20回日本がん転移学会学術集会・総会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation2011
- Author(s)
  山口英樹
- Organizer
  Podosomes, Invadopodia, and Focal Adhesions in Physiology and Pathology
- Place of Presentation
  マドリード、スペイン(招待講演)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PUBLICLY-23113729
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation2011
- Author(s)
  山口英樹
- Organizer
  Podosomes, Invadopodia, and Focal Adhesions in Physiology and Pathology(招待講演)
- Place of Presentation
  マドリード、スペイン
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] 細胞膜脂質による癌細胞浸潤の制御機構2011
- Author(s)
  山口英樹、深見希代子、堺隆一
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation2011
- Author(s)
  山口英樹
- Organizer
  第１０２回米国がん学会大会
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] Protein domains of cortactin have diverse functions in the stages of invadopodium assembly and maturation2008
- Author(s)
  Oser, M., Yamaguchi, H., Arias, M., Eddy, R., DesMarais, V., Van Rheenen, J., Condeelis, J.
- Organizer
  48^<th> The American Society for Cell Biology Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] C3H10T1/2間葉系幹細胞の脂肪細胞分化における間葉系幹細胞の脂肪細胞分化におけるPLCdelta1の関与2008
- Author(s)
  平田真之、一戸学、桜井和之、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 浸潤性乳癌細胞における浸潤突起形成の分子機構2008
- Author(s)
  山口英樹、深見希代子
- Organizer
  第60回日本細胞生物学会(ワークショップオーガナイザー、招待講演)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase Cd1はFoxn1下流で体毛形成に関与する2008
- Author(s)
  一戸学、中村由和、山口英樹、深見希代子
- Organizer
  第50回日本脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] ホスホリパーゼCδ3はNeuro2a細胞における神経突起伸長に関与する2008
- Author(s)
  河内全、五十嵐隆公、中原真道、柴山奈美、中村由和、山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] PLCd3はNeuro2a細胞における神経突起伸長に関与する2008
- Author(s)
  河内全、五十嵐隆公、中原真道、中村由和、山口英樹、深見希代子
- Organizer
  第50回日本脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for nude mutation, in normal hair development2008
- Author(s)
  Ichinohe, M., Nakamura, Y., Hirata, M., Yamaguchi, H., Fukami, K.
- Organizer
  The 33rd FEBS Congress & 11t IUBMB Conference
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase Cδ3はmyosin VIと結合し内耳有毛細胞において共発現する2008
- Author(s)
  櫻井和之、平田真之、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第60回日本細胞生物学会
- Place of Presentation
  横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20770108
[Presentation] 浸潤突起形成におけるイノシトールリン脂質の役割2008
- Author(s)
  山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(シンポジウム、招待講演)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 創傷治癒におけるPhospholipase Cδ1の役割2008
- Author(s)
  稲野邊俊一、一戸学、中村由和、平田真之、河内全、山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年会・第81回日本31回日本分子生物学会年会・第81回日本
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase Cd3はmyosinVIと結合し内耳有毛細胞において共発現する2008
- Author(s)
  櫻井和之、平田真之、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] The effect of phospholipase C-delta 1 on differentiation of C3H10T1/2 mesenchymal cell line into adipocytes and chondrocytes2008
- Author(s)
  Hirata, M., Ichinohe, M., Sakurai, K., Nakamura, Y., Kouchi, Z., Yamaguchi, H., Fukami, K.
- Organizer
  33^<rd> FEBS Congress & 11^<th>IUBMB Conference
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] MyosinVIの膜輸送機能におけるホスフォリパーゼCδ3の関与2008
- Author(s)
  櫻井和之、平田真之、石井里佳、中村由和、河内全、山口英樹、深見希代
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20770108
[Presentation] 創傷治癒におけるホスホリパーゼ Cδ1の役割2008
- Author(s)
  稲野辺俊一、一戸学、中村由和、平田真之、河内全、山口英樹、深見希代子
- Organizer
  第60回日本細胞生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase Cd3はNeuro2a細胞における神経突起伸長に関与する2008
- Author(s)
  河内全、五十嵐隆公、中村由和、山口英樹、深見希代子
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase C-delta1はFoxn1下流で体毛形成に関与する2008
- Author(s)
  一戸学、中村由和、平田真之、山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] MyosinVIの膜輸送機能におけるホスフォリパーゼCδ3の関与2008
- Author(s)
  桜井和之、平田真之、石井里佳、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第31回日本分子生物学会年第31回日本分子生物学会年
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Protein domains of cortactin have diverse roles in the formation, dynamics, and matrix degradation of invadopodia2007
- Author(s)
  Oser, M., Yamaguchi, H., Van Rheenen, J., Cortesio, C., Hottenlocher, A., and Condeelis, J.
- Organizer
  47th The American Society for Cell Biology Annual Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 神経細胞特異的に発現するホスホリパーゼC(PLC)η2の結合タンパク質の解析2007
- Author(s)
  橋口祥子, 中原真道、永田静香、山口英樹、深見希代子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 浸潤突起形成の分子機構と癌浸潤転移における役割2007
- Author(s)
  山口英樹、深見希代子
- Organizer
  第40回日本発生生物学会第59回日本細胞生物学会合同大会(ミニシンポジウム、招待講演)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 神経細胞におけるホスフォリパーゼCh2の生理機能の解析2007
- Author(s)
  中原真道、橋口祥子、永田静香、山口英樹、深見希代子
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Phospholipase Cd3はmyosin IVと結合し内耳有毛細胞において共発現する2007
- Author(s)
  櫻井和之、平田真之、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Molecular mechanisms of invadopodium formation : the roles of phosphoinositides and lipid microdomains2007
- Author(s)
  Yamaguchi, H., Fukami, K.
- Organizer
  5^<th> Korea-Japan Conference on Cellular Signaling for Young Scientists
- Place of Presentation
  Gyeongju, South Korea
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] ホスホリパーゼC(PLC)d3の神経突起伸長への関与2007
- Author(s)
  五十嵐隆公、中村由和、河内全、山口英樹、深見希代子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] Use of Biosensors to track the initiation of cell motility in tumor cells in vitro and in vivo2007
- Author(s)
  Van Rheenen, J., Oser, M., Kedrin, D., Wyckoff, J., Yamaguchi, H., van Roosmalen, W., Segall, J., and Condeelis, J.
- Organizer
  47th The American Society for Cell Biology Annual Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19370057
[Presentation] 癌細胞による浸潤突起形成の分子機構と転移における役割
- Author(s)
  山口英樹、堺隆一
- Organizer
  第73回癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] The role of PI3-kinase signaling pathway in invadopodia formation
- Author(s)
  Yamaguchi H
- Organizer
  AACR Special Conference of Tumor Invasion and Metastasis
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23701069
[Presentation] 間質線維芽細胞との相互作用を標的としたスキルス胃癌治療薬の探索
- Author(s)
  山口英樹、堺隆一
- Organizer
  第23回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25430126
[Presentation] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells
- Author(s)
  Yamaguchi H, Yanagihara K, Yashiro M, and Sakai R
- Organizer
  105th Annual meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25430126

1. FUKAMI Kiyoko (40181242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
2. UEKITA TAKAMASA (50373402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. Sakai Ryuichi (40215603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. 今井俊夫 (20342884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大木理恵子 (70356252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 辻田和也 (10457054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kurosawa Gene

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Shirakihara Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. SAITO Emi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OKABE Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOSAKAI Ruri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中村由和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 加藤俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井上弘樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 市川美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 中川原章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 清木元治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Hideki 山口 英樹

YAMAGUCHI Hideki 山口 英樹

Research Projects

Research Products

Co-Researchers

細胞膜メカニクスによるがん幹細胞性の機械的制御と新規治療戦略

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Analysis of the molecular function of PLEKHA5 involved in the onset of scirrhous gastric carcinoma and cleft lip and palatePrincipal Investigator

Principal Investigator

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Review Section

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Mechanisms of Met specific signaling for cancer malignancy mediated by a novel target molecule PLEKHA5Principal Investigator

Principal Investigator

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Review Section

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Mechanistic analysis of cooperative invasion between cancer cells and stromal fibroblasts

Principal Investigator

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Analysis of tumor heterogeneity in peritoneal dissemination of scirrhous gastric carcinoma by multi-color fluorescent imagingPrincipal Investigator

Principal Investigator

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Analysis of the regulatory mechanisms of the actin cytoskeleton in invadopodia formation by cancer cellsPrincipal Investigator

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Analysis of the mechanism of cancer progression that overcome the cellular senescence by activated Ras

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細胞内ロジスティクスによる癌細胞浸潤能の制御機構の解明Principal Investigator

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Functional analysis of phosphoinositides in invasion and metastasis of breast cancer cellsPrincipal Investigator

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Functional analysis of phospholipase Cδ3 in inner hair cellsPrincipal Investigator

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Mechanism of hair follicle formation regulated by Phosphoinositide metabolism

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[Journal Article] Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis.2023

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[Journal Article] がん細胞のクラスター形成を介した腹膜播種機構2023

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Yamaguchi Hideki 山口英樹

YAMAGUCHI Hideki 山口英樹