SUGAI Hidemitsu 須貝英光

Researcher Number	10345712
Affiliation (based on the past Project Information) *help	2007: University of Yamanashi, Hospital, Research Associate 2003 – 2006: University of Yamanashi, Hospital, Research Associate, 医学部附属病院, 助手 2002: University of Yamanashi, Faculty of Medicine, Research Associate, 医学部, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery Except Principal Investigator Digestive surgery / Digestive surgery
Keywords	Principal Investigator 単球 / H2O2 / Cytokine / Monocyte / Gastric Cancer / 活性酸素 / 細胞内サイトカイン / 胃癌 / gastric cancer / intracellular cytokine … More / monocytes / 胆癌 / サイトカイン / 担癌 … More Except Principal Investigator HER-2 / 癌ワクチン療法 / Cancer vaccination / 食道癌 / gastric cancer / 樹状細胞 / 胃癌 / 胃がん / Esophageal cancer / esophageal cancer / Antibody therapy / Herceptin / 食道がん / 抗体療法 / immunotherapy / dendritic cells / cancer vaccine / 癌ワクチン / neu / 免疫療法 / ガンワクチン療法 / リンパ節 / 免疫抑制 / regulatory T細胞 Less

Cancer vaccination therapy for gastric and esophageal cancer as an adjuvant setting after resection
- Principal Investigator
  
  KONO Koji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Analysis of monocyte heterogeneity related to intracellular cytokine profile in patients with gastric cancerPrincipal Investigator
- Principal Investigator
  
  SUGAI Hidemitsu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
消化器癌におけるregulatory T細胞の分布と抗腫瘍免疫における役割の検討
- Principal Investigator
  
  KONO Koji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Cell-and antibody-therapy targeting HER-2/neu molecules in patients with gastric and esophageal cancer
- Principal Investigator
  
  KONO Koji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Induction of M2 type-monocytes induced by esophagectomy and its relationship to T cell-dysfunctionPrincipal Investigator
- Principal Investigator
  
  SUGAI Hidemitsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
  山梨医科大学
Cell therapy for gastric cancer using cancer vaccination and adoptive immunotherapy
- Principal Investigator
  
  KONO Koji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi, Faculty of Medicine

All 2008 2007 2006 2005 2004

All Journal Article

[Journal Article] CCL17 and CCL22 chemokines within Tumor Microenvironment are related to Accumulation of Foxp3^+ Regulatory T cells in Gastric Cancer.2008
- Author(s)
  Yoshiki Mizukami, Koji Kono, Yoshihiko Kawaguchi, Hidemitsu Sugai, et. al.
- Journal Title
  
  International Journal of Cancer 122
  
  Pages: 2286-2293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] CCL17 and CCL22 chemokines within Tumor Microenvironment are related to Accumulation of Foxp3^+ Regulatory T cells in Gastric Cancer2008
- Author(s)
  Yoshiki, Mizukami, Koji, Kono, Yoshihiko, Kawaguchi, Hidemitsu, Sugai
- Journal Title
  
  International Journal of Cancer 122
  
  Pages: 2286-2293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma.2007
- Author(s)
  Yoshihiko Kawaguchi, Koji Kono, Hidemitsu Sugai, et. al.
- Journal Title
  
  International Journal of Cancer. 120
  
  Pages: 781-787
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Expression of High Mobility Group Box Chromosonal Protein-1(HMGB-1)in Gastric Cancer2007
- Author(s)
  Hidenori Akaike, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Anticancer Research (In press)
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma.2007
- Author(s)
  Kawaguchi Y, Kono K, Mimura K, Sugai H, Akaike H, Fujii H
- Journal Title
  
  International Journal of Cancer. 120
  
  Pages: 781-787
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] A newly identified MAGE-3 derived, HLA-A24 restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells.2007
- Author(s)
  Naoto Miyagawa, Koji Kono, Hidemitsu Sugai, et. al.
- Journal Title
  
  Oncology 70
  
  Pages: 54-62
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomy.2007
- Author(s)
  Koji Kono, Hidemitsu Sugai, Hideo Omata, Hideki Fujii.
- Journal Title
  
  World Journal of Surgery (in press)
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma2007
- Author(s)
  Yoshihiko Kawaguti, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Int J Cancer (In press)
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma2007
- Author(s)
  Yoshihiko, Kawaguti, Koji, Kono, Hidemitsu, Sugai, et. al.
- Journal Title
  
  Int J Cancer 120
  
  Pages: 781-787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Clinical significance of CD4(+)CD25^<high> regulatory T-cells in patients with gastric and exophageal cancers.2006
- Author(s)
  Koji Kono, Hiromichi Kawaida, Akihiro Takahashi, Hidemitsu Sugai, Kosaku Mimura et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1064-1071
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] A newly identified MAGE-3 derived, ITLA-A24 restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells2006
- Author(s)
  Naoto, Miyagawa, Koji, Kono, Hidemitsu, Sugai, et. al.
- Journal Title
  
  Oncology 70
  
  Pages: 54-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs2006
- Author(s)
  Kousaku, Mimura, Koji, Kono, Hidemitsu, Sugai, et. al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1358-1366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma2006
- Author(s)
  Yoshihiko Kawaguti, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Int J Cancer (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs.2006
- Author(s)
  Kousaku Mimura, Koji Kono, Hidemitsu Sugai et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy (In press)
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] A newly identified MAGE-3 derived, HLA-A24 restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells.2006
- Author(s)
  Naoto Miyagawa, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Oncology 70
  
  Pages: 54-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs.2006
- Author(s)
  Kousaku Mimura, Koji Kono, Hidemitsu Sugai et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55(11)
  
  Pages: 1358-1366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Clinical significance of CD4(+)CD25^<high> regulatory T-cells in patients with gastric and esophageal cancers.2006
- Author(s)
  Koji Kono, Hidemitsu Sugai, et. al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1064-1071
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs.2006
- Author(s)
  Kousaku Mimura, Koji Kono, Hidemitsu Sugai, et. al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1358-1366
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Clinical significance of CD4(+)CD25^<high> regulatory T-cells in patients with gastric and esophageal cancers2006
- Author(s)
  Koji, Kono, Hidemitsu, Sugai, et. al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1064-1071
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Clinical significance of CD4(+)CD25high regulatory T-cells in patients with gastric and esophageal cancers.2006
- Author(s)
  Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1064-1071
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Expression of High Mobility Group Box Chromosonal Protein-l(HMGB-1)in Gastric Cancer2006
- Author(s)
  Hidenori Akaike, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Anticancer Research (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific. HLA-A24 restricted CTLs.2006
- Author(s)
  Kousaku Mimura, Koji Kono, Hidemitsu Sugai et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55(11)
  
  Pages: 1358-1366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Expression of High Mobility Group Box Chromosonal Protein-1(HMGB-1)in Gastric Cancer2006
- Author(s)
  Hidenori Akaike, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Anticancer Research (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Clinical significance of CD4(+)CD25^<high> regulatory T-cells in patients with gastric and esophageal cancers.2006
- Author(s)
  Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy 55
  
  Pages: 1064-1071
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] A newly identified MAGE-3 derived, HLA-A24 restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells.2006
- Author(s)
  Naoto Miyagawa, Koji Kono, Kousaku Mimura, Hideo Omata, Hidemitsu Sugai, Hideki Fujii.
- Journal Title
  
  Oncology 70
  
  Pages: 54-62
- Data Source
  KAKENHI-PROJECT-18591459
[Journal Article] Clinical significance of CD4(+)CD25^<high> regulatory T-cells in patients with gastric and esophageal cancers.2006
- Author(s)
  Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Cancer Immunology and Immunotherapy (In press)
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Distribution of regulatory T cells in tumor-draining lymph nodes in patients with gastrie cancer2005
- Author(s)
  Hiromichi Kawaida, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Journal of Surgical Research 124
  
  Pages: 151-157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Frequencies of HER-2/neu expression and gene amplification in patients with esophageal squamous cell carcinoma2005
- Author(s)
  Kousaku Mimura, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  British Journal of Cancer 92
  
  Pages: 1253-1260
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Distribution of regulatory T cells in tumor-draining lymph nodes in patients with gastric cancer2005
- Author(s)
  Hiromichi Kawaida, Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  Journal of Surgical Research 124
  
  Pages: 151-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Frequencies of HER-2/new expression and gene amplification in patients with esophageal squamous cell carcinoma.2005
- Author(s)
  Kousaku Mimura, Koji Kono, Mitsuhiko Hanawa, Fumihiko Mitsui, Hidemitsu Sugai, Naoto Miyagawa, Akishi Ooi, Hideki Fujii
- Journal Title
  
  British Journal of Cancer 92(7)
  
  Pages: 1253-1260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390392
[Journal Article] Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity.2005
- Author(s)
  Koji Kono, Hidemitsu Sugai, et al.
- Journal Title
  
  American Journal of Surgery 190
  
  Pages: 412-417
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591385
[Journal Article] Distribution of regulatory T cells in tumor-draining lymph nodes in patients with gastric cancer.2005
- Author(s)
  Hiromichi Kawaida, Koji Kono, Akihiro Takahashi, Hidemitsu Sugai, Kosaku Mimura, Naoto Miyagawa, Hideo Omata, Hiroshi Kumamoto, Akishi Ooi, Hideki Fujii
- Journal Title
  
  Journal of Surgical Research 124
  
  Pages: 151-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390392
[Journal Article] Characteristic alteration of monocytes with increased intracellular IL-10 and IL-12 in patients with advanced-stage gastric cancer.2004
- Author(s)
  Hidemitsu Sugai, Koji Kono, Akihiro Takahashi, Fumiko Ichihara, Hiromitsu Kawaida, Hideki Fujii, Yoshiro Matsumoto
- Journal Title
  
  Journal of Surgical Research 116
  
  Pages: 277-287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390392
[Journal Article] Characteristic alteration of monocytes with increased intracellular IL-10 and IL-12 in patients with advanced-stage gastric cancer.2004
- Author(s)
  Hidemitsu Sugai, Koji Kono, et al.
- Journal Title
  
  Journal of Surgical Research 116
  
  Pages: 277-287
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390392
[Journal Article] Characteristic alteration of monocytes with increased intracellular IL-10 and IL-12 in patients with advanced-stage gastric cancer.2004
- Author(s)
  Hidemitsu Sugai, Koji Kono, et al.
- Journal Title
  
  Journal of Surgical Research 116
  
  Pages: 277-287
- Data Source
  KAKENHI-PROJECT-15659309
[Journal Article] Vascular Endothelial Growth Factor Induces Dendric Cell-Apoptosis and Down-Regulation of its Costimulatory Molecules2004
- Author(s)
  Akihiro Takahashi, Koji Kono, Hidemitsu Sugai, Fumiko Ichihara, Hideki Amemiya, Hidehiko Iizuka, Hideki Fujii, Yoshiro Matsumoto
- Journal Title
  
  Cancer Immunology and Immunotherapy 53
  
  Pages: 543-550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390392

1. KONO Koji (40283204)

# of Collaborated Projects: 6 results

# of Collaborated Products: 36 results
2. KAWAGUCHI Yoshihiko (80402048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 飯塚秀彦 (60184347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 赤池英憲 (00402032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

SUGAI Hidemitsu 須貝 英光

Research Projects

Research Products

Co-Researchers

Cancer vaccination therapy for gastric and esophageal cancer as an adjuvant setting after resection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of monocyte heterogeneity related to intracellular cytokine profile in patients with gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

消化器癌におけるregulatory T細胞の分布と抗腫瘍免疫における役割の検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell-and antibody-therapy targeting HER-2/neu molecules in patients with gastric and esophageal cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of M2 type-monocytes induced by esophagectomy and its relationship to T cell-dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell therapy for gastric cancer using cancer vaccination and adoptive immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CCL17 and CCL22 chemokines within Tumor Microenvironment are related to Accumulation of Foxp3^+ Regulatory T cells in Gastric Cancer.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] CCL17 and CCL22 chemokines within Tumor Microenvironment are related to Accumulation of Foxp3^+ Regulatory T cells in Gastric Cancer2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of High Mobility Group Box Chromosonal Protein-1(HMGB-1)in Gastric Cancer2007

Author(s)

Journal Title

Data Source

[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma.2007

Author(s)

Journal Title

Data Source

[Journal Article] A newly identified MAGE-3 derived, HLA-A24 restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomy.2007

Author(s)

Journal Title

Data Source

[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma2007

Author(s)

Journal Title

Data Source

[Journal Article] Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma2007

Author(s)

Journal Title

Description

SUGAI Hidemitsu 須貝英光