Sakashita Kazuo 坂下一夫

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坂下一夫サカシタカズオ

SAKASHITA Kazuo 坂下一夫

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Researcher Number	10345746
Affiliation (Current)	2025: 地方独立行政法人長野県立病院機構長野県立こども病院(生命科学研究センター), 生命科学研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2023: 地方独立行政法人長野県立病院機構長野県立こども病院(生命科学研究センター), 生命科学研究センター, 主任研究員 2021: 地方独立行政法人長野県立病院機構長野県立こども病院(生命科学研究センター), 生命科学研究センター, 主任研究員 2014 – 2020: 信州大学, 医学部附属病院, 特任研究員 2013: 信州大学, 医学部附属病院, 講師 2009 – 2012: 信州大学, 医学部附属病院, 助教 … More 2010 – 2011: 信州大学, 医学部・附属病院, 助教 2010: 信州大学, 医学部, 助教 2007: 信州大学, 医学部, 助教 2003 – 2004: 信州大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator 若年性骨髄単球性白血病 / 白血病幹細胞 / 白血病性幹細胞 / PCDH17 / ＪＭＭＬ / 造血環境 / 接着分子 / ＰＣＤＨ１７ / 幹細胞 / 若年性骨髄単球白血病 … More / 白血病 / ヒストンアセチル化酵素 / JMML / アセチル化 / ヒストン / ヒストン修飾 / メチル化酵素 / DNAメチル化 / メチル化 / p15 / 再生不良性貧血 … More Except Principal Investigator GM-CSF / methylation / 骨髄異形成症候群 / histone acetylation / p15 / JMML / メチル化 / 造血幹細胞 / 白血病性幹細胞 / 小児血液学 / AML / MO7F Cells / Stem cells / MO7e細胞 / メチル化ヒストンH3 / アセチル化ヒストンH3 / ヒストン修飾 / DNAメチル化 / p15遺伝子 / 小児急性骨髄性白血病 / RAS遺伝子異常 / PTPN11遺伝子異常 / locked nucleic acid / mutant allele-specific PCR / 若年性慢性骨髄性白血病 / DNMT / 若年型慢性骨髄性白血病 / ヘリコバクター・ピロリ菌感染 / エピジェネティック / DNAメチル化異常 / ヘリコバクター・ピロリ感染 / 潰瘍性大腸炎 / 炎症関連発癌 / epigenetic / ulcerative colitis / Helicobacter pylori / CAR T細胞 / 免疫療法 / GM-CSF receptor / CD34陽性細胞 / 若年性骨髄単球性白血病 / 小児白血病 / キメラ抗原受容体T細胞 / 活性酸素産生酵素 / リンパ性白血病 / 活性酸素種 / iPS細胞 Less

Development of new JMML therapy based on cell adhesion molecules and cell proliferation signal analysisPrincipal Investigator
- Principal Investigator
  
  坂下一夫
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Local Incorporated Administrative Agency, Nagano Prefectural Hospital Organization, Nagano Children
  Shinshu University
Development of new treatment for juvenile myelomonocytic leukemia focusing on hematopoietic microenvironmentPrincipal Investigator
- Principal Investigator
  
  Sakashita Kazuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Leukemic stem cell and genetic analysis in Juvenile myelomonocytic LeukemiaPrincipal Investigator
- Principal Investigator
  
  SAKASHITA Kazuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
DNA methylation of microRNA genes in gastrointestinal mucosa from pediatric patients with chronic gut inflammation
- Principal Investigator
  
  Sugiyama(Nakayama) Yoshiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Establishment of T lymphocytes expressing chimeric antigen receptor for leukemic stem cells
- Principal Investigator
  
  KOIKE Kenichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Histone modification change of Juvenile myelomonocytic leukemia (JMML) and establishment of JMML stem cell expansion systemPrincipal Investigator
- Principal Investigator
  
  SAKASHITA Kazuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Analysis of pathogenesis of refractory childhood myelodysplastic syndrome using disease-specific iPS cells
- Principal Investigator
  
  KOIKE Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Establishment of basic molecular mechanism of carcinogenesis by ROS in malignant leukemia in aim of molecular targeting therapy
- Principal Investigator
  
  SHIOHARA Masaaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Epigenetic regulation of proliferation and differentiation of hematopoietic stem cells
- Principal Investigator
  
  KOIKE Kenichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
小児再生不良性貧血における発症関連遺伝子群のDNAメチル化による発現調節の解析Principal Investigator
- Principal Investigator
  
  坂下一夫
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Epigenetic regulation of p15 mRNA expression in juvenile myelomonocytic
- Principal Investigator
  
  KOIKE Kenichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University

[Journal Article] Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation2020
- Author(s)
  Shigemura T, Sakashita K, Okura E, Morita D, Komori K, Kurata T, Hirabayashi K, Saito S, Tanaka M, Yanagisawa R, Nakazawa Y. Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation
- Journal Title
  
  Int J Hematol
  
  Volume: 111 Issue: 5 Pages: 702-710
- DOI
  10.1007/s12185-020-02826-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10021, KAKENHI-PROJECT-17K10104, KAKENHI-PROJECT-17K10105, KAKENHI-PROJECT-20K08227
[Journal Article] Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.2019
- Author(s)
  Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K
- Journal Title
  
  Br J Haematol
  
  Volume: 187 Issue: 2 Pages: 163-173
- DOI
  10.1111/bjh.16060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07816, KAKENHI-PROJECT-17K10105
[Journal Article] Panobinostat inhibits the proliferation of CD34(+) CD38(-) cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia. Pediatr Blood Cancer.2018
- Author(s)
  Kurata T, Matsuda K, Hirabayashi K, Shigemura T, Sakashita K, Nakahata T, Koike K.
- Journal Title
  
  Pediatr Blood Cancer.
  
  Volume: 65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10105
[Journal Article] Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia2017
- Author(s)
  Uyen TN, Sakashita K, Al-Kzayer LF, Nakazawa Y, Kurata T, Koike K.
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: in press Issue: 3 Pages: 200-5
- DOI
  10.1002/pbc.26259
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04874, KAKENHI-PROJECT-26461575
[Journal Article] Juvenile myelomonocytic leukemia (JMML): recent advances in molecular pathogenesis and treatment2016
- Author(s)
  Sakashita K.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 57 Issue: 2 Pages: 137-146
- DOI
  10.11406/rinketsu.57.137
- NAID
  130005132712
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26461575
[Journal Article] Diagnosis and Treatment of Juvenile Myelomonocytic Leukemia2016
- Author(s)
  Sakashita K, Matsuda K, Koike K
- Journal Title
  
  Pediatr Int
  
  Volume: 58 Issue: 8 Pages: 681-90
- DOI
  10.1111/ped.13068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04874, KAKENHI-PROJECT-26461575, KAKENHI-PROJECT-15K19177
[Journal Article] In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia.2015
- Author(s)
  Sakashita K, Kato I, Daifu T, Saida S, Hiramatsu H, Nishinaka Y, Ebihara Y, Ma F, Matsuda K, Saito S, Hirabayashi K, Kurata T, Uyen LT, Nakazawa Y, Tsuji K, Heike T, Nakahata T, Koike K.
- Journal Title
  
  Leukemia
  
  Volume: in press
- NAID
  120007110642
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Reduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies.2015
- Author(s)
  Hirabayashi K, Nakazawa Y, Sakashita K, Kurata T, Saito S, Yoshikawa K, Tanaka M, Yanagisawa R, Koike K.
- Journal Title
  
  Sci Rep
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] In vitro expansion of CD34(+)CD38(-) cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia.2015
- Author(s)
  Sakashita K, Kato I, Daifu T, Saida S, Hiramatsu H, Nishinaka Y, Ebihara Y, Ma F, Matsuda K, Saito S, Hirabayashi K, Kurata T, Uyen Lt, Nakazawa Y, Tsuji K, Heike T, Nakahata T, Koike K.
- Journal Title
  
  Leukemia.
  
  Volume: 29(3) Issue: 3 Pages: 606-14
- DOI
  10.1038/leu.2014.239
- NAID
  120007110642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390272, KAKENHI-PROJECT-26293243, KAKENHI-PROJECT-26461575, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-26670511
[Journal Article] Frequent coexistence of RAS mutations in RUNX1-mutated acute myeloid leukemia in Arab Asian children.2014
- Author(s)
  Al-Kzayer LF, Sakashita K, Al-Jadiry MF, Al-Hadad SA, Uyen LT, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Hasan JG, Al-Abdullah HM, Inoshita T, Kamata M, Sughayer MA, Madanat FF, Koike K.
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 61 Pages: 1980-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Analysis of Class I and II Aberrations in Iraqi Childhood Acute Myeloid Leukemia Using Filter Paper Cards.2014
- Author(s)
  Al-Kzayer LF, Uyen LT, Al-Jadiry MF, Al-Hadad SA, Al-Badri SA, Ghali HH, Ameen NA, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Khalil HM, Inoshita T, Kamata M, Koike K, Sakashita K.
- Journal Title
  
  Ann Hematol
  
  Volume: 93 Pages: 949-55
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Myeloid progenitors with PTPN11 and non-RAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia.2014
- Author(s)
  Matsuda K, Nakazawa Y, Iwashita C, Kurata T, Hirabayashi K, Saito S, Tanaka M, Yoshikawa K, Yanagisawa R, Sakashita K, Sasaki S, Honda T, Koike K.
- Journal Title
  
  Leukemia
  
  Volume: 28 Pages: 1545-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Analysis of Class I and II Aberrations in Iraqi Childhood Acute Myeloid Leukemia Using Filter Paper Cards.2014
- Author(s)
  Al-Kzayer LF, Uyen LT, Al-Jadiry MF, Al-Hadad SA, Al-Badri SA, Ghali HH, Ameen NA, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Khalil HM, Inoshita T, Kamata M, Koike K, Sakashita K.
- Journal Title
  
  Annals of Hematology
  
  Volume: 2014 Jan 25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid.2013
- Author(s)
  Hirabayashi K, Sakashita K
- Journal Title
  
  Infection.
  
  Volume: 41 Issue: 1 Pages: 219-23
- DOI
  10.1007/s15010-012-0329-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis.2013
- Author(s)
  Shigemura T, Nakazawa Y, Yoshikawa K, Hirabayashi K, Saito S, Kobayashi N, Sakashita K, Shiohara M, Wada T, Shimodaira S, Agematsu K and Koike K.
- Journal Title
  
  Transfusion
  
  Volume: 54 Issue: 3 Pages: 516-21
- DOI
  10.1111/trf.12325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390260, KAKENHI-PROJECT-24591542
[Journal Article] Ewing sarcoma of the thoracic epidural space in a young child.2013
- Author(s)
  Kobayashi S, Sakashita K
- Journal Title
  
  Eur Spine J
  
  Volume: 22 Issue: S3 Pages: 373-9
- DOI
  10.1007/s00586-012-2481-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature.2013
- Author(s)
  Sakashita K, Saito S, Yanagisawa R Miyuki Tanaka M, Yoshikawa K, Hirabayashi K, Tsukahara K, Motobayashi M, Nakazawa Y, Koike K.
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 60 Issue: 11 Pages: E140-E142
- DOI
  10.1002/pbc.24622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390260
[Journal Article] Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies:comparison of mutant levels with autologous DNA percentage by short tandem repeat-PCR2012
- Author(s)
  Taira C, Sakashita K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 18 Issue: 3-4 Pages: 516-9
- DOI
  10.1016/j.cca.2011.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards2012
- Author(s)
  Al-Kzayer LF, Sakashita K, Matsuda K, Al-Hadad SA, Al-Jadiry MF, Abed WM, Abdulkadhim JM, Al-Shujairi TA, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Inoshita T, Kamata M, Koike K
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 59 Issue: 3 Pages: 461-7
- DOI
  10.1002/pbc.24055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308, KAKENHI-PROJECT-22591154, KAKENHI-PROJECT-24390260
[Journal Article] Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations.2012
- Author(s)
  Matsuda K, Sakashita K
- Journal Title
  
  Br J Haematol.
  
  Volume: 157 Issue: 5 Pages: 647-50
- DOI
  10.1111/j.1365-2141.2012.09063.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154, KAKENHI-PROJECT-24390260
[Journal Article] Critical illness polyneuropathy and myopathy caused by bacillus cereus sepsis in acute lymphoblastic leukemia2012
- Author(s)
  Hirabayashi K, Shiohara M, Suzuki T, Saito S, Tanaka M, Yanagisawa R, Tsuruta G, Fukuyama T, Hidaka Y, Nakazawa Y, Shimizu T, Sakashita K, Koike K
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 34 Pages: 110-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations2012
- Author(s)
  Matsuda K, Yoshida N, Miura S, Nakazawa Y, Sakashita K, Hyakuna N, Saito M, Kato F, Ogawa A, Watanabe A, Sotomatsu M, Kobayashi C, Ito T, Ishida F, Manabe A, Kojima S, Koike K
- Journal Title
  
  Br J Haematol
  
  Volume: 157 Pages: 647-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Food allergy after cord blood transplantation in children.2012
- Author(s)
  Sakashita K, Koike K.
- Journal Title
  
  Br J Haematol.
  
  Volume: 158 Issue: 5 Pages: 672-6
- DOI
  10.1111/j.1365-2141.2012.09204.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154, KAKENHI-PROJECT-24390260
[Journal Article] Critical illness polyneuropathy and myopathy caused by Bacillus Cereus sepsis in acute lymphoblastic leukemia2012
- Author(s)
  Hirabayashi K, Shiohara M, Suzuki T, Saito S, Tanaka M, Yanagisawa R, Tsuruta G, Fukuyama T, Hidaka Y, Nakazawa Y, Shimizu T, Sakashita K, Koike K
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 34 Issue: 3 Pages: 110-113
- DOI
  10.1097/mph.0b013e318234620b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Replaced platelet concentrates containing a new additive solution, M-sol: safety and efficacy for pediatric patients.2012
- Author(s)
  Yanagisawa R, Sakashita K
- Journal Title
  
  Transfusion.
  
  Volume: 53 Issue: 9 Pages: 2053-60
- DOI
  10.1111/trf.12025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154, KAKENHI-PROJECT-24390260
[Journal Article] Disappearance of minimal residual disease after the early withdrawal of immnunosuppressants in a patient with juvenile myelomonocytic leukemia2011
- Author(s)
  Yanagisawa R, Matsuda K, Sakashita K, Nakazawa Y, Tanaka M, Saito S, Yoshikawa K, Kamijo T, Shiohara M, Koike K
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 56 Issue: 3 Pages: 166-71
- DOI
  10.1002/pbc.22849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308, KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Quantitative monitoring of single nucleotide mutations by allele-specific quantitative PCR can be used for the assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course.2011
- Author(s)
  Taira C, Sakashita K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 14 Issue: 1-2 Pages: 53-8
- DOI
  10.1016/j.cca.2010.09.011
- NAID
  120007137790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT2011
- Author(s)
  Yanagisawa R, Katsuyama Y, Shigemura T, Saito S, Tanaka M, Nakazawa Y, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Bone Marrow Transplant
  
  Volume: 46 Issue: 1 Pages: 90-97
- DOI
  10.1038/bmt.2010.64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia.2011
- Author(s)
  Saito S, Sakashita K
- Journal Title
  
  Leuk Res.
  
  Volume: 235 Issue: 12 Pages: 1578-84
- DOI
  10.1016/j.leukres.2011.06.027
- NAID
  120007108235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia2011
- Author(s)
  Saito S, Matsuda K, Taira C, Sano K, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 1578-84
- NAID
  120007108235
- URL
  http://dx.doi.org/10.1016/j.leukres.2011.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357
[Journal Article] Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia2011
- Author(s)
  Saito S, Matsuda K, Taira C, Sano K, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 1578-84
- NAID
  120007108235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Retrospective analysis of risk factors for development of liver dysfunction in transient leukemia of Down syndrome2011
- Author(s)
  Hirabayashi K, Shiohara M, Takahashi D, Saito S, Tanaka M, Yanagisawa R, Sakashita K, Nakamura T, Ishii E, Koike K
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 52 Pages: 1523-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Engraftment syndrome, but not acute graft-versus-host disease, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic stem cell transplantation2011
- Author(s)
  Yanagisawa R, Katsuyama Y, Shigemura T, Saito S, Tanaka M, Nakazawa Y, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 46 Pages: 90-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] 小児慢性特定疾患治療研究事業における「血小板の異常をきたす疾患」の登録状況2011
- Author(s)
  草刈麻衣、塩原正明、齋藤章治、田中美幸、柳沢龍、坂下一夫、加藤忠明、藤本純一郎、小池健一
- Journal Title
  
  日小血会誌
  
  Volume: 25 Pages: 74-80
- NAID
  10029312127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357
[Journal Article] A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2.2011
- Author(s)
  Shigemura T, Sakashita K
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 50 Issue: 7 Pages: 1342-4
- DOI
  10.1093/rheumatology/ker137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154, KAKENHI-PROJECT-22591155
[Journal Article] Retrospective analysis of risk factors for development of liver dysfunction transient leukemia of Down syndrome2011
- Author(s)
  Hirabayashi K, Shiohara M, Takahashi D, Saito S, Tanaka M, Yanagisawa R, Sakashita K, Nakamura T, Ishii E, Koike K
- Journal Title
  
  Luek Lymphoma
  
  Volume: 52 Issue: 8 Pages: 1523-1527
- DOI
  10.3109/10428194.2011.573888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia2011
- Author(s)
  Saito S, Matsuda K, Taira C, Sano K, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Leuk Res.
  
  Volume: 35 Pages: 1578-84
- NAID
  120007108235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Disappearance of minimal residual disease after the early withdrawal of immunosuppressants in a patient with juvenile myelomonocytic leukemia2011
- Author(s)
  Yanagisawa R, Matsuda K, Sakashita K, Nakazawa Y, Tanaka M, Saito S, Yoshikawa K, Kamijo T, Shiohara M, Koike K
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 56 Pages: 501-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Long-term survival after non-intensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of normal individuals with the mutations2010
- Author(s)
  Matsuda K, Taira C, Sakashita K, Saito S, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Shiohara M, Fukushima K, Oda M, Honda T, Nakahata T, Koike K
- Journal Title
  
  Blood
  
  Volume: 115 Pages: 5429-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Increased pretransplant QT dispersion as a risk factor for the development of cardiac complications during and after preparative conditioning for pediatric allogeneic hematopoietic stem cell transplantation2010
- Author(s)
  Motoki N, Shimizu T, Akazawa Y, Saito S, Tanaka M, Yanagisawa R, Motoki H, Nakazawa Y, Sakashita K, Iwasaki Y, Shiohara M, Koike K
- Journal Title
  
  Pediatr Transplant
  
  Volume: 14 Pages: 986-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation.2010
- Author(s)
  Katoh N, Sakashita K
- Journal Title
  
  Muscle Nerve
  
  Volume: 41 Issue: 1 Pages: 138-43
- DOI
  10.1002/mus.21483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations2010
- Author(s)
  Matsuda K, Sakashita K
- Journal Title
  
  Blood.
  
  Volume: 115 Issue: 26 Pages: 5429-31
- DOI
  10.1182/blood-2009-12-260729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591154
[Journal Article] Long-term survival after non-intensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations2010
- Author(s)
  Matsuda K, Taira C, Sakashita K, Saito S, Tanaka M, Yanagisawa R, Nakazawa Y, Shiohara M, Fukushima K, Oda M, Honda T, Nakahata T, Koike K
- Journal Title
  
  Blood
  
  Volume: 115 Pages: 5429-5431
- URL
  http://intl.bloodjournal.org
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357
[Journal Article] Polymyxin-direct hemoperfusion for sepsisinduced multiple organ failure2010
- Author(s)
  Hirabayashi K, Shiohara M, Saito S, Tanaka M, Yanagisawa R, Tsuruta G, Fukuyama T, Hidaka Y, Nakazawa Y, Shimizu T, Sakashita K, Koike K
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 55 Pages: 202-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Increased pretransplant QT dispersion as a risk factor for the development of cardiac complications during and after preparative conditioning for pediatric hematopoietic stem cell transplantation2010
- Author(s)
  Motoki N, Shimizu T, Akazawa Y, Saito S, Tanaka M, Yanagisawa R, Motoki H, Nakazawa Y, Sakashita K, Iwasaki Y, Shiohara M, Koike K
- Journal Title
  
  Pediatr Transplant
  
  Volume: 14 Issue: 8 Pages: 986-992
- DOI
  10.1111/j.1399-3046.2010.01389.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Polymyxin-directed hemoperfusion for sepsis-induced multiple organ failure2010
- Author(s)
  Hirabayashi K, Shiohara M, Saito S, Tanaka M, Yanagisawa R, Tsuruta G, Fukuyama T, Hidaka Y, Nakazawa Y, Shimizu T, Sakashita K, Koike K
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 55 Issue: 1 Pages: 202-205
- DOI
  10.1002/pbc.22447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591154
[Journal Article] Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies2009
- Author(s)
  Yanagisawa R, Nakazawa Y, Sakashita K, Tanaka M, Shikama N, Kamijo T, Shiohara M, Koike K
- Journal Title
  
  Pediatric Transplantation
  
  Volume: 13 Pages: 737-45
- NAID
  120007110436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia2009
- Author(s)
  Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa D, Kawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K
- Journal Title
  
  Br J Haematol
  
  Volume: 141 Pages: 567-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.2009
- Author(s)
  Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Koike K, et al.
- Journal Title
  
  Br J Haematol 141
  
  Pages: 567-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Ela2 mutations and clinical manifestations in familial congenital neutropenia2009
- Author(s)
  Shiohara M, Shigemura T, Saito S, Tanaka M, Yanagisawa R, Sakashita K, Asada H, Ishii E, Koike K, Chin M, Kobayashi M, Koike K
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 31 Pages: 319-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.2009
- Author(s)
  Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa DKawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K
- Journal Title
  
  Br J Haematol
  
  Volume: 141 Issue: 4 Pages: 567-575
- DOI
  10.1111/j.1365-2141.2009.07968.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591357, KAKENHI-PROJECT-22591149, KAKENHI-PROJECT-22591154
[Journal Article] Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation2009
- Author(s)
  Nakazawa Y, Suzuki T, Fukuyama T, Katsuyama Y, Tanaka M, Yanagisawa R, Sakashita K, Shiohara M, Koike K
- Journal Title
  
  Pediatric Transplantation
  
  Volume: 13 Pages: 632-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood stem cell transplantation from the mother in a patient with relapsed leukemia2007
- Author(s)
  Nakazawa Y, Saito S. Hasegawa Y. Yanagisawa Y. Sakashita K. Kamijo T. Miyazaki T. Sato S. Ikeda H. Ikebuchi K. Koike K
- Journal Title
  
  Transfusion 47
  
  Pages: 326-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] A complex karyotype. including a three-way translocation generating a NUP98-HOXD13 transcript. in an infant with acute myeloid leukemia.2007
- Author(s)
  Hidaka E, Tanaka M, Matsuda K, Ishikawa-Matsumura M, Yamauchi K, Sano K, Honda T, Wakui K, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Ishii E, Koike K.
- Journal Title
  
  Cancer Genet Cytogenet. 176
  
  Pages: 137-43
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia.2007
- Author(s)
  Hidaka E, Tanaka M, Matsuda K, Ishikawa-Matsumura M, Yamauchi K, Sano K, Honda T, Wakui K, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Ishii E, Koike K.
- Journal Title
  
  Cancer Genet Cytogenet 176
  
  Pages: 137-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Analysis of histone modification around the CpG island region of the pl5 gene in acute myeloblastic leukemia2007
- Author(s)
  Ogawa M, Sakashita K, Zhao XY, Hayakawa A, Kubota T, Koike K
- Journal Title
  
  Leukemia Res 31
  
  Pages: 611-21
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia.2007
- Author(s)
  Ogawa M. Sakashita K. Zhao XY. Hayakawa A. Kubota T. Koile K
- Journal Title
  
  Leukemia Res 31
  
  Pages: 611-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood stem cell transplantation from the mother in a patient with relapsed leukemia2007
- Author(s)
  Nakazawa Y, Saito S, Hasegawa Y, Yanagisawa Y, Sakashita K, Kamijo T, Miyazaki T, Sato S, Ikeda H, Ikebuchi K, Koike K
- Journal Title
  
  Transfusio 47
  
  Pages: 326-34
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Acquirement of loss of the wild-type NRAS locus with aggres sive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation.2007
- Author(s)
  Matsuda K, Nakazawa Y. Sakashita K, Shiohara M, Yamauchi K, Koike K.
- Journal Title
  
  Haematologica. 92
  
  Pages: 1576-1578
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Acquirement of loss of the wild-type NRAS locus with aggressive disease progression in a patient. with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation.2007
- Author(s)
  Matsuda K. Nakazawa Y. Sakashita K. Shiohara M. Yamauchi K. Koike K.
- Journal Title
  
  Haematologica. 92
  
  Pages: 1576-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Chromosomal change during 6-mercaptopurine(6-MP)therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset.2006
- Author(s)
  Matsuda K, Matsuzaki S, Miki J, Hidaka E, Yanagisawa R, Nakazawa Y, Sakashita K, Kamijo T, Asami K, Sano K, Koike K
- Journal Title
  
  Leukemia 20
  
  Pages: 485-490
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia : the growth of a 6-MP-refractory clone that already exists at onset.2006
- Author(s)
  Matsuda K, Matsuzaki S, Miki J, Hidaka E, Yanagisawa R, Nakazawa Y, Sakashita K, Kamijo T, Asami K, Sano K, Koike K
- Journal Title
  
  Leukemia 20
  
  Pages: 485-485
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia.2005
- Author(s)
  Matsuzaki S. Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K
- Journal Title
  
  Leukemia Res, 29
  
  Pages: 1069-1072
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia.2005
- Author(s)
  Matsuzaki S, Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K
- Journal Title
  
  Leukemia Res (in press)
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Methylation status of the ρ15 and ρ16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia2005
- Author(s)
  Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY. Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, and Nakahata T
- Journal Title
  
  Br J Heamatol 128
  
  Pages: 805-12
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells2005
- Author(s)
  Zhao XY, Sakashita K, Kamijo T, Hidaka E, Sugane, K, Kubota T, Koike K
- Journal Title
  
  Cytokine, 31
  
  Pages: 203-212
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.2005
- Author(s)
  Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
- Journal Title
  
  Br J Haematol 128
  
  Pages: 805-812
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells2005
- Author(s)
  Zhao XY, Sakashita K, Kamijo T, Hidaka E, Sugane K, Kubota T, Koike K
- Journal Title
  
  Cytokine 31
  
  Pages: 203-212
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.2005
- Author(s)
  Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
- Journal Title
  
  Br J Heamatol (in press)
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia.2005
- Author(s)
  Matsuzaki S, Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K
- Journal Title
  
  Leukemia Res 29
  
  Pages: 1069-1072
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Bilineage acute leukemia of T-lymphoid and myeloid lineages.2004
- Author(s)
  Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R, Koike K.
- Journal Title
  
  Haematologica. 89
  
  Pages: 1139-1141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Long-term survival after non-intensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of normal individuals with the mutations
- Author(s)
  Matsuda K, Taira C, Sakashita K, Koike K, et al.
- Journal Title
  
  Blood (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390308
[Journal Article] Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia
- Author(s)
  Ogawa M, Sakashita K, Zhao XY, Hayakawa A, Kubota T, Koike K
- Journal Title
  
  Leukemia Res (印刷中)(未定)
- Data Source
  KAKENHI-PROJECT-17390300
[Journal Article] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia.
- Author(s)
  Matsuzaki S, Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K
- Journal Title
  
  Leukemia Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
- Author(s)
  Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
- Journal Title
  
  Br J Heamatol
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia.
- Author(s)
  Matsuzaki S, Matsuda K, Miki J, Nakazawa Y, Sakashita K, Kamijo T, Hidaka E, Koike K
- Journal Title
  
  Leukemia Res
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591099
[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
- Author(s)
  Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
- Journal Title
  
  Br J Heamatol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591099
[Presentation] 2.MRD assessment of juvenile myelomonocytic leukemia using next-generation sequencing2019
- Author(s)
  Noriko Kubota, Kazuo Sakashita, Nao Yoshida，Koshi Akahane , Takeshi Mori, Nobuhisa Takahashi, Atsushi Kikuta，Jun Kobayashi，Takashi Kurata，Eiko Hidaka,
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-17K10105
[Presentation] 若年性骨髄単球性白血病における晩期合併症全国調査2019
- Author(s)
  大園秀一、坂下一夫、吉田奈央、角田治美、百名伸之、中山秀樹、渡邉健一郎、前田美穂
- Organizer
  日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-17K10105
[Presentation] In vitro expansion of leukemia stem cells in juvenile myelomonocytic leukemia.2012
- Author(s)
  Kazuo Sakashita
- Organizer
  第74回日本血液学会総会.
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-22591154
[Presentation] Genetic evaluation of Iraqi pediatric acute myeloid leukemia using FTA cards.2012
- Author(s)
  Lika'a F. Al-Kzayer, Kazuo Sakashita
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-22591154
[Presentation] Long-term hematological improvement and poor correlation with spliceosome-related mutations in JMML.2012
- Author(s)
  Kazuyuki Matsuda, Kazuo Sakashita
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-22591154
[Presentation] 若年性骨髄単球性白血病患者由来の iPS細胞の樹立.2012
- Author(s)
  重村倫成、中沢洋三、松田和之、坂下一夫、小池健一.
- Organizer
  第54回日本小児血液・がん学会総会
- Place of Presentation
  横浜
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22591154
[Presentation] 小児期同種造血幹細胞移植経験者における晩期耐糖能異常の発症および危険因子2012
- Author(s)
  平林香佳奈枝、坂下一夫、小池健一
- Organizer
  第54回日本小児血液・がん学会総会
- Place of Presentation
  横浜
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22591154
[Presentation] FTA cards for genetic evaluation of childhood ALL in Iraq2011
- Author(s)
  Al Kzayer, Sakashita K, Koike K, et al
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21390308
[Presentation] 小児同種造血幹細胞移植後再発の予後に関する検討2011
- Author(s)
  Sakashita K, Koike K, et al
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-21390308
[Presentation] 小児同種造血幹細胞移植後再発の予後に関する検討2011
- Author(s)
  Sakashita K, Koike K, et al
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21390308
[Presentation] FTA cards for genetic evaluation of childhood ALL in Iraq2011
- Author(s)
  Al Kzayer, Sakashita K, Koike K, et al
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-21390308
[Presentation] Acquirement of loss of the wild-type NRASlocus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation2007
- Author(s)
  Matsuda, K., Nakazawa, Y., Sakashita, K., Shiohara, M., Yamauchi, K., Koike, K
- Organizer
  Pediatr Blood Cancer
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia2007
- Author(s)
  Hidaka, E., Tanaka, M., Matsuda, K., Ishilawa-Matsumura, M., Yamauchi, K., Sano, K., Honda, T., Wakui, K., Yanagisawa, R., Nakazawa, Y., Sakashita, K., Shiohara, M., Ishii, E., Koike, K
- Organizer
  Cancer Genet Cytogenet
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] 腸管型ベーチェット病を併発しtrisomy 8とPTPN11遺伝子異常を認めた骨髄異形成症候群(RAEB-M6)の1例2007
- Author(s)
  重村倫成、高山和生、齋藤章治、田中美幸、柳沢龍、坂下一夫、山崎崇志、塩原正明、上松一永、小池健一、松田和之、樋口由美子
- Organizer
  第49回日本小児血液学会
- Place of Presentation
  仙台市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood stem cell transplantation from the mother in a patient with relapsed leukemia2007
- Author(s)
  Nakazawa, Y., Saito, S., Hasegawa, Y., Yanagisawa, Y., Sakashita, K., Kamijo, T., Miyazaki, T., Sato, S., Ikeda, H., Ikebuchi, K., Koike, K
- Organizer
  Transfusion
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] Analysis of histone modification around the CpG island region of the p 15 gene in acute myeloblastic leukemia2007
- Author(s)
  Ogawa, M., Sakashita, K., Zhao, XY., Hayakawa, A., Kubota, T., Koike, K
- Organizer
  Leukemia Res
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia : the growth of a 6-MP-refractory clone that already exists at onset2006
- Author(s)
  Matsuda, K., Matsuzaki, S., Mild, J., Hidaka, E., Yanagisawa, R., Nakazawa, Y., Sakashita, K., Kamijo, T., Asami, K., Sano, K., Koike, K
- Organizer
  Leukemia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia2005
- Author(s)
  Matsuzaki, S., Matsuda, K., Miki, J., Nakazawa, Y., Sakashita, K., Kamijo, T., Hidaka, E., Koike, K
- Organizer
  Leukemia Res
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] 若年性慢性骨髄性白血病におけるp15遺伝子のDNAメチル化とヒストン修飾2005
- Author(s)
  小川美奈、坂下一夫、小池健一
- Organizer
  第108回日本小児科学会学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells2005
- Author(s)
  Zhao, XY., Sakashita, K., Kamijo, T., Hidaka, E., Sugane, K., Kubota, T., Koike, K
- Organizer
  Cytokine
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia2005
- Author(s)
  Hasegawa, D., Manabe, A., Kubota, T., Kawasaki, H., Hirose, I., Ohtsuka, Y., Tsuruta, T., Ebihara, Y., Goto, Y., Zhao, XY., Sakashita, K., Koike, K., Isomura, M., Kojima, S.,Hoshika, A., Tsuji, K., Nakahata, T
- Organizer
  Br J Heamatol
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390300
[Presentation] International cooperation for Belarus and Iraq
- Author(s)
  Sakashita K, Koike K
- Organizer
  第117回日本小児科学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-24390260

1. KOIKE Kenichi (40143979)

# of Collaborated Projects: 7 results

# of Collaborated Products: 69 results
2. SHIOHARA Masaaki (00293514)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
3. NAKAZAWA Yozo (60397312)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
4. KAMIJO Takehiro (90262708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. HIGUCHI Tsukasa (80397306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Sugiyama(Nakayama) Yoshiko (20600498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 日高奈緒 (30626023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 加藤沢子 (80762814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUSAKARI Mai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MURAMATSU Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 奥野友介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 海老原康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 辻浩一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 柳沢龍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakashita Kazuo 坂下 一夫

坂下 一夫 サカシタ カズオ

SAKASHITA Kazuo 坂下 一夫

Research Projects

Research Products

Co-Researchers

Development of new JMML therapy based on cell adhesion molecules and cell proliferation signal analysisPrincipal Investigator

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Review Section

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Development of new treatment for juvenile myelomonocytic leukemia focusing on hematopoietic microenvironmentPrincipal Investigator

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Leukemic stem cell and genetic analysis in Juvenile myelomonocytic LeukemiaPrincipal Investigator

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DNA methylation of microRNA genes in gastrointestinal mucosa from pediatric patients with chronic gut inflammation

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Establishment of T lymphocytes expressing chimeric antigen receptor for leukemic stem cells

Principal Investigator

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Histone modification change of Juvenile myelomonocytic leukemia (JMML) and establishment of JMML stem cell expansion systemPrincipal Investigator

Principal Investigator

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Analysis of pathogenesis of refractory childhood myelodysplastic syndrome using disease-specific iPS cells

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Establishment of basic molecular mechanism of carcinogenesis by ROS in malignant leukemia in aim of molecular targeting therapy

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Epigenetic regulation of proliferation and differentiation of hematopoietic stem cells

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小児再生不良性貧血における発症関連遺伝子群のDNAメチル化による発現調節の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Epigenetic regulation of p15 mRNA expression in juvenile myelomonocytic

Principal Investigator

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Research Institution

[Journal Article] Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.2019

Author(s)

Journal Title

Sakashita Kazuo 坂下一夫

坂下一夫サカシタカズオ

SAKASHITA Kazuo 坂下一夫