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Oishi Naoki  大石 直樹

… Alternative Names

OISHI Naoki  大石 直樹

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Researcher Number 10348740
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8204-9518
External Links
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 慶應義塾大学, 医学部(信濃町), 准教授
2018: 慶應義塾大学, 医学部(信濃町), 講師
2017: 慶應義塾大学, 医学部, 講師
2016: 慶應義塾大学, 医学部(信濃町), 講師
2013 – 2015: 慶應義塾大学, 医学部, 講師
2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords
Principal Investigator
小胞体ストレス / 加齢性難聴 / 蝸牛神経 / 顔面神経 / 中耳側頭骨 / 術中神経モニタリング / 機械学習 / 電極 / 耳音響放射 / データベース … More / 純音聴力閾値 / 術中聴覚モニタリング / 後迷路性難聴 / 蝸牛内刺激電極 / 蝸牛神経背側核活動電位 / 術中聴覚持続モニタリング / 純音聴力検査 / 蝸電図 / 聴性脳幹反応 / 聴神経腫瘍 / 蛋白質 / シグナル伝達 / ラセン神経節細胞 / コルチ器 / 有毛細胞 / 難聴 / 蝸牛 / 驚愕反射 / 加齢 / 耳鳴 / 内耳生化学 … More
Except Principal Investigator
聴神経腫瘍 / 両耳聴 / 利得 / 骨伝導 / 軟骨伝導 / Cochlear Synaptopathy / 加齢性難聴 / 新規検査法 / 新規治療法 / MMP14 / ドライバー遺伝子 / ゲノム解析 / 網羅的遺伝子解析 / qPCR / NF2遺伝子 / 孤発性聴神経腫瘍 / 臨床応用 / MLPA法 / メチル化解析 / 全エクソーム解析 / 網羅的ゲノム解析 / 一側性聴神経腫瘍 / 雑音下語音検査 / 一側性難聴 / ヒトiPS細胞 / 橋渡し研究 / コモンマーモセット / 遺伝性難聴 / Wolfram症候群 / WFS1 / 疾患iPS創薬 Less
  • Research Projects

    (11 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (27 People)
  •  The role of MMP14 in Vestibular Schwannoma and the development of novel treatments and diagnostic methods

    • Principal Investigator
      百束 紘
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  Aging change and Cochlear Synaptopathy in spiral ganglion neurons of the common marmoset, a primate model animal

    • Principal Investigator
      上野 真史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Keio University
  •  中耳側頭骨手術における術中神経モニタリング新技術の開発Principal Investigator

    • Principal Investigator
      大石 直樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Keio University
  •  一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索

    • Principal Investigator
      山田 悠祐
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      International University of Health and Welfare
  •  一側伝音・混合難聴に対し軟骨伝導と骨伝導が与える聴覚利得の差とその起源の研究

    • Principal Investigator
      西山 崇経
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Keio University
  •  一側性聴神経腫瘍の遺伝子プロファイルに基づいた臨床的特徴に関する検討

    • Principal Investigator
      若林 毅
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Keio University
  •  Development of a Novel Auditory Evoked Potential Measurement Method and Algorithm for Improving Hearing Prognosis in Vestibular SchwannomasPrincipal Investigator

    • Principal Investigator
      Oishi Naoki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Keio University
  •  Endoplasmic stress response in cochlear culturePrincipal Investigator

    • Principal Investigator
      Oishi Naoki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University
  •  In vitro "virtual biopsy" of cochlear cells by using Wolfram syndrome patients derived hiPSCs

    • Principal Investigator
      Fujioka Masato
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University
  •  tinnitus in aging model micePrincipal Investigator

    • Principal Investigator
      Oishi Naoki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University
  •  ER stress and presbycusisPrincipal Investigator

    • Principal Investigator
      OISHI Naoki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University

All 2024 2023 2022 2021 2016 2015 2012 Other

All Journal Article Presentation

  • [Journal Article] Natural history of hearing and tumor growth in vestibular schwannoma in neurofibromatosis type 2-related schwannomatosis2024

    • Author(s)
      Wakabayashi Takeshi、Tamura Ryota、Karatsu Kosuke、Hosoya Makoto、Nishiyama Takanori、Inoue Yasuhiro、Ogawa Kaoru、Kanzaki Jin、Toda Masahiro、Ozawa Hiroyuki、Oishi Naoki
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: - Issue: 8 Pages: 4175-4182

    • DOI

      10.1007/s00405-024-08601-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K09750
  • [Journal Article] Characteristics of pure tone audiogram in patients with untreated sporadic vestibular schwannoma: Analysis of audiometric shape and interaural differences stratified by age and mode of onset2024

    • Author(s)
      Tsuzuki Nobuyoshi、Kitama Tsubasa、Wasano Koichiro、Wakabayashi Takeshi、Hosoya Makoto、Nishiyama Takanori、Ozawa Hiroyuki、Oishi Naoki
    • Journal Title

      Auris Nasus Larynx

      Volume: 51 Issue: 2 Pages: 347-355

    • DOI

      10.1016/j.anl.2023.09.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09574, KAKENHI-PROJECT-21K09565
  • [Journal Article] A novel intraoperative continuous monitoring method combining dorsal cochlear nucleus action potentials monitoring with auditory nerve test system2023

    • Author(s)
      Hosoya Makoto、Nagaoka Yuriko、Wakabayashi Takeshi、Shimanuki Marie N.、Nishiyama Takanori、Ueno Masafumi、Ozawa Hiroyuki、Oishi Naoki
    • Journal Title

      Journal of Otolaryngology - Head & Neck Surgery

      Volume: 52 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s40463-023-00671-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Journal Article] Vestibular Schwannoma Surgery with Endoscope-Assisted Retrolabyrinthine Approach under Modified Reinforced Continuous Intraoperative Monitoring for Hearing Preservation: Experience of 33 Cases in a Single Center2023

    • Author(s)
      Makoto Hosoya , Takanori Nishiyama, Takeshi Wakabayashi, Marie N Shimanuki , Hidemi Miyazaki, Hiroyuki Ozawa, Naoki Oishi
    • Journal Title

      Diagnostics

      Volume: 13 Issue: 2 Pages: 275-275

    • DOI

      10.3390/diagnostics13020275

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Journal Article] Understanding the Molecular Mechanism of Vestibular Schwannoma for Hearing Preservation Surgery: Otologists’ Perspective from Bedside to Bench2022

    • Author(s)
      Makoto Hosoya, Takeshi Wakabayashi, Koichiro Wasano,Takanori Nishiyama,Nobuyoshi Tsuzuki,Naoki Oishi
    • Journal Title

      Diagnostics

      Volume: 12 Issue: 5 Pages: 1044-1044

    • DOI

      10.3390/diagnostics12051044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09565, KAKENHI-PROJECT-22K09750
  • [Journal Article] Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.2016

    • Author(s)
      Suzuki N, Hosoya M, Oishi N, Okano H, Fujioka M, Ogawa K.
    • Journal Title

      Neuroreport.

      Volume: 3;27(11) Issue: 11 Pages: 833-6

    • DOI

      10.1097/wnr.0000000000000624

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-16K20277, KAKENHI-PROJECT-15H04991
  • [Journal Article] Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.2016

    • Author(s)
      Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K.
    • Journal Title

      PLoS One in press

      Volume: 11 Issue: 4 Pages: e0153957-e0153957

    • DOI

      10.1371/journal.pone.0153957

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10762, KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-15H04991, KAKENHI-PROJECT-26462714
  • [Presentation] 聴力温存聴神経腫瘍手術2024

    • Author(s)
      大石直樹
    • Organizer
      日本頭頸部外科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] メチル化解析を用いた孤発性聴神経腫瘍のNF2遺伝子プロモーター領域におけるエピゲノム変化の網羅的検討2023

    • Author(s)
      若林 毅、和佐野 浩一郎、大石 直樹、細谷 誠、島貫 茉莉江、西山 崇経、小澤 宏之
    • Organizer
      第124回 日本耳鼻咽喉科頭頸部外科学会 総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09750
  • [Presentation] 当科における聴神経腫瘍に対する後迷路法での聴力温存手術の術後成績の検討2023

    • Author(s)
      細谷 誠, 西山 崇経, 若林 毅, 島貫 茉莉江, 小澤 宏之, 大石 直樹
    • Organizer
      日本耳鼻咽喉科頭頸部外科学会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 聴神経腫瘍摘出と同時同側人工内耳植え込み術のための蝸牛内電気刺激による新規術中持続聴覚モニタリング法2023

    • Author(s)
      細谷 誠, 若林 毅, 島貫 茉莉江, 上野 真史, 西山 崇経, 小澤 宏之, 大石 直樹
    • Organizer
      日本耳科学会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 聴神経腫瘍による突発難聴と突発性難聴の純音聴力像 聴力型の比較解析2023

    • Author(s)
      都築 伸佳, 大石 直樹, 和佐野 浩一郎, 辺土名 貢, 島貫 茉莉江, 西山 崇経, 平賀 良彦, 北間 翼, 新田 清一, 小川 郁, 小澤 宏之
    • Organizer
      日本耳鼻咽喉科頭頸部外科学会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 当科におけるTM電極を用いた蝸電図測定の実際2023

    • Author(s)
      上野 真史, 細谷 誠, 堀 明美, 島貫 茉莉江, 西山 崇経, 小澤 宏之, 大石 直樹
    • Organizer
      日本聴覚医学会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 聴神経腫瘍と人工内耳 聴神経腫瘍手術における蝸牛神経温存と人工内耳埋め込み術2023

    • Author(s)
      大石直樹
    • Organizer
      日本耳科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 未治療聴神経腫瘍症例における語音聴力・耳音響放射の特徴2022

    • Author(s)
      北間 翼, 大石 直樹, 都築 伸佳, 南 隆二, 若林 毅, 細谷 誠, 西山 崇経, 和佐野 浩一郎, 小澤 宏之
    • Organizer
      第125回日本耳鼻咽喉科頭頸部外科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 後迷路法による聴神経腫瘍手術における聴力温存率向上に寄与する当科の取り組み2022

    • Author(s)
      細谷 誠, 西山 崇経, 若林 毅, 島貫 茉莉江, 小澤 宏之, 大石 直樹
    • Organizer
      第32回日本耳科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 孤発性前庭神経鞘腫におけるNF2遺伝子変化についての検討 -PCRを用いた定量評価-2022

    • Author(s)
      若林 毅、和佐野 浩一郎、大石 直樹、細谷 誠、 都築 伸佳、秋山 武紀、戸田 正博
    • Organizer
      第31回 日本聴神経腫瘍研究会
    • Data Source
      KAKENHI-PROJECT-22K09750
  • [Presentation] HEARING-FOCUSED STRATEGY IN THE MANAGEMENT OF VESTIBULAR SCHWANNOMA2022

    • Author(s)
      Naoki Oishi
    • Organizer
      ICORL 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 未治療聴神経腫瘍症例における聴力型の特徴2022

    • Author(s)
      都築 伸佳, 大石 直樹, 北間 翼, 南 隆二, 若林 毅, 細谷 誠, 西山 崇経, 和佐野 浩一郎, 小澤 宏之
    • Organizer
      第125回日本耳鼻咽喉科頭頸部外科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 孤発性聴神経腫瘍の包括的ゲノム解析による病因解明について2022

    • Author(s)
      若林 毅、和佐野 浩一郎、大石 直樹、細谷 誠、 都築 伸佳、西山 崇経、小澤 宏之
    • Organizer
      第123回 日本耳鼻咽喉科頭頸部外科学会 総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09750
  • [Presentation] 当科における蝸電図検査の工夫2021

    • Author(s)
      堀 明美, 細谷 誠, 大石 直樹, 山野邉 義晴, 藤岡 正人, 忰田 かおり, 西山 崇経, 都築 伸佳, 若林 毅, 南 隆二
    • Organizer
      第66回日本聴覚医学会学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 術前スケールアウトから著明に術後聴力回復を認めた聴神経腫瘍手術例2021

    • Author(s)
      榊 悠佑, 細谷 誠, 大石 直樹, 西山 崇経, 都築 伸佳, 若林 毅, 南 隆二, 藤岡 正人, 神崎 晶, 小澤 宏之
    • Organizer
      第31回日本耳科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09565
  • [Presentation] 母親にのみ新規<I>EYA4</I>遺伝子変異を認めた家族性難聴の1例2016

    • Author(s)
      藤岡正人・松永達雄・長谷部夏希・神崎晶・大石直樹・平賀良彦・鈴木法臣・松崎佐栄子・川浦光弘・小川郁
    • Organizer
      第78回耳鼻咽喉科臨床学会総会・学術講演会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2016-06-23
    • Data Source
      KAKENHI-PROJECT-15K15624
  • [Presentation] 両側進行性内耳性難聴の病態生理研究~疾患iPS創薬の立場から~2016

    • Author(s)
      藤岡正人・細谷誠・鈴木法臣・大石直樹・松崎佐栄子・小川郁
    • Organizer
      第26回日本耳科学会総会・学術講演会
    • Place of Presentation
      ホテル国際21(長野県長野市)
    • Year and Date
      2016-10-05
    • Data Source
      KAKENHI-PROJECT-15K15624
  • [Presentation] 9.4T MRIを用いたヒト固定側頭骨の高解像度描出のこころみ(第2報)2015

    • Author(s)
      藤岡正人 大石 直樹・栗原 渉・神崎 晶・小島 博己・小川 郁
    • Organizer
      第60回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-21
    • Data Source
      KAKENHI-PROJECT-15K15624
  • [Presentation] Endoplasmic reticulum stress in aminoglycoside ototoxicity2012

    • Author(s)
      大石直樹
    • Organizer
      日本耳科学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24890231
  • [Presentation] 小胞体ストレスと内耳性難聴

    • Author(s)
      大石直樹
    • Organizer
      東大慶應ジョイントカンファレンス
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24890231
  • 1.  細谷 誠 (30645445)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 2.  和佐野 浩一郎 (40528866)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 3.  Fujioka Masato (70398626)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  高橋 英俊 (90625485)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  藤田 岳 (90533711)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  小川 郁 (00169179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  山田 悠祐 (30839303)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  松田 悠佑 (00774340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  東野 哲也 (80145424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高橋 優宏 (50315800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  岩崎 聡 (00232653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  鬼頭 良輔 (80419358)
    # of Collaborated Projects: 1 results
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  • 16.  吉田 忠雄 (90567017)
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  • 19.  若林 毅 (40868600)
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  • 20.  中村 康平 (10775802)
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  • 21.  百束 紘 (80712794)
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  • 22.  都築 伸佳 (60836633)
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  • 23.  荒井 康裕 (90614818)
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  • 24.  上野 真史 (10973844)
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  • 25.  文入 悠 (60991180)
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  • 26.  西山 崇経 (90627168)
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  • 27.  神崎 晶
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