Takeshima Tsuguhide 武島嗣英

… Alternative Names

TAKESHIMA Tsuguhide 武島嗣英

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Researcher Number	10360950
Other IDs	https://orcid.org/0000-0003-4350-0315
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, QST病院重粒子線治療研究部, 研究統括 2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所重粒子線治療研究部, 主幹研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, QST病院重粒子線治療研究部, 研究統括 2021 – 2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所重粒子線治療研究部, 主幹研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所重粒子線治療研究部, 主幹研究員(定常) 2012: 北海道大学, 大学院・医学研究科, 助教 2009 – 2011: Hokkaido University, 大学院・医学研究科, 特任助教
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science
Keywords	Principal Investigator 免疫治療 / 放射線治療 / がん特異的CTL / 免疫療法 / 癌特異的キラーT細胞 / 担癌マウス / 癌治療法開発 / 癌 / CD8+細胞 / 抗腫瘍免疫 … More / 重粒子線治療 / Ｘ線治療 / がん特異的抗体 / 癌反応性CTL / 癌反応性抗体 / 放射線療法 / 樹状細胞療法 / がん反応性CTL / がん結合抗体 / 樹状細胞 / 所属リンパ節 / 癌特異キラーT細胞 / 光イメージング / 転移 / 癌免疫治療 / 放射線治療生物学 … More Except Principal Investigator 放射線 / 放射線治療 / 免疫チェックポイント阻害剤 / 免疫微小環境 / 膵管癌 / 骨肉腫 / 同所移植 / 腫瘍免疫 / アブスコパル効果 / Abscopal 効果 / 免疫 / 免疫療法併用 / 放射線療法 / 免疫併用療法 / 重粒子線 / 遠隔腫瘍 / 併用療法 / 抗腫瘍免疫 / Abscopal効果 / 重粒子線がん治療 / HIF/alpha / 低酸素 / translation / trascription / HIF-1a / HIF / UTR / 放射線生物学 Less

X-ray and carbon ion therapy, how do they promote tumor-specific CD8+ cells?Principal Investigator
- Principal Investigator
  
  武島嗣英
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
同所移植モデルによる難治性腫瘍免疫応答を誘導する免疫療法と放射線の併用戦略の検討
- Principal Investigator
  
  高橋豊
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka University
Improvement of conventional adoptive cell therapy for cancer utilized tumor-specific immune responses induced by radiation therapyPrincipal Investigator
- Principal Investigator
  
  Takeshima Tsuguhide
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes for Quantum Science and Technology
Quantitative evaluation of radiation-induced immunostimulating effect
- Principal Investigator
  
  Shimokawa Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
がん細胞は自身の生存をかけ放射線域を逃れるべく上皮間葉移行をなしうるか
- Principal Investigator
  
  西岡健
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
癌特異的キラーT細胞を軸にした新規放射線・免疫併用癌治療モデルの開発Principal Investigator
- Principal Investigator
  
  武島嗣英
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of a new radiation therapy to improve tumor immunity using tumor-bearing mouse with in vivo imaging techniquePrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Tsuguhide
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University

All 2025 2024 2021 2011 2010 2009

All Journal Article Presentation

[Journal Article] Experimental evidence that carbon-ion radiotherapy utilizes cytotoxic T lymphocyte-mediated anti-tumor immunity for shrinking tumors compared to X-ray therapy2024
- Author(s)
  Takeshima Tsuguhide、Hirayama Ryoichi、Hasegawa Sumitaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 718 Pages: 150058-150058
- DOI
  10.1016/j.bbrc.2024.150058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07097
[Journal Article] Radiation-induced Cancer Cell Repop ulation : A possible mechanism impli ed by experiments using transplanta ble mouse-derived sarcoma cell line.2011
- Author(s)
  Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, Shibata KI, Yamaza ki R, Shirato H, Teduka M, Date H.
- Journal Title
  
  Cell Struct Funct. 31(1)
  
  Pages: 13-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791164
[Journal Article] Radiation-induced Cancer Cell Repopulation : A possible mechanismimplied by experiments using transplantable mouse-derived sarcoma cell line.2011
- Author(s)
  Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, Shibata KI, Yamazaki R, Shirato H, Teduka M, Date H.
- Journal Title
  
  Cell Struct Funct.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791164
[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Journal Title
  
  Cancer Res.
  
  Volume: 70(7) Pages: 2697-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791164
[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Journal Title
  
  Cancer Res 70
  
  Pages: 2697-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791164
[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, O hkuri T, Togashi Y, Shirato H, Kita mura H, Nishimura T.
- Journal Title
  
  Cancer Res. 70(7)
  
  Pages: 2697-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] X 線治療と重粒子線治療、どちらがより免疫を使って治療をするのか？2025
- Author(s)
  武島　嗣英
- Organizer
  第16回Quantum Medicine研究会
- Data Source
  KAKENHI-PROJECT-23K07097
[Presentation] X線 vs 重粒子線：抗腫瘍免疫をより使う治療法はどちらか？2025
- Author(s)
  武島　嗣英
- Organizer
  第25回菅原・大西記念癌治療増感シンポジウム, 国際癌治療増感研究協会 IASCT
- Invited
- Data Source
  KAKENHI-PROJECT-23K07097
[Presentation] Creating New Therapy Models by Animal experiments: Utilizing Anti-Tumor Immune ResponsesInduced by Radiation Therapy2024
- Author(s)
  武島　嗣英
- Organizer
  第83回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07097
[Presentation] 次世代の重粒子線治療開発とその臨床利用に向けた放射線生物学研究2021
- Author(s)
  下川　卓志, 黒澤　ふき, 小池　幸子, 小久保　年章, 鵜澤　玲子, 武島　嗣英, 稲庭　拓, 長谷川　純崇, 白井　敏之, 山田　滋
- Organizer
  放射線による制癌シンポジウム, 日本放射線腫瘍学会　生物部会
- Data Source
  KAKENHI-PROJECT-19K08110
[Presentation] Functional analysis of tumor-infiltrating neutrophils induced by tumor irradiation2011
- Author(s)
  武島嗣英、脇田大功、角田健太郎、白土博樹、佐藤崇之、北村秀光、西村孝司
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23791377
[Presentation] Therapeutic applicatons of tumor-specific T lymphocytes (CTL) induced by tumor irradiation2011
- Author(s)
  Takeshima T, Chamoto K, Ohkuri T, Shirato H, Kitamura H, Nishimura T
- Organizer
  14^<th> ICRR2010 (International Gongress of Radiation Research 2011
- Place of Presentation
  Warsaw, The Palace of Science and Culture, Poland
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-23791377
[Presentation] The role of tumor-infiltration neutrophils induced by tumor irradiation2011
- Author(s)
  Takeshima T, Wakita D, Kitamura H, Nishimura T, Shirato H
- Organizer
  The 9th Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  札幌、北大フラテ会館
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23791377
[Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸・神戸国際展示場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] 放射線治療による腫瘍縮小には癌特異的免疫が関与する2010
- Author(s)
  武島嗣英、茶本健司、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌・ホテルさっぽろ芸文館
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Organizer
  RRS2010 (Radiation Research Society 2010)
- Place of Presentation
  Hawaii
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010
- Author(s)
  Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
- Organizer
  RRS2010 (Radiation Research Society 2010)
- Place of Presentation
  Hawaii (USA), Grand Wailea Resort Hotel
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Application of radiation-induced tumor-specific CTL for tumor therapy2010
- Author(s)
  武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第53回日本放射線影響学会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Application of radiation-induced tumor-specific CTL to adoptive tumor immunotherapy2010
- Author(s)
  武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] 放射線治療による腫瘍縮小には癌特異的免疫が関与する2010
- Author(s)
  武島嗣英、茶本健司、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Application of radiation-induced tumor-specific CTL to adoptive tumor immunotherapy2010
- Author(s)
  武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪・大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Application of radiation-induced tumor-specific CTL for tumor therapy2010
- Author(s)
  武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
- Organizer
  第53回日本放射線影響学会
- Place of Presentation
  京都・京都テルサ
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Augmentation of the therapeutic efficacy of Th1 cell-adjuvant therapy enhanced the therapeutic efficacy of combination with radiation therapy2009
- Author(s)
  武島嗣英、茶本健司、脇田大功、大栗敬幸、白土博樹、北村秀光、西村孝司
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] 放射線癌治療におけるTh1細胞治療との併用効果2009
- Author(s)
  武島嗣英、茶本健司、北村秀光、西村孝司、白土博樹
- Organizer
  日本医学放射線学会北日本地方会
- Place of Presentation
  東北大学医学部艮陵会館(宮城県)
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] 放射線癌治療におけるTh1細胞治療との併用効果2009
- Author(s)
  武島嗣英、茶本健司、北村秀光、西村孝司、白土博樹
- Organizer
  日本医学放射線学会北日本地方会
- Place of Presentation
  仙台
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Augmentation of the therapeutic efficacy of Th1 cell-adjuvant therapy enhanced the therapeutic efficacy of combination with radiation therap2009
- Author(s)
  武島嗣英、茶本健司、脇田大功、大栗敬幸、白土博樹、北村秀光、西村孝司
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Synergistic efficacy of radiation therapy and Th1 cell adjuvant therapy in mice-transplanted tumor2009
- Author(s)
  Takeshima T., Chamoto K., Kitamura H., Nishimura T., Shirato H
- Organizer
  The 7^<th> Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  札幌
- Year and Date
  2009-10-07
- Data Source
  KAKENHI-PROJECT-21791164
[Presentation] Synergistic efficacy of radiation therapy and Th1 cell adjuvant therapy in mice-transplanted tumor2009
- Author(s)
  武島嗣英, 茶本健司, 北村秀光, 西村孝司, 白土博樹
- Organizer
  The 7^<th> Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学学術交流会館(北海道)
- Year and Date
  2009-10-07
- Data Source
  KAKENHI-PROJECT-21791164

1. 高橋豊 (40353461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Shimokawa Takashi (20608137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 西岡健 (80271659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 芳賀永 (00292045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 安田元昭 (90239765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中島菜花子 (50402863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 西尾禎治 (40415526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小泉雅彦 (90186594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 皆巳和賢 (90634593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takeshima Tsuguhide 武島 嗣英

TAKESHIMA Tsuguhide 武島 嗣英

Research Projects

Research Products

Co-Researchers

X-ray and carbon ion therapy, how do they promote tumor-specific CD8+ cells?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

同所移植モデルによる難治性腫瘍免疫応答を誘導する免疫療法と放射線の併用戦略の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of conventional adoptive cell therapy for cancer utilized tumor-specific immune responses induced by radiation therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quantitative evaluation of radiation-induced immunostimulating effect

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん細胞は自身の生存をかけ放射線域を逃れるべく上皮間葉移行をなしうるか

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌特異的キラーT細胞を軸にした新規放射線・免疫併用癌治療モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new radiation therapy to improve tumor immunity using tumor-bearing mouse with in vivo imaging techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Experimental evidence that carbon-ion radiotherapy utilizes cytotoxic T lymphocyte-mediated anti-tumor immunity for shrinking tumors compared to X-ray therapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiation-induced Cancer Cell Repop ulation : A possible mechanism impli ed by experiments using transplanta ble mouse-derived sarcoma cell line.2011

Author(s)

Journal Title

Data Source

[Journal Article] Radiation-induced Cancer Cell Repopulation : A possible mechanismimplied by experiments using transplantable mouse-derived sarcoma cell line.2011

Author(s)

Journal Title

Data Source

[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

Author(s)

Journal Title

Data Source

[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy2010

Author(s)

Journal Title

Data Source

[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

Author(s)

Journal Title

Data Source

[Presentation] X 線治療と重粒子線治療、どちらがより免疫を使って治療をするのか？2025

Author(s)

Organizer

Data Source

[Presentation] X線 vs 重粒子線：抗腫瘍免疫をより使う治療法はどちらか？2025

Author(s)

Organizer

Data Source

Takeshima Tsuguhide 武島嗣英

TAKESHIMA Tsuguhide 武島嗣英