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Tsukahara Tomonori  塚原 智典

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TSUKAHARA Tomonri  塚原 智典

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Researcher Number 10362120
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help 2014 – 2017: 自治医科大学, 医学部, 講師
2009 – 2013: 自治医科大学, 医学部, 助教
2009: 医学部, 助教
2007 – 2008: Shinshu University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Tumor therapeutics / Clinical oncology / Virology
Except Principal Investigator
Tumor therapeutics / Hematology / Biological Sciences
Keywords
Principal Investigator
遺伝子治療 / T細胞 / T細胞療法 / 免疫療法 / 成人T細胞白血病 / 造血器腫瘍 / キメラ抗原受容体 / 免疫遺伝子療法 / 腫瘍標的化 / 悪性リンパ腫 / 伝子治療 / ウイルスベクター / 分子 … More
Except Principal Investigator
… More 遺伝子治療 / 細胞老化 / 細胞疲弊化 / 非ホジキンリンパ腫 / CD19抗原 / 遺伝子改変T細胞療法 / 血液腫瘍学 / 造血器腫瘍 / Tリンパ球 / キメラ抗原受容体 / 細胞療法 / 免疫療法 / 担癌ヌードマウス / ヒストン脱アセチル化酵素阻害剤 / 組織特異性 / リンパ行性転移抑制 / 抗腫瘍血管遺伝子療法 / VEGF-C / sFlt-4 / sFlt-1 / リンパ管新生 / 血管新生 / バキュロウイルス / AAVベクター / がん遺伝子治療 / バイオテクノロジー / 癌 / ウイルス / 遺伝子 Less
  • Research Projects

    (6 results)
  • Research Products

    (56 results)
  • Co-Researchers

    (10 People)
  •  Safety and persistence of genetically modified T-cells in patients with non-Hodgkin lymphoma

    • Principal Investigator
      OHMINE KEN
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Jichi Medical University
  •  Development of immunogene therapy using T-cells expressing a chimeric antigen receptor for adult T-cell leukemiaPrincipal Investigator

    • Principal Investigator
      Tsukahara Tomonori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Jichi Medical University
  •  Development of gene therapy for refractory non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor

    • Principal Investigator
      OZAWA keiya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical University
  •  Development research on immuno-gene therapy for malignant B-cell lymphomaPrincipal Investigator

    • Principal Investigator
      TSUKAHARA Tomonori
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Clinical oncology
    • Research Institution
      Jichi Medical University
  •  Identification of cellular factors involved in regulation of integration preferences of gene therapeutic MLV vectorPrincipal Investigator

    • Principal Investigator
      TSUKAHARA Tomonori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Shinshu University
  •  Development of AAV (adeno-associated virus) vectors and their application to cancer therapy

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University

All 2015 2014 2013 2012 2011 2010 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] 遺伝子操作Tリンパ球を用いた癌遺伝子治療2015

    • Author(s)
      塚原智典
    • Journal Title

      Pharma Medica

      Volume: 33 Pages: 41-45

    • Data Source
      KAKENHI-PROJECT-25430155
  • [Journal Article] The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies2015

    • Author(s)
      Tsukahara, T., Iwase, N., Kawakami, K., Iwasaki, M., Yamamoto, C., Ohmine, K., Uchibori, R., Teruya, T., Ido, H., Saga, Y., Urabe, M., Mizukami, H., Kume, A., Nakamura, M., Brentjens, R., and Ozawa, K.
    • Journal Title

      Gene Therapy

      Volume: 22 Issue: 2 Pages: 209-215

    • DOI

      10.1038/gt.2014.104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23241063, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-26430168
  • [Journal Article] L-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014

    • Author(s)
      Yamamoto C , Tsukahara T, Ohmine K, Teruya T, Ido H, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Journal Title

      Jichi Medical University Journal

      Volume: 36 Pages: 23-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014

    • Author(s)
      Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 1 Pages: 72-80

    • DOI

      10.1111/cas.12315

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24592594, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-25461460
  • [Journal Article] Cancer gene therapy using mesenchymal stem cells.2014

    • Author(s)
      Uchibori R, Tsukahara T, Ohmine K, Ozawa K.
    • Journal Title

      Int J Hematol.

      Volume: 99 Issue: 4 Pages: 377-82

    • DOI

      10.1007/s12185-014-1537-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-26430168
  • [Journal Article] IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014

    • Author(s)
      Yamamoto C, Tsukahara T, Omine K, Teruya T, Ido H, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Journal Title

      Jichi Medical University Journal

      Volume: 36 Pages: 23-31

    • NAID

      120006408261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Journal Article] Mechanisms of resistance to azacitidine in human leukemia cell lines.2014

    • Author(s)
      Sripayap P, Nagai T, Uesawa M, Kobayashi H, Tsukahara T, Ohmine K, Muroi K, Ozawa K.
    • Journal Title

      Exp Hematol.

      Volume: 42 Issue: 4 Pages: 294-306

    • DOI

      10.1016/j.exphem.2013.12.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25461435, KAKENHI-PROJECT-26430168
  • [Journal Article] NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.2013

    • Author(s)
      Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    • Journal Title

      Cancer Research

      Volume: 73 Issue: 1 Pages: 364-372

    • DOI

      10.1158/0008-5472.can-12-0088

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24700995, KAKENHI-PROJECT-25430155
  • [Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models2013

    • Author(s)
      Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 438 Issue: 1 Pages: 84-89

    • DOI

      10.1016/j.bbrc.2013.07.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24700995, KAKENHI-PROJECT-25430155
  • [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats2012

    • Author(s)
      Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, and Ozawa K.
    • Journal Title

      Gene Ther

      Volume: 19巻 Issue: 5 Pages: 476-82

    • DOI

      10.1038/gt.2011.183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390296, KAKENHI-PROJECT-21591248, KAKENHI-PROJECT-22700923, KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247
  • [Journal Article] キメラ抗原受容体発現T細胞を用いた難治性B細胞腫瘍に対する養子免疫遺伝子療法2011

    • Author(s)
      塚原智典
    • Journal Title

      医学のあゆみ

      Volume: 237 Pages: 223-226

    • Data Source
      KAKENHI-PROJECT-22700923
  • [Journal Article] キメラ抗原受容体発現T細胞による癌に対する養子免疫遺伝子療法2010

    • Author(s)
      塚原智典
    • Journal Title

      最新医学

      Volume: 65 Pages: 1813-1818

    • Data Source
      KAKENHI-PROJECT-22700923
  • [Journal Article] キメラ抗原受容体発現T細胞によるがんに対する養子免疫遺伝子療法2010

    • Author(s)
      塚原智典
    • Journal Title

      最新医学

      Volume: 65(8) Pages: 1813-1818

    • NAID

      40017239752

    • Data Source
      KAKENHI-PROJECT-22700923
  • [Journal Article] Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin 2 receptor βchain2008

    • Author(s)
      Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Kurotori N, Tanaka N, Sugamura K, Takeshita K
    • Journal Title

      J Cell Sci. 121

      Pages: 1727-1738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Journal Article] Ubiquitin-independent binding of hrs mediates endossomal sorting of the interleukin-2 receptor β chain

    • Author(s)
      Yamashita Y, Kojima K, Tsukahara T, et. al.
    • Journal Title

      Journal of Cell Science (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Presentation] キメラ抗原受容体からの抗原刺激特異的な遺伝子発現誘導系の開発.2014

    • Author(s)
      内堀 亮介, 二宮 空暢, 照屋 武志, 塚原 智典, 大嶺 謙, 峰野 純一, 竹迫 一任, 小澤 敬也.
    • Organizer
      第6回血液疾患免疫療法研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-06
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] The NFAT response elements in the IL-2 gene promoter permit visualization and quantification of activation status in CAR-expressing PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Activation signals from CAR permit NFAT-controlled inducible expression of transgenes in PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Activation signals from chimeric antigen receptors permit NFAT-controlled inducible expression of transgene in PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Analysis of function and response specificity of a switch promoter driven by activation signals from a CD19-targeted chimeric antigen receptor.2014

    • Author(s)
      Uchibori R, Takeshi T, Tsukahara T, Ohmine K, Riviere I, Brentjens RJ, Sadelain M, Mineno J, Takesako K, Ozawa K.
    • Organizer
      The 5th Meeting of Asian Cellular Therapy Organization.
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Data Source
      KAKENHI-PROJECT-26430168
  • [Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Development of switch promoters that is activated to induce exogenous gene expression upon the recognition of CD19 by chimeric antigen receptors.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      17th Annual Meeting of the American Society of Gene & Cell Therapy.
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2014-05-22
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Data Source
      KAKENHI-PROJECT-26430168
  • [Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-26430168
  • [Presentation] Validation of anti-tumor activity mediated by T-lymphocytes with chimeric antigen receptor targeting CD19 for B cellymphoma2012

    • Author(s)
      塚原智典
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Evaluation of anti-tumor effects mediated by engineered Tlymphocytes expressing a CD19 specific CAR for B cell lymphoma2012

    • Author(s)
      Tsukahara, T.
    • Organizer
      The 15th Annual Meeeting of The American Society of Gene and Cell Therapy
    • Place of Presentation
      Pennsylvania Convention Center (USA)
    • Year and Date
      2012-05-19
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Bリンパ腫に対する抗CD19キメラ抗原受容体発現T細胞の抗腫瘍効果2012

    • Author(s)
      塚原智典
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Engineered T lymphocytes expressing an anti-CD19 CAR specifically eradicate B-lymphoma cells2011

    • Author(s)
      Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Riviere, I., Sadelain, M., Brentjens, R. J., Ozawa K.
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-07-07
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Engineered T lymphocytes expressing an anti-CD19 CAR specifically eradicate B-lymphoma cells2011

    • Author(s)
      Tomonori Tsukahara, Ken Ohmine, Ryosuke Uchibori, Masashi Urabe, Hiroaki Mizukami, Akihiro Kume, Isabelle Riviere, Michel Sadelain, Renier J.Brentjens, Keiya Ozawa
    • Organizer
      日本遺伝子治療学会
    • Place of Presentation
      九州大学百年講堂(福岡)
    • Year and Date
      2011-07-17
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Ex vivo expansion of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 with antigen stimulation2010

    • Author(s)
      Tsukahara, T., Sakurai, C., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Riviere, I., Sadelain, M., Brentjens, R. J., Ozawa K.
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Utsunomiya
    • Year and Date
      2010-07-01
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Bリンパ腫細胞に対する抗CD19キメラ抗原受容体発現T細胞の細胞障害活性2010

    • Author(s)
      塚原智典, 大嶺謙, 内堀亮介, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也
    • Organizer
      第2回造血器腫瘍免疫療法研究会
    • Place of Presentation
      大和屋本店(松山)
    • Year and Date
      2010-08-29
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Cytotoxicity of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 against B-cell lymphoma cells2010

    • Author(s)
      Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
    • Organizer
      Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Osaka
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Bリンパ腫細胞に対する抗CD19キメラ抗原受容体発現T細胞の細胞障害活性2010

    • Author(s)
      塚原智典, 大嶺謙, 内堀亮介, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也
    • Organizer
      造血器腫瘍免疫療法研究会
    • Place of Presentation
      松山
    • Year and Date
      2010-08-29
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Ex vivo expansion of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 with antigen stimulation2010

    • Author(s)
      Tsukahara T., Sakurai C., Ohmine K., Uchibori R., Urabe M., Mizukami H., Kume A., Riviere I., Sadelain M., Brentjens R.J., Ozawa K
    • Organizer
      第16回日本遺伝子治療学会
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Validation of anti-tumor effects mediated by anti-CD19CAR T-cells for B cell lymphoma2010

    • Author(s)
      Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
    • Organizer
      XXIII Annual Congress of the European Society of Gene and Cell Therapy
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2010-10-23
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Cytotoxicity of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 against B-cell lymphoma cells2010

    • Author(s)
      T Tsukahara, K Ohmine, R Uchibori, M Urabe, H Mizukami, A Kume, K Ozawa
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] Validation of anti-tumor effects mediated by anti-CD19CAR T-cells for B cell lymphoma2010

    • Author(s)
      T Tsukahara, K Ohmine, R Uchibori, M Urabe, H Mizukami, A Kume, I Riviere, M Sadelain, R Brentjens, K Ozawa
    • Organizer
      XXIII Annual Congress of the European Society of Gene and Cell Therapy
    • Place of Presentation
      Stella Polare convention center (Milano), Italia
    • Year and Date
      2010-10-23
    • Data Source
      KAKENHI-PROJECT-22700923
  • [Presentation] LMO2の転写開始点近傍におけるMLVベクターの組み込み特性2008

    • Author(s)
      塚原智典, 田中伸幸, 竹下敏一
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山コンベンショナルセンター(岡山)
    • Year and Date
      2008-10-26
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Presentation] LMO2近傍でのレトロウイルスベクター挿入頻度2008

    • Author(s)
      山田幸一郎, 塚原智典, 小嶋克彦, 山下勇毅, 天野勇治, 田中伸幸, 竹下敏一
    • Organizer
      第67回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Presentation] Ubiquitin-independent binding of Hrs to Interleukin 2 receptor chain B mediates its endosomal sorting2007

    • Author(s)
      Yamashita Y, Kojima K, Tsukahara T, et. al.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Presentation] Ubiquitin-independent binding of Hrs to Interleukin 2 receptor chain β mediates its endosomal sorting2007

    • Author(s)
      山下勇毅, 小嶋克彦, 塚原智典, 阿川英之, 山田幸一郎, 天野勇治, 黒鳥直樹, 竹下敏一
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19790335
  • [Presentation] Tumor targeting and anti-tumor activity mediated by T-lymphocytes with an anti-CD19 CAR in human B-cell lymphoma models.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第18日本遺伝子治療学会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Tumor targeting using T-lymphocytes with an anti-CD19 chimeric antigen receptor for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Anti-tumor activity of CD19-specific chimeric antigen receptor-modified T-cells for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Tumor targeting and anti-tumor activity mediated by T-lymphocytes with an anti-CD19 CAR in human B-cell lymphoma models.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      岡山市
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Development of switch promoters driven by activation signals from the chimeric antigen receptors.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Anti-tumor activity of CD19-specific chimeric antigen receptor-modified T-cells for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25430155
  • [Presentation] Tumor targeting using T-lymphocytes with an anti-CD19 chimeric antigen receptor for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] DEVELOPMENT OF SIN RETROVIRAL VECTORS EQUIPPED WITH SWITCH PROMOTERS DRIVEN BY ACTIVATION SIGNALS FROM THE CHIMERIC ANTIGEN RECEPTORS.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      岡山市
    • Data Source
      KAKENHI-PROJECT-24390247
  • [Presentation] Development of switch promoters that would respond to activation signals from the chimeric antigen receptors.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-24390247
  • 1.  OHMINE Ken (90316521)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 27 results
  • 2.  OZAWA Keiya (30137707)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 3.  MIZUKAMI Horoaki (20311938)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  URABE Masashi (40213516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  MATSUSHITA Takashi (20343444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OKADA Takashi (00326828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  UCHIBORI Ryousuke (20458285)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 8.  MORISHITA Kazuhiro (80260321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  久米 晃啓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 10.  川上 浩一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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