Tsukahara Tomonori 塚原智典

… Alternative Names

TSUKAHARA Tomonri 塚原智典

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Researcher Number	10362120
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2014 – 2017: 自治医科大学, 医学部, 講師 2009 – 2013: 自治医科大学, 医学部, 助教 2009: 医学部, 助教 2007 – 2008: Shinshu University, 医学部, 助教
Review Section/Research Field	Principal Investigator Tumor therapeutics / Clinical oncology / Virology Except Principal Investigator Tumor therapeutics / Hematology / Biological Sciences
Keywords	Principal Investigator 遺伝子治療 / T細胞 / T細胞療法 / 免疫療法 / 成人T細胞白血病 / 造血器腫瘍 / キメラ抗原受容体 / 免疫遺伝子療法 / 腫瘍標的化 / 悪性リンパ腫 / 伝子治療 / ウイルスベクター / 分子 … More Except Principal Investigator … More 遺伝子治療 / 細胞老化 / 細胞疲弊化 / 非ホジキンリンパ腫 / CD19抗原 / 遺伝子改変T細胞療法 / 血液腫瘍学 / 造血器腫瘍 / Tリンパ球 / キメラ抗原受容体 / 細胞療法 / 免疫療法 / 担癌ヌードマウス / ヒストン脱アセチル化酵素阻害剤 / 組織特異性 / リンパ行性転移抑制 / 抗腫瘍血管遺伝子療法 / VEGF-C / sFlt-4 / sFlt-1 / リンパ管新生 / 血管新生 / バキュロウイルス / AAVベクター / がん遺伝子治療 / バイオテクノロジー / 癌 / ウイルス / 遺伝子 Less

Safety and persistence of genetically modified T-cells in patients with non-Hodgkin lymphoma
- Principal Investigator
  
  OHMINE KEN
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Jichi Medical University
Development of immunogene therapy using T-cells expressing a chimeric antigen receptor for adult T-cell leukemiaPrincipal Investigator
- Principal Investigator
  
  Tsukahara Tomonori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Jichi Medical University
Development of gene therapy for refractory non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor
- Principal Investigator
  
  OZAWA keiya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Development research on immuno-gene therapy for malignant B-cell lymphomaPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tomonori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Jichi Medical University
Identification of cellular factors involved in regulation of integration preferences of gene therapeutic MLV vectorPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tomonori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Shinshu University
Development of AAV (adeno-associated virus) vectors and their application to cancer therapy
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University

All 2015 2014 2013 2012 2011 2010 2008 2007 Other

All Journal Article Presentation

[Journal Article] 遺伝子操作Tリンパ球を用いた癌遺伝子治療2015
- Author(s)
  塚原智典
- Journal Title
  
  Pharma Medica
  
  Volume: 33 Pages: 41-45
- Data Source
  KAKENHI-PROJECT-25430155
[Journal Article] The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies2015
- Author(s)
  Tsukahara, T., Iwase, N., Kawakami, K., Iwasaki, M., Yamamoto, C., Ohmine, K., Uchibori, R., Teruya, T., Ido, H., Saga, Y., Urabe, M., Mizukami, H., Kume, A., Nakamura, M., Brentjens, R., and Ozawa, K.
- Journal Title
  
  Gene Therapy
  
  Volume: 22 Issue: 2 Pages: 209-215
- DOI
  10.1038/gt.2014.104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23241063, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-26430168
[Journal Article] L-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014
- Author(s)
  Yamamoto C , Tsukahara T, Ohmine K, Teruya T, Ido H, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Journal Title
  
  Jichi Medical University Journal
  
  Volume: 36 Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430155
[Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014
- Author(s)
  Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 1 Pages: 72-80
- DOI
  10.1111/cas.12315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24592594, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-25461460
[Journal Article] Cancer gene therapy using mesenchymal stem cells.2014
- Author(s)
  Uchibori R, Tsukahara T, Ohmine K, Ozawa K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 99 Issue: 4 Pages: 377-82
- DOI
  10.1007/s12185-014-1537-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-26430168
[Journal Article] IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014
- Author(s)
  Yamamoto C, Tsukahara T, Omine K, Teruya T, Ido H, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Journal Title
  
  Jichi Medical University Journal
  
  Volume: 36 Pages: 23-31
- NAID
  120006408261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390247
[Journal Article] Mechanisms of resistance to azacitidine in human leukemia cell lines.2014
- Author(s)
  Sripayap P, Nagai T, Uesawa M, Kobayashi H, Tsukahara T, Ohmine K, Muroi K, Ozawa K.
- Journal Title
  
  Exp Hematol.
  
  Volume: 42 Issue: 4 Pages: 294-306
- DOI
  10.1016/j.exphem.2013.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25461435, KAKENHI-PROJECT-26430168
[Journal Article] NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.2013
- Author(s)
  Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
- Journal Title
  
  Cancer Research
  
  Volume: 73 Issue: 1 Pages: 364-372
- DOI
  10.1158/0008-5472.can-12-0088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24700995, KAKENHI-PROJECT-25430155
[Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models2013
- Author(s)
  Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 438 Issue: 1 Pages: 84-89
- DOI
  10.1016/j.bbrc.2013.07.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24700995, KAKENHI-PROJECT-25430155
[Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats2012
- Author(s)
  Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, and Ozawa K.
- Journal Title
  
  Gene Ther
  
  Volume: 19巻 Issue: 5 Pages: 476-82
- DOI
  10.1038/gt.2011.183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390296, KAKENHI-PROJECT-21591248, KAKENHI-PROJECT-22700923, KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247
[Journal Article] キメラ抗原受容体発現T細胞を用いた難治性B細胞腫瘍に対する養子免疫遺伝子療法2011
- Author(s)
  塚原智典
- Journal Title
  
  医学のあゆみ
  
  Volume: 237 Pages: 223-226
- Data Source
  KAKENHI-PROJECT-22700923
[Journal Article] キメラ抗原受容体発現T細胞による癌に対する養子免疫遺伝子療法2010
- Author(s)
  塚原智典
- Journal Title
  
  最新医学
  
  Volume: 65 Pages: 1813-1818
- Data Source
  KAKENHI-PROJECT-22700923
[Journal Article] キメラ抗原受容体発現T細胞によるがんに対する養子免疫遺伝子療法2010
- Author(s)
  塚原智典
- Journal Title
  
  最新医学
  
  Volume: 65(8) Pages: 1813-1818
- NAID
  40017239752
- Data Source
  KAKENHI-PROJECT-22700923
[Journal Article] Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin 2 receptor βchain2008
- Author(s)
  Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Kurotori N, Tanaka N, Sugamura K, Takeshita K
- Journal Title
  
  J Cell Sci. 121
  
  Pages: 1727-1738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790335
[Journal Article] Ubiquitin-independent binding of hrs mediates endossomal sorting of the interleukin-2 receptor β chain
- Author(s)
  Yamashita Y, Kojima K, Tsukahara T, et. al.
- Journal Title
  
  Journal of Cell Science (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790335
[Presentation] キメラ抗原受容体からの抗原刺激特異的な遺伝子発現誘導系の開発.2014
- Author(s)
  内堀亮介, 二宮空暢, 照屋武志, 塚原智典, 大嶺謙, 峰野純一, 竹迫一任, 小澤敬也.
- Organizer
  第6回血液疾患免疫療法研究会
- Place of Presentation
  京都
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] The NFAT response elements in the IL-2 gene promoter permit visualization and quantification of activation status in CAR-expressing PBMCs.2014
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
- Organizer
  第20回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Activation signals from CAR permit NFAT-controlled inducible expression of transgenes in PBMCs.2014
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Activation signals from chimeric antigen receptors permit NFAT-controlled inducible expression of transgene in PBMCs.2014
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Analysis of function and response specificity of a switch promoter driven by activation signals from a CD19-targeted chimeric antigen receptor.2014
- Author(s)
  Uchibori R, Takeshi T, Tsukahara T, Ohmine K, Riviere I, Brentjens RJ, Sadelain M, Mineno J, Takesako K, Ozawa K.
- Organizer
  The 5th Meeting of Asian Cellular Therapy Organization.
- Place of Presentation
  大阪
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-26430168
[Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
- Organizer
  第20回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Development of switch promoters that is activated to induce exogenous gene expression upon the recognition of CD19 by chimeric antigen receptors.2014
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
- Organizer
  17th Annual Meeting of the American Society of Gene & Cell Therapy.
- Place of Presentation
  Washington, D.C.
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
- Organizer
  第20回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014
- Author(s)
  Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
- Organizer
  第20回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-26430168
[Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26430168
[Presentation] Validation of anti-tumor activity mediated by T-lymphocytes with chimeric antigen receptor targeting CD19 for B cellymphoma2012
- Author(s)
  塚原智典
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Evaluation of anti-tumor effects mediated by engineered Tlymphocytes expressing a CD19 specific CAR for B cell lymphoma2012
- Author(s)
  Tsukahara, T.
- Organizer
  The 15th Annual Meeeting of The American Society of Gene and Cell Therapy
- Place of Presentation
  Pennsylvania Convention Center (USA)
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Bリンパ腫に対する抗CD19キメラ抗原受容体発現T細胞の抗腫瘍効果2012
- Author(s)
  塚原智典
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(札幌)
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Engineered T lymphocytes expressing an anti-CD19 CAR specifically eradicate B-lymphoma cells2011
- Author(s)
  Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Riviere, I., Sadelain, M., Brentjens, R. J., Ozawa K.
- Organizer
  Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Fukuoka
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Engineered T lymphocytes expressing an anti-CD19 CAR specifically eradicate B-lymphoma cells2011
- Author(s)
  Tomonori Tsukahara, Ken Ohmine, Ryosuke Uchibori, Masashi Urabe, Hiroaki Mizukami, Akihiro Kume, Isabelle Riviere, Michel Sadelain, Renier J.Brentjens, Keiya Ozawa
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  九州大学百年講堂(福岡)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Ex vivo expansion of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 with antigen stimulation2010
- Author(s)
  Tsukahara, T., Sakurai, C., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Riviere, I., Sadelain, M., Brentjens, R. J., Ozawa K.
- Organizer
  Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Utsunomiya
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Bリンパ腫細胞に対する抗CD19キメラ抗原受容体発現T細胞の細胞障害活性2010
- Author(s)
  塚原智典, 大嶺謙, 内堀亮介, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也
- Organizer
  第2回造血器腫瘍免疫療法研究会
- Place of Presentation
  大和屋本店(松山)
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Cytotoxicity of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 against B-cell lymphoma cells2010
- Author(s)
  Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Organizer
  Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Osaka
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Bリンパ腫細胞に対する抗CD19キメラ抗原受容体発現T細胞の細胞障害活性2010
- Author(s)
  塚原智典, 大嶺謙, 内堀亮介, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也
- Organizer
  造血器腫瘍免疫療法研究会
- Place of Presentation
  松山
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Ex vivo expansion of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 with antigen stimulation2010
- Author(s)
  Tsukahara T., Sakurai C., Ohmine K., Uchibori R., Urabe M., Mizukami H., Kume A., Riviere I., Sadelain M., Brentjens R.J., Ozawa K
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  栃木県総合文化センター(宇都宮)
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Validation of anti-tumor effects mediated by anti-CD19CAR T-cells for B cell lymphoma2010
- Author(s)
  Tsukahara, T., Ohmine, K., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Organizer
  XXIII Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Milano, Italy
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Cytotoxicity of primary T-lymphocytes expressing a chimeric antigen receptor targeting CD19 against B-cell lymphoma cells2010
- Author(s)
  T Tsukahara, K Ohmine, R Uchibori, M Urabe, H Mizukami, A Kume, K Ozawa
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] Validation of anti-tumor effects mediated by anti-CD19CAR T-cells for B cell lymphoma2010
- Author(s)
  T Tsukahara, K Ohmine, R Uchibori, M Urabe, H Mizukami, A Kume, I Riviere, M Sadelain, R Brentjens, K Ozawa
- Organizer
  XXIII Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Stella Polare convention center (Milano), Italia
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-22700923
[Presentation] LMO2の転写開始点近傍におけるMLVベクターの組み込み特性2008
- Author(s)
  塚原智典, 田中伸幸, 竹下敏一
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山コンベンショナルセンター(岡山)
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19790335
[Presentation] LMO2近傍でのレトロウイルスベクター挿入頻度2008
- Author(s)
  山田幸一郎, 塚原智典, 小嶋克彦, 山下勇毅, 天野勇治, 田中伸幸, 竹下敏一
- Organizer
  第67回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19790335
[Presentation] Ubiquitin-independent binding of Hrs to Interleukin 2 receptor chain B mediates its endosomal sorting2007
- Author(s)
  Yamashita Y, Kojima K, Tsukahara T, et. al.
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19790335
[Presentation] Ubiquitin-independent binding of Hrs to Interleukin 2 receptor chain β mediates its endosomal sorting2007
- Author(s)
  山下勇毅, 小嶋克彦, 塚原智典, 阿川英之, 山田幸一郎, 天野勇治, 黒鳥直樹, 竹下敏一
- Organizer
  第37回日本免疫学会学術集会
- Place of Presentation
  グランドプリンスホテル新高輪(東京)
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19790335
[Presentation] Tumor targeting and anti-tumor activity mediated by T-lymphocytes with an anti-CD19 CAR in human B-cell lymphoma models.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
- Organizer
  第18日本遺伝子治療学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Tumor targeting using T-lymphocytes with an anti-CD19 chimeric antigen receptor for B cell lymphoma.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Anti-tumor activity of CD19-specific chimeric antigen receptor-modified T-cells for B cell lymphoma.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Tumor targeting and anti-tumor activity mediated by T-lymphocytes with an anti-CD19 CAR in human B-cell lymphoma models.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
- Organizer
  第18回日本遺伝子治療学会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Development of switch promoters driven by activation signals from the chimeric antigen receptors.
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Anti-tumor activity of CD19-specific chimeric antigen receptor-modified T-cells for B cell lymphoma.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25430155
[Presentation] Tumor targeting using T-lymphocytes with an anti-CD19 chimeric antigen receptor for B cell lymphoma.
- Author(s)
  Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] DEVELOPMENT OF SIN RETROVIRAL VECTORS EQUIPPED WITH SWITCH PROMOTERS DRIVEN BY ACTIVATION SIGNALS FROM THE CHIMERIC ANTIGEN RECEPTORS.
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
- Organizer
  第18回日本遺伝子治療学会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-24390247
[Presentation] Development of switch promoters that would respond to activation signals from the chimeric antigen receptors.
- Author(s)
  Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24390247

1. OHMINE Ken (90316521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
2. OZAWA Keiya (30137707)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. MIZUKAMI Horoaki (20311938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. URABE Masashi (40213516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MATSUSHITA Takashi (20343444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKADA Takashi (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. UCHIBORI Ryousuke (20458285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
8. MORISHITA Kazuhiro (80260321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 久米晃啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 川上浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukahara Tomonori 塚原 智典

TSUKAHARA Tomonri 塚原 智典

Research Projects

Research Products

Co-Researchers

Safety and persistence of genetically modified T-cells in patients with non-Hodgkin lymphoma

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Development of immunogene therapy using T-cells expressing a chimeric antigen receptor for adult T-cell leukemiaPrincipal Investigator

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Development of gene therapy for refractory non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor

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Development research on immuno-gene therapy for malignant B-cell lymphomaPrincipal Investigator

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Identification of cellular factors involved in regulation of integration preferences of gene therapeutic MLV vectorPrincipal Investigator

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Development of AAV (adeno-associated virus) vectors and their application to cancer therapy

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[Journal Article] 遺伝子操作Tリンパ球を用いた癌遺伝子治療2015

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[Journal Article] The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies2015

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DOI

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[Journal Article] L-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014

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[Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014

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[Journal Article] Cancer gene therapy using mesenchymal stem cells.2014

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[Journal Article] IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014

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NAID

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[Journal Article] Mechanisms of resistance to azacitidine in human leukemia cell lines.2014

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[Journal Article] NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.2013

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[Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models2013

Tsukahara Tomonori 塚原智典

TSUKAHARA Tomonri 塚原智典