NAKADAI Tomoyoshi 中太智義

Researcher Number	10364770
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所がんエピゲノム研究部, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 公益財団法人がん研究会, がん研究所がんエピゲノムプロジェクト, 研究員 2006 – 2007: 埼玉医科大学, 医学部, 助教 2004 – 2006: 埼玉医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Molecular biology Except Principal Investigator Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Molecular biology
Keywords	Principal Investigator 変異体 / 乳がん / 再構成転写系 / 変異体タンパク質 / 新規シングルセルATAC-seq / 再発 / 転移 / レンチウイルスベクター / scATAC-seq解析 / scRNA-seq解析 … More / ミスセンス突然変異 / 転写制御機構 / がん / １細胞RNA-seq / NGS / 内分泌療法 / ミスセンス変異体 / 転写制御異常 / 点変異体 / エストロゲン受容体α / 転写制御 / ERα / K303R / ChIP-seq / ATAC-seq / NcoA2 / FoxA1 / Mutation / Breast cancer / ERa / バキュロウイルス発現 / RNAポリメラーゼ / コアクチベーター / コアクチペーター / NF複合体 / 基本転写因子 / バキュロウイルス発現系 / RPB / RNAポリメラーゼII … More Except Principal Investigator TFIID / コアクチベーター / バキュロウイルス / エピゲノム / シングルセル解析 / エストロゲン受容体 / scATAC-seq / 腫瘍内不均一性 / 乳がん / basal transcriptional machinery / activator / baculovirus / coactivator / transcription factor / 基本転写装置 / アクチベーター / バキュロウイスル / 転写因子 / クロマチン / 発現制御 / 遺伝子 / 一本鎖RNA / 基本転写因子 / ガン遺伝子 / 転写調節 Less

転移性乳癌で生じる多様な変異体タンパク質の機能異常性の網羅的解析と病的意義の解明Principal Investigator
- Principal Investigator
  
  中太智義
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Stratification of breast cancer based on single-cell analysis
- Principal Investigator
  
  MARUYAMA Reo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Comprehensive analysis of mutant ERa found in cancers to reveal their aberrant functionsPrincipal Investigator
- Principal Investigator
  
  NAKADAI Tomoyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
新規コアクチベーターによる転写過程の包括的調節機構の解析
- Principal Investigator
  
  久武幸司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
NF複合体によるc-fos遺伝子のクロマチン修飾と発現制御
- Principal Investigator
  
  HISATAKE Koji
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
組み換え蛋白質によるRNAポリメラーゼII再構成と各サブユニットの新規機能の探索Principal Investigator
- Principal Investigator
  
  中太智義
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Saitama Medical University
Analysis of a novel coactivator that activates the c-fos gene
- Principal Investigator
  
  HISATAKE Koji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  University of Tsukuba
  Saitama Medical University

All 2024 2023 2022 2021 2020 2019 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 転写因子・転写制御キーワードブック2006
- Author(s)
  中太智義
- Total Pages
  12
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines2024
- Author(s)
  Yang Liying、Kumegawa Kohei、Saeki Sumito、Nakadai Tomoyoshi、Maruyama Reo
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 31 Issue: 5 Pages: 736-745
- DOI
  10.1038/s41417-024-00745-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07161
[Journal Article] Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility2023
- Author(s)
  Kumegawa Kohei、Saeki Sumito、Takahashi Yoko、Yang Liying、Osako Tomo、Nakadai Tomoyoshi、Amino Sayuri、Maeda Tetsuyo、Takahata Chikako、Mori Seiichi、Noda Tetsuo、Ohno Shinji、Ueno Takayuki、Maruyama Reo
- Journal Title
  
  British Journal of Cancer
  
  Volume: 128 Issue: 7 Pages: 1208-1222
- DOI
  10.1038/s41416-023-02178-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-21H02793, KAKENHI-PROJECT-20K07708
[Journal Article] <scp>SETD1A</scp> function in leukemia is mediated through interaction with mitotic regulators <scp>BuGZ</scp>/<scp>BUB3</scp>2023
- Author(s)
  Perlee Sarah、Kikuchi Sota、Nakadai Tomoyoshi、Masuda Takeshi、Ohtsuki Sumio、Matsumoto Makoto、Rahmutulla Bahityar、Fukuyo Masaki、Cifani Paolo、Kentsis Alex、Roeder Robert G、Kaneda Atsushi、Hoshii Takayuki
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 10 Pages: 1-19
- DOI
  10.15252/embr.202357108
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-22K07164, KAKENHI-PUBLICLY-22H05546, KAKENHI-PROJECT-23K23867, KAKENHI-PROJECT-23K24359
[Journal Article] Two target gene activation pathways for orphan ERR nuclear receptors2023
- Author(s)
  Nakadai Tomoyoshi、Shimada Miho、Ito Keiichi、Cevher Murat Alper、Chu Chi-Shuen、Kumegawa Kohei、Maruyama Reo、Malik Sohail、Roeder Robert G
- Journal Title
  
  Cell Research
  
  Volume: 33 Issue: 2 Pages: 165-183
- DOI
  10.1038/s41422-022-00774-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06482, KAKENHI-PROJECT-22K07161
[Journal Article] GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer2022
- Author(s)
  Kumegawa Kohei、Takahashi Yoko、Saeki Sumito、Yang Liying、Nakadai Tomoyoshi、Osako Tomo、Mori Seiichi、Noda Tetsuo、Ohno Shinji、Ueno Takayuki、Maruyama Reo
- Journal Title
  
  npj Breast Cancer
  
  Volume: 8 Issue: 1 Pages: 70-70
- DOI
  10.1038/s41523-022-00438-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-21H02793, KAKENHI-PROJECT-20K07708
[Journal Article] Phosphorylated MED1 links transcription recycling and cancer growth2022
- Author(s)
  Chen Zhong、Ye Zhenqing、Soccio Raymond E、Nakadai Tomoyoshi、Hankey William、Zhao Yue、Huang Furong、Yuan Fuwen、Wang Hongyan、Cui Zhifen、Sunkel Benjamin、Wu Dayong、Dzeng Richard?K、Thomas-Ahner Jennifer?M、Huang Tim H M、Clinton Steven?K、Huang Jiaoti、Lazar Mitchell?A、Jin Victor?X、Roeder Robert?G、Wang Qianben
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 8 Pages: 4450-4463
- DOI
  10.1093/nar/gkac246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07161
[Journal Article] Estrogen receptor α K303R mutation reorganizes its binding to forkhead box protein A1 regions and induces chromatin opening2022
- Author(s)
  Nakadai Tomoyoshi、Yang Liying、Kumegawa Kohei、Maruyama Reo
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 50 Issue: 2 Pages: 1209-1220
- DOI
  10.1007/s11033-022-08089-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07161, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20K07708
[Journal Article] Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts2021
- Author(s)
  Calvin Jon A Leonen, Miho Shimada, Caroline E Weller, Tomoyoshi Nakadai, Peter L Hsu, Elizabeth L Tyson, Arpit Mishra, Patrick Mm Shelton, Martin Sadilek, R David Hawkins, Ning Zheng, Robert G Roeder, Champak Chatterjee
- Journal Title
  
  eLife
  
  Volume: 8
- DOI
  10.7554/elife.67952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07651, KAKENHI-PROJECT-19K06482
[Journal Article] Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer2021
- Author(s)
  Kenichi Miyata, Yoshinori Imai, Satoshi Hori, Mika Nishio, Tze Mun Loo, Ryo Okada, Liying Yang, Tomoyoshi Nakadai, et. al.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2025647118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07651, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-20K16163, KAKENHI-PUBLICLY-20H04789, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-19H03507
[Journal Article] c-fos遺伝子の転写誘導時に起こるヒストンH,3リン酸化の誘導機構2007
- Author(s)
  嶋田, 美穂・中太, 智義・福田, 綾・久武, 幸司
- Journal Title
  
  実験医学 25
  
  Pages: 85-89
- Data Source
  KAKENHI-PROJECT-18055030
[Journal Article] The fission yeast protein, Ker1p, is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae, and is required for stable association of Rrn3p and RPA21 in Pol2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi Y
- Journal Title
  
  Journal of Biochemistry 280(12)
  
  Pages: 11467-11474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570148
[Journal Article] The fission yeast protein, Kerlp, is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae, and is required for stable association of Rm3p and RPA21 in Pol2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi Y
- Journal Title
  
  J. Biol. Chem 280・12
  
  Pages: 11467-11474
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570148
[Journal Article] The Fission Yeast Protein Kerlp Is an Ortholog of RNA Polymerase I Subunit A14 in Saccharomyces cerevisiae and Is Required for Stable Association of Rrn3p and RPA21 in RNA Polymerase I.2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi
- Journal Title
  
  Journal of Biological Chemistry 280・12
  
  Pages: 11467-11474
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] The Fission Yeast Protein Ker1p Is an Ortholog of RNA Polymerase I Subunit A14 in Saccharomyces cerevisiae and is Required for Stable Association of Rn3p and RPA21 in RNA Polymerase I.2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 11467-11474
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] The fission yeast protein, Kerlp, is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae, and is required for stable association of Rrn3p and RPA21 in Pol I.2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi Y
- Journal Title
  
  J.Biol.Chem 280・12
  
  Pages: 11467-11474
- Data Source
  KAKENHI-PROJECT-16570148
[Journal Article] The fission yeast protein, Ker1p, is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae, and is required for stable association of Rrn3p and RPA21 in Pol I.2005
- Author(s)
  Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi Y
- Journal Title
  
  J.Biol.Chem. 280・12
  
  Pages: 11467-11474
- Data Source
  KAKENHI-PROJECT-17054037
[Journal Article] Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP162004
- Author(s)
  Fukuda A, Nakadai T, Shimoda M, Tsukui T, Matsumoto M, Nogi Y, Meisterernst M, Hisatake K
- Journal Title
  
  Molecular and Cellular Biology 24
  
  Pages: 6525-6535
- Data Source
  KAKENHI-PROJECT-16570148
[Journal Article] Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP162004
- Author(s)
  Fukuda A, Nakadai T, Shimada M, Tsukui T, Matsumoto M, Nogi Y, Meisterernst M, Hisatake K
- Journal Title
  
  Molecular and Cellular Biology 24
  
  Pages: 6525-6535
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] TBP-like protein as a novel G2-check point factor.2004
- Author(s)
  Shimada M, Nakadai T, Tanaka Y, Mabuchi T, Park K, Tamura T
- Journal Title
  
  Recent Research of Developmental Cell Science 1
  
  Pages: 129-139
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF)2004
- Author(s)
  Nakadai T, Shimada M, Shima D, Handa H, Tamura TA
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 7447-7455
- Data Source
  KAKENHI-PROJECT-16770130
[Journal Article] Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein(TLP/TRF2/TLF)2004
- Author(s)
  Nakadai T, Shimoda M, Shima D, Handa H, Tamura TA
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 7447-7455
- Data Source
  KAKENHI-PROJECT-16570148
[Presentation] 癌て検出される多様な変異体ERaの分子機能異常性の網羅的解析と病的意義の解明2021
- Author(s)
  中太智義、粂川晃平、丸山玲緒
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07651
[Presentation] 癌で検出される多様な変異体ERαの網羅的解析と分子機能異常性の解明2021
- Author(s)
  中太智義、楊美麗、大塚裕美、粂川晃平、宮木里帆、丸山玲緒
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07651
[Presentation] Dissecting tumor heterogeneity and cancer cell plasticity in human breast cancer with chromatin accessibility profiling2021
- Author(s)
  丸山玲緒、粂川昂平、佐伯澄人、高橋洋子、中太智義、野田哲生、大野真司、上野貴之
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07708
[Presentation] scATAC-seq解析を用いた乳癌の多様性評価の試み2021
- Author(s)
  丸山玲緒、高橋洋子、佐伯澄人、楊麗英、宮木理帆、粂川昂平、中太智義、大野真司、上野貴之.
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-20K07708
[Presentation] Comprehensive analysis of mutant ERa detected in various cancers to reveal their aberrant molecular functions and pathological significances2020
- Author(s)
  中太智義
- Organizer
  第４３回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07651
[Presentation] ATAC-seq解析を用いた乳癌の多様性の評価2020
- Author(s)
  丸山玲緒、高橋洋子、佐伯澄人、楊麗英、中太智義、大野真司、上野貴之.
- Organizer
  第28回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07708
[Presentation] Comprehensive analysis of mutant ERa detected in various cancers to reveal their aberrant molecular functions and pathological significances2020
- Author(s)
  中太智義
- Organizer
  第７９回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07651
[Presentation] single-cell ATAC-seq解析による乳癌の腫瘍内不均一性評価の試み2020
- Author(s)
  粂川昂平、高橋洋子、佐伯澄人、楊麗英、尾辻和尊、中太智義、大野真司、上野貴之、丸山玲緒.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07708
[Presentation] 癌で検出される多様な変異体ERaの分子機能異常性の網羅的解析と病的意義の解明2019
- Author(s)
  中太智義、楊麗英、丸山玲緒
- Organizer
  日本分子生物学会第４２回年会
- Data Source
  KAKENHI-PROJECT-19K07651
[Presentation] c-fos遺伝子の転写調節機構の解析2007
- Author(s)
  福田綾・中太智義・嶋田美穂・久武幸司
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフイコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18055030

1. HISATAKE Koji (70271236)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. MARUYAMA Reo (60607985)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 嶋田美穂 (50383287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 高橋洋子 (70383809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

NAKADAI Tomoyoshi 中太 智義

Research Projects

Research Products

Co-Researchers

転移性乳癌で生じる多様な変異体タンパク質の機能異常性の網羅的解析と病的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stratification of breast cancer based on single-cell analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of mutant ERa found in cancers to reveal their aberrant functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規コアクチベーターによる転写過程の包括的調節機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NF複合体によるc-fos遺伝子のクロマチン修飾と発現制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

組み換え蛋白質によるRNAポリメラーゼII再構成と各サブユニットの新規機能の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel coactivator that activates the c-fos gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 転写因子・転写制御キーワードブック2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>SETD1A</scp> function in leukemia is mediated through interaction with mitotic regulators <scp>BuGZ</scp>/<scp>BUB3</scp>2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two target gene activation pathways for orphan ERR nuclear receptors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylated MED1 links transcription recycling and cancer growth2022

Author(s)

Journal Title

DOI

NAKADAI Tomoyoshi 中太智義