Nagakubo Daisuke 長久保大輔

… Alternative Names

NAGAKUBO Daisuke 長久保大輔

NAGAKUDO Daisuke 長久保大輔

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Researcher Number	10368293
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2022: 姫路獨協大学, 薬学部, 教授 2017: 滋賀医科大学, 医学部, 准教授 2007 – 2009: 近畿大学, 医学部, 助教 2005 – 2006: 近畿大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Experimental pathology / Immunology Except Principal Investigator Biological Sciences / Immunology / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator ケモカイン / 免疫学 / 上皮間葉転換 / 粘液 / 杯細胞 / 大腸 / 炎症 / CCL28 / 細胞浸潤 / 免疫細胞 / アレルギー性鼻炎 / 発現制御 / 発生・分化 … More Except Principal Investigator … More 制御性T細胞 / 転写因子 / ケモカイン受容体 / CCR4 / Ets-1 / IL-21 / CCR10 / Th2細胞 / 発がん遺伝子 / 白血病 / ATL / Vitamin D3 receptor / vitamin D / transcription factor / mucosal immunity / plasma cell / Ikaros / Ets / プローモーター / ケモカインレセプター / ビタミンDレセプター / ビタミンD / 粘膜免疫 / 形質細胞 / T細胞分化 / 胸腺 / ケモカイン / ブレオマイシン誘導肺線維症 / MDC / TARC / アトピー / 喘息 / アレルギー / Treg / Th2 / CCL22 / CCL17 / 原がん遺伝子 / GATA-3 / JunD / Fra-2 Less

Constructing a molecular basis for regulation of colonic mucus production and drug discoveryPrincipal Investigator
- Principal Investigator
  
  NAGAKUBO Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Himeji Dokkyo University
Elucidation and control of immune cell infiltration mechanism involved in the pathogenesis of allergic rhinitis.Principal Investigator
- Principal Investigator
  
  NAGAKUBO Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Himeji Dokkyo University
  Shiga University of Medical Science
Study on the pathophysiological role of the Th2-type chemokine receptor CCR4
- Principal Investigator
  
  YOSHIE Osamu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kinki University
ATLにおけるケモカイン受容体CCR4高頻度発現と発がん機構との関係の解明
- Principal Investigator
  
  義江修
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kinki University
ATLにおけるケモカイン受容体CCR4高頻度発現と発がん機構との関係
- Principal Investigator
  
  YOSHIE Osamu
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kinki University
生物種間で高度に保存されたケモカインBRAK/CXCL14の生理的機能の解明Principal Investigator
- Principal Investigator
  
  長久保大輔
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kinki University
Transcriptional regulation of CCR10 expression in plasma cells
- Principal Investigator
  
  YOSHIE Osamu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kinki Univeristy

All 2023 2022 2021 2020 2019 2018 2017 2009 2008 2007

All Journal Article Presentation

[Journal Article] The altered production and property of saliva induced by ingesting fermented food ingredients affect the oral microbiome composition in mice2023
- Author(s)
  Kaibori Y, Yamashita K, Nagakubo D
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 87 Issue: 2 Pages: 228-235
- DOI
  10.1093/bbb/zbac186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15336, KAKENHI-PROJECT-20K07456
[Journal Article] CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines.2023
- Author(s)
  Kaibori Y, Nagakubo D
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 30 Issue: 1 Pages: 137-148
- DOI
  10.1038/s41417-022-00532-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15336, KAKENHI-PROJECT-20K07456
[Journal Article] A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury2021
- Author(s)
  Okano Junko、Nakae Yuki、Nakagawa Takahiko、Katagi Miwako、Terashima Tomoya、Nagakubo Daisuke、Nakayama Takashi、Yoshie Osamu、Suzuki Yoshihisa、Kojima Hideto
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 5653-5653
- DOI
  10.1038/s41598-021-84818-1
- NAID
  120007009030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07456, KAKENHI-PROJECT-17K11537, KAKENHI-PROJECT-20K09862
[Journal Article] CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis2021
- Author(s)
  Matsuo Kazuhiko、Kitahata Kosuke、Kaibori Yuichiro、Arima Yuka、Iwama Arisa、Ito Mana、Hara Yuta、Nagakubo Daisuke、Quan Ying-Shu、Kamiyama Fumio、Oiso Naoki、Kawada Akira、Yoshie Osamu、Nakayama Takashi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: － Issue: 8 Pages: 1985-1994
- DOI
  10.1016/j.jid.2020.12.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07456, KAKENHI-PROJECT-20K08700, KAKENHI-PROJECT-21K15336
[Journal Article] A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model2020
- Author(s)
  Matsui Makoto、Nagakubo Daisuke、Satooka Hiroki、Hirata Takako
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 526 Issue: 3 Pages: 599-606
- DOI
  10.1016/j.bbrc.2020.03.122
- NAID
  120006839260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08785, KAKENHI-PROJECT-18K15183, KAKENHI-PROJECT-19K07621
[Journal Article] A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment2018
- Author(s)
  Yamamoto Shinya、Matsuo Kazuhiko、Nagakubo Daisuke、Higashiyama Shintaro、Nishiwaki Keiji、Oiso Naoki、Kawada Akira、Yoshie Osamu、Nakayama Takashi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 136 Issue: 3 Pages: 165-171
- DOI
  10.1016/j.jphs.2018.02.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08785
[Journal Article] CCR4 Is Critically Involved in Skin Allergic Inflammation of BALB/c Mice2018
- Author(s)
  Matsuo Kazuhiko、Nagakubo Daisuke、Komori Yuhei、Fujisato Shun、Takeda Natsumi、Kitamatsu Mizuki、Nishiwaki Keiji、Quan Ying-Shu、Kamiyama Fumio、Oiso Naoki、Kawada Akira、Yoshie Osamu、Nakayama Takashi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 138 Issue: 8 Pages: 1764-1773
- DOI
  10.1016/j.jid.2018.02.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08785
[Journal Article] CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon2017
- Author(s)
  Matsuo Kazuhiko、Nagakubo Daisuke、Yamamoto Shinya、Shigeta Akiko、Tomida Shuta、Fujita Mitsugu、Hirata Takako、Tsunoda Ikuo、Nakayama Takashi、Yoshie Osamu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 200 Issue: 2 Pages: 800-809
- DOI
  10.4049/jimmunol.1700037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08831, KAKENHI-PROJECT-17K08785, KAKENHI-PROJECT-16H07356
[Journal Article] アレルギー性鼻炎におけるCD4+ T細胞の動態制御機構2017
- Author(s)
  長久保　大輔
- Journal Title
  
  アレルギーの臨床
  
  Volume: 37 Pages: 60-62
- Data Source
  KAKENHI-PROJECT-17K08785
[Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: Functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.2009
- Author(s)
  Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
- Journal Title
  
  J. Immunol 183
  
  Pages: 5608-5614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390277
[Journal Article] Expression of CCL17 and CCL22 by latent membrane protein 1-positive tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder.2008
- Author(s)
  Takegawa S, Jin Z, Nakayama T, Oyama T, Hieshima K, Nagakubo D, Shirakawa AK, Tsuzuki T, Nakamura S, Yoshie O
- Journal Title
  
  Cancer Sci 99
  
  Pages: 296-302
- NAID
  10024002305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390277
[Journal Article] Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells.2008
- Author(s)
  Hieshima K, Nagakubo D, Nakayama T, Shirakawa AK, Jin Z, Yoshie O
- Journal Title
  
  J. Immunol 180
  
  Pages: 931-939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390277
[Journal Article] Differential regulatory function of resting and preactivated allergen-specific CD4+CD25+ regulatory T cells in Th2-type airway inflammation.2008
- Author(s)
  Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, Nagakubo D, Nitta N, Kanegasaki S, Hieshima K, Yoshie O, Gabazza EC, Katayama N, Shiku H, Kuribayashi K, Kato T
- Journal Title
  
  J. Immunol 181
  
  Pages: 6889-6897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390277
[Journal Article] Expression of CCR9 in HTLV-1+T cells an ATL cells expressing Tax2007
- Author(s)
  Nagakubo, D., 他10名
- Journal Title
  
  International Journal of Cancer 120(7)
  
  Pages: 1591-1597
- Data Source
  KAKENHI-PROJECT-18012047
[Presentation] ケモカインCCL28はHippo経路を介して大腸杯細胞分化を誘導する2022
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] ケモカインCCL28によるCCR10/YAP経路を介した大腸粘液産生機構の解明2022
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第68回　日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] ケモカイン受容体CCR3の阻害によるがん悪性化への影響2021
- Author(s)
  海堀　祐一郎、長久保　大輔
- Organizer
  第67回　日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] 乾癬モデルマウスにおけるTh17細胞増幅に対するCCR4の寄与2021
- Author(s)
  北畑　孝祐、松尾　一彦、海堀　祐一郎、長久保　大輔、義江　修、中山　隆志
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] 大腸杯細胞への分化におけるケモカインの関与2021
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第71回　日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] ケモカイン受容体CCR3の阻害によるがん悪性化機構の解明2021
- Author(s)
  海堀　祐一郎、長久保　大輔
- Organizer
  第94回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] ケモカイン受容体CCR4はメモリーTh17細胞増幅を介して乾癬発症に関与する2020
- Author(s)
  北畑　孝祐、松尾　一彦、海堀　祐一郎、長久保　大輔、義江　修、中山　隆志
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] ケモカインによる粘液・唾液生成制御機構の解析2020
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] 大腸粘液・唾液の産生メカニズムの解析2020
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第93回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] ケモカインによる大腸粘液産生機構の解析2020
- Author(s)
  海堀　祐一郎、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第70回　日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07456
[Presentation] CCR4 is involved in psoriasis pathogenesis by inducing Th17 cell proliferation and skin-migration.2019
- Author(s)
  Kitahata Kosuke、Matsuo Kazuhiko、Arima Yuka、Iwama Arisa、Nagakubo Daisuke、Yoshie Osamu、Nakayama Takashi
- Organizer
  第48回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] ケモカイン受容体 CCR4 を介した乾癬の病態形成メカニズムの解明2019
- Author(s)
  北畑　孝祐、松尾　一彦、有馬　優香、岩間　有咲、長久保　大輔、義江　修、中山　隆志
- Organizer
  第69回　日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] 唾液・粘液生成の制御機構の解析2019
- Author(s)
  海堀　祐一郎、小川　愛生、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第69回　日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] 腸管での粘液産生におけるケモカインCCL28の影響の検討2018
- Author(s)
  辰巳　蒼波、松尾　啓司、松尾　一彦、中山　隆志、長久保　大輔
- Organizer
  第68回　日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] Role of neutrophils in the nasal mucosa in a mouse model of allergic rhinitis2017
- Author(s)
  Matsui Makoto、Nagakubo Daisuke、Satooka Hiroki、Hirata Takako
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] Involvement of CCL28 in the pathogenesis of allergic rhinitis in a mouse model2017
- Author(s)
  Nagakubo Daisuke、Matsui Makoto、Satooka Hiroki、Sato Tomomi、Matsuo Kazuhiko、Yamamoto Shinya、Nakayama Takashi、Yoshie Osamu、Hirata Takako
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08785
[Presentation] T細胞依存性の好酸球性気道炎症に対するCCR4拮抗薬の作用2008
- Author(s)
  神沼修、大友隆之、森晶夫、長久保大輔、稗島州雄、義江修、鈴木一矢、廣井隆親
- Organizer
  第59回日本アレルギー学会秋季学術大会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-19390277
[Presentation] 加齢関連EBV+B細胞リンパ増殖症における多様なケモカインの発現2008
- Author(s)
  義江修、竹川澄男、中山隆志、白川愛子、樋口智紀、長久保大輔、重田暁子、稗島州雄、中村栄男
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390277
[Presentation] CCR4を発現するATLとCTCLにおけるFra-2の異常発現2008
- Author(s)
  中山隆志、樋口智紀、竹川澄男、長久保大輔、重田暁子、白川愛子、稗島州雄、義江修
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390277
[Presentation] O. Role of Fra-2/JunD heterodimer in CCR4 expression and cell proliferation in adult T-cell leukemia.2007
- Author(s)
  Nakayama, T., Hieshima, K., Jin, Z., Nagakubo, D., Shirakawa, A., Yoshie, O
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390277
[Presentation] HTLV-1 Tax誘導性ケモカインCCL22のHTLV-1初期感染における役割2007
- Author(s)
  稗島州雄、中山隆志、長久保大輔、白川愛子、金哲、義江修
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390277
[Presentation] Fra-2とJunDのヘテロダイマーはATL細胞におけるCCR4発現と細胞増殖を促進する2007
- Author(s)
  中山隆志、稗島州雄、金哲、長久保大輔、白川愛子、山田恭暉、藤井雅寛、義江修
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390277

1. YOSHIE Osamu (10166910)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. HIESHIMA Kunio (10322570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. NAKAYAMA Takashi (60319663)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
4. SHIRAKAWA Aiko (30260285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 稗島州男

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
6. 今野愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
7. 海堀祐一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 平田多佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagakubo Daisuke 長久保 大輔

NAGAKUBO Daisuke 長久保 大輔

NAGAKUDO Daisuke 長久保 大輔

Research Projects

Research Products

Co-Researchers

Constructing a molecular basis for regulation of colonic mucus production and drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation and control of immune cell infiltration mechanism involved in the pathogenesis of allergic rhinitis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the pathophysiological role of the Th2-type chemokine receptor CCR4

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ATLにおけるケモカイン受容体CCR4高頻度発現と発がん機構との関係の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ATLにおけるケモカイン受容体CCR4高頻度発現と発がん機構との関係

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生物種間で高度に保存されたケモカインBRAK/CXCL14の生理的機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional regulation of CCR10 expression in plasma cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The altered production and property of saliva induced by ingesting fermented food ingredients affect the oral microbiome composition in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment2018

Author(s)

Journal Title

DOI

Data Source

Nagakubo Daisuke 長久保大輔

NAGAKUBO Daisuke 長久保大輔

NAGAKUDO Daisuke 長久保大輔