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Kumada Kazuki  熊田 和貴

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KUMADA Kazuki  熊田 和貴

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Researcher Number 10370149
Other IDs
Affiliation (Current) 2025: 東北大学, 東北メディカル・メガバンク機構, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 東北大学, 東北メディカル・メガバンク機構, 教授
2013 – 2015: 沖縄科学技術大学院大学, G0細胞ユニット, 研究員
2011 – 2012: 公益財団法人がん研究会, がん研究所・実験病理部, 博士研究員
2011: 公益財団法人がん研究会, がん研究所・実験病理部, 研究員
2011: 公益財団法人がん研究会, がん研究所実験病理部, 研究員 … More
2011: 公益財団法人がん研究会がん研究所, 実験病理部, 博士研究員
2009 – 2010: Japanese Foundation For Cancer Research, 癌研究所細胞生物部, 研究員
2009: Japanese Foundation For Cancer Research, 細胞生物部, 研究員
2008: Japanese Foundation For Cancer Research, 細胞生物部, 研究員 Less
Review Section/Research Field
Principal Investigator
Genetics/Chromosome dynamics / Carcinogenesis / Cell biology
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Chemical biology / Molecular biology / Biological Sciences
Keywords
Principal Investigator
ゲノム不安定性 / 細胞周期 / 染色体分配 / 姉妹染色分体分離 / 姉妹染色体分離 / 細胞周期制御 / 形質転換 / プロテアーゼ / 癌 / 糖尿病 / 発がん / ノックアウトマウス / DNA損傷応答 … More
Except Principal Investigator
… More 染色体 / 細胞分裂 / 膵癌 / 微小管 / 染色体分配 / Aurora B / 動原体 / 分裂期キナーゼ / 肝転移 / 肺転移 / 癌微小環境 / 腫瘍免疫 / マルチオミックス解析 / 腫瘍微小環境 / 膵癌肺転移 / メタボローム / 遺伝学的リスク / 生活習慣病 / 胆道癌 / Plk1 / 異数性 / がん / 染色体動態 / キナーゼ阻害薬 / がん細胞 / M期 / 後期促進因子 / 紡錘体形成チェックポイント / 中期後期移行 / M期チェックポイント / FRAP解析 / 紡錘体チェックポイント / セントロメア / リン酸化 / コンデンシン / サイクリン依存性キナーゼ / コヒーシン複合体 / コンデンシン複合体 / Auroraキナーゼ / Poloキナーゼ / 紡錘体 Less
  • Research Projects

    (9 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (14 People)
  •  Advocacy for personalized treatment of pancreatic and biliary cancer based on genome evolution and expression type diversity

    • Principal Investigator
      海野 倫明
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Tohoku University
  •  Study regarding metabolomics of participants with higher genetic risk of life-style related diseases

    • Principal Investigator
      寳澤 篤
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
    • Research Institution
      Tohoku University
  •  膵癌肺転移及び腹膜播種の免疫微小環境をターゲットとした新規治療開発

    • Principal Investigator
      青木 修一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Tohoku University
  •  セパラーゼの自己切断による染色体分離の一斉性制御Principal Investigator

    • Principal Investigator
      熊田 和貴
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genetics/Chromosome dynamics
    • Research Institution
      Okinawa Institute of Science and Technology Graduate University
  •  A new method to evaluate the function of mitotic kinases by monitoring chromosome dynamics

    • Principal Investigator
      HIROTA Toru
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Chemical biology
    • Research Institution
      Japanese Foundation For Cancer Research
  •  The regulation of separase-securin in the maintenance of chromosomal stability, and its abnormality in cancer developmentPrincipal Investigator

    • Principal Investigator
      KUMADA Kazuki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Carcinogenesis
    • Research Institution
      公益財団法人がん研究会
      Japanese Foundation For Cancer Research
  •  Role of kinetochore stretching in controlling the spindle-assembly checkpoint

    • Principal Investigator
      HIROTA Toru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      公益財団法人がん研究会
      Japanese Foundation For Cancer Research
  •  Analysis of securin and separase functions in mammalian cell cycle regulation.Principal Investigator

    • Principal Investigator
      KUMADA Kazuki
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Control of mitotic apparatus by mitotic kinases

    • Principal Investigator
      HIROTA Toru
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      公益財団法人がん研究会・がん研究所
      Japanese Foundation For Cancer Research

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book Patent

  • [Book] Separase, Handbook of Proteolytic Enzymes, Third edition2013

    • Author(s)
      Kazuki Kumada, Toru Hirota
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Book] Review. Handbook of Proteolytic Enzymes. Third Edition, Edited by Rawlings and Salvesen, Elsevier.2012

    • Author(s)
      Kumada, K., and *Hirota, T
    • Publisher
      Separase
    • Data Source
      KAKENHI-PROJECT-23651243
  • [Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011

    • Author(s)
      Kumada, K., *Hirota, T.
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011

    • Author(s)
      Kumada, K., Hirota, T
    • Data Source
      KAKENHI-PROJECT-21370082
  • [Journal Article] Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition2012

    • Author(s)
      Shindo, N., Kumada, K., *Hirota, T
    • Journal Title

      Dev. Cell

      Volume: 23 Pages: 112-123

    • Data Source
      KAKENHI-PROJECT-23651243
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T., and *Hirota, T.
    • Journal Title

      J. Cell Biol.

      Volume: 184 Pages: 383-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T. Hirota, T.
    • Journal Title

      J. Cell Biol. 184

      Pages: 383-390

    • Data Source
      KAKENHI-PLANNED-19057008
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      K. S. Uchida, K. Takagaki, K. Kumada, Y. Hirayama, T. Noda and T. Hirota
    • Journal Title

      J. Cell Biol. 184

      Pages: 383-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Journal Article] Kinetochore stretching in activates the spindle assembly checkpoint.2009

    • Author(s)
      Uchida K, Takagaki K, Kumada K, Noda T, Hirota T,
    • Journal Title

      Journal of cell Biology 184

      Pages: 4188-4196

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint2009

    • Author(s)
      Uchida, K. S. K., Takagaki, K., Kumada, K, Noda, T., and Hirota, T
    • Journal Title

      J. Cell Biol

      Volume: 184 Pages: 384-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21370082
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      Uchida KS, Takagaki K, Kumada K, Hirayama Y, Noda T, Hirota T.
    • Journal Title

      Journal of Cell Biology. Vol.184

      Pages: 383-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007

    • Author(s)
      Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T
    • Journal Title

      J. Cell Sci. 120

      Pages: 4188-4196

    • Data Source
      KAKENHI-PLANNED-19057008
  • [Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007

    • Author(s)
      Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., and *Hirota, T.
    • Journal Title

      J. Cell Sci.

      Volume: 120 Pages: 4188-4196

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007

    • Author(s)
      Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., Hirota, T.
    • Journal Title

      Journal of Cell Science 120

      Pages: 4188-4196

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Patent] 細胞観察用蛍光プローブ、及びこれを使用する方法2013

    • Inventor(s)
      広田亨、進藤軌久、熊田和貴
    • Industrial Property Rights Holder
      広田亨、進藤軌久、熊田和貴
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Overseas
    • Data Source
      KAKENHI-PROJECT-25440183
  • [Patent] セパレース・バイオセンサー2012

    • Inventor(s)
      広田亨、進藤軌久、熊田和貴
    • Industrial Property Rights Holder
      公益財団法人がん研究会
    • Filing Date
      2012
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23651243
  • [Patent] セハレース・バイオセンサーに関する国際特許2012

    • Inventor(s)
      広田亨、進藤軌久、熊田和貴
    • Industrial Property Rights Holder
      広田亨、進藤軌久、熊田和貴
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-24
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23651243
  • [Presentation] Separaseの自己切断による染色体分配制御2012

    • Author(s)
      熊田和貴
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      秋保温泉ホテルニュー水戸屋(宮城)
    • Year and Date
      2012-01-27
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Presentation] Separaseの自己切断による染色体分配制御2012

    • Author(s)
      熊田和貴、広田亨
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      秋保温泉
    • Data Source
      KAKENHI-PROJECT-21370082
  • [Presentation] Separase の自己切断による染色体分配制御2012

    • Author(s)
      熊田和貴、広田 亨
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      (秋保温泉)
    • Data Source
      KAKENHI-PROJECT-23651243
  • [Presentation] Separase の自己切断による染色体分配制御2012

    • Author(s)
      熊田和貴, 広田 亨
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      秋保温泉
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Presentation] 変異securinタンパク質発現による染色体分配異常と細胞形質転換2011

    • Author(s)
      熊田和貴
    • Organizer
      第28回 染色体ワークショップ
    • Place of Presentation
      山代温泉 瑠璃光(石川)
    • Year and Date
      2011-01-12
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Presentation] 変異securinタンパク質発現による染色体分配異常と細胞形質転換2011

    • Author(s)
      熊田和貴
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      山代温泉瑠璃光(石川)
    • Year and Date
      2011-01-29
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Presentation] 変異securinタンパク質を発現することによる染色体不安定性と細胞の形質転換2010

    • Author(s)
      熊田和貴
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Presentation] 変異securinタンパク質を発現することによる染色体不安定性と細胞の形質転換2010

    • Author(s)
      熊田和貴
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-22700866
  • [Presentation] 変異securinタンパク質発現による形質転換と細胞周期異常2010

    • Author(s)
      熊田和貴
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場高原ホテルB.U.
    • Year and Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] 変異 securin タンパク質発現による形質転換と細胞周期異常2010

    • Author(s)
      熊田和貴
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場高原ホテルB.U.
    • Year and Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] 細胞周期・DNA損傷応答・細胞形質転換に対する変異 securin タンパク質発現の影響2009

    • Author(s)
      熊田和貴
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] separaseとsecurinのノックアウトマウスを用いた機能解析2009

    • Author(s)
      熊田和貴
    • Organizer
      第26回染色体ワークショップ
    • Place of Presentation
      ウェルサンピア姫路ゆめさき
    • Year and Date
      2009-01-27
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] 細胞周期・DNA損傷応答・細胞形質転換に対する変異securinタンパク質発現の影響2009

    • Author(s)
      熊田和貴
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] How cells silence the spindle assembly checkpoint.2009

    • Author(s)
      Uchida, K., Takagaki, K., Kumada, K., Hirota, T.
    • Organizer
      MEXT Priority Research, International Symposium “Cell Cycle and Cell Architecture”
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-02-27
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Presentation] separaseとsecurinのノックアウトマウスを用いた機能解析2009

    • Author(s)
      熊田和貴、野田哲生
    • Organizer
      第26回染色体ワークショップ
    • Place of Presentation
      兵庫県姫路市・ウエルサンピア姫路ゆめさき
    • Year and Date
      2009-01-27
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] 染色体腕部コヒーシン解離におけるセパレースの関与について2008

    • Author(s)
      中島真人, 熊田和貴, 野田哲生, 広田 亨
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PLANNED-19057008
  • [Presentation] 哺乳類セキュリンとセパラーゼはDNA損傷後の正常な細胞周期進行に強調して機能する2008

    • Author(s)
      熊田和貴、野田哲生
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市・名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20770162
  • [Presentation] 哺乳類セキュリンとセパラーゼはDNA損傷後の正常な細胞周期進行に協調して機能する2008

    • Author(s)
      熊田和貴
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20770162
  • 1.  HIROTA Toru (50421368)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 2.  UCHIDA Kazuhiko (40380555)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  SHINDO Norihisa (00512253)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  高垣 謙太郎 (70419951)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  青木 修一 (30844451)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  ABE Yusuke (50615896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  海野 倫明 (70282043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  安田 純 (00281684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  古川 徹 (30282122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  寳澤 篤 (00432302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小柴 生造 (70332301)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  井上 亨悦 (30912711)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  松居 彩 (40609632)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  村上 圭吾 (60742707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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