Kumada Kazuki 熊田和貴

… Alternative Names

KUMADA Kazuki 熊田和貴

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Researcher Number	10370149
Other IDs
Affiliation (Current)	2025: 東北大学, 東北メディカル・メガバンク機構, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 東北メディカル・メガバンク機構, 教授 2013 – 2015: 沖縄科学技術大学院大学, G0細胞ユニット, 研究員 2011 – 2012: 公益財団法人がん研究会, がん研究所・実験病理部, 博士研究員 2011: 公益財団法人がん研究会, がん研究所・実験病理部, 研究員 2011: 公益財団法人がん研究会, がん研究所実験病理部, 研究員 … More 2011: 公益財団法人がん研究会がん研究所, 実験病理部, 博士研究員 2009 – 2010: Japanese Foundation For Cancer Research, 癌研究所細胞生物部, 研究員 2009: Japanese Foundation For Cancer Research, 細胞生物部, 研究員 2008: Japanese Foundation For Cancer Research, 細胞生物部, 研究員 Less
Review Section/Research Field	Principal Investigator Genetics/Chromosome dynamics / Carcinogenesis / Cell biology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Chemical biology / Molecular biology / Biological Sciences
Keywords	Principal Investigator ゲノム不安定性 / 細胞周期 / 染色体分配 / 姉妹染色分体分離 / 姉妹染色体分離 / 細胞周期制御 / 形質転換 / プロテアーゼ / 癌 / 糖尿病 / 発がん / ノックアウトマウス / DNA損傷応答 … More Except Principal Investigator … More 染色体 / 細胞分裂 / 膵癌 / 微小管 / 染色体分配 / Aurora B / 動原体 / 分裂期キナーゼ / 肝転移 / 肺転移 / 癌微小環境 / 腫瘍免疫 / マルチオミックス解析 / 腫瘍微小環境 / 膵癌肺転移 / メタボローム / 遺伝学的リスク / 生活習慣病 / 胆道癌 / Plk1 / 異数性 / がん / 染色体動態 / キナーゼ阻害薬 / がん細胞 / M期 / 後期促進因子 / 紡錘体形成チェックポイント / 中期後期移行 / M期チェックポイント / FRAP解析 / 紡錘体チェックポイント / セントロメア / リン酸化 / コンデンシン / サイクリン依存性キナーゼ / コヒーシン複合体 / コンデンシン複合体 / Auroraキナーゼ / Poloキナーゼ / 紡錘体 Less

Advocacy for personalized treatment of pancreatic and biliary cancer based on genome evolution and expression type diversity
- Principal Investigator
  
  海野倫明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Study regarding metabolomics of participants with higher genetic risk of life-style related diseases
- Principal Investigator
  
  寳澤篤
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Tohoku University
膵癌肺転移及び腹膜播種の免疫微小環境をターゲットとした新規治療開発
- Principal Investigator
  
  青木修一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
セパラーゼの自己切断による染色体分離の一斉性制御Principal Investigator
- Principal Investigator
  
  熊田和貴
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Okinawa Institute of Science and Technology Graduate University
A new method to evaluate the function of mitotic kinases by monitoring chromosome dynamics
- Principal Investigator
  
  HIROTA Toru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Japanese Foundation For Cancer Research
The regulation of separase-securin in the maintenance of chromosomal stability, and its abnormality in cancer developmentPrincipal Investigator
- Principal Investigator
  
  KUMADA Kazuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  公益財団法人がん研究会
   Japanese Foundation For Cancer Research
Role of kinetochore stretching in controlling the spindle-assembly checkpoint
- Principal Investigator
  
  HIROTA Toru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  公益財団法人がん研究会
   Japanese Foundation For Cancer Research
Analysis of securin and separase functions in mammalian cell cycle regulation.Principal Investigator
- Principal Investigator
  
  KUMADA Kazuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Japanese Foundation For Cancer Research
Control of mitotic apparatus by mitotic kinases
- Principal Investigator
  
  HIROTA Toru
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  公益財団法人がん研究会・がん研究所
   Japanese Foundation For Cancer Research

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] Separase, Handbook of Proteolytic Enzymes, Third edition2013
- Author(s)
  Kazuki Kumada, Toru Hirota
- Data Source
  KAKENHI-PROJECT-22700866
[Book] Review. Handbook of Proteolytic Enzymes. Third Edition, Edited by Rawlings and Salvesen, Elsevier.2012
- Author(s)
  Kumada, K., and *Hirota, T
- Publisher
  Separase
- Data Source
  KAKENHI-PROJECT-23651243
[Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011
- Author(s)
  Kumada, K., *Hirota, T.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PLANNED-19057008
[Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011
- Author(s)
  Kumada, K., Hirota, T
- Data Source
  KAKENHI-PROJECT-21370082
[Journal Article] Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition2012
- Author(s)
  Shindo, N., Kumada, K., *Hirota, T
- Journal Title
  
  Dev. Cell
  
  Volume: 23 Pages: 112-123
- Data Source
  KAKENHI-PROJECT-23651243
[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009
- Author(s)
  Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T., and *Hirota, T.
- Journal Title
  
  J. Cell Biol.
  
  Volume: 184 Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057008
[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009
- Author(s)
  Uchida, K.S.K., Takagaki, K., Kumada, K,, Noda, T. Hirota, T.
- Journal Title
  
  J. Cell Biol. 184
  
  Pages: 383-390
- Data Source
  KAKENHI-PLANNED-19057008
[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009
- Author(s)
  K. S. Uchida, K. Takagaki, K. Kumada, Y. Hirayama, T. Noda and T. Hirota
- Journal Title
  
  J. Cell Biol. 184
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770162
[Journal Article] Kinetochore stretching in activates the spindle assembly checkpoint.2009
- Author(s)
  Uchida K, Takagaki K, Kumada K, Noda T, Hirota T,
- Journal Title
  
  Journal of cell Biology 184
  
  Pages: 4188-4196
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057008
[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint2009
- Author(s)
  Uchida, K. S. K., Takagaki, K., Kumada, K, Noda, T., and Hirota, T
- Journal Title
  
  J. Cell Biol
  
  Volume: 184 Pages: 384-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370082
[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009
- Author(s)
  Uchida KS, Takagaki K, Kumada K, Hirayama Y, Noda T, Hirota T.
- Journal Title
  
  Journal of Cell Biology. Vol.184
  
  Pages: 383-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770162
[Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007
- Author(s)
  Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, J.M., Hirota, T
- Journal Title
  
  J. Cell Sci. 120
  
  Pages: 4188-4196
- Data Source
  KAKENHI-PLANNED-19057008
[Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007
- Author(s)
  Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., and *Hirota, T.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 120 Pages: 4188-4196
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057008
[Journal Article] The complete removal of cohesin from chromosome arms depends on separase.2007
- Author(s)
  Nakajima, M., Kumada, K., Hatakeyama, K., Noda, T., Peters, JM., Hirota, T.
- Journal Title
  
  Journal of Cell Science 120
  
  Pages: 4188-4196
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057008
[Patent] 細胞観察用蛍光プローブ、及びこれを使用する方法2013
- Inventor(s)
  広田亨、進藤軌久、熊田和貴
- Industrial Property Rights Holder
  広田亨、進藤軌久、熊田和貴
- Industrial Property Rights Type
  特許
- Filing Date
  2013
- Overseas
- Data Source
  KAKENHI-PROJECT-25440183
[Patent] セパレース・バイオセンサー2012
- Inventor(s)
  広田亨、進藤軌久、熊田和貴
- Industrial Property Rights Holder
  公益財団法人がん研究会
- Filing Date
  2012
- Overseas
- Data Source
  KAKENHI-PROJECT-23651243
[Patent] セハレース・バイオセンサーに関する国際特許2012
- Inventor(s)
  広田亨、進藤軌久、熊田和貴
- Industrial Property Rights Holder
  広田亨、進藤軌久、熊田和貴
- Industrial Property Rights Type
  特許
- Filing Date
  2012-07-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23651243
[Presentation] Separaseの自己切断による染色体分配制御2012
- Author(s)
  熊田和貴
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  秋保温泉ホテルニュー水戸屋(宮城)
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-22700866
[Presentation] Separaseの自己切断による染色体分配制御2012
- Author(s)
  熊田和貴、広田亨
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  秋保温泉
- Data Source
  KAKENHI-PROJECT-21370082
[Presentation] Separase の自己切断による染色体分配制御2012
- Author(s)
  熊田和貴、広田亨
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  (秋保温泉)
- Data Source
  KAKENHI-PROJECT-23651243
[Presentation] Separase の自己切断による染色体分配制御2012
- Author(s)
  熊田和貴, 広田亨
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  秋保温泉
- Data Source
  KAKENHI-PLANNED-19057008
[Presentation] 変異securinタンパク質発現による染色体分配異常と細胞形質転換2011
- Author(s)
  熊田和貴
- Organizer
  第28回染色体ワークショップ
- Place of Presentation
  山代温泉瑠璃光(石川)
- Year and Date
  2011-01-12
- Data Source
  KAKENHI-PROJECT-22700866
[Presentation] 変異securinタンパク質発現による染色体分配異常と細胞形質転換2011
- Author(s)
  熊田和貴
- Organizer
  第28回染色体ワークショップ
- Place of Presentation
  山代温泉瑠璃光(石川)
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22700866
[Presentation] 変異securinタンパク質を発現することによる染色体不安定性と細胞の形質転換2010
- Author(s)
  熊田和貴
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22700866
[Presentation] 変異securinタンパク質を発現することによる染色体不安定性と細胞の形質転換2010
- Author(s)
  熊田和貴
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22700866
[Presentation] 変異securinタンパク質発現による形質転換と細胞周期異常2010
- Author(s)
  熊田和貴
- Organizer
  第27回染色体ワークショップ
- Place of Presentation
  御殿場高原ホテルB.U.
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] 変異 securin タンパク質発現による形質転換と細胞周期異常2010
- Author(s)
  熊田和貴
- Organizer
  第27回染色体ワークショップ
- Place of Presentation
  御殿場高原ホテルB.U.
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] 細胞周期・DNA損傷応答・細胞形質転換に対する変異 securin タンパク質発現の影響2009
- Author(s)
  熊田和貴
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] separaseとsecurinのノックアウトマウスを用いた機能解析2009
- Author(s)
  熊田和貴
- Organizer
  第26回染色体ワークショップ
- Place of Presentation
  ウェルサンピア姫路ゆめさき
- Year and Date
  2009-01-27
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] 細胞周期・DNA損傷応答・細胞形質転換に対する変異securinタンパク質発現の影響2009
- Author(s)
  熊田和貴
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] How cells silence the spindle assembly checkpoint.2009
- Author(s)
  Uchida, K., Takagaki, K., Kumada, K., Hirota, T.
- Organizer
  MEXT Priority Research, International Symposium “Cell Cycle and Cell Architecture”
- Place of Presentation
  Nagoya
- Year and Date
  2009-02-27
- Data Source
  KAKENHI-PLANNED-19057008
[Presentation] separaseとsecurinのノックアウトマウスを用いた機能解析2009
- Author(s)
  熊田和貴、野田哲生
- Organizer
  第26回染色体ワークショップ
- Place of Presentation
  兵庫県姫路市・ウエルサンピア姫路ゆめさき
- Year and Date
  2009-01-27
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] 染色体腕部コヒーシン解離におけるセパレースの関与について2008
- Author(s)
  中島真人, 熊田和貴, 野田哲生, 広田亨
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PLANNED-19057008
[Presentation] 哺乳類セキュリンとセパラーゼはDNA損傷後の正常な細胞周期進行に強調して機能する2008
- Author(s)
  熊田和貴、野田哲生
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市・名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20770162
[Presentation] 哺乳類セキュリンとセパラーゼはDNA損傷後の正常な細胞周期進行に協調して機能する2008
- Author(s)
  熊田和貴
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20770162

1. HIROTA Toru (50421368)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. UCHIDA Kazuhiko (40380555)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. SHINDO Norihisa (00512253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 高垣謙太郎 (70419951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 青木修一 (30844451)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ABE Yusuke (50615896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 海野倫明 (70282043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安田純 (00281684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 古川徹 (30282122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 寳澤篤 (00432302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小柴生造 (70332301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 井上亨悦 (30912711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松居彩 (40609632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 村上圭吾 (60742707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kumada Kazuki 熊田 和貴

KUMADA Kazuki 熊田 和貴

Research Projects

Research Products

Co-Researchers

Advocacy for personalized treatment of pancreatic and biliary cancer based on genome evolution and expression type diversity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study regarding metabolomics of participants with higher genetic risk of life-style related diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵癌肺転移及び腹膜播種の免疫微小環境をターゲットとした新規治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

セパラーゼの自己切断による染色体分離の一斉性制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new method to evaluate the function of mitotic kinases by monitoring chromosome dynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation of separase-securin in the maintenance of chromosomal stability, and its abnormality in cancer developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of kinetochore stretching in controlling the spindle-assembly checkpoint

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of securin and separase functions in mammalian cell cycle regulation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of mitotic apparatus by mitotic kinases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Separase, Handbook of Proteolytic Enzymes, Third edition2013

Author(s)

Data Source

[Book] Review. Handbook of Proteolytic Enzymes. Third Edition, Edited by Rawlings and Salvesen, Elsevier.2012

Author(s)

Publisher

Data Source

[Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011

Author(s)

Publisher

Data Source

[Book] Separase. Review. Handbook of Proteolytic Enzymes 3rd Edition2011

Author(s)

Data Source

[Journal Article] Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition2012

Author(s)

Journal Title

Data Source

[Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

Author(s)

Journal Title

Kumada Kazuki 熊田和貴

KUMADA Kazuki 熊田和貴