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Totoki Yasushi  十時 泰

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… Alternative Names

TOTOKI Yasushi  十時 泰

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Researcher Number 10373333
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2024: 大阪大学, 大学院医学系研究科, 准教授
2016: 国立研究開発法人国立がん研究センター研究所, がんゲノミクス研究分野, ユニット長
2015: 国立研究開発法人国立がん研究センター, 研究所がんゲノミクス研究分野, ユニット長
2012: 独立行政法人国立がん研究センター, 研究所, ユニット長
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related
Except Principal Investigator
Gastroenterology / Medical genome science / Medical genome science
Keywords
Principal Investigator
癌予防 / リスク因子 / 変異シグネチャー / 変異原 / 胆道癌
Except Principal Investigator
融合遺伝子 / トランスクリプトーム / 分子標的 / 治療標的遺伝子 / 分子診断 … More / 胆道がん / 癌の個性診断 / 分子標的治療 / 発現異常 / 治療標的分子 / 胃癌 / ゲノム構造異常解析 / 遺伝子変異 / 個別化医療 / エクソンシークエンス / リンパ節転移 / 乳癌 Less
  • Research Projects

    (4 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (11 People)
  •  胆道癌の日本人特有な変異原と発癌要因の解明Principal Investigator

    • Principal Investigator
      十時 泰
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka University
  •  Whole transcriptome analysis and novel therapeutic targets in biliary tract cancer

    • Principal Investigator
      Arai Yasuhito
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      National Cancer Center Japan
  •  Identification of novel fusion genes in gastric cancer by whole transcriptome sequencing: Discovery of potential therapeutic targets for gastric cancer

    • Principal Investigator
      Hosoda Fumie
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical genome science
    • Research Institution
      National Cancer Center Japan
  •  Studies on cancer genomics to develop personalized therapy and medicine in breast cancer: Whole exome sequencing analysis of primary breast cancer and its metastatic tumor.

    • Principal Investigator
      HOSODA Fumie
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical genome science
    • Research Institution
      National Cancer Center Japan

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.2015

    • Author(s)
      Shirota T, Ojima H, Hiraoka N, Shimada K, Rokutan H, Arai Y, Kanai Y, Miyagawa S, Shibata T.
    • Journal Title

      Mol Cancer Ther.

      Volume: 14 Issue: 9 Pages: 1985-93

    • DOI

      10.1038/ng.3375

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460501, KAKENHI-PROJECT-26461040, KAKENHI-PROJECT-25290074
  • [Journal Article] Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma.2014

    • Author(s)
      Arai Y, Totoki Y, Hosoda F, Shirota T, Hama N, Nakamura H, Ojima, Furuta K, Shimada K, Okusaka T, Kosuge T, Shibata T.
    • Journal Title

      Hepatology

      Volume: 59 Issue: 4 Pages: 1427-1434

    • DOI

      10.1002/hep.26890

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461040
  • [Journal Article] Mouse Model for ROS1-Rearranged Lung Cancer.2013

    • Author(s)
      Arai Y, Totoki Y, Takahashi H, Nakamura H, Hama N, Kohno T, Tsuta K, Yoshida A, Asamura H, Mutoh M, Hosoda F, Tsuda H, Shibata T
    • Journal Title

      PLoS One

      Volume: 8(2) Issue: 2 Pages: e56010-e56010

    • DOI

      10.1371/journal.pone.0056010

    • Data Source
      KAKENHI-PROJECT-22310123
  • [Journal Article] Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.2012

    • Author(s)
      Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H
    • Journal Title

      Nature Genetic

      Volume: 44 Issue: 7 Pages: 760-764

    • DOI

      10.1038/ng.2291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22310123, KAKENHI-PROJECT-24659368, KAKENHI-PLANNED-22116010, KAKENHI-PLANNED-22134004, KAKENHI-PLANNED-22134008
  • [Journal Article] High-resolution characterization of a hepatocellular carcinoma genome2011

    • Author(s)
      Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S,Sonoda K, Totsuka H, Shirakihara T,Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kusuda J, Yoshida T, Aburatani H & S h i b a t a T
    • Journal Title

      Nat Genet

      Volume: 43(5) Issue: 5 Pages: 464-9

    • DOI

      10.1038/ng.804

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20221009, KAKENHI-PROJECT-22310123
  • [Presentation] Oncogenic driver fusion genes in biliary tract cancer2016

    • Author(s)
      新井康仁、中村浩実、十時 泰、濱 奈津子、尾島英知、細田文恵、島田和明、森実千種、奥坂拓志、柴田龍弘
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26461040
  • [Presentation] Identification of novel fusion genes in 218 gastric primary cancers by paired-end RNA sequencing.2015

    • Author(s)
      Hosoda F, Totoki Y, Rokutan H, Hama N, Arai Y, Taniguchi H, Shibata T.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25290074
  • [Presentation] High-throughput sequencing analysis uncovers actionable molecular alterations in cholangiocarcinoma.2015

    • Author(s)
      Arai Y, Nakamura H, Totoki Y, Shirota T, Hama N, Ojima H, Hosoda F, Shimada K, Morizane C, Okusaka T, Shibata T.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-25290074
  • [Presentation] 網羅的シークエンス解析による胆管がん分子標的の同定2015

    • Author(s)
      新井康仁、中村浩実、十時 泰、代田智樹、濱 奈津子、尾島英知、細田文恵、島田和明、森実千種、奥坂拓志、柴田龍弘
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26461040
  • [Presentation] 乳がん原発巣とリンパ節転移巣における遺伝的変異の解析2012

    • Author(s)
      細田文恵、十時 泰、新井康仁、津田 均、 井本逸勢、稲澤譲治、大木 操、柴田龍弘
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-09-21
    • Data Source
      KAKENHI-PROJECT-22310123
  • [Presentation] Comparison of genetic alterations in primary breast cancer and its metastatic tumor2011

    • Author(s)
      Hosoda F, Totoki Y, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22310123
  • [Presentation] Comparison of genetic alterations in primary breast cancer and its metastatic tumor.2011

    • Author(s)
      Hosoda F, Totoki Y, Arai Y, Tsuda H, Imoto I, Inazawa J, Ohki M, Shibata T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22310123
  • [Presentation] 全ゲノムシークエンスによる肝癌のゲノム構造異常解析2010

    • Author(s)
      山本尚吾、十時 泰、薗田幸太郎、細田 文恵、白木原琢哉、辰野健二、柴田龍弘、油 谷浩幸
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-22310123
  • [Presentation] Identification of aberrant long non-coding RNA transcripts in gastric cancer

    • Author(s)
      Hosoda F, Totoki Y, Arai Y, Hama N, Taniguchi H, Shibata T
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-25290074
  • [Presentation] 胆管がんにおける分子標的としてのFGFR2融合遺伝子の同定

    • Author(s)
      新井康仁、十時 泰、細田文恵、代田智樹、濱 奈津子、中村浩実、尾島英知、古田 耕、島田和明、小菅智男、森実千種、奥坂拓志、柴田龍弘
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26461040
  • 1.  SHIBATA Tatsuhiro (90311414)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 2.  HOSODA Fumie (30219191)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 3.  ARAI Yasuhito (80222727)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  TSUDA Hitoshi (70217321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  TANIGUCHI Hirokazu (30415525)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  谷内田 真一 (20359920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ROKUTAN Hirofumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  堤 修一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  石川 俊平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  油谷 浩幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  尾島 英知
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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