NISHIMURA Osamu 西村紀

Researcher Number	10374125
Other IDs
Affiliation (based on the past Project Information) *help	2008: 大阪大学, 蛋白質研究所, 特任教授 2008: 大阪大学, 蛋白質研究所寄付研究部門, 教授 2007: (株)島津製作所, ライフサイエンス研究所, 所長
Review Section/Research Field	Except Principal Investigator General surgery / Living organism molecular science
Keywords	Except Principal Investigator プロテオミクス / 基盤整備 / 個別化医療 / 分子診断 / 大規模症例登録 / バイオマーカー / 臨床応用 / DNAチップ / 個別医療 / 消化器がん … More / C末端標識 / 活性エステル / C末端アミノ酸配列分析 / タンパク質のC末端 / Terminal Proteomics / ペプチド化学 / タンパク質 / アミノ酸配列解析 / Terminus proteomics / 翻訳後修飾 / オキサゾロン / 質量分析 / MALDI-MS / 化学修飾 / C末端アミノ酸配列解析 Less

Synthetic strategy for clinical application of personalized medicinefor gastrointestinal cancers
- Principal Investigator
  
  MONDEN Morito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Development of the method for proteome analysis based on a novel chemical derivatization specific to C-termini of proteins
- Principal Investigator
  
  NAKAZAWA Takashi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Nara Women's University

All 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Selective isolation of N-terminal peptides from proteins and their de novo sequencing by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry without regard to unblocking or blocking of N-terminal amino acids2008
- Author(s)
  Minoru Yamaguchi, Daisuke Nakayama, Keisuke Shima, Hiroki Kuyama, Eiji Ando, Taka-aki Okamura, Norikazu Ueyama, Takashi Nakazawa, Shigemi Norioka, Osamu Nishimura, and Susumu Tsunasawa
- Journal Title
  
  Rapid Commun. Mass Spectrom 22
  
  Pages: 3313-3319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310146
[Journal Article] Terminal proteomics : N-and C-terminal analyses for high-fidelity identification of proteins using mass spectrometry2008
- Author(s)
  Takashi Nakazawa, Minoru Yamaguchi, Taka-aki Okamura, Eiji Ando, Osamu Nishimura, and Susumu Tsunasawa
- Journal Title
  
  Proteomics 8
  
  Pages: 673-685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310146
[Journal Article] An Application of the 2-Nitrobenzenesulfenyl(NBS) Method to Proteomic Profiling of Human Colorectal Carcinoma: A Novel Approach for Biomarker Discovery2008
- Author(s)
  Watanabe M., Takemasa I. Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden., Nishimura O.
- Journal Title
  
  PROTEOMICS-Clinical Applications (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209042
[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008
- Author(s)
  Watanabe M., Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
- Journal Title
  
  Proteomics Clin Appl 2
  
  Pages: 925-935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209042
[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008
- Author(s)
  Watanabe M.,Takemasa I., Kawaguchi N., Miyake M., Nishimura N., Matsubara T., Matsuo E., Sekimoto M., Nagai K., Matsuura N., Monden M., Nishimura O.
- Journal Title
  
  Proteomics Clin Appl.
  
  Pages: 925-935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209042
[Journal Article] Specific isolation of N-terminal fragments from proteins and their high-fidelity de novo sequencing2007
- Author(s)
  Minoru Yamaguchi, Takashi Obama, Hiroki Kuyama, Daisuke Nakayama, Eiji Ando, Taka-aki Okamura, Norikazu Ueyama, Takashi Nakazawa, Shigemi Norioka, Osamu Nishimura, and Susumu Tsunasawa
- Journal Title
  
  Rapid Commun. Mass Spectrom 21
  
  Pages: 3329-3326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310146
[Journal Article] Enhancement of MALDI-MS spectra of Cterminal peptides by the modification of proteins via an active ester generated in situ from an oxazolone2006
- Author(s)
  Minoru Yamaguchi, Mutsumi Oka, Kimiko Nishida, Mayu Ishida, Ayako Hamazaki, Hiroki Kuyama, Eiji Ando, Taka-aki Okamura, Norikazu Ueyama, Shigemi Norioka, Osamu Nishimura, Susumu Tsunasawa, and Takashi Nakazawa
- Journal Title
  
  Anal. Chem. 78
  
  Pages: 7861-7869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310146
[Journal Article] A new approach for detecting C-terminal amidation of proteins and peptides by mass spectrometry in conjunction with chemical derivatization
- Author(s)
  Hiroki Kuyama, Chihiro Nakajima, Takashi Nakazawa, Osamu Nishimura, and Susumu Tsunasawa
- Journal Title
  
  Proteomics, 9 (in press)
- NAID
  40017076671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] Isolation of C-terminal peptides of proteins by exhaustive amidation followed by proteolytic digestion for sequencing with mass spectrometry2008
- Author(s)
  Mariko Nakagawa, Minoru Yamaguchi, Hiroki Kuyama, Chihiro Nakajima, Eiji Ando, Susumu Tsunasawa, Osamu Nishimura, and Takashi Nakazawa
- Organizer
  17^<th> Meeting of Methods in Proteins Structure Analysis
- Place of Presentation
  北海道大学
- Year and Date
  2008-08-27
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] NBS法による大腸癌組織を用いた新規転移関連蛋白の検討2008
- Author(s)
  徳岡優佳、竹政伊知朗、渡辺真、三宅正和、人羅俊貴、野村昌哉、池田正孝、山本浩文、関本貢嗣、西村紀、門田守人
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19209042
[Presentation] Isolation of C-terminal peptides of proteins by exhaustive amidation followed by proteolytic digestion for mass spectrometric sequencing2008
- Author(s)
  Mariko Nakagawa, Minoru Yamaguchi, Hiroki Kuyama, Eiji Ando, Susumu Tsunasawa, Osamu Nishimura, and Takashi Nakazawa
- Organizer
  56^<th> ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] Isolation and mass spectrometric sequencing of C-terminal peptides based on exhaustive amidation of proteins2008
- Author(s)
  Mariko Nakagawa, Minoru Yamaguchi, Hiroki Kuyama, Chihiro Nakajima, Susumu Tsunasawa, Osamu Nishimura, Eiji Ando, and Takashi Nakazawa
- Organizer
  BMB2007(第31回日本分子生物学会・第81回日本生化学会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] MALDI-MSを用いたタンパク質のC末端ヒドラジド化によるアミノ酸配列解析法2007
- Author(s)
  中島ちひろ, 中川真理子, 水谷文, 辻智恵美, 岡むつみ, 山口実, 綱澤進, 西村紀, 中沢隆
- Organizer
  BMB2007(第30回日本分子生物学会・第80回日本生化学会合同大会)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] NBS法を用いた新規プロテーム解析-大腸癌のタンパクプロファイル解析-2007
- Author(s)
  竹政伊知朗、渡辺真、三宅正和、徳岡優佳、人羅俊貴、池田正孝、山本浩文、関本貢嗣、松浦成昭、西村紀、永井克、門田守人
- Organizer
  第18回日本消化器癌発生学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19209042
[Presentation] MALDI質量分析のためのC末端ヒドラジド化に基づくペプチドの標識法2007
- Author(s)
  中川真理子,中島ちひろ, 山口実, 岡むつみ, 辻智恵美, 九山浩樹, 安藤英治, 岡村高明, 綱澤進, 西村紀, 中沢隆
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  東北大学
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PROJECT-18310146
[Presentation] C-Terminal Derivatization of proteins via hydrazides for sequencing with MALDI-MS2007
- Author(s)
  Takashi Nakazawa, Minoru Yamaguchi, Mariko Nakagawa, Mutsumi Oka, Chihiro Nakajima, Hiroki Kuyama, Eiji Ando, Daisuke Nakayama, Taka-aki Okamura, Osamu Nishimura, and Susumu Tsunasawa
- Organizer
  55^<th> ASMS Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  Indianapolis, Indiana, USA
- Year and Date
  2007-06-05
- Data Source
  KAKENHI-PROJECT-18310146

1. NAKAZAWA Takashi (30175492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. KUYAMA Hiroki (60437332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. MONDEN Morito (00127309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. SEKIMOTO Mitugu (10273658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. DOKI Yuichiro (20291445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKEMASA Ichiro (50379252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. DONO Keizo (60283769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. GASKELL Simonj

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NISHIMURA Osamu 西村 紀

Research Projects

Research Products

Co-Researchers

Synthetic strategy for clinical application of personalized medicinefor gastrointestinal cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the method for proteome analysis based on a novel chemical derivatization specific to C-termini of proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selective isolation of N-terminal peptides from proteins and their de novo sequencing by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry without regard to unblocking or blocking of N-terminal amino acids2008

Author(s)

Journal Title

Data Source

[Journal Article] Terminal proteomics : N-and C-terminal analyses for high-fidelity identification of proteins using mass spectrometry2008

Author(s)

Journal Title

Data Source

[Journal Article] An Application of the 2-Nitrobenzenesulfenyl(NBS) Method to Proteomic Profiling of Human Colorectal Carcinoma: A Novel Approach for Biomarker Discovery2008

Author(s)

Journal Title

Data Source

[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008

Author(s)

Journal Title

Data Source

[Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery.2008

Author(s)

Journal Title

Data Source

[Journal Article] Specific isolation of N-terminal fragments from proteins and their high-fidelity de novo sequencing2007

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of MALDI-MS spectra of Cterminal peptides by the modification of proteins via an active ester generated in situ from an oxazolone2006

Author(s)

Journal Title

Data Source

[Journal Article] A new approach for detecting C-terminal amidation of proteins and peptides by mass spectrometry in conjunction with chemical derivatization

Author(s)

Journal Title

NAID

Data Source

[Presentation] Isolation of C-terminal peptides of proteins by exhaustive amidation followed by proteolytic digestion for sequencing with mass spectrometry2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] NBS法による大腸癌組織を用いた新規転移関連蛋白の検討2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Isolation of C-terminal peptides of proteins by exhaustive amidation followed by proteolytic digestion for mass spectrometric sequencing2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Isolation and mass spectrometric sequencing of C-terminal peptides based on exhaustive amidation of proteins2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] MALDI-MSを用いたタンパク質のC末端ヒドラジド化によるアミノ酸配列解析法2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] NBS法を用いた新規プロテーム解析-大腸癌のタンパクプロファイル解析-2007

Author(s)

NISHIMURA Osamu 西村紀