Kawasaki Yoshihiro 川崎善博

… Alternative Names

KAWASAKI Yoshihiro 川崎善博

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Researcher Number	10376642
Other IDs
Affiliation (Current)	2025: 関西医科大学, 附属光免疫医学研究所, 准教授 2025: 東京大学, 定量生命科学研究所, 客員准教授
Affiliation (based on the past Project Information) *help	2023: 関西医科大学, 附属光免疫医学研究所, 准教授 2021 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2018 – 2021: 東京大学, 定量生命科学研究所, 客員准教授 2017 – 2018: 東京大学, 定量生命科学研究所, 特任准教授 2014 – 2017: 東京大学, 分子細胞生物学研究所, 准教授 … More 2009 – 2013: The University of Tokyo, 分子細胞生物学研究所, 講師 2007 – 2009: The University of Tokyo, 分子細胞生物学研究所, 助教 2005 – 2006: 東京大学, 分子細胞生物学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Tumor biology / Cell biology / Basic Section 50010:Tumor biology-related / Tumor biology and related fields / Biological Sciences / Pathological medical chemistry / General medical chemistry Except Principal Investigator Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Biological Sciences
Keywords	Principal Investigator APC / lncRNA / c-Myc / Wnt / Lgr5 / NGF / ユビキチン化 / 神経突起伸長 / Neurodap1 / Asef … More / LncRNA / Reg4 / 大腸癌 / 癌幹細胞 / SPAL-1 / p42/44MAPK / 神経疾患 / 記憶と学習 / 海馬 / PSD95 / NMDA受容体 / PSD-95 / SPAL / 運動 / 細胞骨格 / growth cone / 突起伸長 / 神経 / がん抑制遺伝子 … More Except Principal Investigator ホログラム光刺激 / ライブイメージング / 超解像イメージング / 光刺激 / ホールセル / 細胞動態 / 細胞形態 / 細胞骨格 / 3Dライブイメージング / ホログラフィー / ホログラフィ / ベッセルビーム / 格子光シート顕微鏡 / 高解像ライブイメージング / β-catenin / B9L / Sam68 / 細胞運動 / Dlg / G蛋白質 / GEF / 血管新生 / 神経突起伸長 / 癌抑制遺伝子 / RICS / カドヘリン / beta-catenin / 細胞運動・浸潤 / 細胞がん化 / Wnt / がん幹細胞 / Asef / APC / p53 / 増殖 / アポトーシス / がん遺伝子 / がん抑制遺伝子 Less

Analysis of a multifunctional Wnt/c-Myc target lncRNA in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Yoshihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kansai Medical University
  Institute of Physical and Chemical Research
Development of cell function editing technology with fast 3D measurement and local-field light perturbation
- Principal Investigator
  
  Mimori-Kiyosue Yuko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Search for novel Lgr5 ligands and receptor of Reg4Principal Investigator
- Principal Investigator
  
  Kawasaki Yoshihiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms underlying colorectal tumorigenesis driven by Wnt/c-Myc signalingPrincipal Investigator
- Principal Investigator
  
  Kawasaki Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Functional analysis of Lgr5 in colon and ovary cancerPrincipal Investigator
- Principal Investigator
  
  Kawasaki Yoshihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
癌抑制遺伝子産物ＡＰＣが関わる上皮管腔形成機構とその破綻による癌発症機構の解明Principal Investigator
- Principal Investigator
  
  川崎善博
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Mechanisms of colon cancer stem cell self-renewal and pluripotencyPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Yoshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
The role of NMDA receptor/PSD-95/SPAL-1/Rap signaling in higher brain functionPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Yoshihiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Functional analysis of APC in neurite outgrowthPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Yoshihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
Molecular mechanism of tumor cell growth
- Principal Investigator
  
  AKIYAMA Tetsu
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
神経突起伸長におけるAPCの機能Principal Investigator
- Principal Investigator
  
  川崎善博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo

[Book] サイクリン依存性キナーゼ関連阻害剤, COX, 酸化ストレス, NO関連阻害剤", 阻害剤・活性化剤ハンドブック2019
- Author(s)
  川崎善博
- Total Pages
  26
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16H04692
[Book] 別冊「医学のあゆみ」がん微小環境の病態理解と制御2017
- Author(s)
  川崎善博, 秋山徹
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16H04692
[Book] 医学のあゆみ2016
- Author(s)
  川崎善博, 秋山徹
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16H04692
[Book] 日本臨床微小環境を標的とした分子標的治療2015
- Author(s)
  川崎善博, 秋山徹
- Total Pages
  5
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-25290043
[Book] サイトカイン・増殖因子キーワード事典2015
- Author(s)
  川崎善博
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25290043
[Journal Article] APC mutant cells exploit compensatory chromosome alterations to restore tumour cell fitness2020
- Author(s)
  Yoshihiro Kawasaki, Tomoko Hamaji, Koji Owada, Akiko Hayashi, Yuping Wu, Taisaku Nogi, Miwa Okada, Yuta Kouyama, Atsushi Niida, Koshi Mimori, (他11名) Wesley R Legant, Bi-Chang Chen, Eric Betzig, Ron Smits, Riccardo Fodde, Hiroko Oshima, Masanobu Oshima, M Mark Taketo, Tetsu Akiyama, Yuko Mimori-Kiyosue
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.09.18.303016
- Open Access
- Data Source
  KAKENHI-PROJECT-20K20379
[Journal Article] サイクリン依存性キナーゼ関連阻害剤2019
- Author(s)
  川崎善博
- Journal Title
  
  決定版阻害剤・活性化剤ハンドブック
  
  Volume: - Pages: 103-112
- Data Source
  KAKENHI-PROJECT-20K20379
[Journal Article] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019
- Author(s)
  Kawasaki Y、Miyamoto M、Oda T、Matsumura K、Negishi L、Nakato R、Suda S、Yokota N、Shirahige K、Akiyama T.
- Journal Title
  
  EMBO reports
  
  Volume: 20 Issue: 8
- DOI
  10.15252/embr.201847052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-20K20379, KAKENHI-PROJECT-16H04692
[Journal Article] COX, 酸化ストレス, NO関連阻害剤2019
- Author(s)
  川崎善博
- Journal Title
  
  決定版阻害剤・活性化剤ハンドブック
  
  Volume: - Pages: 394-409
- Data Source
  KAKENHI-PROJECT-20K20379
[Journal Article] Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p272018
- Author(s)
  Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T.
- Journal Title
  
  Oncol Lett.
  
  Volume: 15 Pages: 4005-4009
- DOI
  10.3892/ol.2018.7793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19584, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-16H04692
[Journal Article] SP5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p272017
- Author(s)
  Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T
- Journal Title
  
  Oncol. Lett.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04692
[Journal Article] The Novel G-quadruplex-Containing Long non-coding RNA GSEC Antagonizes DHX36 and Modulates Colon Cancer Cell Migration2017
- Author(s)
  Matsumura K, Kawasaki Y, Miyamoto M, Kamoshida Y, Nakamura J, Negishi L, Suda S, Akiyama T
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 9 Pages: 1191-1199
- DOI
  10.1038/onc.2016.282
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04692, KAKENHI-PROJECT-17K19584
[Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.2016
- Author(s)
  G. Sawada (他43名, 山本21番目)
- Journal Title
  
  Gastroenterology
  
  Volume: 150 Issue: 5 Pages: 1171-1182
- DOI
  10.1053/j.gastro.2016.01.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05577, KAKENHI-PROJECT-15K12139, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-14J10908, KAKENHI-PROJECT-25461953, KAKENHI-PROJECT-26670608, KAKENHI-PROJECT-25730173, KAKENHI-PROJECT-26861003, KAKENHI-PROJECT-25290043, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-16H04692, KAKENHI-PROJECT-26293303, KAKENHI-PROJECT-26461994, KAKENHI-PROJECT-15K15496
[Journal Article] MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression.2016
- Author(s)
  Kawasaki Y, Komiya M, Matsumura K, Negishi L, Suda S, Okuno M, Yokota N, Osada T, Nagashima T, Hiyoshi M, Okada-Hatakeyama M, Kitayama J, Shirahige K, Akiyama T.
- Journal Title
  
  Cell Rep.
  
  Volume: 16(10) Issue: 10 Pages: 2554-64
- DOI
  10.1016/j.celrep.2016.08.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02369, KAKENHI-PROJECT-16H04692
[Journal Article] Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury2016
- Author(s)
  Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B
- Journal Title
  
  J. Neurosci.
  
  Volume: 36 Pages: 11904-11917
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04692
[Journal Article] SP5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p27.2016
- Author(s)
  Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T.
- Journal Title
  
  Oncol. Lett.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290043
[Journal Article] Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.2016
- Author(s)
  Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, Nagashima T, Okada-Hatakeyama M, Oyama M, Kozuka-Hata H, Hiyoshi M, Kitayama J, Negishi L, Kawasaki Y, Akiyama T.
- Journal Title
  
  Proceedings of the National Academy of Sciences U S A.
  
  Volume: 113 Issue: 5 Pages: 1273-8
- DOI
  10.1073/pnas.1500992113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08299, KAKENHI-PROJECT-26505001, KAKENHI-PUBLICLY-15H01464, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-16H04692
[Journal Article] Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.2015
- Author(s)
  Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 308 Issue: 5 Pages: 452-463
- DOI
  10.1152/ajplung.00170.2014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
[Journal Article] SOX9-mediated upregulation of LGR5 is important for glioblastoma tumorigenicity.2015
- Author(s)
  Hiraoka K, Hayashi T, Kaneko R, Nasu-Nishimura Y, Koyama-Nasu R, Kawasaki Y, Akiyama T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 460 Issue: 2 Pages: 4097-4109
- DOI
  10.1016/j.bbrc.2015.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-24501313, KAKENHI-PROJECT-25290043
[Journal Article] Asef controls vascular endothelial permeability and barrier recovery in the lung.2015
- Author(s)
  Tian X, Tian Y, Gawlak G, Meng F, Kawasaki Y, Akiyama T, Birukova AA.
- Journal Title
  
  Mol Biol Cell.
  
  Volume: 26 Issue: 4 Pages: 636-650
- DOI
  10.1091/mbc.e14-02-0725
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
[Journal Article] HGF-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier.2015
- Author(s)
  Tian Y, Gawlak G, Shah AS, Higginbotham K, Tian X, Kawasaki Y, Akiyama T, Sacks DB, Birukova AA.
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Issue: 7 Pages: 4097-4109
- DOI
  10.1074/jbc.m114.620377
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25290043
[Journal Article] REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis.2015
- Author(s)
  Kawasaki Y, Matsumura K, Miyamoto M, Tsuji S, Okuno M, Suda S, Hiyoshi M, Kitayama J, Akiyama T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 14291-14291
- DOI
  10.1038/srep14291
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25290043
[Journal Article] Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells2015
- Author(s)
  Hironobu Sugimasa, Kenzui Taniue, Akiko Kurimoto, Yasuko Takeda, Yoshihiro Kawasaki, Tetsu Akiyama
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: Volume 459, Issue 1 Issue: 1 Pages: 29-35
- DOI
  10.1016/j.bbrc.2015.02.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J10303, KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-25830073, KAKENHI-PROJECT-15K08299, KAKENHI-PUBLICLY-15H01464, KAKENHI-PROJECT-25290043
[Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis2014
- Author(s)
  Tsuji S
- Journal Title
  
  Nat. Commun.
  
  Volume: 5 Issue: 1 Pages: 3150-3150
- DOI
  10.1038/ncomms4150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138, KAKENHI-PROJECT-25830073
[Journal Article] Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells2013
- Author(s)
  Yoshihiro Kawasaki, Shiori Furukawa, Rina Sato, Tetsu Akiyama
- Journal Title
  
  Cancer Sci.
  
  Volume: 8 Issue: 8 Pages: 1135-1138
- DOI
  10.1111/cas.12180
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138
[Journal Article] The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration2013
- Author(s)
  Shiori Furukawa,Yoshihiro Kawasaki, Masaya Miyamoto, Masaya Hiyoshi,Joji Kitayama, Tetsu Akiyama
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 11 Pages: e80609-e80609
- DOI
  10.1371/journal.pone.0080609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PUBLICLY-24112506, KAKENHI-PROJECT-25290043, KAKENHI-PROJECT-25670138
[Journal Article] Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells2013
- Author(s)
  川崎善博・古川史織・佐藤梨奈・秋山徹
- Journal Title
  
  Cancer Science
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689019
[Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.2010
- Author(s)
  Kawasaki Y., Jigami T., Furukawa S., Sagara M., Echizen K., Shibata Y., Sato R., Akiyama T.
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 1199-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] The APC-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.2010
- Author(s)
  Kawasaki Y, Jigami T, Furukawa S, Sagara M, Echizen K, Shibata Y, Sato R, Akiyama T.
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages: 1199-1207
- Data Source
  KAKENHI-PROJECT-21790265
[Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis2010
- Author(s)
  Kawasaki Y
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 1199-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc^<Min/+> mice2009
- Author(s)
  Kawasaki, Y.
- Journal Title
  
  EMBO Rep. 27
  
  Pages: 1355-1362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009
- Author(s)
  Sagara M., Kawasaki Y., Iemura S., Natsume T., Takai Y., Akiyama T.
- Journal Title
  
  Oncogene 28
  
  Pages: 1357-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] APC and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.2009
- Author(s)
  Kawasaki Y, Tsuji S, Sagara M, Echizen K, Shibata Y, Akiyama T.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 22436-22443
- Data Source
  KAKENHI-PROJECT-21790265
[Journal Article] APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase.2009
- Author(s)
  Kawasaki Y., Tsuji S., Sagara M., Echizen K., Shibata Y., Akiyama T.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 22436-22443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice.2009
- Author(s)
  Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 1355-1362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc^<min/+> mice.2009
- Author(s)
  Kawasaki Y, Tsuji S, Muroya K, Furukawa S, Shibata Y, Okuno M, Ohwada S, Akiyama T.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 1355-1362
- Data Source
  KAKENHI-PROJECT-21790265
[Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009
- Author(s)
  Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.
- Journal Title
  
  Oncogene 28
  
  Pages: 1357-1365
- Data Source
  KAKENHI-PROJECT-21790265
[Journal Article] Asef2 and Neurabin2 cooperatively regulat actin cytoskeletal organization and are involved in HGF-induced cell migration2009
- Author(s)
  Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T
- Journal Title
  
  Oncogene 28
  
  Pages: 1357-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli2008
- Author(s)
  Kouzmenko AP, Takeyama K, Kawasaki Y, Akiyama T, Kato S
- Journal Title
  
  Oncogene 27
  
  Pages: 4888-4899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli2008
- Author(s)
  Kouzmenko AP, Takeyama K, Kawasaki Y, Akiyama T, Kato S
- Journal Title
  
  Genes Cells 13
  
  Pages: 723-730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc422007
- Author(s)
  Kawasaki Y., Sagara M., Shibata Y., Shirouzu M., Yokoyama S., Akiyama T
- Journal Title
  
  Oncogene 26
  
  Pages: 7620-7627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism2007
- Author(s)
  Murayama K., Shirouzu M., Kawasaki Y., Kato-Murayama M., Hanawa-Suetsugu K., Sakamoto A., Katsura Y., Suenaga A., Toyama M., Terada T., Taiji M., Akiyama T., Yokoyama S
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 4238-4242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.2007
- Author(s)
  Kawasaki Y., Sagara M., Shibata S., Shirouzu M., Yokoyama S., Akiyama T.
- Journal Title
  
  Oncogene 26
  
  Pages: 7620-7627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.2007
- Author(s)
  Kawasaki. Y, et. al.
- Journal Title
  
  Oncogene 26
  
  Pages: 7620-7627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] PH domain-mediated membrane targeting of Asef2007
- Author(s)
  Muroya K., Kawasaki Y., Hayashi T., Ohwada S., Akiyama.T
- Journal Title
  
  Biochem. Biophys. Res. Commun 355
  
  Pages: 85-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770162
[Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Racl and Cdc42.2007
- Author(s)
  Kawasaki Y.
- Journal Title
  
  Oncogene 26
  
  Pages: 7620-7627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014011
[Journal Article] Differences in the localization of the APC- Asef/ Asef2 complex between APC wild- typeand mutant cells
- Author(s)
  川崎善博・古川史織・佐藤梨奈・秋山徹
- Journal Title
  
  Cancer Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689019
[Patent] ＴＡ細胞の検出試薬、がん幹細胞の増殖性の検出試薬、ＴＡ細胞の検出方法、増殖性のがん幹細胞の検出方法、ＴＡ細胞の精製方法、増殖性のがん幹細胞の精製方法、細胞集団、および非ヒト動物2024
- Inventor(s)
  川崎善博、清末優子、日笠幸一郎
- Industrial Property Rights Holder
  関西医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-058370
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-21H02771
[Patent] 大腸癌抑制遺伝子関連蛋白質2009
- Inventor(s)
  秋山徹, 川崎善博
- Industrial Property Rights Holder
  第一三共株式会社
- Filing Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] APC変異細胞は染色体異常を起こしてがん化能を獲得する2023
- Author(s)
  川崎善博, 林昭子, 酒井晶子, 徳重直子, 笹川翔太, 中川英刀, 清末優子
- Organizer
  日本組織培養学会第95回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] APC mutant cells exploit compensatory chromosome alterations to gain tumor initiation and progression potential2023
- Author(s)
  Yoshihiro Kawasaki, Akiko Hayashi, Shoko Sakai, Naoko Tokushige, Shota Sasagawa, Hidewaki Nakagawa, Yuko Mimori-Kiyosue
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] APC mutant cells exploit compensatory chromosome alterations to improve proliferative potential2022
- Author(s)
  Kawasaki Y, Hayashi A, Sakai S, Tokushige N, Sasagawa S, Nakagawa H, Mimori-Kiyosue Y
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] Toward the analysis of mechanisms regulating the mode of cell division of intestinal stem cells2022
- Author(s)
  Kawasaki Y, Tokushige N, Sakai S, Hayashi A, Mimori-Kiyosue Y
- Organizer
  理研BDR Retreat 2022
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] APC mutant cells exploit compensatory chromosome alterations to improve proliferative potential2022
- Author(s)
  Kawasaki Y, Hayashi A, Sakai S, Tokushige N, Sasagawa S, Nakagawa H, Mimori-Kiyosue Y
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K20379
[Presentation] Toward the analysis of mechanisms regulating the mode of cell division of intestinal stem cells2022
- Author(s)
  Kawasaki Y, Tokushige N, Sakai S, Hayashi A, Mimori-Kiyosue Y
- Organizer
  理研BDRオルガノイドプロジェクトAnnual meeting
- Invited
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] Compensatory chromosome alterations to restore tumor cell fitness2021
- Author(s)
  Yoshihiro Kawasaki, Tetsu Akiyama, Yuko Mimori-Kiyosue
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20379
[Presentation] Compensatory chromosome alterations to restore tumor cell fitness2021
- Author(s)
  Kawasaki Y, Akiyama T, Mimori-Kiyosue Y
- Organizer
  第80回日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02771
[Presentation] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019
- Author(s)
  Yoshihiro Kawasaki, Masaya Miyamoto, Kosuke Matsumura, Lumi Negishi, Takeaki Oda, Ryuichiro Nakato2, Sakiko Suda, Naoko Yokota, Katsuhiko Shirahige, Tetsu Akiyama
- Organizer
  第７１回細胞生物学会
- Data Source
  KAKENHI-PROJECT-16H04692
[Presentation] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019
- Author(s)
  Yoshihiro Kawasaki, Masaya Miyamoto, Kosuke Matsumura, Lumi Negishi, Takeaki Oda, Ryuichiro Nakato2, Sakiko Suda, Naoko Yokota, Katsuhiko Shirahige, Tetsu Akiyama
- Organizer
  第７１回細胞生物学会
- Data Source
  KAKENHI-PROJECT-20K20379
[Presentation] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019
- Author(s)
  Yoshihiro Kawasaki, Masaya Miyamoto, Kosuke Matsumura, Lumi Negishi, Takeaki Oda, Ryuichiro Nakato2, Sakiko Suda, Naoko Yokota, Katsuhiko Shirahige, Tetsu Akiyama
- Organizer
  第７８回日本癌学会
- Data Source
  KAKENHI-PROJECT-16H04692
[Presentation] The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis2019
- Author(s)
  Yoshihiro Kawasaki, Masaya Miyamoto, Kosuke Matsumura, Lumi Negishi, Takeaki Oda, Ryuichiro Nakato2, Sakiko Suda, Naoko Yokota, Katsuhiko Shirahige, Tetsu Akiyama
- Organizer
  第７８回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K20379
[Presentation] The novel lncRNA CASCA induces the expression of AXL to promote colon cancer cell migration and drug resistance2017
- Author(s)
  Yoshihiro Kawasaki, Masaya Miyamoto, Sakiko Suda and Tetsu Akiyama
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16H04692
[Presentation] The novel lncRNA CASCA induces the expression of AXL to promote colon cancer cell migration and drug resistance2017
- Author(s)
  川崎善博、宮本昌弥、須田咲希子、秋山徹
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-17K19584
[Presentation] The Novel G-quadruplex-Containing lncRNA GSEC Modulates Colon Cancer Cell Migration2016
- Author(s)
  Kawasaki Y, Akiyama T
- Organizer
  第75回日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-16H04692
[Presentation] Wnt/c-Myc経路の新規標的lncRNA：MYUはCDK6の発現を誘導して細胞周期を進める2016
- Author(s)
  川崎善博、小宮美文、松村厚佑、根岸瑠美、須田咲希子、奥野ます美、横田直子、長田知也、長嶋剛史、日吉雅也、岡田眞里子、北山丈二、白髭克彦、秋山徹
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H04692
[Presentation] The Achilles' heel of cancers.2015
- Author(s)
  Kawasaki Y, Akiyama T.
- Organizer
  International Symposium on “Integrative Research on Cancer Microenvironment Network”
- Place of Presentation
  東京大学小柴ホール（東京都文京区）
- Year and Date
  2015-09-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression2015
- Author(s)
  Kawasaki Y, Akiyama T.
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis2013
- Author(s)
  川崎善博
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PUBLICLY-24112506
[Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis2013
- Author(s)
  川崎善博、辻真之介、古川史織、谷上賢瑞、林寛敦、日吉雅也、北山丈二、秋山徹
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] miR-1-Notch3-Asef経路は大腸癌細胞の運動能亢進に重要である2012
- Author(s)
  川崎善博
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PUBLICLY-24112506
[Presentation] miR-1-Notch3-Asef経路は大腸癌細胞の運動能亢進に重要である2012
- Author(s)
  川崎善博・古川史織・秋山徹
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23689019
[Presentation] miR-1-Notch3-Asef経路は大腸癌細胞の運動能亢進に重要である2012
- Author(s)
  川崎善博・古川史織・秋山徹
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23689019
[Presentation] 癌抑制遺伝子産物APCの機能解析2011
- Author(s)
  川崎善博・秋山徹
- Organizer
  第70回日本癌学会年会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23689019
[Presentation] 癌抑制遺伝子産物APCの機能解析2011
- Author(s)
  川崎善博・秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場(招待講演)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23689019
[Presentation] APCの異常と発癌2010
- Author(s)
  川崎善博、秋山徹
- Organizer
  第1回構造生物学社会連携講座シンポジゥム
- Data Source
  KAKENHI-PROJECT-21790265
[Presentation] Function of the tumour suppressor APC2010
- Author(s)
  川崎善博、秋山徹
- Organizer
  ENS de Lyon-Todai Workshop
- Data Source
  KAKENHI-PROJECT-21790265
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009
- Author(s)
  川崎善博、辻真之介、室谷研、古川史織、大和田進、秋山徹
- Organizer
  日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-21790265
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009
- Author(s)
  川崎善博, 辻真之介, 室谷研, 古川史織大和田進, 秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009
- Author(s)
  川崎善博、辻真之介、室谷研、古川史織、大和田進、秋山徹
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-21790265
[Presentation] APCの異常と発癌2009
- Author(s)
  川崎善博
- Organizer
  九州大学グローバルCOE「Wnt シグナルシンポジウム」
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009
- Author(s)
  川崎善博, 辻真之介, 室谷研, 古川史織, 大和田進, 秋山徹
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009
- Author(s)
  川崎善博、辻真之介、室谷研、古川史織、大和田進、秋山徹
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21790265
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2008
- Author(s)
  川崎善博, 地神貴史, 古川史織, 相良将樹, 柴田葉子, 佐藤梨奈, 秋山徹
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2008
- Author(s)
  川崎善博
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] Role of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc422008
- Author(s)
  相良将樹, 川崎善博, 秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2008
- Author(s)
  川崎善博
- Organizer
  日本細胞生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] 癌抑制遺伝子APCの異常を介したポリープ形成におけるAsef/Asef2の関わり2008
- Author(s)
  川崎善博
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in intestinal adenoma formation, dentification and Characterization of2007
- Author(s)
  辻真之介, 川崎善博, 秋山徹, 相良将樹, 川崎善博, 秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014011
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2007
- Author(s)
  川崎善博
- Organizer
  癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2007
- Author(s)
  川崎善博
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19770162
[Presentation] MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression
- Author(s)
  Kawasaki Y, Akiyama T
- Organizer
  Joint International Symposium on TGF-β Family and Cancer: TGF-β Family and Cancer: Signal Network in Tumor Micoroenvironment
- Place of Presentation
  筑波
- Year and Date
  2015-01-12 – 2015-01-13
- Invited
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] The role of the novel long non-coding RNA in human colorectal cancer stem cell
- Author(s)
  松村厚佑、宮本昌弥、川崎善博、斎藤晋祐、日吉雅也、北山丈二、秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] GATA6を介した細胞癌化におけるReg4とLgr5の協調作用
- Author(s)
  川崎善博、辻真之介、宮本昌弥、平岡巧士、松村厚佑、奥野ます美、須田咲希子、日吉雅也、北山丈二、秋山徹
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] Cooperation between Reg4 and Lgr5 in GATA6-mediated colorectal tumorigenesis
- Author(s)
  川崎善博、辻真之介、宮本昌弥、平岡巧士、松村厚佑、奥野ます美、須田咲希子、日吉雅也、北山丈二、秋山徹
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25290043
[Presentation] 大腸がん幹細胞における新規長鎖非コードRNAの機能解析
- Author(s)
  松村厚佑、宮本昌弥、川崎善博、斎藤晋祐、日吉雅也、北山丈二、秋山徹
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25290043

1. AKIYAMA Tetsu (70150745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
2. NASU Ryo (30466859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAKAMURA Tsutomu (30302798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKAMOTO Aikou (20204026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Mimori-Kiyosue Yuko (90568403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 和氣弘明 (90455220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 的場修 (20282593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ARJUNAN SATYA (70575125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山本健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 谷上賢瑞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawasaki Yoshihiro 川崎 善博

KAWASAKI Yoshihiro 川崎 善博

Research Projects

Research Products

Co-Researchers

Analysis of a multifunctional Wnt/c-Myc target lncRNA in tumorigenesisPrincipal Investigator

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Development of cell function editing technology with fast 3D measurement and local-field light perturbation

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Search for novel Lgr5 ligands and receptor of Reg4Principal Investigator

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Elucidation of molecular mechanisms underlying colorectal tumorigenesis driven by Wnt/c-Myc signalingPrincipal Investigator

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Functional analysis of Lgr5 in colon and ovary cancerPrincipal Investigator

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癌抑制遺伝子産物ＡＰＣが関わる上皮管腔形成機構とその破綻による癌発症機構の解明Principal Investigator

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Mechanisms of colon cancer stem cell self-renewal and pluripotencyPrincipal Investigator

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The role of NMDA receptor/PSD-95/SPAL-1/Rap signaling in higher brain functionPrincipal Investigator

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Functional analysis of APC in neurite outgrowthPrincipal Investigator

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Molecular mechanism of tumor cell growth

Principal Investigator

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神経突起伸長におけるAPCの機能Principal Investigator

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[Book] サイクリン依存性キナーゼ関連阻害剤, COX, 酸化ストレス, NO関連阻害剤", 阻害剤・活性化剤ハンドブック2019

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[Book] 別冊「医学のあゆみ」がん微小環境の病態理解と制御2017

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Kawasaki Yoshihiro 川崎善博

KAWASAKI Yoshihiro 川崎善博

[Book] 日本臨床微小環境を標的とした分子標的治療2015