Takenokuchi Mariko 炬口真理子

… Alternative Names

炬口真理子タケノクチマリコ

TAKENOKUCHI Makoto 炬口真理子

Less

Researcher Number	10379430
Other IDs
Affiliation (Current)	2025: 第一薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 第一薬科大学, 薬学部, 教授 2013 – 2018: 姫路獨協大学, 薬学部, 准教授 2008: 姫路獨協大学, 薬学部, 講師 2007: 神戸大学, 医学部附属病院, 臨床検査技師
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 52010:General internal medicine-related Except Principal Investigator Laboratory medicine / Tumor diagnostics
Keywords	Principal Investigator ユビキチン-プロテアソーム系 / 多発性骨髄腫 / ユビキチンープロテアソーム系 / プロテアソーム阻害剤 / 免疫調整薬（IMiDs) / 免疫調整薬(IMiDs) / ユビキチン結合酵素 / セレブロン / バイオマーカー / レナリドミド … More / ユビキチン化酵素 / M蛋白 / ユビキチン-プロテアソーム / ERストレス / PML/RARA … More Except Principal Investigator 酸化ストレス / フローサイトメトリー / シトルリン化ヒストン / エンドトキシン / へミン / 自動血球計数装置 / アセテート / デフェラシロクス / ヘミン / 細胞外トラップ / 好中球 / 癌診断 / バイオマーカー / ユビキチン / 診断 / がん / ARF / E2活性 / ユビキチンリガーゼ / がん診断 / ユビキチン化 / 血小板マイクロパーティクル / トロンボポエチ / 染色体 / 骨髄異形成症候群 / 血小板輸血 / 自動計測法 / 幼若血小板 / 臨床検査医学 Less

Identification and clinical usefulness of biomarkers for treatment option of multiple myelomaPrincipal Investigator
- Principal Investigator
  
  炬口真理子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Evaluation of M-protein related ubiquitin enzyme as a new biomarker for Multiple MyelomaPrincipal Investigator
- Principal Investigator
  
  Mariko Takenokuchi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Himeji Dokkyo University
Establishment of clinical and pathological evaluation method of NETs
- Principal Investigator
  
  Saigo Katsuyasu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Himeji Dokkyo University
Highly sensitive detection of ubiquitination using tumor-bearing mouse model
- Principal Investigator
  
  Miyamoto Kazuhide
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Himeji Dokkyo University
Evaluation of serum ubiquitin enzyme as a new biomarker for PML-RARA leukemiaPrincipal Investigator
- Principal Investigator
  
  Takenokuchi Mariko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Himeji Dokkyo University
)Usefulness of immature platelet fraction (IPF) on decision making of platelet transfusion for the patients with hematologic malignancies.
- Principal Investigator
  
  SAIGO Katsuyasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Himeji Dokkyo University
  Kobe University

All 2019 2018 2017 2016 2015 2012 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Acetate moderately attenuates the generation of neutrophil extracellular traps2018
- Author(s)
  Ohbuchi Ayako、Kono Mari、Takenokuchi Mariko、Imoto Shion、Saigo Katsuyasu
- Journal Title
  
  Blood Research
  
  Volume: 53 Issue: 2 Pages: 177-180
- DOI
  10.5045/br.2018.53.2.177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08983
[Journal Article] 鉄キレート療法の多彩な効果2018
- Author(s)
  大渕絢子、河野麻理、炬口真理子、井本しおん、西郷勝康
- Journal Title
  
  兵庫県医師会医学雑誌
  
  Volume: 60 Pages: 30-35
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08983
[Journal Article] Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model2018
- Author(s)
  Takenokuchi Mariko、Kadoyama Keiichi、Yoshida Daisuke、Takaki Shigeki、Yamamoto Ryoma、Saigo Katsuyasu、Taniguchi Taizo
- Journal Title
  
  Biology and Medicine
  
  Volume: 10 Issue: 5 Pages: 1-9
- DOI
  10.4172/0974-8369.1000448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08983
[Journal Article] 鉄キレート療法の多彩な効果2018
- Author(s)
  大渕絢子　河野麻理　炬口真理子　井本しおん　西郷勝康
- Journal Title
  
  兵庫県医師会医学雑誌
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08660
[Journal Article] Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon.2017
- Author(s)
  Ohbuchi A, Kono M, Kitagawa K, Takenokuchi M, Imoto S, Saigo K.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 11 Pages: 47-153
- DOI
  10.1016/j.bbrep.2017.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08660
[Journal Article] Iron chelating agent, Deferasirox, inhibits neutrophil activation and extracellular trap (NET) formation.2016
- Author(s)
  Mari Kono, Katsuyasu Saigo, Shiori Yamamoto, Kohei Shirai, Shuta Iwamoto, Tomoko Uematsu, Takayuki Takahashi, Shion Imoto, Makoto Hashimoto, Yosuke Minami, Atsushi Wada, Mariko Takenokuchi, Seiji Kawano
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology
  
  Volume: 43 Pages: 915-920
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08660
[Journal Article] Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML–RARA2015
- Author(s)
  Takenokuchi M, Miyamoto K, Saigo K, et al
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 3307-3316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08660
[Journal Article] Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML-RARA2015
- Author(s)
  Mariko Takenokuchi, Kazuhide Miyamoto, Katsuyasu Saigo, Taizo Taniguchi
- Journal Title
  
  ANTICANCER RESEARCH
  
  Volume: 35(6) Pages: 3307-3316
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460711
[Journal Article] Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity.2012
- Author(s)
  Bao, X.H
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Issue: 3 Pages: 2827-2834
- DOI
  10.1159/000218708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390323, KAKENHI-PROJECT-25460711
[Journal Article] Efficient quantitative real-time PCR method of PML-RARαfusion transcripts by means of LightCycler with a single primer pair.2009
- Author(s)
  Takenokuchi M, Nakamachi Y, Yoneda K, Joho K, Kawano S, Tatsumi E, Saigo K, Kumagai S
- Journal Title
  
  Journal of Clinical Laboratory Analysis (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] Usefulness of immature platelet fraction (IPF) for clinical evaluation of myelodysplastic syndromes.2009
- Author(s)
  Saigo K, Takenokuchi M, Imai J, Numata K, Isono S, Zenibayashi M, Tanioka H, Yoshioka T, Nishizawa A, Takada M, Nomura T, Kubota Y.
- Journal Title
  
  Laboratory Hematology 15
  
  Pages: 13-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 医療系学生の病院実習前健診としてのツベルクリン反応実施経験2009
- Author(s)
  冨士原やよい、池田卓代、森田恵子、片山俊郎、炬口真理子、西郷勝康
- Journal Title
  
  CAMPUS HEALTH 46(1)
  
  Pages: 238-239
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 医療系学生の病院実習前健診としてのツベルクリン反応実施経験2009
- Author(s)
  冨士原やよい, 池田卓代, 森田恵子, 片山俊郎, 炬口真理子, 西郷勝康
- Journal Title
  
  CAMPUS HEALTH 46
  
  Pages: 138-139
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] DR negativity is a dinstinctive feature of M1/M2 AML cases with NPM1 mutation.2008
- Author(s)
  Syampurnawati M, Tatsumi E, Ardianto B, Takenokuchi M, Nakamachi Y, Kawano S, Kumagai S, Saigo K, Matsui T, Takahashi T, Nagai K, Nishio H, Yabe H, Kondo S, Hayashi Y.
- Journal Title
  
  Leukemia Research 32
  
  Pages: 1141-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] DR negativity is a dinstinctive feature of M1/M2 AML cases with NPM1 mutation.2008
- Author(s)
  Syampurnawati M, Tatsumi E, Ardianto B, Takenokuchi M, Nakamachi Y, Kawano S, Kumagai S, Saigo K, ほか
- Journal Title
  
  Leukemia Research 32
  
  Pages: 1141-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] Automatic detection of immature platelets for decision making regarding platelet transfusion indication for pediatric patients.2008
- Author(s)
  Saigo K, Sakota Y, Masuda Y, Matsunaga K, Takenokuchi M, Nishimura K, Sugimoto T, Sakurai K, Hashimoto M, Yanai T, Hayakawa A, Takeshima Y, Nomura T, Kubota Y, Kumagai S.
- Journal Title
  
  Transfusion and Apheresis Scinece 38
  
  Pages: 127-132
- NAID
  120002055776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 臨床検査としての好中球機能と酸化ストレス2008
- Author(s)
  西郷勝康、炬口真理子、井本しおん
- Journal Title
  
  臨床病理 56
  
  Pages: 791-801
- NAID
  10024960452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] ヘミンによるヒト好中球の活性化2008
- Author(s)
  西郷勝康、橋本誠、淨慶幸江、炬口真理子、杉本健、數村公子、土屋広司、井本しおん、熊谷俊一
- Journal Title
  
  臨床病理 56(11)
  
  Pages: 967-972
- NAID
  10024960739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 輸血・移植医療と臨床検査2008
- Author(s)
  西郷勝康、橋本誠、杉本健、炬口真理子、井本しおん、熊谷俊一
- Journal Title
  
  臨床病理 56
  
  Pages: 203-210
- NAID
  10024356170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] HLA-DR-Negative AML (M1 and M2) : FLT3 mutations (ITD and D835) and cell-surface antigen expression.2007
- Author(s)
  Syampurnawati M, Tatsumi E, Furuta K, Takenokuchi M, Nakamachi Y, Kawano S, Kumagai S, Saigo K, Matsui T, Takahashi T, Nagai K, Yabe H, Kondo S, Hayashi Y.
- Journal Title
  
  Leukemia Research 31
  
  Pages: 921-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] XE-2100 RETチャンネルを用いた新しい指標の臨床的有用性2007
- Author(s)
  西郷勝康、迫田裕之、増田由佳子、松永恭子、成田浩子、橋本誠、炬口真理子、窪田良次、野村努、信原由実子、杉本健、井本しおん、熊谷俊一
- Journal Title
  
  Sysmex Journal 30
  
  Pages: 3-18
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 無侵襲ヘモグロビン測定装置と健康管理2007
- Author(s)
  西郷勝康、炬口真理子、井本しおん、三戸壽
- Journal Title
  
  Medical Postgraduates 45(2)
  
  Pages: 145-148
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] 網血小板計測の意義と幼若血小板自動計数法の臨床的有用性2007
- Author(s)
  西郷勝康、炬口真理子
- Journal Title
  
  網血小板計測の意義と幼若血小板自動計数法の臨床的有用性 50
  
  Pages: 68-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Journal Article] Efficient quantitative real-time PCR method of PML-RARαfusion transcripts by means of LightCycler with a single primer pair.
- Author(s)
  Takenokuchi M, Nakamachi Y, Yoneda K, Joho K, Kawano S, Tatsumi E, Saigo K , Kumagai S .
- Journal Title
  
  Journal of Clinical Laboratory Analysis in press
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590559
[Presentation] アセテートによる好中球細胞外トラップ形成の阻害2019
- Author(s)
  大渕絢子、河野麻里、炬口真理子、井本しおん、西郷勝康、山本直樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08983
[Presentation] デフェラシロックスは急性肺傷害モデルマウスの好中球の活性化と細胞外トラップを抑制する2017
- Author(s)
  河野麻理、山本志緒里、松岡広、河野誠司、井本しおん、炬口真理子、大渕絢子、西郷勝康
- Organizer
  第38回日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] 鎖脂肪酸アセテートによる好中球細胞外トラップ形成の抑制2017
- Author(s)
  大渕絢子　伊藤翔子　炬口真理子　西郷勝康河野麻理　井本しおん
- Organizer
  日本臨床検査医学会
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] 急性肺障害モデルマウスの肺に動員された好中球の電子顕微鏡による観察2017
- Author(s)
  山本志緒里　河野麻理　中澤文恵　海道雅子　大渕絢子　炬口真理子　井本しおん　西郷勝康
- Organizer
  第33回医学生物学電子顕微鏡技術学会
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] Bortezomib causes ER stress-related cell death in APL cells through excessive accumulation of PML-RARA2016
- Author(s)
  Mariko Takenokuchi
- Organizer
  4th Biotechnology World Congress, University of Sharjah, UAE
- Place of Presentation
  Sharjah University, UAE
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460711
[Presentation] Sytox Greenを用いたNET定量計測法の検討とヘミンの効果2016
- Author(s)
  大渕絢子、北川開平、炬口真理子、河野麻理、井本しおん、西郷勝康
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] プロテアソーム阻害剤の治療効果を反映する疾患特異的ユビキチン化酵素測定の有用性2016
- Author(s)
  炬口真理子
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場、神戸国際展示場、神戸ポートピアホテル
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-25460711
[Presentation] 感染症による肺障害モデルマウスを用いた活性化好中球の形態観察2016
- Author(s)
  河野麻理、山本志緒里、松岡広、河野誠司、井本しおん、炬口真理子、大渕絢子、西郷勝康
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] Detection method of neutrophil after extracellular trap formation using flow cytometry2016
- Author(s)
  Mari Kono、Shiori Yamamoto、Yuri Takagi、Makoto Hashimoto、Yosuke Minami、Shion Imoto、Mariko Takenokuchi、Ayako Obuchi、Katsuyasu Saigo
- Organizer
  第78回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08660
[Presentation] Bortezomib causes ER stress-related cell death in APL through excessive accumulation of PML-RARA2015
- Author(s)
  Mariko Takenokuchi
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460711
[Presentation] ヒストンは好中球細胞外トラップの生成を誘導する2015
- Author(s)
  西郷勝康、河野麻理、高木由里、高橋隆幸、和田淳、橋本誠、南陽介、井本しおん、炬口真理子
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08660

1. SAIGO Katsuyasu (20304107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
2. MIYAMOTO Kazuhide (10415317)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. TANIGUCHI Taizo (70346253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. HASHIMOTO Makoto (40379433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. KUMAGAI Shunichi (00153346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 角山圭一 (70454767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KONO Mari

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. HIRAMATSU Yasushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAMOTO Mitsuteru

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. OKAMURA Akiharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takenokuchi Mariko 炬口 真理子

炬口 真理子 タケノクチ マリコ

TAKENOKUCHI Makoto 炬口 真理子

Research Projects

Research Products

Co-Researchers

Identification and clinical usefulness of biomarkers for treatment option of multiple myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of M-protein related ubiquitin enzyme as a new biomarker for Multiple MyelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of clinical and pathological evaluation method of NETs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Highly sensitive detection of ubiquitination using tumor-bearing mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of serum ubiquitin enzyme as a new biomarker for PML-RARA leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

)Usefulness of immature platelet fraction (IPF) on decision making of platelet transfusion for the patients with hematologic malignancies.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Acetate moderately attenuates the generation of neutrophil extracellular traps2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 鉄キレート療法の多彩な効果2018

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 鉄キレート療法の多彩な効果2018

Author(s)

Journal Title

Data Source

[Journal Article] Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Iron chelating agent, Deferasirox, inhibits neutrophil activation and extracellular trap (NET) formation.2016

Author(s)

Journal Title

Data Source

[Journal Article] Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML&#8211;RARA2015

Author(s)

Journal Title

Data Source

[Journal Article] Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML-RARA2015

Author(s)

Journal Title

Data Source

[Journal Article] Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity.2012

Author(s)

Journal Title

Takenokuchi Mariko 炬口真理子

炬口真理子タケノクチマリコ

TAKENOKUCHI Makoto 炬口真理子

[Journal Article] Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML–RARA2015