Takahashi Etsuhisa 高橋悦久

… Alternative Names

TAKAHASHI Etsuhisa 高橋悦久

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Researcher Number	10380065
Other IDs
Affiliation (Current)	2025: 徳島大学, 先端酵素学研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 徳島大学, 先端酵素学研究所(デザイン), 特任助教 2015: 徳島大学, 疾患酵素学研究センター, 特任助教
Review Section/Research Field	Principal Investigator Infectious disease medicine Except Principal Investigator Infectious disease medicine
Keywords	Principal Investigator ノイラミニダーゼ阻害剤 / ケモカイン / 宿主プロテアーゼ / 再感染 / 免疫記憶 / クラリスロマイシン / サイトカイン / 免疫メモリー / マクロライド / インフルエンザ … More Except Principal Investigator … More トリプシン / 治療薬 / サイトカインストーム / 代謝破綻 / 重症化 / MCP-1 / MMP-9 / イムノモジュレーター / ウイルス / 乳酸菌 / マクロライド / イムノモデュレータ / 血管内皮細胞 / 多臓器不全 / 脂質代謝 / 糖代謝 / ミトコンドリア / サイトカイン / インフルエンザ / 感染症 Less

Study on the pathogenesis of severe influenza virus infection associated with cytokine storm and its effective treatment options
- Principal Investigator
  
  KIDO Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  The University of Tokushima
Clarithromycin improves immune memory in influenza infectionPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Etsuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  The University of Tokushima

All 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.2019
- Author(s)
  Kimoto T, Kim H, Sakai S, Takahashi E, Kido H
- Journal Title
  
  Vaccine
  
  Volume: 37 Issue: 4 Pages: 612-622
- DOI
  10.1016/j.vaccine.2018.12.002
- NAID
  120007042440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-17K16267
[Journal Article] Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice2018
- Author(s)
  Kim Hyejin、Kimoto Takashi、Sakai Satoko、Takahashi Etsuhisa、Kido Hiroshi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 1 Pages: 1-15
- DOI
  10.1371/journal.pone.0191133
- NAID
  120006812010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16267, KAKENHI-PROJECT-16H05348
[Journal Article] Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus2018
- Author(s)
  Takahashi Etsuhisa、Indalao Irene L.、Sawabuchi Takako、Mizuno Keiko、Sakai Satoko、Kimoto Takashi、Kim Hyejin、Kido Hiroshi
- Journal Title
  
  Comparative Immunology, Microbiology and Infectious Diseases
  
  Volume: 56 Pages: 6-13
- DOI
  10.1016/j.cimid.2017.11.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16267, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-15K09569
[Journal Article] Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.2018
- Author(s)
  Hayashi H, Kubo Y, Izumida M, Takahashi E, Kido H, Sato K, Yamaya M, Nishimura H, Nakayama K, Matsuyama T.
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 8 Pages: 91-91
- DOI
  10.3389/fcimb.2018.00091
- NAID
  120006937672
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15319, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-15K08499
[Journal Article] Prion protein protects mice from lethal infection with influenza A viruses2018
- Author(s)
  Chida Junji、Hara Hideyuki、Yano Masashi、Uchiyama Keiji、Das Nandita Rani、Takahashi Etsuhisa、Miyata Hironori、Tomioka Yukiko、Ito Toshihiro、Kido Hiroshi、Sakaguchi Suehiro
- Journal Title
  
  PLOS Pathogens
  
  Volume: 14 Issue: 5 Pages: e1007049-e1007049
- DOI
  10.1371/journal.ppat.1007049
- NAID
  120006524496
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07499, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
[Journal Article] Anti-influenza virus activity of extracts from stems of Jatropha multifida Linn. collected in Myanmar2017
- Author(s)
  M. Shoji, S. Woo, A. Masuda, N. N. Win, H. Ngwe, E. Takahashi, H. Kido, H. Morita, T. Ito.
- Journal Title
  
  BMC Complem Altern Med
  
  Volume: 17 Issue: 1 Pages: 96-96
- DOI
  10.1186/s12906-017-1612-8
- NAID
  120006814109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05138, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-17K08333
[Journal Article] IL-1 beta is a key cytokine which induces trypsin upregulation in influenza virus-cytokine-trypsin cycle2016
- Author(s)
  Indalao IK, Sawabuchi T, Takahashi E, Kido H.
- Journal Title
  
  Arch Virol
  
  Volume: 162 Issue: 1 Pages: 201-211
- DOI
  10.1007/s00705-016-3093-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05348
[Journal Article] Energy metabolic disorder is a major risk factor in severe influenza virus infection. Proposals for new therapeutic options based on animal model experiments.2016
- Author(s)
  Kido H, Indalao IL, Kim H, Kimoto T, Sakai S, Takahashi E
- Journal Title
  
  Respir Investg
  
  Volume: 54 Pages: 312-319
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] A型インフルエンザ感染においてマクロライド薬は単球走化性タンパク質(MCP-1)産生を抑制し感染局所の炎症性細胞浸潤を軽減すると共に、長期免疫メモリーを増強する2018
- Author(s)
  高橋　悦久、澤淵　貴子、木戸　博
- Organizer
  第25回マクロライド新作用研究会
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] SF-10 adjuvant derived from pulmonary surfactant enhances incorporation of antigens into intestinal antigen presenting cells and induces antigen specific immunities.2018
- Author(s)
  Kimoto T, Sakai S, Kameda K, Takahashi E, Kido H
- Organizer
  第54 回日本肺サーファクタント・界面医学界
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] インフルエンザ感染モデル動物実験法2018
- Author(s)
  高橋　悦久、木戸　博
- Organizer
  第25回マクロライド新作用研究会
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] 肺サーファクタント由来人工合成SF-10アジュバントは、小腸粘膜の抗原提示細胞への抗原取り込みを増強し、消化管と気道粘膜の抗原特異的抗体産生細胞を誘導する2018
- Author(s)
  木本　貴士、堺　聡子、亀田　桂子、高橋　悦久、木戸　博
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] インフルエンザAウイルス感染においてクラリスロマイシン投与によりMMP-9とMCP-1の発現誘導が抑制され、肺と心臓の炎症が軽減される2017
- Author(s)
  高橋悦久、澤淵貴子、木本貴士、堺聡子、木戸博
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] インフルエンザ感染により発現増加するMMP-9とMCP-1はクラリスロマイシンの経口投与により抑制され、炎症が軽減される2017
- Author(s)
  高橋悦久、澤淵貴子、木本貴士、堺聡子、木戸博
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] インフルエンザAウイルス感染においてクラリスロマイシン投与によりMMP-9とMCP-1の発現誘導が抑制され、肺と心臓の炎症が軽減される2017
- Author(s)
  高橋悦久、澤淵貴子、木本貴士、堺　聡子、木戸　博
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15K09569
[Presentation] インフルエンザ感染により発現増加するMMP-9とMCP-1はクラリスロマイシンの経口投与により抑制され、炎症が軽減される2017
- Author(s)
  高橋悦久、澤淵貴子、木本貴士、堺　聡子、木戸　博
- Organizer
  日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09569
[Presentation] IL-1 beta; signaling induces trypsin upregulation in influenza virus-cytokine-trypsin cycle in multiple organ failure by infection2016
- Author(s)
  Indalao IK, Sawabuchi T, Takahashi E, Kido H.
- Organizer
  Option IX
- Place of Presentation
  Chicago, Sheraton Grand Chicago, USA
- Year and Date
  2016-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] Trypsin upregulation is mainly affected by IL-1β in influenza-cytokine protease cycle2016
- Author(s)
  Indalao IK, Sawabuchi T, Takahashi E, Kido H.
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] Trypsin upregulation is mainly affected by IL-1β in influenza-cytokine protease cycle2016
- Author(s)
  Indalao IK, Sawabuchi T, Takahashi E, Kido H.
- Organizer
  日本生化学会
- Place of Presentation
  東北大学　川内キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05348
[Presentation] インフルエンザ重症化におけるクラリスロマイシンの治療効果の検討2015
- Author(s)
  高橋悦久、木戸博
- Organizer
  マクロライド新作用研究会
- Place of Presentation
  飯田橋レインボービル「東京都新宿区」
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K09569
[Presentation] インフルエンザ重症化で発現増加するMMP-9はクラリスロマイシンの投与により抑制される2015
- Author(s)
  高橋悦久、Irene Lorinda Indalao、澤淵貴子、冨永ゆかり、木戸博
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  ANAクラウンプラザホテルグランコート名古屋「愛知県名古屋市」
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K09569
[Presentation] IL-1beta signaling potentiates trypsin upregulation in influenza virus-cytokine-trypsin cycle in the lungs2015
- Author(s)
  Irene Lorinda Indalao、澤淵貴子、高橋悦久、木戸博
- Organizer
  日本生化学会
- Place of Presentation
  神戸ポートアイランド「兵庫県神戸市」
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K09569

1. KIDO Hiroshi (50144978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. SAWAFUCHI Takako

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. IL INDALAO

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KUBO Yoshinao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. ITO Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. MORITA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 木本貴士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 林日出喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 原英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Etsuhisa 高橋 悦久

TAKAHASHI Etsuhisa 高橋 悦久

Research Projects

Research Products

Co-Researchers

Study on the pathogenesis of severe influenza virus infection associated with cytokine storm and its effective treatment options

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarithromycin improves immune memory in influenza infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Prion protein protects mice from lethal infection with influenza A viruses2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Anti-influenza virus activity of extracts from stems of Jatropha multifida Linn. collected in Myanmar2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] IL-1 beta is a key cytokine which induces trypsin upregulation in influenza virus-cytokine-trypsin cycle2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Energy metabolic disorder is a major risk factor in severe influenza virus infection. Proposals for new therapeutic options based on animal model experiments.2016

Author(s)

Journal Title

Data Source

[Presentation] A型インフルエンザ感染においてマクロライド薬は単球走化性タンパク質(MCP-1)産生を抑制し感染局所の炎症性細胞浸潤を軽減すると共に、長期免疫メモリーを増強する2018

Author(s)

Organizer

Data Source

[Presentation] SF-10 adjuvant derived from pulmonary surfactant enhances incorporation of antigens into intestinal antigen presenting cells and induces antigen specific immunities.2018

Author(s)

Organizer

Data Source

[Presentation] インフルエンザ感染モデル動物実験法2018

Author(s)

Organizer

Data Source

[Presentation] 肺サーファクタント由来人工合成SF-10アジュバントは、小腸粘膜の抗原提示細胞への抗原取り込みを増強し、消化管と気道粘膜の抗原特異的抗体産生細胞を誘導する2018

Author(s)

Organizer

Data Source

[Presentation] インフルエンザAウイルス感染においてクラリスロマイシン投与によりMMP-9とMCP-1の発現誘導が抑制され、肺と心臓の炎症が軽減される2017

Author(s)

Organizer

Takahashi Etsuhisa 高橋悦久

TAKAHASHI Etsuhisa 高橋悦久