IMAMURA Morikazu 今村守一

… Alternative Names

IMAMURA MORIKAZU 今村守一

今村守一イマムラモリカズ

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Researcher Number	10391442
Affiliation (Current)	2025: 宮崎大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 宮崎大学, 医学部, 准教授 2015: 国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門越境性感染症研究領域, 上級研究員 2013 – 2014: 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所インフルエンザ・プリオン病研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Virology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator PMCA / プリオン / 補因子 / プリオン病 / 牛海綿状脳症 / 試験管内増幅 / BSE / 異常プリオン蛋白質 / 試験管内プリオン生成 / 試験管内変換 … More / 遺伝性プリオン病 / 孤発性プリオン病 / 構造変換補因子 / 異常型プリオン蛋白質 … More Except Principal Investigator プリオン / TDP-43 / タウ蛋白 / 多系統萎縮症 / アルファシヌクレイン / レビー小体病 / プリオンタンパク質 / RT-QuIC法 / 融合タンパク質 / GPIアンカー / プリオンタンパク / αシヌクレイン Less

Elucidation of the origin of typical bovine spongiform encephalopathyPrincipal Investigator
- Principal Investigator
  
  Imamura Morikazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  University of Miyazaki
Does GPI-anchored modification promote the pathogenicity and transmissibility of alpha-synucleinopathies?
- Principal Investigator
  
  Atarashi Ryuichiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  University of Miyazaki
Elucidation of the mechanism of spontaneous prion production in sporadic and familial prion diseasesPrincipal Investigator
- Principal Investigator
  
  IMAMURA MORIKAZU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  University of Miyazaki
試験管内増幅法を用いた異常プリオン蛋白質の複製に関与する補因子の探索Principal Investigator
- Principal Investigator
  
  今村守一
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Agriculture and Food Research Organization

All 2023 2022 2019 2018 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures2022
- Author(s)
  Takatsuki H, Imamura M, Mori T, Atarashi R.
- Journal Title
  
  Sci Rep.
  
  Volume: － Issue: 1 Pages: 7923-7923
- DOI
  10.1038/s41598-022-12049-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-21K07277, KAKENHI-PROJECT-20K07807
[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 613 Pages: 67-72
- DOI
  10.1016/j.bbrc.2022.04.137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-20K07807
[Journal Article] First case of atypical scrapie in a goat in Japan2019
- Author(s)
  Matsuura Y, Miyazawa K, Imamura M, Yokoyama T, Iwamaru Y.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 81 Issue: 7 Pages: 986-989
- DOI
  10.1292/jvms.18-0710
- NAID
  130007677812
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07393
[Journal Article] Multiple-affinity purification of a baculovirusderived recombinant prion protein with in vitro ability to convert to its pathogenic form2016
- Author(s)
  Morikazu Imamura, Nobuko Kato, Yoshifumi Iwamaru, Shirou Mohri, Takashi Yokoyama, Yuichi Murayama
- Journal Title
  
  Preparative Biochemistry and Biotechnology
  
  Volume: Epub ahead of print Issue: 1 Pages: 1-7
- DOI
  10.1080/10826068.2016.1155058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460575
[Journal Article] Insect Cell-Derived Cofactors Become Fully Functional after Proteinase K and Heat Treatment for High-Fidelity Amplification of Glycosylphosphatidylinositol-Anchored Recombinant Scrapie and BSE Prion Proteins2013
- Author(s)
  Morikazu Imamura, Nobuko Kato, Hiroyuki Okada, Miyako Yoshioka, Yoshifumi Iwamaru, Yoshihisa Shimizu, Shirou Mohri, Takashi Yokoyama, Yuichi Murayama
- Journal Title
  
  PLOS ONE
  
  Volume: 8(12) Issue: 12 Pages: e82538-e82538
- DOI
  10.1371/journal.pone.0082538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460575
[Presentation] Demonstration of multiple prion conformers in natural scrapie isolates by PMCA2023
- Author(s)
  Morikazu Imamura
- Organizer
  Asian Pacific Prion Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05938
[Presentation] H-BSE prions adapted to ovine PrP in vitro acquired C-BSE-like properties.2022
- Author(s)
  Morikazu Imamura, Hiroyuki Okada, Kotaro Miyazawa, Yuichi Matsuura, Yoshifumi Iwamaru, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi
- Organizer
  Asian Pacific Prion Symposium 2022
- Data Source
  KAKENHI-PROJECT-21K05938
[Presentation] Isolation of hidden minor prion conformers from classical scrapie isolates in advanced protein misfolding cyclic amplification in the presence of arginine ethyl ester.2019
- Author(s)
  Imamura M, Miyazawa K, Matsuura Y, Iwamaru Y, Kitamoto T, Mohri S, Takatsuki H, Mori T, Atarashi R
- Organizer
  APPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07393
[Presentation] Highly sensitive detection of PrPSc derived from various prion strains by simultaneous addition of digitonin, heparin and arginine ethyl ester to protein misfolding cyclic amplification.2018
- Author(s)
  Imamura M, Tabeta N, Matsuura Y, Iwamaru Y, Kitamoto T, Ma J, Mohri S, Murayama Y, Takatsuki H, Mori T, Atarashi R
- Organizer
  Prion 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07393
[Presentation] Simultaneous addition of digitonin, heparin and arginine ethyl ester improves in vitro amplification of PrPSc derived from various prion strains.2018
- Author(s)
  Imamura M, Tabeta N, Matsuura Y, Iwamaru Y, Kitamoto T, Ma J, Mohri S, Murayama Y, Takatsuki H, Mori T, Atarashi R
- Organizer
  APPS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07393
[Presentation] In vitro approach to estimate the human transmission risk of prions2018
- Author(s)
  Iwamaru Y, Imamura M, Matsuura Y, Miyazawa K, Yokoyama T
- Organizer
  Prion 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07393
[Presentation] Estimating the risk of transmission of BSE and scrapie to ruminants and humans by protein misfolding cyclic amplification2015
- Author(s)
  Morikazu Imamura, Naoko Tabeta, Yoshifumi Iwamaru, Yuichi Murayama
- Organizer
  Asian Pacific Prion Symposium (APPS) 2015
- Place of Presentation
  石川県立音楽堂　（石川県金沢市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-25460575
[Presentation] Risk estimation of transmission of BSE and scrapie by PMCA2015
- Author(s)
  Morikazu Imamura, Naoko Tabeta, Yoshifumi Iwamaru, Yuichi Murayama
- Organizer
  Prion 2015
- Place of Presentation
  Colorado, USA
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-25460575
[Presentation] グリコサミノグリカンは昆虫細胞由来異常プリオン蛋白質の試験管内増幅における核酸の役割を代替できる2013
- Author(s)
  今村守一、加藤紳子、岩丸祥史、横山隆、村山裕一
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25460575
[Presentation] Glycosaminoglycans can be used as substitutes for nucleic acids in in vitro amplification of insect cell-derived abnormal form of prion protein
- Author(s)
  今村守一、加藤伸子、岩丸祥史、横山隆、村山裕一
- Organizer
  Asia Pacific Prion Symposium 2014
- Place of Presentation
  済州（韓国）
- Year and Date
  2014-07-06 – 2014-07-07
- Data Source
  KAKENHI-PROJECT-25460575

1. Atarashi Ryuichiro (90452846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 岩丸祥史 (20355142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

IMAMURA Morikazu 今村 守一

IMAMURA MORIKAZU 今村 守一

今村 守一 イマムラ モリカズ

Research Projects

Research Products

Co-Researchers

Elucidation of the origin of typical bovine spongiform encephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Does GPI-anchored modification promote the pathogenicity and transmissibility of alpha-synucleinopathies?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of spontaneous prion production in sporadic and familial prion diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

試験管内増幅法を用いた異常プリオン蛋白質の複製に関与する補因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First case of atypical scrapie in a goat in Japan2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Multiple-affinity purification of a baculovirusderived recombinant prion protein with in vitro ability to convert to its pathogenic form2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insect Cell-Derived Cofactors Become Fully Functional after Proteinase K and Heat Treatment for High-Fidelity Amplification of Glycosylphosphatidylinositol-Anchored Recombinant Scrapie and BSE Prion Proteins2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Demonstration of multiple prion conformers in natural scrapie isolates by PMCA2023

Author(s)

Organizer

Data Source

[Presentation] H-BSE prions adapted to ovine PrP in vitro acquired C-BSE-like properties.2022

Author(s)

Organizer

Data Source

[Presentation] Isolation of hidden minor prion conformers from classical scrapie isolates in advanced protein misfolding cyclic amplification in the presence of arginine ethyl ester.2019

Author(s)

Organizer

Data Source

[Presentation] Highly sensitive detection of PrPSc derived from various prion strains by simultaneous addition of digitonin, heparin and arginine ethyl ester to protein misfolding cyclic amplification.2018

Author(s)

Organizer

Data Source

[Presentation] Simultaneous addition of digitonin, heparin and arginine ethyl ester improves in vitro amplification of PrPSc derived from various prion strains.2018

Author(s)

Organizer

Data Source

[Presentation] In vitro approach to estimate the human transmission risk of prions2018

Author(s)

IMAMURA Morikazu 今村守一

IMAMURA MORIKAZU 今村守一

今村守一イマムラモリカズ