SHINOHARA HISAAKI 篠原久明

… Alternative Names

篠原久明シノハラヒサアキ

SHINOHARA Hisaaki 篠原久明

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Researcher Number	10391971
Other IDs	https://orcid.org/0000-0002-6331-2138
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2018: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2015 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 2008 – 2010: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2007: The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 2006: 独立行政法人理化学研究所, 分化制御研究グループ, 研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 54010:Hematology and medical oncology-related / Complex systems / Biological Sciences
Keywords	Principal Investigator シグナル動態 / B細胞 / NF-κB / シグナル伝達 / シグナルネットワーク / 細胞分化 / シグナル活性動態 / 免疫制御 / 抗原受容体シグナル / CBMシグナロソーム … More / 数理解析 / 免疫応答 / 動態モデル / 情報伝達 / モデリング / 遺伝子発現 / 生体生命情報学 / 蛋白質 / 免疫学 / 数理モデル / BCRシグナル / ユビキチン化酵素 / 活性動態 / 分化決定システム / シグナル動態制御 / 遺伝子発現解析 / 数理モデル解析 / 分子活性動態 / 反応速度数理モデル / B細胞シグナル / 抗原受容体 / 獲得免疫 / MAP3K / NF-kappaB / TAK1 / Bcl10 / PKCβ / BCR / IKKβ / CARMA1 / B細胞抗原受容体 Less

An interdisciplinary analysis of CBM signalosome assemblyPrincipal Investigator
- Principal Investigator
  
  篠原久明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Control mechanism of signal kinetics encoding B cell differentiationPrincipal Investigator
- Principal Investigator
  
  篠原久明
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo University of Science, Yamaguchi
  Institute of Physical and Chemical Research
Control of B cell differentiation by manipulation of signal dynamicsPrincipal Investigator
- Principal Investigator
  
  SHINOHARA HISAAKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
B細胞分化シグナルの動態を制御するユビキチン修飾の解析Principal Investigator
- Principal Investigator
  
  篠原久明
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
MAP3K regulation of immune cell development and functionPrincipal Investigator
- Principal Investigator
  
  SHINOHARA Hisaaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
NF-kB活性化を制御する新規標的CARMA1の機能発現部位決定と機構の解析Principal Investigator
- Principal Investigator
  
  篠原久明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2016 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Regulation mechanisms of <scp>CARMA1</scp> ?Bcl10? <scp>MALT1</scp> complex assembly inferred from the analysis of <scp>TRAF6</scp> ‐deficient cells2023
- Author(s)
  Inoue Kentaro、Yasuda Tomoharu、Baba Yoshihiro、Yamamoto Tadashi、Kurosaki Tomohiro、Shinohara Hisaaki
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 6 Pages: 411-421
- DOI
  10.1111/gtc.13022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08484, KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-21H02751
[Journal Article] Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling.2016
- Author(s)
  Shinohara H, Inoue K, Yumoto N, Nagashima T, Okada-Hatakeyama M.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 27706-27706
- DOI
  10.1038/srep27706
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15KT0084, KAKENHI-PROJECT-15K08534
[Journal Article] TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells.2016
- Author(s)
  Shinohara H, Nagashima T, Cascalho MI, Kurosaki T.
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 11 Pages: 1233-1243
- DOI
  10.1111/gtc.12442
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15K08534
[Journal Article] Negative role of TAK1 for marginal zone B-cell development incidental to activation of the NF-κB non-canonical pathway.2016
- Author(s)
  Shinohara H, and Kurosaki T.
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01195
[Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016
- Author(s)
  Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25738-25738
- DOI
  10.1038/srep25738
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15H04705, KAKENHI-PROJECT-15H04746, KAKENHI-PROJECT-15J07574, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-15K08534, KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15217
[Journal Article] Negative role of TAK1 for marginal zone B-cell development incidental to activation of the NF-κB non-canonical pathway2016
- Author(s)
  Shinohara H, Kurosaki T.
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08534
[Journal Article] Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.2016
- Author(s)
  Shinohara H, Kurosaki T.
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 94 Issue: 9 Pages: 821-829
- DOI
  10.1038/icb.2016.44
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15K08534
[Journal Article] A.LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-κB activation2016
- Author(s)
  3.Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Yuhei K, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08534
[Journal Article] TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation.2016
- Author(s)
  Shinohara H, Yasuda T, Kurosaki T.
- Journal Title
  
  FEBS Letters.
  
  Volume: 590 Issue: 18 Pages: 3264-3269
- DOI
  10.1002/1873-3468.12342
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15K08534
[Journal Article] Oscillation Dynamics Underlies Functional Switching of NF-κB for B Cell Activation.2016
- Author(s)
  Inoue K, Shinohara H, Behar M, Yumoto N, Tanaka G, Hoffmann A, Aihara K, Okada-Hatakeyama M.
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 2 Issue: 1 Pages: 16024-16024
- DOI
  10.1038/npjsba.2016.24
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15K08534, KAKENHI-PROJECT-15K21624, KAKENHI-PROJECT-15H05707
[Journal Article] LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-κB activation.2016
- Author(s)
  Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Yuhei K, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 25738-25738
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01195
[Journal Article] Dephosphorylation of Carma1 by PP2A negatively regulates T cell activation2011
- Author(s)
  Eitelhuber A C., Warth S., Schimmack G., Duwel M., Hadian K., Demski K., Beisker W., Shinohara H., Kurosaki T., Heissmeyer V., Krappmann D.
- Journal Title
  
  EMBO J 30(3)
  
  Pages: 594-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] B cell signaling and fate decision.2010
- Author(s)
  Kurosaki T., Shinohara H., Baba Y.
- Journal Title
  
  Ann Rev Immunol. 28
  
  Pages: 21-55
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-κB activity.2010
- Author(s)
  Moreno-Garcia M.E., Sommer K., Shinohara H., Bandaranayake A.D, Kurosaki T., Rawlings D.J.
- Journal Title
  
  Mol Cell Biol. 30(4)
  
  Pages: 922-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK3.2009
- Author(s)
  Shinohara H., Yamasaki S., Maeda S., Saito T., Kurosaki T.
- Journal Title
  
  Int.Immunol. 21(4)
  
  Pages: 393-401
- NAID
  10025385463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] Comprehending the Complex Connection between PKCβ, TAK1, and IKK in BCR-signaling.2009
- Author(s)
  Shinohara H., Kurosaki T.
- Journal Title
  
  Immunol Rev. 232
  
  Pages: 300-318
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] Comprehending the Complex Connection between PKCβ, TAK1, and IKK in BCR-signaling2009
- Author(s)
  Shinohara, H., Kurosaki T.
- Journal Title
  
  Immunological Review 232
  
  Pages: 300-318
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] PLCγ2 and Vav cooperate within 'microsignalosomes' to propagate B cell spreading in response to membrane-bound antigen.2008
- Author(s)
  Weber M., Treanor B, Depoil D., Shinohara H., Harwood N.E., Hikida M., Kurosaki T, Batista F.D.
- Journal Title
  
  J Exp Med. 205
  
  Pages: 853-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] IκB kinase β-induced phosphorylation of CARMA1 contributes to CARMAl-Bcl10-MALTl complex formation in B cells2007
- Author(s)
  Shinohara, H., et. al.
- Journal Title
  
  J. Exp. Med. 204
  
  Pages: 3285-3293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790347
[Journal Article] B cell signaling and fate decision
- Author(s)
  Kurosaki T., Shinohara H., Baba Y.
- Journal Title
  
  Annual Review of Immunology (in press)
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-κB activity
- Author(s)
  Moreno-Garcia M.E., Sommer K., Shinohara H., et al.
- Journal Title
  
  Molecular and Cellular Biology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK3
- Author(s)
  Shinohara, H., et al.
- Journal Title
  
  International Immunology
- NAID
  10025385463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590496
[Presentation] Mathematical model of NFkB signaling regulated by TRAF6 in B cell2023
- Author(s)
  井上健太郎, 篠原久明
- Organizer
  2023年日本バイオインフォマティクス学会年会第12回生命医薬情報学連合大会（IIBMP2023）
- Data Source
  KAKENHI-PROJECT-22K08484
[Presentation] Integrated analysis of the dynamic gene expression regulated by NF-κB.2016
- Author(s)
  Iwamoto K, Shinohara H, Hayashi T, Nikaido I, Suzuki Y and Okada M.
- Organizer
  International Conference on Systems Biology (ICSB 2016).
- Place of Presentation
  Barcelona, Spain.
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08534
[Presentation] 免疫・生体応答を制御するシステムの探究2016
- Author(s)
  篠原久明
- Organizer
  九州工業大学：BMIRCセミナー
- Place of Presentation
  九州工業大学(福岡県飯塚市)
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01195
[Presentation] 免疫・生体応答を制御するシステムの探究2016
- Author(s)
  篠原久明
- Organizer
  九州工業大学：BMIRCセミナー
- Place of Presentation
  九州工業大学 (福岡県飯塚市)
- Invited
- Data Source
  KAKENHI-PROJECT-15K08534
[Presentation] Integrated analysis of the dynamic gene expression regulated by NF-κB.2016
- Author(s)
  1.Iwamoto K, Shinohara H, Hayashi T, Nikaido I, Suzuki Y and Okada M.
- Organizer
  International Conference on Systems Biology (ICSB 2016).
- Place of Presentation
  Barcelona, Spain.
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195
[Presentation] IκB kinase β-induced phosphorylation of CARMAl contributes to CARMAl-Bcl10-MALTl complex formation in B cells2007
- Author(s)
  Shinohara, H. and Kurosaki, T.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18790347

1. Inoue Kentarou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Hoffman Alexander

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHINOHARA HISAAKI 篠原 久明

篠原 久明 シノハラ ヒサアキ

SHINOHARA Hisaaki 篠原 久明

Research Projects

Research Products

Co-Researchers

An interdisciplinary analysis of CBM signalosome assemblyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control mechanism of signal kinetics encoding B cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of B cell differentiation by manipulation of signal dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

B細胞分化シグナルの動態を制御するユビキチン修飾の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MAP3K regulation of immune cell development and functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NF-kB活性化を制御する新規標的CARMA1の機能発現部位決定と機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation mechanisms of <scp>CARMA1</scp> ?Bcl10? <scp>MALT1</scp> complex assembly inferred from the analysis of <scp>TRAF6</scp> ‐deficient cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Negative role of TAK1 for marginal zone B-cell development incidental to activation of the NF-κB non-canonical pathway.2016

Author(s)

Journal Title

Data Source

[Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Negative role of TAK1 for marginal zone B-cell development incidental to activation of the NF-κB non-canonical pathway2016

Author(s)

Journal Title

Data Source

[Journal Article] Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A.LRRK1 controls B-cell responses by regulating CARMA1-dependent NF-κB activation2016

Author(s)

Journal Title

Data Source

[Journal Article] TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation.2016

SHINOHARA HISAAKI 篠原久明

篠原久明シノハラヒサアキ

SHINOHARA Hisaaki 篠原久明