SHINKAI Akeo 新海暁男

… Alternative Names

新海暁男シンカイアケオ

Less

Researcher Number	10391989
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究所, 特別嘱託研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 開拓研究本部, 上級研究員 2018 – 2019: 国立研究開発法人理化学研究所, 開拓研究本部, 先任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 横山構造生物学研究室, 先任研究員 2013 – 2014: 独立行政法人理化学研究所, 横山構造生物学研究室, 先任研究員 2010 – 2012: 独立行政法人理化学研究所, 機能解析第1研究チーム, チームリーダー
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Structural biochemistry / Molecular biology / Genome biology
Keywords	Principal Investigator リボヌクレアーゼ / 低分子RNA / 超分子複合体 / CRISPR-Cas / Thermus thermophilus / 細菌 / 機能未知タンパク質 / 構造生物学 / 無細胞タンパク質合成法 / リボヌクレオタンパク質 … More / Cmr複合体 / CRISPR-Casシステム / 国際情報交換（オランダ、アメリカ） / タンパク質 / 電子顕微鏡構造 / 獲得免疫 / mRNA / 機能未知遺伝子 / 転写制御 / 機能ゲノム科学 / 転写因子 / TetRファミリー / 蛋白質 / 高度好熱菌 / 機能発見 / X線結晶構造 / 遺伝子発現調節 Less

DNA維持メチル化制御因子HELLS-CDCA7の新規機能の探求Principal Investigator
- Principal Investigator
  
  新海暁男
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the bacterial adaptive immune system of extremely thermophilic bacterium by high-resolution structural studiesPrincipal Investigator
- Principal Investigator
  
  Shinkai Akeo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research
Systematic understanding of novel anti-virus system in a cellPrincipal Investigator
- Principal Investigator
  
  Shinkai Akeo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
Classification of functionally unknown genes based on their transcriptional regulationPrincipal Investigator
- Principal Investigator
  
  SHINKAI Akeo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning.2015
- Author(s)
  Taylor D.W., Zhu Y., Staals R.H.J., Kornfeld J.E., Shinkai A., van der Oost J., Nogales E., Doudna J.A.
- Journal Title
  
  Science
  
  Volume: 348 Issue: 6234 Pages: 581-585
- DOI
  10.1126/science.aaa4535
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440013
[Journal Article] Structure and function of Type III-B CRISPR-Cmr complex from Thermus thermophilus2015
- Author(s)
  新海　暁男
- Journal Title
  
  生化学
  
  Volume: 87 Issue: 4 Pages: 454-458
- DOI
  10.14952/SEIKAGAKU.2015.870454
- ISSN
  0037-1017
- Year and Date
  2015-08-25
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440013
[Journal Article] Structure and Function of CRISPR-Cas System2014
- Author(s)
  新海　暁男
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 54 Issue: 5 Pages: 247-252
- DOI
  10.2142/biophys.54.247
- NAID
  130004693950
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440013
[Journal Article] RNA-targeting by the Type III-A CRISPR-Cas complex of Thermus thermophilus.2014
- Author(s)
  Staals R.H.J., Zhu Y., Taylor D.W., Kornfeld J.E., Sharma K., Barendregt A., Koehorst J.J., Vlot M., Varossieau K., Neupane N., Sakamoto K., Suzuki T., Dohmae N., Yokoyama S., Schaap P.J., Urlaub H., Heck A.J.R., Nogales E., Doudna J.A., Shinkai A., van der Oost J.
- Journal Title
  
  Molecular　Cell
  
  Volume: 56 Issue: 4 Pages: 518-530
- DOI
  10.1016/j.molcel.2014.10.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440013
[Journal Article] LdrP, a cAMP receptor protein/FNR family transcriptional regulator, serves as a positive regulator for the light-inducible gene cluster in the megaplasmid of Thermus thermophilus2014
- Author(s)
  Hideaki Takano, Yoshihiro Agari, Kenta Hagiwara, Ren Watanabe, Ryuta Yamazaki, Teruhiko Beppu, Akeo Shinkai, Kenji Ueda
- Journal Title
  
  Microbiology
  
  Volume: 160 Issue: 12 Pages: 2650-2660
- DOI
  10.1099/mic.0.082263-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510208, KAKENHI-PROJECT-25450113
[Journal Article] Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus2013
- Author(s)
  Staals, R. H. J., Agari, Y., Maki-Yonekura, S., Zhu, Y., Taylor, D. W., van Duijn, E., Barendregt, A., Vlot, M., Koehorst, J. J., Sakamoto, K., Masuda, A., Dohmae, N., Schaap, P. J., Doudna, J. A., Heck, A. J. R., Yonekura, K., van der Oost, J. and Shinkai, A.
- Journal Title
  
  Molecular Cell
  
  Volume: 52 Issue: 1 Pages: 135-145
- DOI
  10.1016/j.molcel.2013.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657111, KAKENHI-PROJECT-25440013
[Journal Article] Structure and function of a TetR family transcriptional regulator, SbtR, from Thermus thermophilus HB82013
- Author(s)
  Agari Y, Sakamoto K, Yutani K, Kuramitsu S, Shinkai A.
- Journal Title
  
  Proteins
  
  Volume: (in press) Issue: 7 Pages: 1166-1178
- DOI
  10.1002/prot.24266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510208, KAKENHI-PROJECT-22570166
[Journal Article] Transcriptional repression mediated by a TetR family protein, PfmR, from Thermus thermophilus HB82012
- Author(s)
  Agari Y, Sakamoto K, Kuramitsu S, Shinkai A.
- Journal Title
  
  J. Bacteriol
  
  Volume: 194(17) Issue: 17 Pages: 4630-4641
- DOI
  10.1128/jb.00668-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510208
[Journal Article] Phenylacetyl-coenzyme A is an effector molecule of TetR family transcriptional repressor PaaR from Thermus thermophilus HB82011
- Author(s)
  Sakamoto K, Agari Y, Kuramitsu S, Shinkai A
- Journal Title
  
  J. Bacteriol
  
  Volume: 193(17) Issue: 17 Pages: 4388-4395
- DOI
  10.1128/jb.05203-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510208
[Journal Article] TetR family transcriptional repressor Thermus thermophilus FadR controls fatty acid degradation2011
- Author(s)
  Agari Y, Agari K, Sakamoto K, Kuramitsu S, Shinkai A
- Journal Title
  
  Microbiology
  
  Volume: 157(Pt 6) Issue: 6 Pages: 1589-1601
- DOI
  10.1099/mic.0.048017-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 大腸菌無細胞タンパク質合成法を用いた、Thermus thermophilus CRISPR-Cmr複合体の再構成2016
- Author(s)
  新海　暁男、横山　茂之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07285
[Presentation] 大腸菌無細胞タンパク質合成法を利用した、Thermus thermophilus CRISPR-Cmr複合体の再構成2016
- Author(s)
  新海　暁男、横山　茂之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター・東北大学（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K07285
[Presentation] 高度好熱菌Thermus thermophilus由来Type III-B CRISPR-Casシステムを構成するCmr複合体の構造と機能2015
- Author(s)
  新海　暁男
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌、北海道札幌市
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25440013
[Presentation] 高度好熱菌Thermus thermophilusのType III CRISPR-Casシステムを構成しているリボヌクレオタンパク質複合体の構造と機能2015
- Author(s)
  新海　暁男
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド、兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25440013
[Presentation] 高度好熱菌Thermus thermophilus HB8株における転写因子の機能解析と機能未知遺伝子の分類2013
- Author(s)
  新海暁男
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館、鳥取
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Functional identification of transcriptional regulators from T. thermophilus HB82012
- Author(s)
  新海暁男
- Organizer
  第2回モデル生物丸ごと一匹学会
- Place of Presentation
  SPring-8、兵庫
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Structural and functional analysis of TetR family transcriptional regulator PfmR from Thermus thermophilus HB82012
- Author(s)
  上利佳弘、坂本恵子、新海暁男
- Organizer
  第2回モデル生物丸ごと一匹学会
- Place of Presentation
  Spring-8、兵庫
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 分子間ジスルフィド結合を持つThermus thermophilus HB8由来TetRファミリー転写因子TTHA0167の構造と機能2012
- Author(s)
  坂本恵子、上利佳弘、倉光成紀、新海暁男
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡、福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Thermus thermophilus HB8由来TetRファミリー転写調節因子 PfmRによる転写抑制2012
- Author(s)
  上利佳弘、坂本恵子、倉光成紀、新海暁男
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡、福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Structural and functional analysis of TetR family transcriptional regulator TTHA0167 from T. thermophilus HB82012
- Author(s)
  坂本恵子、上利佳弘、新海暁男
- Organizer
  第2回モデル生物丸ごと一匹学会
- Place of Presentation
  SPring-8、兵庫
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Functional and structural characterization of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB82011
- Author(s)
  Keiko Sakamoto, Yoshihiro Agari, Seiki Kuramitsu, Akeo Shinkai
- Organizer
  第1回モデル生物丸ごと一匹学会(高度好熱菌丸ごと一匹プロジェクト第10回連携研究会共催)
- Place of Presentation
  スプリング-8(兵庫県)
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Thermus thermophilus PaaR, a TetR family transcriptional repressor, is involved in phenylacetic acid degradation2011
- Author(s)
  Keiko Sakamoto, Yoshihiro Agari, Seiki Kuramitsu, Akeo Shinkai
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Study of transcriptional regulatory system of T.thermophilus HB8 : Structure and function of two TetR family proteins2011
- Author(s)
  Akeo Shinkai, Yoshihiro Agari, Keiko Sakamoto
- Organizer
  第1回モデル生物丸ごと一匹学会(高度好熱菌丸ごと一匹プロジェクト第10回連携研究会共催)
- Place of Presentation
  スプリング-8(兵庫県)(招待講演)
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Structural and functional genomics of a model organism Thermus thermophilus HB8: toward functional discovery of functionally unknown proteins2011
- Author(s)
  Shinkai A, Bessho Y, Agari Y, Iino H, Fukui K, Kitamura A, Sakamoto K, Kim K, Masui R, Yokoyama S, Kuramitsu S
- Organizer
  International Conference on Structural Genomics
- Place of Presentation
  Chestnut Conference Centre、トロント、カナダ
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 高度好熱菌Thermus thermophilus HB8株をモデル生物とし、転写制御の観点から機能未知遺伝子を分類する:転写因子の機能発見研究と機能未知遺伝子の分類2011
- Author(s)
  新海暁男、上利佳弘、坂本恵子
- Organizer
  第84回日本生化学大会
- Place of Presentation
  京都国際会館、京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Functional and structural characterization of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB82011
- Author(s)
  坂本恵子、上利佳弘、倉光成紀、新海暁男
- Organizer
  第1回モデル生物丸ごと一匹学会
- Place of Presentation
  SPring-8、兵庫
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Study of transcriptional regulatory system of T. thermophilus HB8: Structure and function of two TetR family proteins2011
- Author(s)
  新海暁男、上利佳弘、坂本恵子
- Organizer
  第1回モデル生物丸ごと一匹学会
- Place of Presentation
  SPring-8、兵庫
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 高度好熱菌Thermus thermophilus HB8株をモデル生物とし、転写制御の観点から機能未知遺伝子を分類する:転写因子の機能発見研究と機能未知遺伝子の分類2011
- Author(s)
  新海暁男、上利佳弘、坂本恵子
- Organizer
  第84回日本生化学大会シンポジウム
- Place of Presentation
  京都国際会館(京都府)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Thermus thermophilus PaaR, a TetR family transcriptional repressor, is involved in phenylacetic acid degradation2011
- Author(s)
  坂本恵子、上利佳弘、倉光成紀、新海暁男
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 脂肪酸の分解を制御する、高度好熱菌Thermus thermophilus HB8 由来TetR ファミリー転写因子FadR の構造と機能"BMB20102010
- Author(s)
  上利佳弘、上利和子、坂本恵子、倉光成紀、新海暁男
- Organizer
  第33回日本分子生物学会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド、神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] 脂肪酸分解を制御する、高度好熱菌Thermus thermophilus HB8由来TetRファミリー転写因子FadRの構造と機能2010
- Author(s)
  上利佳弘、上利和子、坂本恵子、倉光成紀、新海暁男
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] The Cmr complex of Thermus thermophilus
- Author(s)
  Raymond H.J. Staals, Yoshihiro Agari, John van der Oost, Akeo Shinkai
- Organizer
  CRISPR: evolution, mechanisms and infection
- Place of Presentation
  University of St Andrews, United Kingdom
- Data Source
  KAKENHI-PROJECT-25440013
[Presentation] 高度好熱菌Thermus thermophilus HB8株における転写因子の機能解析と機能未知遺伝子の分類
- Author(s)
  新海暁男
- Organizer
  第13回日本蛋白質科学会年会ワークショップ
- Place of Presentation
  とりぎん文化会館、鳥取
- Invited
- Data Source
  KAKENHI-PROJECT-22510208
[Presentation] Functional and structural genomics studies on Thermus thermophilus CRISPR-Cas systems
- Author(s)
  Akeo Shinkai
- Organizer
  The 65th Fujihara Seminar, Internal Symposium on Synthetic Biology of Unnatural Base Pairs and Amino Acids, The Fujihara Foundation of Science
- Place of Presentation
  グランドホテルニュー王子、北海道苫小牧市
- Data Source
  KAKENHI-PROJECT-25440013

1. AGARI Yoshihiro (50469889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. YONEKURA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. MAKI-YONEKURA Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHINKAI Akeo 新海 暁男

新海 暁男 シンカイ アケオ

Research Projects

Research Products

Co-Researchers

DNA維持メチル化制御因子HELLS-CDCA7の新規機能の探求Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the bacterial adaptive immune system of extremely thermophilic bacterium by high-resolution structural studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Systematic understanding of novel anti-virus system in a cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Classification of functionally unknown genes based on their transcriptional regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and function of Type III-B CRISPR-Cmr complex from Thermus thermophilus2015

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Structure and Function of CRISPR-Cas System2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] RNA-targeting by the Type III-A CRISPR-Cas complex of Thermus thermophilus.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LdrP, a cAMP receptor protein/FNR family transcriptional regulator, serves as a positive regulator for the light-inducible gene cluster in the megaplasmid of Thermus thermophilus2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and function of a TetR family transcriptional regulator, SbtR, from Thermus thermophilus HB82013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional repression mediated by a TetR family protein, PfmR, from Thermus thermophilus HB82012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenylacetyl-coenzyme A is an effector molecule of TetR family transcriptional repressor PaaR from Thermus thermophilus HB82011

Author(s)

Journal Title

DOI

Data Source

SHINKAI Akeo 新海暁男

新海暁男シンカイアケオ