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Manabe Noriyoshi  真鍋 法義

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… Alternative Names

真鍋 法義  マナベ ノリヨシ

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Researcher Number 10392383
Other IDs
Affiliation (Current) 2025: 東北医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2022 – 2023: 東北医科薬科大学, 薬学部, 講師
2017 – 2020: 東北医科薬科大学, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Ophthalmology
Keywords
Principal Investigator
多糖認識機構 / βグルカン / Dectin-1 / レクチン受容体 / βグルカン認識 / 白内障 / 眼病理学 / 眼科学 / 計算化学と生化学実験 / リン酸触媒 … More / 乳酸触媒 / 紫外線の影響 / アミノ酸残基の非酵素反応 / アスパラギン酸残基異性化 / 白内障の病態形成 / NMR / 計算化学 / 白内障病態形成 Less
  • Research Projects

    (2 results)
  • Research Products

    (48 results)
  • Co-Researchers

    (2 People)
  •  βグルカンの構造多様性を受容するDectin-1受容体の分子メカニズムの解明Principal Investigator

    • Principal Investigator
      真鍋 法義
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  Elucidation of the mechanism of D-amino acid residue formation in crystallin involved in the pathogenesis of cataractPrincipal Investigator

    • Principal Investigator
      Manabe Noriyoshi
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Tohoku Medical and Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Solution NMR Analysis of O-Glycopeptide?Antibody Interaction2024

    • Author(s)
      Kokubu Ryoka、Ohno Shiho、Manabe Noriyoshi、Yamaguchi Yoshiki
    • Journal Title

      Methods in Molecular Biology

      Volume: 2763 Pages: 321-327

    • DOI

      10.1007/978-1-0716-3670-1_26

    • ISBN
      9781071636695, 9781071636701
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Comparative Conformational Analysis of Acyclic Sugar Alcohols Ribitol, Xylitol and d-Arabitol by Solution NMR and Molecular Dynamics Simulations2024

    • Author(s)
      Ohno Shiho、Manabe Noriyoshi、Uzawa Jun、Yamaguchi Yoshiki
    • Journal Title

      Molecules

      Volume: 29 Issue: 5 Pages: 1072-1072

    • DOI

      10.3390/molecules29051072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-19H05648
  • [Journal Article] A convenient assay for soluble Dectin-1 lectin domain binding to insoluble β-glucans2024

    • Author(s)
      Chiba Hanako、Manabe Noriyoshi、Naito Junko、Nishida Norihisa、Ohno Naohito、Yamaguchi Yoshiki
    • Journal Title

      Carbohydrate Research

      Volume: 536 Pages: 109041-109041

    • DOI

      10.1016/j.carres.2024.109041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] NMR characterization of uniformly <sup>13</sup>C‐ and/or <sup>15</sup>N‐labeled, unsulfated chondroitins with high molecular weights2024

    • Author(s)
      Ichikawa Megumi、Otsuka Yuya、Minamisawa Toshikazu、Manabe Noriyoshi、Yamaguchi Yoshiki
    • Journal Title

      Magnetic Resonance in Chemistry

      Volume: 62 Issue: 6 Pages: 439-451

    • DOI

      10.1002/mrc.5426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Prediction of protein structure and AI2024

    • Author(s)
      Ohno Shiho、Manabe Noriyoshi、Yamaguchi Yoshiki
    • Journal Title

      Journal of Human Genetics

      Volume: - Issue: 10 Pages: 477-480

    • DOI

      10.1038/s10038-023-01215-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Molecular Dynamics Simulation and Docking of MUC1 O-Glycopeptide2024

    • Author(s)
      Kokubu Ryoka、Ohno Shiho、Manabe Noriyoshi、Yamaguchi Yoshiki
    • Journal Title

      Methods in Molecular Biology

      Volume: 2763 Pages: 373-379

    • DOI

      10.1007/978-1-0716-3670-1_32

    • ISBN
      9781071636695, 9781071636701
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Each N-glycan on human IgA and J-chain uniquely affects oligomericity and stability.2023

    • Author(s)
      Pan S, Manabe N, Ohno S, Komatsu S, Fujimura T, Yamaguchi Y.
    • Journal Title

      Biochim Biophys Acta Gen Subj.

      Volume: 1868 Issue: 2 Pages: 130536-130536

    • DOI

      10.1016/j.bbagen.2023.130536

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05880, KAKENHI-PROJECT-22K06562
  • [Journal Article] Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL2023

    • Author(s)
      Aoki Eriko、Manabe Noriyoshi、Ohno Shiho、Aoki Taiga、Furukawa Jun-Ichi、Togayachi Akira、Aoki-Kinoshita Kiyoko、Inokuchi Jin-Ichi、Kurosawa Kenji、Kaname Tadashi、Yamaguchi Yoshiki、Nishihara Shoko
    • Journal Title

      Molecular Genetics and Metabolism Reports

      Volume: 37 Pages: 101016-101016

    • DOI

      10.1016/j.ymgmr.2023.101016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-23K24759
  • [Journal Article] AlphaFill: Docking Ligands and Cofactors into AlphaFold Models2023

    • Author(s)
      Manabe Noriyoshi
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 35 Issue: 206 Pages: E61-E61

    • DOI

      10.4052/tigg.2316.6E

    • ISSN
      0915-7352, 1883-2113
    • Year and Date
      2023-07-25
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Chemical and Chemo-Enzymatic Syntheses of Glycans Containing Ribitol Phosphate Scaffolding of Matriglycan2022

    • Author(s)
      Tamura Jun-ichi、Tamura Takahiro、Hoshino Shunsuke、Imae Rieko、Kato Ryuichi、Yokono Mizuki、Nagase Mao、Ohno Shiho、Manabe Noriyoshi、Yamaguchi Yoshiki、Manya Hiroshi、Endo Tamao
    • Journal Title

      ACS Chemical Biology

      Volume: 17 Issue: 6 Pages: 1513-1523

    • DOI

      10.1021/acschembio.2c00181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-19K07058, KAKENHI-PROJECT-19H05648
  • [Journal Article] Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin2022

    • Author(s)
      Tamura Takahiro、Omura Yuka、Kotera Kota、Ito Ryota、Ohno Shiho、Manabe Noriyoshi、Yamaguchi Yoshiki、Tamura Jun-ichi
    • Journal Title

      Organic &amp; Biomolecular Chemistry

      Volume: 20 Issue: 43 Pages: 8489-8500

    • DOI

      10.1039/d2ob01388f

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-19H05648
  • [Journal Article] A Data Set of Ion Mobility Collision Cross Sections and Liquid Chromatography Retention Times from 71 Pyridylaminated N-Linked Oligosaccharides2022

    • Author(s)
      Manabe Noriyoshi、Ohno Shiho、Matsumoto Kana、Kawase Taiji、Hirose Kenji、Masuda Katsuyoshi、Yamaguchi Yoshiki
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 33 Issue: 9 Pages: 1772-1783

    • DOI

      10.1021/jasms.2c00165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Journal Article] Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A)2022

    • Author(s)
      Nagae Masamichi、Hirata Tetsuya、Tateno Hiroaki、Mishra Sushil K.、Manabe Noriyoshi、Osada Naoko、Tokoro Yuko、Yamaguchi Yoshiki、Doerksen Robert J.、Shimizu Toshiyuki、Kizuka Yasuhiko
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 695-695

    • DOI

      10.1038/s42003-022-03661-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-20H03207, KAKENHI-PROJECT-20K06575
  • [Journal Article] O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations2022

    • Author(s)
      Kokubu Ryoka、Ohno Shiho、Kuratani Hirohide、Takahashi Yuka、Manabe Noriyoshi、Shimizu Hiroki、Chiba Yasunori、Denda-Nagai Kaori、Tsuiji Makoto、Irimura Tatsuro、Yamaguchi Yoshiki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 14 Pages: 7855-7855

    • DOI

      10.3390/ijms23147855

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-22K06562, KAKENHI-PROJECT-22K06603
  • [Journal Article] Phosphate-Catalyzed Succinimide Formation from an NGR-Containing Cyclic Peptide: A Novel Mechanism for Deammoniation of the Tetrahedral Intermediate2018

    • Author(s)
      Ryota Kirikoshi, Noriyoshi Manabe, Ohgi Takahashi
    • Journal Title

      Molecules

      Volume: 23 Issue: 9 Pages: 2217-2217

    • DOI

      10.3390/molecules23092217

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Journal Article] Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism2018

    • Author(s)
      Ryota Kirikoshi, Noriyoshi Manabe and Ohgi Takahashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 2 Pages: 637-637

    • DOI

      10.3390/ijms19020637

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Journal Article] Racemization of Serine Residues Catalyzed by Dihydrogen Phosphate Ion: A Computational Study2017

    • Author(s)
      Ohgi Takahashi, Ryota Kirikoshi and Noriyoshi Manabe
    • Journal Title

      Catalysts

      Volume: 7 Issue: 12 Pages: 363-363

    • DOI

      10.3390/catal7120363

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] ヒトDectin-1レクチンドメインの大量発現方法の検討とその性状解析2024

    • Author(s)
      千葉 花子,真鍋 法義,内藤 淳子,西田 典永,大野 尚仁,山口 芳樹
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] レクチン受容体Dectin-1の不溶性βグルカン結合における構造特異性2023

    • Author(s)
      千葉 花子, 真鍋 法義, 内藤 淳子, 西田 典永, 髙橋 円, 大野 尚仁, 山口 芳樹
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] ヒト免疫グロブリン A1 の Fc 結合糖鎖の構造と機能2023

    • Author(s)
      潘 順麗,真鍋 法義,小松 祥子,藤村 務,山口 芳樹
    • Organizer
      第62回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] 分子動力学計算によるO-マンノース糖鎖の動的構造および相互作用の解析2023

    • Author(s)
      大野 詩歩,佐々木 南波,湊谷 敬太,真鍋 法義,山口 芳樹
    • Organizer
      日本生化学会東北支部第89回例会シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] イオンモビリティー質量分析法によるピリジルアミノ化糖鎖の異性体識別2023

    • Author(s)
      真鍋 法義, 大野 詩歩, 川瀬 泰司, 廣瀬 賢治, 益田 勝吉, 山口 芳樹
    • Organizer
      第71回質量分析総合討論会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] イオンモビリティー質量分析法によるピリジルアミノ化糖鎖の分離・同定2023

    • Author(s)
      真鍋法義, 大野詩歩, 川瀬泰司, 廣瀬賢治, 益田勝吉, 山口芳樹
    • Organizer
      第42回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Ion mobility mass spectrometry analysis of 71 pyridylaminated N-linked oligosaccharides for database construction2023

    • Author(s)
      Noriyoshi Manabe, Shiho Ohno, Taiji Kawase, Kenji Hirose, Katsuyoshi Masuda, Yoshiki Yamaguchi
    • Organizer
      Glyco26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] ヒトDectin-1レクチンドメインの大量発現とその性状解析2023

    • Author(s)
      千葉花子, 真鍋法義, 内藤淳子, 西田典永, 大野尚仁, 山口芳樹
    • Organizer
      第42回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Dectin-1レクチンドメインの大量発現およびβグルカンとの結合試験2023

    • Author(s)
      真鍋 法義,山口 芳樹
    • Organizer
      第17 回東北糖鎖研究会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Ion mobility mass spectrometry analysis of pyridylaminated oligosaccharides including isomers2023

    • Author(s)
      Noriyoshi Manabe
    • Organizer
      The 2nd TMPU - Academia Sinica Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] リガンド結合により形成されるDectin-1オリゴマーの物理化学的解析2023

    • Author(s)
      真鍋 法義, 大崎 暁斗, 兒玉 篤治, 内山 進, 内橋 貴之, 加藤 晃一, 山口 芳樹
    • Organizer
      第7回東北医真菌研究会東北支部会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] O-マンノース糖鎖を構成するリビトールおよびその類縁体のダイナミクス解析2023

    • Author(s)
      大野 詩歩, 真鍋 法義, 山口 芳樹
    • Organizer
      第62回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Dectin-1レクチンドメインとパラミロンを含む不溶性βグルカンとの結合試験法の確立2022

    • Author(s)
      千葉 花子, 真鍋 法義, 内藤 淳子, 西田 典永, 髙橋 円, 大野 尚仁, 山口 芳樹
    • Organizer
      第41回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] NMR データを組み込んだドッキングシミュレーションによる R-13E 抗体-糖鎖リガンド複合体のモデル構築2022

    • Author(s)
      大内 陽翔,大野 詩歩,齋藤 祐希,真鍋 法義,湯浅 徳行,松崎 祐二,築地 信,川嵜 敏祐,山口 芳樹
    • Organizer
      第16回東北糖鎖研究会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] マウス・ヒトDectin-1 レクチンドメインの大量発現とその性状比較2022

    • Author(s)
      真鍋法義、山口 芳樹
    • Organizer
      第6回東北医真菌研究会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Chemical and chemo-enzymatic syntheses of glycans containing ribitol phosphate scaffolding of matriglycan2022

    • Author(s)
      Jun-ichi Tamura, Takahiro Tamura, Shunsuke Hoshino, Rieko Imae, Mao Nagase, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi, Hiroshi Manya,
    • Organizer
      30 th International Carbohydrate Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] 抗未分化iPS細胞抗体R-13Eとlacto-N-fucopentaose Iの相互作用解析2022

    • Author(s)
      大野 詩歩,大内 陽翔,齋藤 祐希,真鍋 法義,湯浅 徳行,松崎 祐二,築地 信,川嵜 敏祐,山口 芳樹
    • Organizer
      第41回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] αXyl-βGlcA の繰り返し構造とラミニンの相互作用解析2022

    • Author(s)
      真鍋 法義, 伊藤 良汰, 大野 詩歩, 田村 敬裕, 田村 純一, 萬谷 博, 遠藤 玉夫, 山口 芳樹
    • Organizer
      第16回東北糖鎖研究会
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] Analysis of conformation and interaction of αXyl-βGlcA repeating unit2022

    • Author(s)
      Yoshiki Yamaguchi,Noriyoshi Manabe,Shiho Ohno,Ryota Ito,Takahiro Tamura,Hiroshi Manya,Tamao Endo,Jun-ichi Tamura
    • Organizer
      30 th International Carbohydrate Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06562
  • [Presentation] NMR法によるペプチド中のAsp残基異性化のin situ判別2021

    • Author(s)
      真鍋 法義、大野 詩歩、山口 芳樹
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] 紫外線照射によるトリプトファン残基の化学構造変化2020

    • Author(s)
      真鍋法義,星憲司,大野詩歩,山口芳樹
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] リン酸二水素イオンを触媒とするAsp-Ser配列からのスクシンイミド生成2019

    • Author(s)
      大野詩歩,真鍋法義,高橋央宜
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] 白内障の病態形成に関与するクリスタリン中Asp残基異性化の乳酸による触媒機構~計算化学的・生化学的検討~2019

    • Author(s)
      真鍋法義,佐々木雅人,田中大,大野賢一,大野詩歩,桐越亮太,加藤創,藤村務,柴田信之,高橋央宜
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] Asp-His配列からのスクシンイミド形成:His側鎖による分子内触媒機構2019

    • Author(s)
      高橋央宜,大野詩歩,真鍋法義
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] スクシンイミド残基のラセミ化:リン酸二水素イオンによる触媒機構の計算化学的研究2018

    • Author(s)
      高橋央宜,安達夢,工藤雅仁,進藤和記子,桐越亮太,真鍋法義
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] 白内障病態形成に関わるクリスタリン中Asp残基異性化の乳酸による触媒機構~計算化学的・生化学的検討~2018

    • Author(s)
      真鍋法義,佐々木雅人,田中大,加藤創,藤村務,柴田信之,高橋央宜
    • Organizer
      第57回白内障学会総会・第44回水晶体研究会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] アスパラギン酸残基からのスクシンイミド生成:リン酸水素イオン-カルシウムイオン接触イオン対による触媒作用の可能性2018

    • Author(s)
      高橋央宜,桐越亮太,大野詩歩,真鍋法義
    • Organizer
      第14回 D-アミノ酸学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] Asp-Aspモチーフにおける非酵素反応:水4分子を含むモデル計算2018

    • Author(s)
      真鍋法義,岩渕明音,山本琴音,桐越亮太,高橋央宜
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] Racemization of serine residues catalyzed by dihydrogen phosphate ion: a computational study2017

    • Author(s)
      Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe
    • Organizer
      The International Conference of D-Amino Acid Research(IDAR2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] Phosphate-catalyzed succinimide formation from Asp residues: a computational study of the mechanism2017

    • Author(s)
      Ryota Kirikoshi, Noriyoshi Manabe, Ohgi Takahashi
    • Organizer
      The International Conference of D-Amino Acid Research(IDAR2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16981
  • [Presentation] Lactic acid-catalyzed non-enzymatic deamidation of asparagine residues to four aspartic acid isomers: a computational study2017

    • Author(s)
      Noriyoshi Manabe, Ryota Kirikoshi, Ohgi Takahashi
    • Organizer
      The International Conference of D-Amino Acid Research(IDAR2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16981
  • 1.  FUJIMURA Tsutomu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  傅田 香里
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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