Tokuda Haruhiko 徳田治彦

… Alternative Names

徳田治彦トクダハルヒコ

TOKUDA Haruhiko 徳田治彦

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Researcher Number	10397325
Other IDs	https://orcid.org/0000-0001-7552-9003
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 病院, 副院長 2025: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 部長 2025: 岐阜大学, 大学院医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立長寿医療研究センター, 病院, 副院長 2022 – 2023: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 部長 2016 – 2019: 岐阜大学, 大学院医学系研究科, 非常勤講師 2014 – 2015: 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 2010 – 2013: 独立行政法人国立長寿医療研究センター, 臨床検査部, 部長 … More 2010: Gifu University, 医学系研究科, 非常勤講師 2007 – 2010: 岐阜大学, 大学院・医学系研究科, 非常勤講師 2008: 岐阜大学, 大学院・医学系研究科・非常勤, 講師 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Laboratory medicine Except Principal Investigator Basic Section 58060:Clinical nursing-related / General internal medicine (including Psychosomatic medicine) / Metabolomics
Keywords	Principal Investigator 骨芽細胞 / MAPキナーゼ / 細胞移動 / ケモカイン / TNF-α M-CSF / M-CSF / osteoprotegerin / bFGF / oncostatin M / 骨マクロファージ … More / 破骨細胞 / 石灰化 / TGF-β / VEGF / IGF-I / HSP70 / 遊走細胞 / MAP キナーゼ / PDGF / HSP90 / 細胞遊走 / ストレスタンパク質 / サイトカイン / 細胞増殖因子 / 細胞運動 / 骨粗鬆症 / 熱ショックタンパク質 / 高分子量 / prostaglandin E2 / SAPK/JNK / p44/p42 MAPキナーゼ / オステオプレテジェリン / プロスタグランジンD2 / オステオプロテジェリン / プロスタグランジン / AMPキナーゼ / エネルギー代謝 / 骨代謝 / ストレス / ストレス蛋白質 / 血栓 / 血小板 / 糖尿病 … More Except Principal Investigator セルフケア / 介入 / 高齢糖尿病 / フットセルフケア / ナッジ / プログラム / 糖尿病 / 高齢者 / フットケア / 縦断研究 / インクレチン / チアゾリジン / 低血糖 / インクレチン関連薬 / 認知症 / 高齢者糖尿病 / ポリフェノール / カテキン / 骨芽細胞 / マップキナーゼ / ストレス蛋白質 Less

骨マクロファージと骨芽細胞の相互作用による骨代謝制御機構の分子基盤に関する研究Principal Investigator
- Principal Investigator
  
  徳田治彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Center for Geriatrics and Gerontology
高齢糖尿病患者のフットケア自立支援に関する介入方法の構築
- Principal Investigator
  
  サブレ森田さゆり
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  National Center for Geriatrics and Gerontology
Roles of high molecular-weight heat shock proteins in bome metabolism, especially osteoblast functionsPrincipal Investigator
- Principal Investigator
  
  Tokuda Haruhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
Roles of AMP-activated protein kinase in bone metabolismPrincipal Investigator
- Principal Investigator
  
  TOKUDA HARUHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
Effects of diabetic clinical manifestation and treatment (thiazolidine and DPP-IV inhibitors) on the cognitive decline in diabetic elderly.
- Principal Investigator
  
  SAKURAI TAKASHI
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  National Center for Geriatrics and Gerontology
Molecular mechanism of platelet hyper-aggregation in patients with type 2 diabetes and development of method for the diagnosisPrincipal Investigator
- Principal Investigator
  
  TOKUDA Haruhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gifu University
Molecular mechanism of chaperone properties in bone metabolism
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Gifu University

All 2024 2023 2019 2018 2017 2016 2015 2014 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony-stimulating factor synthesis in bFGF-stimulated osteoblast-like cells.2024
- Author(s)
  Hioki Tomoyuki、Tachi Junko、Ueda Kyohei、Matsushima-Nishiwaki Rie、Iida Hiroki、Kozawa Osamu、Tokuda Haruhiko
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 27 Issue: 1 Pages: 1-9
- DOI
  10.3892/etm.2023.12322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09438
[Journal Article] Oncostatin M attenuates tumor necrosis factor-α-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts.2023
- Author(s)
  Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Connect. Tissue Res.
  
  Volume: 64 Issue: 2 Pages: 139-147
- DOI
  10.1080/03008207.2022.2109468
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09438, KAKENHI-PROJECT-19K18471
[Journal Article] HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase2019
- Author(s)
  Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O.
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 4 Pages: 169-178
- DOI
  10.2220/biomedres.40.169
- NAID
  130007689874
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.2019
- Author(s)
  Kim W, Tokuda H, Kawabata T, Fujita K, Sakai G, Nakashima D, Tachi J, Kuroyanagi G, Matsushima-Nishiwaki R, Tanabe K, Otsuka T, Iida H, Kozawa O.
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 143 Pages: 106327-106327
- DOI
  10.1016/j.prostaglandins.2019.03.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-17K11002
[Journal Article] HSP90 limits thrombin-stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells: Regulation of p38 MAPK.2018
- Author(s)
  Fujita K, Otsuka T, Kawabata T, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 42 Pages: 2185-2192
- DOI
  10.3892/ijmm.2018.3785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling.2018
- Author(s)
  Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Otsuka T, Kozawa O.
- Journal Title
  
  Biomed. Rep.
  
  Volume: 9 Pages: 318-326
- DOI
  10.3892/br.2018.1140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] (-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity.2018
- Author(s)
  Kawabata T, Otsuka T, Fujita K, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 42 Pages: 3149-3156
- DOI
  10.3892/ijmm.2018.3884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Inhibitors of heat shock protein 90 augment endothelin-1-induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.2018
- Author(s)
  Fujita K, Otsuka T, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 17 Pages: 8542-8547
- DOI
  10.3892/mmr.2018.8878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Association of HSP22 with mTOR in osteoblasts: regulation of TNF-α-stimulated IL-6 synthesis2018
- Author(s)
  Sakai Go、Tokuda Haruhiko、Yamamoto Naohiro、Matsushima-Nishiwaki Rie、Fujita Kazuhiko、Kawabata Tetsu、Kozawa Osamu、Otsuka Takanobu
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 7 Pages: 1202-1210
- DOI
  10.1002/1873-3468.13028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10487, KAKENHI-PROJECT-17K11002
[Journal Article] HSP70 Inhibitor Suppresses IGF-I-Stimulated Migration of Osteoblasts through p44/p42 MAP Kinase.2018
- Author(s)
  Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Kuroyanagi G, Otsuka T, Kozawa O.
- Journal Title
  
  Biomedicines.
  
  Volume: 6 Issue: 4 Pages: 109-109
- DOI
  10.3390/biomedicines6040109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-17H07009
[Journal Article] HSP70 Inhibitors Reduce The Osteoblast Migration By Epidermal Growth Factor.2018
- Author(s)
  Kawabata T, Otsuka T, Fujita K, Sakai G, Kim W, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
- Journal Title
  
  Curr. Mol. Med.
  
  Volume: 18 Issue: 7 Pages: 486-495
- DOI
  10.2174/1566524019666181213112847
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-17H07009
[Journal Article] Heat shock protein 70 negatively regulates TGF-β-stimulated VEGF synthesis via p38 MAP kinase in osteoblasts.2017
- Author(s)
  Sakai G, Tokuda H, Fujita K, Kainuma S, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 44 Issue: 3 Pages: 1133-1145
- DOI
  10.1159/000485418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-15K10487
[Journal Article] Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts.2016
- Author(s)
  Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O and Tokuda H.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 4 Issue: 4 Pages: 3363-3369
- DOI
  10.3892/mmr.2016.4900
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462289, KAKENHI-PROJECT-26462309
[Journal Article] Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts.2016
- Author(s)
  Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O and Tokuda H.
- Journal Title
  
  Exp Ther Med.
  
  Volume: 5 Pages: 2042-2048
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462289
[Journal Article] PGD2 stimulates osteoprotegerin synthesis via AMP-activated protein kinase in osteoblasts: regulation of ERK and SAPK/JNK.2015
- Author(s)
  Kainuma S, Tokuda H, Kuroyanagi G, Yamamoto N, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O and Otsuka T.
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids.
  
  Volume: 101 Pages: 23-29
- DOI
  10.1016/j.plefa.2015.08.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462289
[Journal Article] Differential subtypes of diabetic elderly diagnosed with Alzheimer's disease2014
- Author(s)
  Sakurai T, Kawashima S, Satake S, Miura H, Tokuda H, Toba K
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 14 Pages: 62-70
- Data Source
  KAKENHI-PROJECT-22590654
[Journal Article] Factors associated with increased caregivers’ burden in several cognitive stages of Alzheimer disease.2014
- Author(s)
  Sakurai T, Kawashima S, Satake S, Miura H, Tokuda H, Toba K
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 14 Issue: S2 Pages: 62-70
- DOI
  10.1111/ggi.12260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590654
[Journal Article] Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling.2014
- Author(s)
  Kuroyanagi G, Tokuda H, Matsushima-Nishiwaki R, Kondo A, Mizutani J, Kozawa O, Otsuka T.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 542 Pages: 39-45
- DOI
  10.1016/j.abb.2013.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-26462289
[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD4OL from human platelets : role of HSP27 phosphorylation via p44/p42 MAPK.2010
- Author(s)
  Kato H, Tokuda H, et al.
- Journal Title
  
  Thromb. Res.
  
  Volume: 126 Pages: 39-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Thromboxane A_2 promotes soluble CD40 ligand release from human platelets.2010
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T, Kozawa O.
- Journal Title
  
  Atherosclerosis 209
  
  Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
- Author(s)
  Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Int.J.Mol.Med. 26
  
  Pages: 387-392
- NAID
  120006341935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
- Author(s)
  Doi T, Tokuda H, et al.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 26 Pages: 387-392
- NAID
  120006341935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD4OL from human platelets : role of HSP27 phosphorylation via p44/p42 MAPK.2010
- Author(s)
  Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Thromb.Res. 126
  
  Pages: 39-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Raloxifene enhances spontaneous microaggregation of platelets through up-regulation of p44/p42 MAP kinase : a case report.2010
- Author(s)
  Tokuda H, Harada A, Adachi S, Matsushima-Nishiwaki R, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
- Journal Title
  
  Osteoporosis Int. 21
  
  Pages: 189-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Thromboxane A2 promotes soluble CD40 ligand release fromhuman platelets.2010
- Author(s)
  Enomoto Y, Tokuda H, et al.
- Journal Title
  
  Atherosclerosis
  
  Volume: 209 Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.2009
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T, Kozawa O.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 2464-2468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts2009
- Author(s)
  Minamitani C, Otsuka T, Takai S, Matsushima Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
- Journal Title
  
  Int. J. Mol. Med. 24
  
  Pages: 77-82
- NAID
  120006340793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Level of collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.2009
- Author(s)
  Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O, Tokuda H.
- Journal Title
  
  Life Sci. 85
  
  Pages: 386-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts2009
- Author(s)
  Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med. 23
  
  Pages: 267-272
- NAID
  120006340794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Antithrombin III suppresses ADP-induced platelet granule secretion : inhibition of HSP27 phosphorylation.2009
- Author(s)
  Doi T, Tokuda H, et al.
- Journal Title
  
  Arch.Biochem.Biophys. 489
  
  Pages: 62-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] αB-crystallin extracellularly suppresses ADP-induced granule secretion from buman platelets.2009
- Author(s)
  Enomoto Y, Tokuda H, et al.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 2464-2468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Rho-kinase inhibitors decrease TGF-β-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts2009
- Author(s)
  Kuno M, Takai S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Otsuka T, Harada A, Adachi S, Kozawa O, Tokuda H.
- Journal Title
  
  Bicohem. Pharmacol 77
  
  Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Antithrombin III suppresses ADP-induced platelet granule secretion : inhibition of HSP27 phosphorylation.2009
- Author(s)
  Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Arch.Biochem.Biophys. 489
  
  Pages: 62-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Function of Rho-kinase in prostaglandin D_2-induced interleukin-6 synthesis in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Adachi S, Minamitani C, Mizutani J, Otsuka T, Kozawa O
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids 79
  
  Pages: 41-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate reduces platelet-derived growth factor BB-stimulated interleukin-6 synthesis in osteoblasts : suppression of SAPK/JNK2008
- Author(s)
  Takai S, Matsushima-Nishiwaki R, Adachi S, Natsume H, Minamitani C, Mizutani J, Otsuka T, Tokuda H, Kozawa O
- Journal Title
  
  Mediators Inflamm 2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor induced interleukin-6 synthesis in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Harada A, Hosoi T, Ohta T, Kozawa O.
- Journal Title
  
  Horm. Metab. Res. 40
  
  Pages: 674-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] A case of raloxifene-induced acceleration of platelet aggregation2008
- Author(s)
  Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H.
- Journal Title
  
  Internal Med. 47
  
  Pages: 1523-1528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Involvement of Rho-kinase in prostaglandin F2α stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts2008
- Author(s)
  Minamitani C, Otsuka T, Takai S, Matsushima Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
- Journal Title
  
  Mol. Cell. Endocrinol 291
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] p70 S6 kinase negatively regulates FGF-2-stimulated IL-6 synthesis in osteoblasts: function at a point downstream from protein kinase C2008
- Author(s)
  Takai S, Hanai Y, Matushima-Nishiwaki R, Minamitani C, Otsuka T, Tokuda H, Kozawa O.
- Journal Title
  
  J. Endocrinol 197
  
  Pages: 131-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.2008
- Author(s)
  Minamitani C, Tokuda H, et al.
- Journal Title
  
  Int. J. Mol. Med. (in press)
- NAID
  120006340793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] (-)-Epigallocatechin gallate reduces transforming growth factor β stimulated HSP27 induction through the suppression of stress activated protein kinase/c-Jun N-terminal kinase in osteoblasts2008
- Author(s)
  Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H, Kozawa O.
- Journal Title
  
  Life Sci. 82
  
  Pages: 1012-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Hanai Y, Harada A, Matsushima Nishiwaki R, Kato H, Ogura S, Kozawa O.
- Journal Title
  
  J. Bone Miner. Metab. 26
  
  Pages: 335-341
- NAID
  10024458639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] A case of raloxifene-induced acceleration of platelet aggregation.2008
- Author(s)
  Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H.
- Journal Title
  
  Internal Med. 47
  
  Pages: 1523-1528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.2008
- Author(s)
  Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
- Journal Title
  
  Arch.Biochem.Biophys. 475
  
  Pages: 80-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation2007
- Author(s)
  Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Hosoi T, Harada A, Ohta T, Kozawa O.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 1311-1316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate inhibits prostaglandin D_2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts2007
- Author(s)
  Yamauchi J, Takai S, Matsushima-Nishiwaki R, Hanai Y, Doi T, Kato H, Ogura S, Kato K, Tokuda H, Kozawa O.
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids 77
  
  Pages: 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Limitation by p70 S6 kinase of PDGF-BB-induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Kozawa O.
- Journal Title
  
  Metabolism 56
  
  Pages: 476-483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts2007
- Author(s)
  Tokuda H, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S, Kozawa O.
- Journal Title
  
  Biochem. Biophys. Res. Commun 362
  
  Pages: 799-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Platelet-derived growth factor-BB amplifies PGF_<2α>-induced VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase2007
- Author(s)
  Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Akamatsu S, Ohta T, Kozawa O
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids. 77
  
  Pages: 187-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Harada A, Yasuda E, Matsushima-Nishiwaki R, Kato H, Ogura S, Ohta T, Kozawa O
- Journal Title
  
  J. Bone Miner. Res. 22
  
  Pages: 337-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate enhances prostaglandin F_<2α>-induced VEGF synthesis via up-regulating SAPK/JNK activation in osteoblasts2007
- Author(s)
  Tokuda H, Takai S, Matsushima-Nishiwaki R, Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T, Kozawa O.
- Journal Title
  
  J. Cell. Biochem 100
  
  Pages: 1146-1153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Kozawa O.
- Journal Title
  
  Mol. Cell. Endocrinol 267
  
  Pages: 46-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T.
- Journal Title
  
  Int.J.Mol.Med. in press
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Presentation] 骨芽細胞においてHSP90の阻害剤はPGF2αによるインターロイキン(IL)-6の産生を促進する2018
- Author(s)
  藤田和彦、徳田治彦、川端　哲、酒井　剛、小澤　修
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてストレス蛋白質(HSP)90阻害剤はプロスタグランジンF2α(PGF)F2αによるインターロイキン(IL)-6産生を増強する－p38 mitogen-activated protein kinase(MAPK) 経路の関与－2018
- Author(s)
  徳田治彦、藤田和彦、原田　敦、新飯田俊平、小澤　修
- Organizer
  第60回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] ResveratrolはSAPK/JNKおよびAktを阻害しepidermal growth factor (EGF) による骨芽細胞の遊走を抑制する2018
- Author(s)
  川端　哲、徳田治彦、藤田和彦、酒井　剛、大塚聖視、小澤　修、大塚隆信
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてHSP70はTGF-βによるVEGF産生をp38 MAP Kinaseを介して抑制的に制御する2018
- Author(s)
  酒井　剛、徳田治彦、藤田和彦、川端　哲、小澤　修
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてHSP22はTNF-αによるIL-6産生をmTORを介して抑制する2018
- Author(s)
  酒井　剛、徳田治彦、小澤　修
- Organizer
  第91回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K11002

1. KOZAWA Osamu (90225417)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
2. SAKURAI TAKASHI (50335444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. HOSOI Takayuki (40240709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高井信治 (60402153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 西脇理英 (90734202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. サブレ森田さゆり (40748802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 前田圭介 (50775179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荒井秀典 (60232021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 安東由佳子 (50314745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大塚隆信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 水谷潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 黒柳元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tokuda Haruhiko 徳田 治彦

徳田 治彦 トクダ ハルヒコ

TOKUDA Haruhiko 徳田 治彦

Research Projects

Research Products

Co-Researchers

骨マクロファージと骨芽細胞の相互作用による骨代謝制御機構の分子基盤に関する研究Principal Investigator

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高齢糖尿病患者のフットケア自立支援に関する介入方法の構築

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Roles of high molecular-weight heat shock proteins in bome metabolism, especially osteoblast functionsPrincipal Investigator

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Roles of AMP-activated protein kinase in bone metabolismPrincipal Investigator

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Effects of diabetic clinical manifestation and treatment (thiazolidine and DPP-IV inhibitors) on the cognitive decline in diabetic elderly.

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Molecular mechanism of platelet hyper-aggregation in patients with type 2 diabetes and development of method for the diagnosisPrincipal Investigator

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Molecular mechanism of chaperone properties in bone metabolism

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[Journal Article] Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony-stimulating factor synthesis in bFGF-stimulated osteoblast-like cells.2024

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[Journal Article] Oncostatin M attenuates tumor necrosis factor-α-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts.2023

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[Journal Article] HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase2019

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[Journal Article] Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.2019

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[Journal Article] HSP90 limits thrombin-stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells: Regulation of p38 MAPK.2018

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Data Source

[Journal Article] Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling.2018

Author(s)

Journal Title

Tokuda Haruhiko 徳田治彦

徳田治彦トクダハルヒコ

TOKUDA Haruhiko 徳田治彦