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TAKAYUKI OHSHIMA  大島 隆幸

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大島 隆幸  オオシマ タカユキ

OHSHIMA Takayuki  大島 隆幸

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Researcher Number 10397557
Affiliation (Current) 2025: 徳島文理大学, 理工学部, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 徳島文理大学, 理工学部, 准教授
2021: 徳島文理大学, 薬学部, 准教授
2014 – 2016: 徳島文理大学, 薬学部, 准教授
2012: 徳島文理大学, 薬学部, 准教授
2010 – 2012: 徳島文理大学, 香川薬学部, 准教授
2007 – 2008: Tokushima Bunri University, 香川薬学部, 准教授
2005 – 2006: 徳島文理大学, 香川薬学部, 講師
Review Section/Research Field
Principal Investigator
Tumor biology / Carcinogenesis / Laboratory animal science / Applied biochemistry
Except Principal Investigator
Basic Section 63030:Chemical substance influence on environment-related / Biological pharmacy
Keywords
Principal Investigator
翻訳後修飾 / 転写制御 / SUMO化修飾 / 細胞死 / オートファジー / 発がん / HBZ / HTLV-1 / ウイルス / ATL … More / mTOR / 白血病 / ウイルス性発がん / 生体防御 / ヒストン修飾 / ユビキチン / 応用微生物 / 遺伝子 / 薬学 / 細胞分化 / 生活習慣病 / 脂肪細胞分化 / 核内受容体 … More
Except Principal Investigator
神経炎症 / 化学物質 / ケモカイン / ミクログリア / 神経回路機能 / 発達神経毒性 / 一酸化窒素(NO) / 神経型一酸化窒素合成酵素 / ペンチレンテトラゾール / SUMO / 一酸化窒素 / 全般てんかん / small ubiquitin-related modifier (SUMO) / ペンチ レンテトラゾール (PTZ) / 一酸化窒素合成酵素 (nNOS) / 一酸化窒素 (NO) / てんかん / 神経薬理学 Less
  • Research Projects

    (6 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (5 People)
  •  Disruption of brain chemokine networks and impaired neural circuit formation due to developmental exposure to chemicals

    • Principal Investigator
      Ishihara Yasuhiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 63030:Chemical substance influence on environment-related
    • Research Institution
      Hiroshima University
  •  Disruption of signaling responsed to stress by HTLV-1 bZIP factorPrincipal Investigator

    • Principal Investigator
      TAKAYUKI OHSHIMA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Tokushima Bunri University
  •  Disruption of transcription network of cellular genes by human T-cell leukemia virus type-1.Principal Investigator

    • Principal Investigator
      OHSHIMA Takayuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Carcinogenesis
    • Research Institution
      Tokushima Bunri University
  •  A study on the roles of nNOS-SUMO-1 conjugation and NO-nNOS machinery in PTZ-induced convulsive seizure

    • Principal Investigator
      WATANABE Masatomo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokushima Bunri University
  •  A role for post-translational modification of PPAR-gamma in vivoPrincipal Investigator

    • Principal Investigator
      OHSHIMA Takayuki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokushima Bunri University
  •  SUMO化修飾を介した脂肪細胞の分化制御機構の解析Principal Investigator

    • Principal Investigator
      大島 隆幸
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied biochemistry
    • Research Institution
      Tokushima Bunri University

All 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Enhanced stabilization of MCL1 by HTLV-1 bZIP factor is modulated by blocking the recruitment of Cullin1 to the SCF complex.2016

    • Author(s)
      Risa Mukai, and Takayuki Ohshima
    • Journal Title

      Mol. Cell. Biol.

      Volume: 36 Pages: 3075-3085

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA binding ability of CENP-B2015

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Journal Title

      J. Gen. Virol.

      Volume: 96 Pages: 159-164

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B2015

    • Author(s)
      Mukai R and Ohshima T.
    • Journal Title

      J. Gen. Virol

      Volume: 96 Issue: 1 Pages: 159-164

    • DOI

      10.1099/vir.0.070201-0

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J08100, KAKENHI-PROJECT-26430128
  • [Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm2014

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Journal Title

      Oncogene

      Volume: 33 Pages: 2317-2328

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Journal Article] Protein inhibitor of activated STAT, PIASy regulates alpha-smooth muscle actin expression by interacting with E12 inmesangial cells.2012

    • Author(s)
      Kazuo Torikoshi, Hideharu Abe, Takeshi Matsubara, Takahiro Hirano, Takayuki Ohshima, Taichi Murakami, Makoto Araki, Akira Mima, Noriyuki Iehara, Atsushi Fukatsu, Toru Kita, Hideyuki Arai, and Toshio Doi.
    • Journal Title

      PLoS One

      Volume: 7

    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 12011

    • Author(s)
      Risa Mukai, Takayuki Ohshima
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 409 Pages: 328-332

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 1.2011

    • Author(s)
      Risa Mukai, and Takayuki Ohshima.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 409 Pages: 328-332

    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.2010

    • Author(s)
      Takayuki Murata, Naoe Hotta, Shigenori Toyama, Sanae Nakayama, Shigeru Chiba, Hiroki Isomura, Takayuki Ohshima, Teru Kanda, and Tatsuya Tsurumi.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 23925-23935

    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppreses transcription through a Maf recognision element.2010

    • Author(s)
      Takayuki Ohshima, Risa Mukai, Norie Nakahara, Jun Matsumoto, Osamu Isono, Yusuke Kobayashi, Satoru Takahashi, and Kunitada Shimotohno.
    • Journal Title

      J. Cell. Biochem.

      Volume: 111 Pages: 187-194

    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLFl protein correlates with association of histone deacethylase.2010

    • Author(s)
      Takayuki Murata, 他9名
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 23925-23935

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element.2010

    • Author(s)
      Takayuki Ohshima, 他7名
    • Journal Title

      J.Cell.Biochem.

      Volume: 111 Pages: 187-194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Journal Article] PIAS1 mediates TGFb-induced SMa-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation2009

    • Author(s)
      Keiko Kawai-Kowase, Takayuki Ohshima, Hiroki Matsui, Toru Tanaka, Takahisa Shimizu,Tatsuya Iso, Masashi Arai, Gary K. Owens, Masahiko Kurabayashi
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol. 29

      Pages: 99-106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] Sumoylation of CoREST modulates its function as a transcriptional repressor2008

    • Author(s)
      Ayako Muraoka, Atsuyo Maeda, Norie Nakahara, Midori Yokota, Tamotsu Nishida, Tokumi Maruyama, and Takayuki Ohshima
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 1031-1035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] HTLV-1 HBZ protein bypasses the targeting function of ubiquitination2008

    • Author(s)
      Osamu Isono, Takayuki Ohshima, ら他5名
    • Journal Title

      J. Biol. Chem. 283

      Pages: 34273-34282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] Synthesis and evaliation of 5'-modified 2'-deoxyadenosine analogues anti-hepatitis C agent2008

    • Author(s)
      Masahiro Ikejiri, Takayuki Ohshima, ら他3
    • Journal Title

      Bioorg. Med. Chem. Letters 15

      Pages: 4638-4641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] 5'-O-Masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus(HCV)therapeutic agents2007

    • Author(s)
      Masahiro Ikejiri, Takayuki Ohshima, ら他2名
    • Journal Title

      Bioorg.Med.Chem 15

      Pages: 6882-6892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] BCL3 acts as a negative regulator of transcription from the HTLV-1 LTR through in teractions with TORC32007

    • Author(s)
      Takayuki Hishiki, Takayuki Ohshima, ら他2名
    • Journal Title

      J.Biol.Chem 282

      Pages: 28335-28343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm.

    • Author(s)
      Risa Mukai, and Takayuki Ohshima.
    • Journal Title

      Oncogene

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] Molecular mechanisms of HBZ-mediated MCL1 stability in HTLV-1 infected cells2017

    • Author(s)
      Risa Mukai and Takayuki Ohshima
    • Organizer
      18th International Conference on Human Retrovirology HTLV and Related Viruses
    • Place of Presentation
      Tokyo
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Presentation] HTLV-1 bZIP factorによるCullin1の機能抑制メカニズムの解析2015

    • Author(s)
      向井理紗、丹由香里、田中雄也、大島隆幸
    • Organizer
      第2回 日本HTLV-1学会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2015-08-27
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Presentation] Ubiquitination-mediated degradation and DNA-binding impairment of IRF-1 were induced by HTLV-1 HBZ2011

    • Author(s)
      Risa Mukai, and Takayuki Ohshima.
    • Organizer
      International Union of Microbiological Societies 2011Congress
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD342011

    • Author(s)
      Risa Mukai, Takayuki Ohshima
    • Organizer
      15^<th> International Conference on Human Retrovirology : HTLV and Related viruses
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD342011

    • Author(s)
      Risa Mukai, and Takayuki Ohshima.
    • Organizer
      15th International Conference on Human Retrovirology: HTLV and Related viruses
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] HTLV-1HBZは転写因子largeMafファミリーと相互作用してMafの活性を抑制する2010

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第9回次世代を担う若手ファーマ・バイオフォーラム2010
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] mTORシグナルの活性化におけるHTLV-1 HBZタンパク質の役割2010

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] mTORシグナルの活性化におけるHTLV-1HBZタンパク質の役割2010

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] HTLV-1HBZタンパク質によるmTORシグナルの活性制御機構2010

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-22501000
  • [Presentation] RNA干渉法を利用したPPAR-γ2特異的ノックダウンマウスの作出と機能解析2009

    • Author(s)
      大島隆幸, ら他3名
    • Organizer
      日本糖尿病・肥満動物学会
    • Place of Presentation
      岡山国際交流センター
    • Year and Date
      2009-02-13
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Presentation] CoREST のSUMO 化修飾と神経特異的転写抑制機構2008

    • Author(s)
      村岡史子、前田敦代、丸山徳見、大島隆幸
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-19500372
  • [Presentation] HTLV-1 由来産物 HBZ タンパク質による CENP-B の機能抑制メカニズムの解析

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 87 回 日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Presentation] CENP-B 依存的なヒストンメチル化修飾における HTLV-1 bZIP factor の役割

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 1 回 日本 HTLV-1 学会学術集会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2014-08-22 – 2014-08-24
    • Data Source
      KAKENHI-PROJECT-26430128
  • [Presentation] HTLV-1 bZIP factor による CENP-B の機能抑制を介したヒストンメチル化制御機構の解析

    • Author(s)
      向井理紗、大島隆幸
    • Organizer
      第 62 回 日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-26430128
  • 1.  WATANABE Masatomo (30306203)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  ITOH Kouichi (30291149)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Ishihara Yasuhiro (80435073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  冨永 貴志 (20344046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  大黒 亜美 (20634497)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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