TAKAYUKI OHSHIMA 大島隆幸

… Alternative Names

大島隆幸オオシマタカユキ

OHSHIMA Takayuki 大島隆幸

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Researcher Number	10397557
Affiliation (Current)	2025: 徳島文理大学, 理工学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 徳島文理大学, 理工学部, 准教授 2021: 徳島文理大学, 薬学部, 准教授 2014 – 2016: 徳島文理大学, 薬学部, 准教授 2012: 徳島文理大学, 薬学部, 准教授 2010 – 2012: 徳島文理大学, 香川薬学部, 准教授 2007 – 2008: Tokushima Bunri University, 香川薬学部, 准教授 2005 – 2006: 徳島文理大学, 香川薬学部, 講師
Review Section/Research Field	Principal Investigator Tumor biology / Carcinogenesis / Laboratory animal science / Applied biochemistry Except Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Biological pharmacy
Keywords	Principal Investigator 翻訳後修飾 / 転写制御 / SUMO化修飾 / 細胞死 / オートファジー / 発がん / HBZ / HTLV-1 / ウイルス / ATL … More / mTOR / 白血病 / ウイルス性発がん / 生体防御 / ヒストン修飾 / ユビキチン / 応用微生物 / 遺伝子 / 薬学 / 細胞分化 / 生活習慣病 / 脂肪細胞分化 / 核内受容体 … More Except Principal Investigator 神経炎症 / 化学物質 / ケモカイン / ミクログリア / 神経回路機能 / 発達神経毒性 / 一酸化窒素(NO) / 神経型一酸化窒素合成酵素 / ペンチレンテトラゾール / SUMO / 一酸化窒素 / 全般てんかん / small ubiquitin-related modifier (SUMO) / ペンチレンテトラゾール (PTZ) / 一酸化窒素合成酵素 (nNOS) / 一酸化窒素 (NO) / てんかん / 神経薬理学 Less

Disruption of brain chemokine networks and impaired neural circuit formation due to developmental exposure to chemicals
- Principal Investigator
  
  Ishihara Yasuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima University
Disruption of signaling responsed to stress by HTLV-1 bZIP factorPrincipal Investigator
- Principal Investigator
  
  TAKAYUKI OHSHIMA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tokushima Bunri University
Disruption of transcription network of cellular genes by human T-cell leukemia virus type-1.Principal Investigator
- Principal Investigator
  
  OHSHIMA Takayuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Tokushima Bunri University
A study on the roles of nNOS-SUMO-1 conjugation and NO-nNOS machinery in PTZ-induced convulsive seizure
- Principal Investigator
  
  WATANABE Masatomo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokushima Bunri University
A role for post-translational modification of PPAR-gamma in vivoPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Takayuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokushima Bunri University
SUMO化修飾を介した脂肪細胞の分化制御機構の解析Principal Investigator
- Principal Investigator
  
  大島隆幸
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Tokushima Bunri University

All 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Enhanced stabilization of MCL1 by HTLV-1 bZIP factor is modulated by blocking the recruitment of Cullin1 to the SCF complex.2016
- Author(s)
  Risa Mukai, and Takayuki Ohshima
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 36 Pages: 3075-3085
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430128
[Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA binding ability of CENP-B2015
- Author(s)
  Risa Mukai and Takayuki Ohshima
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 96 Pages: 159-164
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430128
[Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B2015
- Author(s)
  Mukai R and Ohshima T.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 96 Issue: 1 Pages: 159-164
- DOI
  10.1099/vir.0.070201-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J08100, KAKENHI-PROJECT-26430128
[Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm2014
- Author(s)
  Risa Mukai and Takayuki Ohshima
- Journal Title
  
  Oncogene
  
  Volume: 33 Pages: 2317-2328
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430128
[Journal Article] Protein inhibitor of activated STAT, PIASy regulates alpha-smooth muscle actin expression by interacting with E12 inmesangial cells.2012
- Author(s)
  Kazuo Torikoshi, Hideharu Abe, Takeshi Matsubara, Takahiro Hirano, Takayuki Ohshima, Taichi Murakami, Makoto Araki, Akira Mima, Noriyuki Iehara, Atsushi Fukatsu, Toru Kita, Hideyuki Arai, and Toshio Doi.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 12011
- Author(s)
  Risa Mukai, Takayuki Ohshima
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 409 Pages: 328-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 1.2011
- Author(s)
  Risa Mukai, and Takayuki Ohshima.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 409 Pages: 328-332
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.2010
- Author(s)
  Takayuki Murata, Naoe Hotta, Shigenori Toyama, Sanae Nakayama, Shigeru Chiba, Hiroki Isomura, Takayuki Ohshima, Teru Kanda, and Tatsuya Tsurumi.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 23925-23935
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppreses transcription through a Maf recognision element.2010
- Author(s)
  Takayuki Ohshima, Risa Mukai, Norie Nakahara, Jun Matsumoto, Osamu Isono, Yusuke Kobayashi, Satoru Takahashi, and Kunitada Shimotohno.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: 111 Pages: 187-194
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLFl protein correlates with association of histone deacethylase.2010
- Author(s)
  Takayuki Murata, 他9名
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 23925-23935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element.2010
- Author(s)
  Takayuki Ohshima, 他7名
- Journal Title
  
  J.Cell.Biochem.
  
  Volume: 111 Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501000
[Journal Article] PIAS1 mediates TGFb-induced SMa-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation2009
- Author(s)
  Keiko Kawai-Kowase, Takayuki Ohshima, Hiroki Matsui, Toru Tanaka, Takahisa Shimizu,Tatsuya Iso, Masashi Arai, Gary K. Owens, Masahiko Kurabayashi
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 29
  
  Pages: 99-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] Sumoylation of CoREST modulates its function as a transcriptional repressor2008
- Author(s)
  Ayako Muraoka, Atsuyo Maeda, Norie Nakahara, Midori Yokota, Tamotsu Nishida, Tokumi Maruyama, and Takayuki Ohshima
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 1031-1035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] HTLV-1 HBZ protein bypasses the targeting function of ubiquitination2008
- Author(s)
  Osamu Isono, Takayuki Ohshima, ら他5名
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 34273-34282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] Synthesis and evaliation of 5'-modified 2'-deoxyadenosine analogues anti-hepatitis C agent2008
- Author(s)
  Masahiro Ikejiri, Takayuki Ohshima, ら他3
- Journal Title
  
  Bioorg. Med. Chem. Letters 15
  
  Pages: 4638-4641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] 5'-O-Masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus(HCV)therapeutic agents2007
- Author(s)
  Masahiro Ikejiri, Takayuki Ohshima, ら他2名
- Journal Title
  
  Bioorg.Med.Chem 15
  
  Pages: 6882-6892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] BCL3 acts as a negative regulator of transcription from the HTLV-1 LTR through in teractions with TORC32007
- Author(s)
  Takayuki Hishiki, Takayuki Ohshima, ら他2名
- Journal Title
  
  J.Biol.Chem 282
  
  Pages: 28335-28343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500372
[Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm.
- Author(s)
  Risa Mukai, and Takayuki Ohshima.
- Journal Title
  
  Oncogene
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] Molecular mechanisms of HBZ-mediated MCL1 stability in HTLV-1 infected cells2017
- Author(s)
  Risa Mukai and Takayuki Ohshima
- Organizer
  18th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Tokyo
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430128
[Presentation] HTLV-1 bZIP factorによるCullin1の機能抑制メカニズムの解析2015
- Author(s)
  向井理紗、丹由香里、田中雄也、大島隆幸
- Organizer
  第2回　日本HTLV-1学会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-26430128
[Presentation] Ubiquitination-mediated degradation and DNA-binding impairment of IRF-1 were induced by HTLV-1 HBZ2011
- Author(s)
  Risa Mukai, and Takayuki Ohshima.
- Organizer
  International Union of Microbiological Societies 2011Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD342011
- Author(s)
  Risa Mukai, Takayuki Ohshima
- Organizer
  15^<th> International Conference on Human Retrovirology : HTLV and Related viruses
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD342011
- Author(s)
  Risa Mukai, and Takayuki Ohshima.
- Organizer
  15th International Conference on Human Retrovirology: HTLV and Related viruses
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] HTLV-1HBZは転写因子largeMafファミリーと相互作用してMafの活性を抑制する2010
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第9回次世代を担う若手ファーマ・バイオフォーラム2010
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] mTORシグナルの活性化におけるHTLV-1 HBZタンパク質の役割2010
- Author(s)
  向井理紗、大島隆幸
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] mTORシグナルの活性化におけるHTLV-1HBZタンパク質の役割2010
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] HTLV-1HBZタンパク質によるmTORシグナルの活性制御機構2010
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22501000
[Presentation] RNA干渉法を利用したPPAR-γ2特異的ノックダウンマウスの作出と機能解析2009
- Author(s)
  大島隆幸, ら他3名
- Organizer
  日本糖尿病・肥満動物学会
- Place of Presentation
  岡山国際交流センター
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19500372
[Presentation] CoREST のSUMO 化修飾と神経特異的転写抑制機構2008
- Author(s)
  村岡史子、前田敦代、丸山徳見、大島隆幸
- Organizer
  BMB2008
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19500372
[Presentation] HTLV-1 由来産物 HBZ タンパク質による CENP-B の機能抑制メカニズムの解析
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第 87 回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26430128
[Presentation] CENP-B 依存的なヒストンメチル化修飾における HTLV-1 bZIP factor の役割
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第 1 回日本 HTLV-1 学会学術集会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26430128
[Presentation] HTLV-1 bZIP factor による CENP-B の機能抑制を介したヒストンメチル化制御機構の解析
- Author(s)
  向井理紗、大島隆幸
- Organizer
  第 62 回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26430128

1. WATANABE Masatomo (30306203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. ITOH Kouichi (30291149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Ishihara Yasuhiro (80435073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 冨永貴志 (20344046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大黒亜美 (20634497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAYUKI OHSHIMA 大島 隆幸

大島 隆幸 オオシマ タカユキ

OHSHIMA Takayuki 大島 隆幸

Research Projects

Research Products

Co-Researchers

Disruption of brain chemokine networks and impaired neural circuit formation due to developmental exposure to chemicals

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Disruption of signaling responsed to stress by HTLV-1 bZIP factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Disruption of transcription network of cellular genes by human T-cell leukemia virus type-1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the roles of nNOS-SUMO-1 conjugation and NO-nNOS machinery in PTZ-induced convulsive seizure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role for post-translational modification of PPAR-gamma in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SUMO化修飾を介した脂肪細胞の分化制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Enhanced stabilization of MCL1 by HTLV-1 bZIP factor is modulated by blocking the recruitment of Cullin1 to the SCF complex.2016

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA binding ability of CENP-B2015

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm2014

Author(s)

Journal Title

Data Source

[Journal Article] Protein inhibitor of activated STAT, PIASy regulates alpha-smooth muscle actin expression by interacting with E12 inmesangial cells.2012

Author(s)

Journal Title

Data Source

[Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 12011

Author(s)

Journal Title

Data Source

[Journal Article] Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 1.2011

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.2010

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppreses transcription through a Maf recognision element.2010

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLFl protein correlates with association of histone deacethylase.2010

TAKAYUKI OHSHIMA 大島隆幸

大島隆幸オオシマタカユキ

OHSHIMA Takayuki 大島隆幸