KOBAYASHI Shin 小林慎

… Alternative Names

小林慎コバヤシシン

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Researcher Number	10397664
Other IDs	https://orcid.org/0000-0001-6639-3810
External Links
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2017 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2010 – 2017: 東京医科歯科大学, 難治疾患研究所, 非常勤講師 2011: 東京医科歯科大学, 難治疾患研究所, 特任講師 2008: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 2007: Osaka University, 微生物病研究所, 特任助教 2005 – 2006: 大阪大学, 微生物病研究所, 特任助手
Review Section/Research Field	Principal Investigator Biological Sciences / Genetics/Genome dynamics / Biological Sciences / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Basic Section 48040:Medical biochemistry-related / Genetics/Chromosome dynamics / Laboratory animal science / Laboratory animal science
Keywords	Principal Investigator エピジェネティクス / 性差 / non-coding RNA / X染色体の不活性化 / 疾患モデルマウス / X染色体不活性化 / Long non-coding RNA / 雌雄差 / 胚盤胞 / 性分化 … More / クロマチン / X染色体 / long non-coding RNA / 疾患モデル動物 / トランスジェニックマウス / GFP / DNAアレイ / 幹細胞 / 個体発生 / 長鎖ノンコ―ディングRNA / ヒト遺伝病 / メンデル遺伝に従わないヒト遺伝病 / 非メンデル遺伝 / 性差を示す遺伝性疾患 / 非メンデル性遺伝 / 発生・分化 / 遺伝学 / 疾患モデルマウ / 表現型のばらつき / 小(無)眼球症 / X連鎖非メンデル遺伝 / X連鎖疾患 / 小（無）眼症 / 長鎖ノンコーディングRNA / KOマウス / ヒト疾患 / long non-codingRNA / 遺伝子組み替え動物 / 遺伝子組み替え / ライブイメージング / イメージング / 遺伝子組換え動物 / ゲノム・インプリンティング / 非コードRNA / smalIRNA / small RNA / グノミック・インプリンティング / 遺伝子 / ゲノムインプリント / ゲノミックインプリンティング Less

新規幹細胞の探索にＸ染色体再活性がマーカーとなりうることを示す。Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Ｘ染色体不活性化をモデルとしたヘテロクロマチン化維持機構の解明Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Epigenetics studies of human diseases whose phenotypes do not follow Mendelian inheritance rules.Principal Investigator
- Principal Investigator
  
  Kobayashi Shin
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
長鎖ノンコ―ディングRNAが制御する個体発生とヘテロクロマチン形成メカニズムPrincipal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
性ホルモン依存しない性差を示す疾患モデルマウスの解析Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Analysis of long non-coding RNA knockout mice that shows substantially female-specific phenotype.Principal Investigator
- Principal Investigator
  
  Kobayashi Shin
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  National Institute of Advanced Industrial Science and Technology
X染色体不活性化を制御する新規non-codingRNAの解析Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
表現型に性差を示すlong ncRNA Fat60 KOマウスの機能解析Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of long non-coding using a mouse modelPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shin
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Medical and Dental University
Live-cell imaging to monitor X-chromosome reactivation and stem cell reasearchPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shin
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Medical and Dental University
X染色体の不活化と機能性非コードRNAの解析Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
雌雄で発現が異なるインプリント遺伝子群の解析Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
  Osaka University
Analysis of functional small RNAs in male and female blastocystsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Tokyo Medical and Dental University
  Osaka University
哺乳類の雄雌はいつ異なり始めるのか?Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
マウスは胚盤胞の頃に既に雌雄の差を有しているのか?Principal Investigator
- Principal Investigator
  
  小林慎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Osaka University

All 2021 2019 2018 2017 2016 2015 2014 2013 2012 2010 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] 動物の事典2017
- Author(s)
  小林慎ほか
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-26430087
[Book] 『動物の事典』2016
- Author(s)
  小林慎（末光隆志ほか編）
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-26430087
[Book] 動物の事典,ゲノム・インプリンティングの項2016
- Author(s)
  小林慎　（末光隆志ほか編）
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PUBLICLY-15H01468
[Book] 動物の事典「ゲノム・インプリンティング」の項2015
- Author(s)
  小林慎
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-26430087
[Journal Article] Visualization of X chromosome reactivation in mouse primordial germ cells in vivo.2021
- Author(s)
  Haramoto Y, Sakata M, Kobayashi S.
- Journal Title
  
  Biol Open.
  
  Volume: 10 Issue: 4
- DOI
  10.1242/bio.058602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07498, KAKENHI-PUBLICLY-19H05279
[Journal Article] Epigenetic differences between naive and primed pluripotent stem cells2018
- Author(s)
  Takahashi Saori、Kobayashi Shin、Hiratani Ichiro
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 75 Issue: 7 Pages: 1191-1203
- DOI
  10.1007/s00018-017-2703-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04892, KAKENHI-PLANNED-18H05530, KAKENHI-PUBLICLY-17H05597, KAKENHI-PROJECT-17K07498, KAKENHI-PROJECT-26430087
[Journal Article] Live Imaging of X-Chromosome Inactivation and Reactivation Kinetics.2018
- Author(s)
  Kobayashi S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1861 Pages: 73-89
- DOI
  10.1007/978-1-4939-8766-5_7
- ISBN
  9781493987658, 9781493987665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07498, KAKENHI-PUBLICLY-17H05597, KAKENHI-PUBLICLY-18H04892
[Journal Article] Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype.2018
- Author(s)
  Hosoi Y, Soma M, Shiura H, Sado T, Hasuwa H, Abe K, Kohda T, Ishino F, Kobayashi S
- Journal Title
  
  Nat Commun
  
  Volume: 9(1） Issue: 1 Pages: 4618-4618
- DOI
  10.1038/s41467-018-06327-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07498, KAKENHI-PROJECT-18K19312, KAKENHI-PUBLICLY-17H05597, KAKENHI-PUBLICLY-17H05606, KAKENHI-PUBLICLY-18H04892, KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-16H02478, KAKENHI-PROJECT-16K14644
[Journal Article] Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny2017
- Author(s)
  Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F, Kubota T, Wakana S.
- Journal Title
  
  Genes & Nutrition
  
  Volume: 12 Issue: 1 Pages: 1-1
- DOI
  10.1186/s12263-016-0550-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-26430098, KAKENHI-PROJECT-26461521, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-26430087, KAKENHI-PUBLICLY-15H01468, KAKENHI-PROJECT-17K07498
[Journal Article] Live imaging of X chromosome inactivation and reactivation dynamics.2017
- Author(s)
  Kobayashi S.
- Journal Title
  
  Dev Growth Differ.
  
  Volume: 59(6) Issue: 6 Pages: 493-500
- DOI
  10.1111/dgd.12365
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05597, KAKENHI-PROJECT-17K07498, KAKENHI-PROJECT-26430087
[Journal Article] Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naive from primed pluripotent stem cells.2016
- Author(s)
  Kobayashi S, Hosoi Y, Shiura H, Yamagata K, Takahashi S, Fujihara Y, Kohda T, Okabe M, Ishino F.
- Journal Title
  
  Development
  
  Volume: 143 Issue: 16 Pages: 2958-2964
- DOI
  10.1242/dev.136739
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-26430087, KAKENHI-PUBLICLY-15H01468
[Journal Article] Ftx is dispensable for imprinted X-chromosome inactivation in preimplantation mouse embryos.2014
- Author(s)
  Soma, M., Fujihara, Y., Okabe, M., Ishino, F. and Kobayashi, S.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5181-5181
- DOI
  10.1038/srep05181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221010, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-26430087
[Journal Article] Ftx is dispensable for imprinted X-chromosome inactivation in preimplantation mouse embryos2014
- Author(s)
  Soma M, Fujihara Y, Okabe M, Ishino F, Kobayashi S
- Journal Title
  
  Sci Rep
  
  Volume: 4 Pages: 5181-5181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500492
[Journal Article] Identification of an Imprinted Gene Cluster in the X-Inactivation Center2013
- Author(s)
  Kobayashi S, Totoki Y , Soma M, Matsumoto K, FujiharaY, Toyoda A, Sakaki Y, Okabe M , Ishino　F
- Journal Title
  
  PlosOne
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500492
[Journal Article] Identification of an Imprinted Gene Cluster in the X-Inactivation Center2013
- Author(s)
  Kobayashi S, Totoki Y , Soma M, Matsumoto K, Fujihara Y, Toyoda A, Sakaki Y, Okabe M , Ishino F
- Journal Title
  
  PlosOne
  
  Volume: 8(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500492
[Journal Article] The X-linked Imprinted Gene Family Fthl17 Shows Predominantly Female Expression Following the 2-cell Stage in Mouse Embryos2010
- Author(s)
  Kobayashi S, et al
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 3672-81
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22115506
[Journal Article] The X-linked Imprinted Gene Family Fthl17 Shows Predominantly Female Expression Following the 2-cell Stage in Mouse Embryos2010
- Author(s)
  Kobayashi S, Fujihara Y, Mise N, Kaseda K, Abe K, Ishino F, Okabe M
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38(11) Pages: 3672-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500492
[Journal Article] 雌雄胚盤胞の遺伝子発現比較により新たに見つけたX染色上のインプリント遺伝子Rhox5/Pem2007
- Author(s)
  小林慎
- Journal Title
  
  「生物の科学遺伝」別冊「日本の遺伝学の潮流」別冊「日本の遺伝学の潮流」 21
  
  Pages: 64-69
- Data Source
  KAKENHI-PROJECT-19770004
[Journal Article] 雌雄胚盤胞の遺伝子発現比較により新たに見つけたX染色上のインプリント遺伝子Rhox5/Pem2007
- Author(s)
  小林慎
- Journal Title
  
  「生物の科学遺伝」別冊「日本の遺伝学の潮流」別冊「日本の遺伝学の潮流」 21
  
  Pages: 64-69
- Data Source
  KAKENHI-PROJECT-19040014
[Journal Article] Comparison of gene expression in male and female mouse blastcysts revealed imprinting of the x-linked gene, Rhox5/Pem, at preimplantation stages.2006
- Author(s)
  Kobayashi S
- Journal Title
  
  Current Biology 16(2)
  
  Pages: 166-172
- Data Source
  KAKENHI-PROJECT-17770005
[Journal Article] Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the x-linked gene, Rhox5/Pem, at preimplantation stages.2006
- Author(s)
  Kobayashi S
- Journal Title
  
  Current Biology 16(2)
  
  Pages: 166-172
- Data Source
  KAKENHI-PROJECT-17052012
[Journal Article] 雌雄胚盤胞の遺伝子発現比較により新たに見つけたX染色上のインプリント遺伝子Phox5/Pem
- Author(s)
  小林慎
- Journal Title
  
  生物の科学遺伝別冊日本の遺伝学の潮流 (in press)
- Data Source
  KAKENHI-PROJECT-17052012
[Journal Article] 雌雄胚盤胞の遺伝子発現比較により新たに見つけたX染色上のインプリント遺伝子Rhox5/Pem
- Author(s)
  小林慎
- Journal Title
  
  生物の科学遺伝別冊日本の遺伝学の潮流 (in press)
- Data Source
  KAKENHI-PROJECT-17770005
[Presentation] 「細胞の脱分化・リプログラミングを1細胞レベルで可視化」2019
- Author(s)
  小林慎
- Organizer
  Bio Japan 2020
- Data Source
  KAKENHI-PUBLICLY-18H04892
[Presentation] Impaired　X-inactivation　caused　by　lack　of　Ftx　lncRNA　exhibits　non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  Kobayashi S
- Organizer
  EMBL epigenetics & chromatin, Heidelberg, 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04892
[Presentation] 「細胞の脱分化・リプログラミングを1細胞レベルで可視化」2019
- Author(s)
  小林慎
- Organizer
  Bio Japan 2020
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] Impaired　X-inactivation　caused　by　lack　of　Ftx　lncRNA　exhibits　non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  Kobayashi S
- Organizer
  EMBL epigenetics & chromatin, Heidelberg, 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05279
[Presentation] Impaired　X-inactivation　caused　by　lack　of　Ftx　lncRNA　exhibits　non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  Kobayashi S
- Organizer
  EMBL epigenetics & chromatin, Heidelberg, 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] Impaired X-inactivation caused by targeted deletion of Ftx lncRNA exhibits non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  小林慎
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] 「細胞の脱分化・リプログラミングを1細胞レベルで可視化」2019
- Author(s)
  小林慎
- Organizer
  Bio Japan 2020
- Data Source
  KAKENHI-PUBLICLY-19H05279
[Presentation] Impaired X-inactivation caused by targeted deletion of Ftx lncRNA exhibits non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  小林慎
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-19H05279
[Presentation] Impaired X-inactivation caused by targeted deletion of Ftx lncRNA exhibits non-Mendelian inheritance of microphthalmia phenotype in mice.2019
- Author(s)
  小林慎
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-18H04892
[Presentation] 表現型が性差を示すFat60 long non-coding RNA　KOマウスの解析2018
- Author(s)
  小林慎
- Organizer
  第6回　Ｘ染色体研究会
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] 表現型が性差を示すFat60 long non-coding RNA　KOマウスの解析2018
- Author(s)
  小林慎
- Organizer
  第6回　Ｘ染色体研究会
- Data Source
  KAKENHI-PUBLICLY-18H04892
[Presentation] 表現型が性差を示すFat60 long non-coding RNA　KOマウスの解析2018
- Author(s)
  小林慎
- Organizer
  第6回　Ｘ染色体研究会
- Data Source
  KAKENHI-PUBLICLY-17H05597
[Presentation] The Ftx lncRNA is required for normal eye development and random X chromosome inactivation in mice.2018
- Author(s)
  Yusuke Hosoi1, Miki Soma1, Hirosuke Shiura1, Takashi Sado4, Hidetoshi Hasuwa5, Kuniya Abe 3 Takashi Kohda1, Fumitoshi Ishino1, Shin Kobayashi1,2
- Organizer
  JAJ RNA 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05597
[Presentation] Ｘ染色体再活性化ライブイメージングシステムを用いた幹細胞研究2018
- Author(s)
  小林慎 (1,2)、細井勇輔 (2)、志浦寛相(2)、山縣一夫(３)、高橋沙央里 (２)、藤原祥高(3)、岡部勝(3)、石野史敏(2)、五島直樹（１）
- Organizer
  第17回産総研・産技連LS-BT合同発表会
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] The Ftx lncRNA is required for normal eye development and random X chromosome inactivation in mice.2018
- Author(s)
  Yusuke Hosoi1, Miki Soma1, Hirosuke Shiura1, Takashi Sado4, Hidetoshi Hasuwa5, Kuniya Abe 3 Takashi Kohda1, Fumitoshi Ishino1, Shin Kobayashi1,2
- Organizer
  JAJ RNA 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] Ｘ染色体再活性化ライブイメージングシステムを用いた幹細胞研究2018
- Author(s)
  小林慎 (1,2)、細井勇輔 (2)、志浦寛相(2)、山縣一夫(３)、高橋沙央里 (２)、藤原祥高(3)、岡部勝(3)、石野史敏(2)、五島直樹（１）
- Organizer
  第17回産総研・産技連LS-BT合同発表会
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] Ｘ染色体再活性化ライブイメージングシステムを用いた幹細胞研究2018
- Author(s)
  小林慎 (1,2)、細井勇輔 (2)、志浦寛相(2)、山縣一夫(３)、高橋沙央里 (２)、藤原祥高(3)、岡部勝(3)、石野史敏(2)、五島直樹（１）
- Organizer
  第17回産総研・産技連LS-BT合同発表会
- Data Source
  KAKENHI-PUBLICLY-17H05597
[Presentation] The Ftx lncRNA is required for normal eye development and random X chromosome inactivation in mice.2018
- Author(s)
  Yusuke Hosoi1, Miki Soma1, Hirosuke Shiura1, Takashi Sado4, Hidetoshi Hasuwa5, Kuniya Abe 3 Takashi Kohda1, Fumitoshi Ishino1, Shin Kobayashi1,2
- Organizer
  JAJ RNA 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04892
[Presentation] 発生におけるX染色体の不活性化および再活性化ダイナミクスのライブイメージング2017
- Author(s)
  小林慎 1, 細井勇輔 1, 志浦寛相 1, 山縣一夫 2, 高橋沙央里 1, 藤原祥高 2, 幸田尚 1, 岡部勝 2, 石野史敏 1
- Organizer
  第11回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] 発生におけるX染色体の不活性化および再活性化ダイナミクスのライブイメージング2017
- Author(s)
  小林慎 1, 細井勇輔 1, 志浦寛相 1, 山縣一夫 2, 高橋沙央里 1, 藤原祥高 2, 幸田尚 1, 岡部勝 2, 石野史敏 1
- Organizer
  第11回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PUBLICLY-17H05597
[Presentation] X染色体再活性化のライブイメージングを可能にする“momijiマウス”の開発と応用2017
- Author(s)
  小林慎
- Organizer
  第5回　Ｘ染色体研究会
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] X染色体再活性化のライブイメージングを可能にする“momijiマウス”の開発と応用2017
- Author(s)
  小林慎
- Organizer
  第5回　Ｘ染色体研究会
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] X染色体再活性化のライブイメージングを可能にする“momijiマウス”の開発と応用2017
- Author(s)
  小林慎
- Organizer
  第5回　Ｘ染色体研究会
- Data Source
  KAKENHI-PUBLICLY-17H05597
[Presentation] 発生におけるX染色体の不活性化および再活性化ダイナミクスのライブイメージング2017
- Author(s)
  小林慎 1, 細井勇輔 1, 志浦寛相 1, 山縣一夫 2, 高橋沙央里 1, 藤原祥高 2, 幸田尚 1, 岡部勝 2, 石野史敏 1
- Organizer
  第11回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-17K07498
[Presentation] X染色体の再活性化ライブイメージング技術を用いた多能性幹細胞の区別2016
- Author(s)
  小林慎 , 細井勇輔 , 志浦寛相 , 山縣一夫 , 高橋沙央里 , 藤原祥高 , 幸田尚 , 岡部勝 , 石野史敏
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] X染色体の再活性化ライブイメージング技術を用いた多能性幹細胞の区別2016
- Author(s)
  小林慎 , 細井勇輔 , 志浦寛相 , 山縣一夫 , 高橋沙央里 , 藤原祥高 , 幸田尚 , 岡部勝 , 石野史敏
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PUBLICLY-15H01468
[Presentation] X染色体再活性化ライブメージング技術と幹細胞研究2015
- Author(s)
  小林慎（Kobayashi Shin）、細井勇輔、藤原祥高、岡部勝、石野史敏
- Organizer
  第９回日本エピジェネティクス研究会
- Place of Presentation
  一ツ橋学術総合センター　(東京都千代田区)
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PUBLICLY-15H01468
[Presentation] Stem cell research using live imaging of X chromosome reactivation2015
- Author(s)
  Shin Kobayashi, Yusuke Hosoi, Saori Tkakahashi, Yoshitaka Fujihara, Masaru Okabe, Fumitoshi Ishino
- Organizer
  THE 40th NAITO CONFERENCE,
- Place of Presentation
  （Chaterase Gateux kingdom） Sapporo
- Year and Date
  2015-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01468
[Presentation] Stem cell research using live imaging of X chromosome reactivation.2015
- Author(s)
  Shin Kobayashi, Yusuke Hosoi, Saori Tkakahashi, Yoshitaka Fujihara, Masaru Okabe, Fumitoshi Ishino,
- Organizer
  THE 40th NAITO CONFERENCE
- Place of Presentation
  （Chaterase Gateux kingdom） Sapporo
- Year and Date
  2015-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] X染色体再活性化ライブメージング技術と幹細胞研究2015
- Author(s)
  小林慎（Kobayashi Shin）、細井勇輔、藤原祥高、岡部勝、石野史敏
- Organizer
  第９回日本エピジェネティクス研究会
- Place of Presentation
  一ツ橋学術総合センター　(東京都千代田区)
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] Ｘ染色体上に発見したインプリント遺伝子のクラスター2013
- Author(s)
  小林慎
- Organizer
  信州生命科学サマーセミナー2013
- Place of Presentation
  信州大学
- Invited
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] X 染色体不活性化中心(Xic)領域に発見したインプリント遺伝子のクラスター2013
- Author(s)
  小林慎, 十時泰, 相馬未來, 松本和也, 藤原祥高, 豊田敦, 榊佳之, 岡部勝, 石野史敏
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] X染色体上に発見したインプリント遺伝子のクラスター2013
- Author(s)
  小林慎
- Organizer
  信州生命科学サマーセミナー
- Place of Presentation
  長野
- Year and Date
  2013-07-23
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] X染色体不活性化中心(Xic)領域に発見したインプリント遺伝子のクラスター2013
- Author(s)
  小林慎,十時泰，相馬未來, 松本和也，藤原祥高，豊田敦，榊佳之，岡部勝，石野史敏
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] マウス着床前胚において雌でのみ発現する small RNA の探索2012
- Author(s)
  相馬未來, 十時泰, 松本和也, 藤原祥高, 豊田敦, 榊佳之, 岡部勝, 石野史敏, 小林慎
- Organizer
  第35回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] 雌雄の発生と X 染色体上のインプリント遺伝子2012
- Author(s)
  小林慎
- Organizer
  第5回生殖研究若手の会
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] マウス着床前胚において雌でのみ発現するsmall RNAの探索2012
- Author(s)
  相馬未來，十時泰，松本和也，藤原祥高，豊田敦，榊佳之，岡部勝，石野史敏，小林慎
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] Discovery of female specific small RNA s in preimplantation embryos2012
- Author(s)
  Shin Kobayashi
- Organizer
  The 22nd CDB Meet ing RNA Sciences in Cell and Developm ental Biology II
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] Discovery of female specific small RNAs in preimplantation embryos2012
- Author(s)
  Shin Kobayashi
- Organizer
  The 22nd CDB Meeting　RNA Sciences in Cell and Developmental Biology II
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23500492
[Presentation] 雌雄の発生におけるエピジェネティックな遺伝子発現制御2010
- Author(s)
  小林慎
- Organizer
  第82回大会日本遺伝学会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PUBLICLY-22115506
[Presentation] 着床前に雌特異的発現を示すFat45ファミリー遺伝子の解析2008
- Author(s)
  小林慎
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19770004
[Presentation] 着床前に雌特異的発現を示すFat45ファミリ-遺伝子の解析2008
- Author(s)
  小林慎
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19770004
[Presentation] 着床前に雌特異的発現を示すFat45ファミリ-遺伝子の解析2008
- Author(s)
  小林慎
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19040014
[Presentation] Xicに位置し、着床前に不活化される父親由来のX染色体から発現するインプリント遺伝子Ftxのノックアウトマウスの作製
- Author(s)
  相馬未來, 藤原祥高, 岡部勝, 石野史敏, 小林慎
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] X染色体不活化中心領域に発見した雌でのみ発現するインプリント遺伝子群の解析
- Author(s)
  小林慎, 十時泰，相馬未來, 松本和也，藤原祥高，豊田敦，榊佳之，岡部勝，石野史敏
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  伊藤国際学術研究センター
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-26430087
[Presentation] X染色体再活性化ライブメージング技術と幹細胞研究
- Author(s)
  小林慎、細井勇輔、藤原祥高、岡部勝、石野史敏
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  東京一ツ橋学術総合センター
- Year and Date
  2015-05-25 – 2015-05-26
- Data Source
  KAKENHI-PROJECT-26430087

1. OKABE Masaru (30089875)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. 幸田尚 (60211893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 石野史敏 (60159754)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 三浦史仁 (50447348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 廣瀬伸一 (60248515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 原本悦和 (30540869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJIHARA Yoshitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 石野知子(金児知子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 若菜茂晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Shin 小林 慎

小林 慎 コバヤシ シン

Research Projects

Research Products

Co-Researchers

新規幹細胞の探索にＸ染色体再活性がマーカーとなりうることを示す。Principal Investigator

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Ｘ染色体不活性化をモデルとしたヘテロクロマチン化維持機構の解明Principal Investigator

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Epigenetics studies of human diseases whose phenotypes do not follow Mendelian inheritance rules.Principal Investigator

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長鎖ノンコ―ディングRNAが制御する個体発生とヘテロクロマチン形成メカニズムPrincipal Investigator

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性ホルモン依存しない性差を示す疾患モデルマウスの解析Principal Investigator

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Analysis of long non-coding RNA knockout mice that shows substantially female-specific phenotype.Principal Investigator

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X染色体不活性化を制御する新規non-codingRNAの解析Principal Investigator

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表現型に性差を示すlong ncRNA Fat60 KOマウスの機能解析Principal Investigator

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Functional analysis of long non-coding using a mouse modelPrincipal Investigator

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Live-cell imaging to monitor X-chromosome reactivation and stem cell reasearchPrincipal Investigator

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X染色体の不活化と機能性非コードRNAの解析Principal Investigator

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雌雄で発現が異なるインプリント遺伝子群の解析Principal Investigator

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Analysis of functional small RNAs in male and female blastocystsPrincipal Investigator

Principal Investigator

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KOBAYASHI Shin 小林慎

小林慎コバヤシシン