Nawa Mikiro 名和幹朗

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NAWA Mikiro 名和幹朗

名和幹朗ナワミキロウ

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Researcher Number	10398620
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東京医科大学, 医学部, 講師 2021 – 2023: 東京医科大学, 医学部, 講師 2016 – 2017: 東京医科大学, 医学部, 講師 2012 – 2015: 東京医科大学, 医学部, 助教 2006: 慶應大, 医学部 2005: 慶應義塾大学, 医学部, 嘱託(非常勤)
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 48030:Pharmacology-related / Basic Section 51030:Pathophysiologic neuroscience-related / General anatomy (including Histology/Embryology)
Keywords	Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / リン酸化 / BTBD10 / 神経細胞死 / 細胞死 / 前頭側頭型認知症 / 運動神経細胞死 / 神経変性疾患 / 新規癌治療法 / マウスHN相同分子 / HN拮抗誘導体 / ヒューマニン(HN)

新たなALS治療法開発に向けたTDP-43の新規リン酸化制御機構の解析Principal Investigator
- Principal Investigator
  
  名和幹朗
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tokyo Medical University
Analysis of cell death mechanisms of ALS/FTD via phosphorylation of TDP-43Principal Investigator
- Principal Investigator
  
  Nawa Mikiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo Medical University
Relationship between reduction of BTBD10 expression in motor neuron and pathogenesis and progression of amyotrophic lateral sclerosis.Principal Investigator
- Principal Investigator
  
  Nawa Mikiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical University
Why is the expression level of BTBD10 in the ALS motor neuron declined?Principal Investigator
- Principal Investigator
  
  NAWA Mikiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical University
細胞死抑制因子ヒューマニンの拮抗誘導体による癌治療の可能性Principal Investigator
- Principal Investigator
  
  名和幹朗
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Keio University

All 2022 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] CLSPCOL rescues Alzheimer’s disease mouse models2022
- Author(s)
  Kusakari Shinya、Nawa Mikiro、Hashimoto Yuichi、Matsuoka Masaaki
- Journal Title
  
  Translational Neuroscience
  
  Volume: 13 Issue: 1 Pages: 11-19
- DOI
  10.1515/tnsci-2022-0209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07329, KAKENHI-PROJECT-21K07284
[Journal Article] Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease2018
- Author(s)
  Shinya Kusakari, Mikiro Nawa, Katsuko Sudo, Masaaki Matsuoka
- Journal Title
  
  Journal of neurochemistry
  
  Volume: 144 Issue: 2 Pages: 218233-218233
- DOI
  10.1111/jnc.14258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08557, KAKENHI-PROJECT-15K08245, KAKENHI-PROJECT-15H04689
[Journal Article] KCTD20, a relative of BTBD10, is a positive regulator of Akt.2014
- Author(s)
  Nawa M, Matsuoka M
- Journal Title
  
  BMC Biochem
  
  Volume: not decided Issue: 1 Pages: 1-7
- DOI
  10.1186/1471-2091-14-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390059, KAKENHI-PROJECT-24790264
[Journal Article] SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide Humanin by inhibiting c-Jun NH2-teminal kinase2013
- Author(s)
  Takeshita Y, Hashimoto Y, Nawa M, Uchino H, Matsuoka M
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 34 Pages: 24691-24704
- DOI
  10.1074/jbc.m113.469692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390059, KAKENHI-PROJECT-24790264, KAKENHI-PROJECT-25460343
[Journal Article] Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor2013
- Author(s)
  Hashimoto Y, Nawa M, Kurita M, Tokizawa M,Iwamatsu A, Matsuoka M
- Journal Title
  
  Cell Death Dis
  
  Volume: 4 Issue: 3 Pages: 555-555
- DOI
  10.1038/cddis.2013.80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590247, KAKENHI-PROJECT-23390059, KAKENHI-PROJECT-23659784, KAKENHI-PROJECT-24790264, KAKENHI-PROJECT-25460343
[Journal Article] Reduced Expression of BTBD10, an Akt activator, Drives Impairment of Motor Function2012
- Author(s)
  Nawa M, et al
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: (in press) Issue: 8 Pages: 1398-1407
- DOI
  10.1038/cdd.2012.19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390063, KAKENHI-PROJECT-23390059, KAKENHI-PROJECT-23790256, KAKENHI-PROJECT-24390053, KAKENHI-PROJECT-24790264
[Presentation] Calmodulin-like skin proteinはアルツハイマー病モデルマウスの空間学習障害を抑制する2017
- Author(s)
  草苅伸也、名和幹朗、須藤カツ子、松岡正明
- Organizer
  第90会日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K08245
[Presentation] Analysis of relationship between BTBD10 and TBK1 in ALS-related neuronal cell death.2016
- Author(s)
  Mikiro Nawa and Masaaki Matsuoka
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-15K08245
[Presentation] Calmodulin-like skin protein prevents spatial learning impairment of Alzheimer's disease model mice2016
- Author(s)
  S. KUSAKARI, M. NAWA, K. SUDO, M. MATSUOKA
- Organizer
  Society for Neuroscience 46th annual meeting
- Place of Presentation
  San Diego
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08245
[Presentation] KCTD20, an isoform of BTBD10, is a novel Akt activator.2014
- Author(s)
  Mikiro Nawa, Masaaki Matsuoka
- Organizer
  日本薬理学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24790264
[Presentation] Decreased expression of BTBD10 in ALS motor neurons may contribute to the ALS pathogenesis2012
- Author(s)
  Mikiro Nawa, Masaaki Matsuoka
- Organizer
  Society for Neuroscience 42nd annual meeting
- Place of Presentation
  New Orleans, LO
- Data Source
  KAKENHI-PROJECT-24790264
[Presentation] 新規ALS関連分子BTBD10の同定と機能解析ーALS運動神経細胞死機構解明を目指して
- Author(s)
  名和　幹朗
- Organizer
  東京線虫勉強会
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24790264
[Presentation] 運動神経細胞における細胞死抑制因子BTBD10発現低下はALS発症の一因である
- Author(s)
  名和　幹朗、中台　枝里子、三谷　昌平、松岡　正明
- Organizer
  第169回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Invited
- Data Source
  KAKENHI-PROJECT-24790264

1. 松岡正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 草苅伸也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 橋本祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nawa Mikiro 名和 幹朗

NAWA Mikiro 名和 幹朗

名和 幹朗 ナワ ミキロウ

Research Projects

Research Products

Co-Researchers

新たなALS治療法開発に向けたTDP-43の新規リン酸化制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cell death mechanisms of ALS/FTD via phosphorylation of TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Relationship between reduction of BTBD10 expression in motor neuron and pathogenesis and progression of amyotrophic lateral sclerosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Why is the expression level of BTBD10 in the ALS motor neuron declined?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞死抑制因子ヒューマニンの拮抗誘導体による癌治療の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CLSPCOL rescues Alzheimer’s disease mouse models2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KCTD20, a relative of BTBD10, is a positive regulator of Akt.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide Humanin by inhibiting c-Jun NH2-teminal kinase2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Expression of BTBD10, an Akt activator, Drives Impairment of Motor Function2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Calmodulin-like skin proteinはアルツハイマー病モデルマウスの空間学習障害を抑制する2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Analysis of relationship between BTBD10 and TBK1 in ALS-related neuronal cell death.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Calmodulin-like skin protein prevents spatial learning impairment of Alzheimer's disease model mice2016

Author(s)

Nawa Mikiro 名和幹朗

NAWA Mikiro 名和幹朗

名和幹朗ナワミキロウ