Ishii Akiko 石井亜紀子

Researcher Number	10400681
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 客員研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 筑波大学, 医学医療系, 客員研究員 2020 – 2022: 筑波大学, 医学医療系, 講師 2016 – 2018: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator カニクイザル / 筋ジストロフィー / 遺伝子治療 / 羊膜由来間葉系幹細胞 / AAV / 経口免疫寛容誘導法 / アデノ関連ウイルス / 歯髄類似細胞 / 組換えAAVベクター / 骨格筋 … More / 組換えＡＡＶ / 免疫寛容誘導 / ＡＡＶベクター / ヒト歯髄類似細胞 / アデノ随伴ウイルス / 免疫寛容 … More Except Principal Investigator 臓器連関 / サルコペニア / 脂肪性肝炎 / 遺伝子改変マウス / 転写因子Nrf2 / 非アルコール性脂肪性肝炎 / Nrf2 / 細胞外小胞 / 筋-肝連関 / 酸化ストレス / NASH / 肥満 / ミトコンドリア / 運動療法 / autophagy / mitophagy / p62 / サルコペニア肥満 / 分子メカニズム / 菌体成分リポ多糖 (LPS) / 腸内細菌叢 / 腸内細菌 / 肝疾患 Less

骨格筋Nrf2は如何にしてNASHを防御するか？ - 細胞外小胞を介した筋-肝連関を探索する
- Principal Investigator
  
  鈴木英雄
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  University of Tsukuba
筋細胞Nrf2の脂肪性肝炎に対する防御効果 - 筋由来損傷ミトコンドリア輸送に着目する
- Principal Investigator
  
  磯辺智範
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Tsukuba
経口減感作による組換えAAVの発現効率の改善―筋ジストロフィー治療を目指してPrincipal Investigator
- Principal Investigator
  
  石井亜紀子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  University of Tsukuba
筋の酸化ストレス応答転写因子Nrf2は筋-肝連関を介してNASH・肝癌を抑止する
- Principal Investigator
  
  磯辺智範
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
p62 in muscles inhibits obesity-related sarcopenia through a control of mitophagy
- Principal Investigator
  
  Shoda Junichi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Tsukuba
Nrf2, a transcription facor for anti-oxidative stress response, ameliorates sarcopenia in obese subjects.
- Principal Investigator
  
  Shoda Junichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
IMPROVED GENE TRANSDUCTION WITH RECOMBINANT AAV FOLLOWING IMMUNE TOLERANCE.Principal Investigator
- Principal Investigator
  
  Ishii Akiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2020 2018 2017 2016

All Journal Article Presentation

[Journal Article] Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration2023
- Author(s)
  法岡菜月、高橋華、中馬越清隆、石井亜紀子、松岡亮太、南木融、玉岡晃、千葉滋、栗田尚樹、加村雄哉、坂本竜弘、加藤貴康、横山泰久、錦井秀和、小原直、坂田（柳元）麻実子
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 64 Issue: 1 Pages: 18-22
- DOI
  10.11406/rinketsu.64.18
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16261, KAKENHI-PROJECT-19K17820, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-21K08365
[Journal Article] Glutamine/arginine site-unedited GluA2 mRNA in cerebrospinal fluid as a biomarker for amyotrophic lateral sclerosis2023
- Author(s)
  Takashi Hosaka, Hiroshi Tsuji, Makoto Terada, Yasushi Tomidokoro, Akiko Ishii, Kiyotaka Nakamagoe, Kazuhiro Ishii, Hiroo Terashi, Hitoshi Aizawa, Akira Tamaoka, Shin Kwak
- Journal Title
  
  J Neurol Neurosurg Psychiatry .
  
  Volume: in press Issue: 10 Pages: 876-878
- DOI
  10.1136/jnnp-2023-331164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15178, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22H04923
[Journal Article] Characteristics of hypersomnia due to inflammatory demyelinating diseases of the central nervous system2023
- Author(s)
  Ishido Hideaki、Chiba Shigeru、Takahashi Hana、Isa Megumi、Ogawa Yasuhiro、Kubota Hiroki、Imanishi Aya、Omori Yuki、Ono Taisuke、Tsutsui Ko、Han GoEun、Kondo Hideaki、Tsuji Hiroshi、Nakamagoe Kiyotaka、Ishii Akiko、Tanaka Keiko、Tamaoka Akira、Shimizu Tetsuo、Nishino Seiji、Miyamoto Tomoyuki、Kanbayashi Takashi
- Journal Title
  
  BMJ Neurology Open
  
  Volume: 5 Issue: 1 Pages: e000428-e000428
- DOI
  10.1136/bmjno-2023-000428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07541, KAKENHI-PROJECT-22K06064
[Journal Article] Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination2023
- Author(s)
  Sadaki Shunya、Fujita Ryo、Hayashi Takuto、Nakamura Ayano、Okamura Yui、Fuseya Sayaka、Hamada Michito、Warabi Eiji、Kuno Akihiro、Ishii Akiko、Muratani Masafumi、Okada Risa、Shiba Dai、Kudo Takashi、Takeda Shin’ichi、Takahashi Satoru
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 4 Pages: 112289-112289
- DOI
  10.1016/j.celrep.2023.112289
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17679, KAKENHI-PROJECT-22KJ0397, KAKENHI-PROJECT-22K06064
[Journal Article] Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study2022
- Author(s)
  Ogawa Yasuhiro、Shimojo Nobutake、Ishii Akiko、Tamaoka Akira、Kawano Satoru、Inoue Yoshiaki
- Journal Title
  
  BMC Research Notes
  
  Volume: 15 Issue: 1
- DOI
  10.1186/s13104-022-06121-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06064
[Journal Article] p62/Sqstm1 Rescue in Muscle Retards the Progression of Steatohepatitis in p62/Sqstm1-null Mice Fed a High-fat Diet.2022
- Author(s)
  Miura I, Okada K, Ishii A, Warabi E, Watahiki T, To K, Shimano H, Ariizumi S, Shoda J.
- Journal Title
  
  Front Physiol.
  
  Volume: 13 Pages: 993995-993995
- DOI
  10.3389/fphys.2022.993995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07933, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22K08072, KAKENHI-PROJECT-20H04119, KAKENHI-PROJECT-21H03372, KAKENHI-PROJECT-20K08275, KAKENHI-PROJECT-21K19694
[Journal Article] Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 92018
- Author(s)
  Tomono Ｔ, Hirai Y, Okada H, Miyagawa Y, Adachi 1, Sakamoto S, Kawano Y, Chono H, Mineno J, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: １１ Pages: 180-190
- DOI
  10.1016/j.omtm.2018.10.015
- NAID
  120007128300
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-16K15093, KAKENHI-PROJECT-26293328
[Journal Article] Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).2016
- Author(s)
  Taro Tomono, Yukihiko Hirai, Hironori Okada, Kumi Adachi, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, and Takashi Okada
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 3 Pages: 15058-15058
- DOI
  10.1038/mtm.2015.58
- NAID
  120007128523
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430102, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644
[Presentation] 非アルコール性脂肪性肝炎に対する筋Nrf2の防御的役割2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 綿引隆久, 陶経緯, 正田純一
- Organizer
  日本筋学会第8回学術集会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] 骨格筋のp62は筋-肝連関を介して脂肪性肝炎の炎症・線維化を抑制する2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 正田純一
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K19694
[Presentation] 骨格筋のp62はインスリン抵抗性の改善を介してマウス脂肪性肝炎の炎症・線維化を軽減させる2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 綿引隆久, 陶経緯, 正田純一
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] 骨格筋のNrf2は筋-肝連関を介してNASHの発症を抑止する2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 綿引隆久, 陶経緯, 正田純一
- Organizer
  第26回日本肝臓学会大会（JDDW2022）
- Data Source
  KAKENHI-PROJECT-21K19694
[Presentation] 非アルコール性脂肪性肝炎に対する筋Nrf2の防御的役割2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 綿引隆久, 陶経緯, 正田純一
- Organizer
  日本筋学会第8回学術集会
- Data Source
  KAKENHI-PROJECT-21K19694
[Presentation] 肥満における骨格筋量・筋力の低下と耐糖能異常に対するp62の役割2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 正田純一
- Organizer
  第77回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-21K19694
[Presentation] 肥満における骨格筋量・筋力の低下と耐糖能異常に対するp62の役割2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 正田純一
- Organizer
  第77回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] 骨格筋のNrf2は筋-肝連関を介してNASHの発症を抑止する2022
- Author(s)
  三浦征, 岡田浩介, 石井亜紀子, 綿引隆久, 陶経緯, 正田純一
- Organizer
  第26回日本肝臓学会大会（JDDW2022）
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] 骨格筋のp62は骨格筋機能を改善させ脂肪性肝炎の炎症・線維化を減弱する2021
- Author(s)
  三浦　征，岡田　浩介，石井　亜紀子，正田　純一
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19694
[Presentation] 骨格筋のp62は骨格筋機能を改善させ脂肪性肝炎の炎症・線維化を減弱する2021
- Author(s)
  三浦　征，岡田　浩介，石井　亜紀子，正田　純一
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] p62遺伝子欠失マウスにおける脂肪性肝炎の発症にはサルコペニア形成が随伴する2020
- Author(s)
  三浦征, 石井亜紀子, 小峰昇一, 岡田浩介, 蕨英治, 正田純一
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] 継続的走運動は筋-肝連関を介して脂肪性肝炎の炎症・線維化を改善する2020
- Author(s)
  三浦征，石井亜紀子，綿引隆久，岡田浩介，和田聖大，正田純一
- Organizer
  第43回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-20H04119
[Presentation] Refinements of rAAV8 Purification Protocol with Chromatography Technology.2018
- Author(s)
  Tomono T, Hirai,Y, Okada H, Miyagawa Y, Adachi K, Ishii A, Shimada T, Tamaoka A, Okada T
- Organizer
  21st Annual Meeting of the American Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07081
[Presentation] Immune response elicited by gene therapy using adeno-associated virus (AAV) vector for muscular dystrophy2018
- Author(s)
  Ishii A, Hayashita-Kinoh H, Okada H, Shin JH, Okada T, Takeda S
- Organizer
  22th Annual Meeting of Japanese Society of Gene and Cell therapy
- Data Source
  KAKENHI-PROJECT-16K07081
[Presentation] rAAV8/9-MEDIATED GENE THERAPY FOR MUSCLULAR DYSTROPHY; TACROLIMUS AMELIORATES IMMUNORESPONCE IN NORMAL PRIMATES2017
- Author(s)
  石井亜紀子
- Organizer
  日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-16K07081
[Presentation] EFFECTIVE MICRODYSTROPHIN EXPRESSION IN NON-HUMAN PRIMATE MUSCLE WITH AAV TYPE 8 VECTORS UNDER IMMUNE SUPPRESSION2016
- Author(s)
  Akiko Ishii, Hironori Okada, Hiromi Hayashita-Kinoh, Jin-Hong Shin, Takashi Okada, Shin’ichi Takeda
- Organizer
  日本遺伝子細胞治療学会
- Place of Presentation
  東京虎ノ門ヒルズ東京都港区
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K07081

1. Shoda Junichi (90241827)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. 岡田浩介 (80757526)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. 鈴木英雄 (00400672)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 喜納裕美 (60532728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 磯辺智範 (70383643)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 三浦征 (20982317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 岡田浩典 (80416271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 柳川徹 (10312852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 呉世昶 (10789639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Okada Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. Takeda Sin'ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. Sankai Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANAKA Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 有泉俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 保坂孝史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岡田尚已

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 藤田諒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishii Akiko 石井 亜紀子

Research Projects

Research Products

Co-Researchers

骨格筋Nrf2は如何にしてNASHを防御するか？ - 細胞外小胞を介した筋-肝連関を探索する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋細胞Nrf2の脂肪性肝炎に対する防御効果 - 筋由来損傷ミトコンドリア輸送に着目する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

経口減感作による組換えAAVの発現効率の改善―筋ジストロフィー治療を目指してPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋の酸化ストレス応答転写因子Nrf2は筋-肝連関を介してNASH・肝癌を抑止する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

p62 in muscles inhibits obesity-related sarcopenia through a control of mitophagy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nrf2, a transcription facor for anti-oxidative stress response, ameliorates sarcopenia in obese subjects.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IMPROVED GENE TRANSDUCTION WITH RECOMBINANT AAV FOLLOWING IMMUNE TOLERANCE.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Glutamine/arginine site-unedited GluA2 mRNA in cerebrospinal fluid as a biomarker for amyotrophic lateral sclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characteristics of hypersomnia due to inflammatory demyelinating diseases of the central nervous system2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p62/Sqstm1 Rescue in Muscle Retards the Progression of Steatohepatitis in p62/Sqstm1-null Mice Fed a High-fat Diet.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 92018

Author(s)

Ishii Akiko 石井亜紀子