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KAWAUCHI DAISUKE  川内 大輔

… Alternative Names

KAWAUCHI Daisuke  川内 大輔

川内 大輔  カワウチ ダイスケ

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Researcher Number 10400996
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1254-9725
Affiliation (Current) 2025: 名古屋市立大学, 医薬学総合研究院(医学), 教授
Affiliation (based on the past Project Information) *help 2024 – 2025: 名古屋市立大学, 医薬学総合研究院(医学), 教授
2020 – 2023: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 病態生化学研究部, 室長
2011: 千葉大学, 大学院・医学研究院, 助教
2009: 千葉大, 医学(系)研究科(研究院), 助教
2008: Chiba University, 大学院・医学研究院, 助教
2007: Chiba University, 大学院・医学研究科, 助教
2006: 千葉大学, 大学院医学研究院, 助手
Review Section/Research Field
Principal Investigator
Medium-sized Section 50:Oncology and related fields / Neuroscience in general / Basic Section 50010:Tumor biology-related / Biological Sciences / 0901:Oncology and related fields
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Neuroscience in general
Keywords
Principal Investigator
小脳 / 髄芽腫 / 脳腫瘍 / マウスモデル / 小児脳腫瘍 / 顆粒細胞 / ホメオボックス / 発生・分化 / 発現制御 / 脳・神経 … More / 神経科学 / 遺伝子 / コネクトミクス / 脳内微小環境 / 神経膠腫 / DREADD / てんかん / ニューロン / 膠芽腫 / PDX / 神経活動 / グリオーマ / マウス / 大脳 / 上衣腫 / WHO脳腫瘍分類 / オミクス解析 / ゲノム編集 / 大脳皮質 … More
Except Principal Investigator
てんかん / BRAF V600E / BRAF / epileptogenesis / LEAT / 電子顕微鏡 / シナプス / 神経 / 腫瘍 / ホメオボックス / 小脳 / 脊髄 / 発生・分化 / 脳・神経 / 神経科学 / 細胞・組織 / 遺伝子 / 細胞神経科学 / 分子 Less
  • Research Projects

    (9 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (9 People)
  •  エピゲノム修飾を介した脳腫瘍と脳細胞の動的相互作用の解明Principal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Nagoya City University
  •  Unveiling the Clonal Dynamics of Extrachromosomal DNA in Refractory Pediatric Brain TumorsPrincipal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Nagoya City University
  •  Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor developmentPrincipal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Nagoya City University
      National Center of Neurology and Psychiatry
  •  手術検体を用いた脳腫瘍細胞と正常神経細胞間のてんかん原性回路の解明

    • Principal Investigator
      飯島 圭哉
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  神経幹細胞由来の脳腫瘍特異的に発現する融合遺伝子の発がん性の検証Principal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      National Center of Neurology and Psychiatry
  •  神経発生工学とヒト腫瘍ゲノム学を駆使した脳腫瘍発症の新規メカニズム解明Principal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Mechanisms to form neural circuits of the spinal cord and cerebellum

    • Principal Investigator
      SAITO Tetsuichiro
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neuroscience in general
    • Research Institution
      Chiba University
  •  小脳興奮性ニューロン群の個性決定機構の解析Principal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      Chiba University
  •  小脳顆粒細胞の分化の初期過程における分子機構の解析Principal Investigator

    • Principal Investigator
      川内 大輔
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      Chiba University

All 2024 2023 2022 2021 2020 2010 2008 2007 2006

All Journal Article Presentation Book Patent

  • [Book] 「個別化治療を目指した小児脳腫瘍の分子遺伝学的診断と腫瘍増殖メカニズム」2022

    • Author(s)
      白石椋・川内大輔
    • Total Pages
      530
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Journal Article] Oncogenic regulation of supratentorial ependymoma-specific fusion genes2023

    • Author(s)
      川内 大輔
    • Journal Title

      生化学

      Volume: 95 Issue: 6 Pages: 807-811

    • DOI

      10.14952/SEIKAGAKU.2023.950807

    • ISSN
      0037-1017
    • Year and Date
      2023-12-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Journal Article] Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting2023

    • Author(s)
      Takayoshi Watanabe, Hayato Laurence Mizuno, Jumpei Norimatsu, Takumi Obara, Horacio Cabral, Kouhei Tsumoto, Makoto Nakakido, Daisuke Kawauchi, Yasutaka Anraku
    • Journal Title

      Polymers

      Volume: 15 Issue: 7 Pages: 1808-1808

    • DOI

      10.3390/polym15071808

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H04525, KAKENHI-PROJECT-22KJ3168, KAKENHI-PROJECT-23KJ0601, KAKENHI-PROJECT-22K19541, KAKENHI-PROJECT-22H00459, KAKENHI-PLANNED-21H05090
  • [Journal Article] Sonic Hedgehog Signaling in Cerebellar Development and Cancer2022

    • Author(s)
      Wang Wanchen、Shiraishi Ryo、Kawauchi Daisuke
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 10 Pages: 864035-864035

    • DOI

      10.3389/fcell.2022.864035

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ3240, KAKENHI-PROJECT-19K24687, KAKENHI-PROJECT-22H00459
  • [Journal Article] Primary cilia control translation and the cell cycle in medulloblastoma2022

    • Author(s)
      Youn Yong Ha、Hou Shirui、Wu Chang-Chih、Kawauchi Daisuke、Orr Brent A.、Robinson Giles W.、Finkelstein David、Taketo Makoto M.、Gilbertson Richard J.、Roussel Martine F.、Han Young-Goo
    • Journal Title

      Genes & Development

      Volume: 36 Issue: 11-12 Pages: 737-751

    • DOI

      10.1101/gad.349596.122

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Journal Article] H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.2021

    • Author(s)
      Haag D, Mack N, Benites Goncalves da Silva P, Statz B, Clark J, Tanabe K, Sharma T, Jäger N, Jones DTW, Kawauchi D, Wernig M, Pfister SM.
    • Journal Title

      Cancer Cell

      Volume: 39 Issue: 3 Pages: 407-422

    • DOI

      10.1016/j.ccell.2021.01.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Journal Article] Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models2021

    • Author(s)
      Shiraishi Ryo、Kawauchi Daisuke
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 8 Pages: 2948-2957

    • DOI

      10.1111/cas.14990

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20J13210, KAKENHI-PROJECT-19K24687
  • [Journal Article] Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas2021

    • Author(s)
      Zheng Tuyu、Ghasemi David R.、Okonechnikov Konstantin、、、Adachi Toma、、、Kawauchi Daisuke、Pajtler Kristian W.
    • Journal Title

      Cancer Discovery

      Volume: 0963 Issue: 9 Pages: 2230-2247

    • DOI

      10.1158/2159-8290.cd-20-0963

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18J20309, KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PROJECT-21K20853, KAKENHI-PROJECT-19K24687
  • [Journal Article] Comparison of tumor-associated YAPI fusions identifies a recurrent set of functions critical for oncogenesis2020

    • Author(s)
      Szulzewsky F, Arora S, Hoellerbauer P, King C, Nathan E, Chan M, Cimino PJ, Ozawa T, Kawauchi D, Pajtler KW, Gilbertson RJ, Paddison PJ, Vasioukhin V, Gujral TS, Holland EC.
    • Journal Title

      Genes and Development

      Volume: 34 Issue: 15-16 Pages: 1051-1064

    • DOI

      10.1101/gad.338681.120

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Journal Article] Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.2020

    • Author(s)
      Kutscher LM, Okonechnikov K, Batora NV, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, Smith KS, Mercier AL, Ayrault O, Hoshino M, Kool M, von Hoff K, Graf N, Fleischhack G, Bardwell VJ, Pfister SM, Northcott PA, Kawauchi D.
    • Journal Title

      Genes and Development

      Volume: 34 Issue: 17-18 Pages: 1161-1176

    • DOI

      10.1101/gad.337584.120

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Journal Article] Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes2010

    • Author(s)
      Daisuke Kawauchi, Yoko Muroyama Tatsuya Sato, Tetsuichiro Saito
    • Journal Title

      Dev.Biol. 344

      Pages: 1026-1034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes2010

    • Author(s)
      Daisuke Kawauchi
    • Journal Title

      Developmental Biology

      Volume: 344 Pages: 1026-1034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Expression of major guidance receptors is differentially regulated in spin al commissural neurons transfated by mammalian Barh genes2010

    • Author(s)
      Daisuke Kawauchi, Yuko Muroyama, Tatsuya Sato and Tetsuichiro Saito
    • Journal Title

      Dev. Biol

      Volume: 344 Issue: 2 Pages: 1026-1034

    • DOI

      10.1016/j.ydbio.2010.06.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Transcriptional cascade from Math1 to Mbhl and Mbh2 is required for cerebellar granule cell differentiation2008

    • Author(s)
      Daisuke Kawauchi, Tetsuichiro Saito
    • Journal Title

      Dev.Biol. 322

      Pages: 345-354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Transcriptional cascade fromMath1 toMbh1and Mbh2is required for cerebellar granule cell differentiation2008

    • Author(s)
      Daisuke Kawauchi Tetsuichiro Saito
    • Journal Title

      Dev. Biol

      Volume: 322 Issue: 2 Pages: 345-354

    • DOI

      10.1016/j.ydbio.2008.08.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation.2008

    • Author(s)
      Daisuke Kawauchi
    • Journal Title

      Developmental Biology 322

      Pages: 345-354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Journal Article] Transcriptional cascade from Mathl to Mbhl and Mbh2 is required for cerebellar granule cell differentiation2008

    • Author(s)
      Daisuke KAWAUCHI
    • Journal Title

      Developmental Biology 322(2)

      Pages: 345-354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20700282
  • [Journal Article] Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain.2006

    • Author(s)
      Hiroki Taniguchi, Daisuke Kawauchi, Kazuhiko Nishida, Fujio Murakami
    • Journal Title

      Development 133・10

      Pages: 1923-1931

    • Data Source
      KAKENHI-PROJECT-18700307
  • [Patent] 神経膠腫治療剤、および神経膠腫細胞の増殖抑制方法2024

    • Inventor(s)
      上阪直史, 川内大輔, 金村米博
    • Industrial Property Rights Holder
      上阪直史, 川内大輔, 金村米博
    • Industrial Property Rights Type
      特許
    • Filing Date
      2024
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Patent] 抗腫瘍剤、抗腫瘍剤のスクリーニング方法、および予後検査薬2023

    • Inventor(s)
      稲垣直之, 馬場健太郎, 川内大輔, 他
    • Industrial Property Rights Holder
      稲垣直之, 馬場健太郎, 川内大輔, 他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] Dynamic chromatin alteration causes oncogenic hijacking by NFIA/B during medulloblastoma tumorigenesis2023

    • Author(s)
      Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Reo Maruyama, Olivier Ayrault, Daisuke Kawauchi
    • Organizer
      第82回日本癌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] Raising the Understanding of Stemness, Plasticity and Hierarchy in CNS Malignancies Cancer stem cells in ependymoma: role of YAP1 and TEAD2022

    • Author(s)
      Daisuke Kawauchi
    • Organizer
      第6回世界連邦脳腫瘍学会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] Dynamic chromatin alteration induces oncogenic hijacking by essential transcriptional factors during SHH medulloblastoma tumorigenesis2022

    • Author(s)
      Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Patricia Benites Goncalves da Silva, Owen Chapman, Wang Wanchen, Maki Jami, Mikio Hoshino, Stefan M. Pfister, Lukas Chavez, Reo Maruyama, Olivier Ayrault, Daisuke Kawauchi
    • Organizer
      第20回国際小児脳腫瘍学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] DNA METHYLATION-BASED BIOBANK OF MURINE MODELS FOR PEDIATRIC TUMORS2022

    • Author(s)
      Tuyu Zheng, Martin Sill, Roland Imle, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Louis Chesler, Daisuke Kawauchi, Olivier Ayrault, Lutsik Pavlo, Stefan M. Pfister, Lena M. Kutscher, Ana Banito, David W. Jones12, Kristian W. Pajtler, Marc Zuckermann
    • Organizer
      第20回国際小児脳腫瘍学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] EVALUATION OF CAR-T CELLS TARGETING CD276 IN MEDULLOBLASTOMA2022

    • Author(s)
      Patricia Benites Goncalves da Silva, Laura Sieber, Norman Mack, Daniel Atar, Lena M. Kutscher, Patrick Schlegel, Martin Ebinger, Daisuke Kawauchi, Christian Seitz, Stefan M. Pfister
    • Organizer
      第20回国際小児脳腫瘍学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] Discovery and Understanding of Oncogenic Signaling for Pediatric Brain Tumors via Understanding of Human Cancer genomes2022

    • Author(s)
      Daisuke Kawauchi
    • Organizer
      第9回日米オンコロジーカンファレンス
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] A NOVEL CRE-CONDITIONAL CMYC-DRIVEN MB GROUP 3 TRANSGENIC MOUSE MODEL SHOWS TRACEABLE LEPTOMENINGEAL DISSEMINATION.2022

    • Author(s)
      Alaide Morcavallo, Karen Barker, Colin Kwok, Jessica KR Boult, Patricia Benites Goncalves da Silva, Konstantin Okonechnikov, Marc Zuckermann, Chiara Gorrini, Thomas S Jacques, Simon P Robinson, Steven C Clifford, William A Weiss, Stefan M Pfister, Daisuke Kawauchi, Louis Chesler
    • Organizer
      第20回国際小児脳腫瘍学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00459
  • [Presentation] Discovery and Understanding of Oncogenic Fusion Genes in Ependymoma2022

    • Author(s)
      川内大輔
    • Organizer
      第6回世界連邦脳腫瘍学会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Presentation] Epigenetic regulation of SHH subgroup medulloblastoma formation2021

    • Author(s)
      川内大輔
    • Organizer
      第44回日本神経科学学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Presentation] Future prospective in preclinical studies of pediatric brain tumors using mouse molecular genetic technologies2020

    • Author(s)
      Daisuke Kawauchi
    • Organizer
      第19回国際小児脳腫瘍シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Presentation] Cllorf95 rearrangements dictate oncogenic dependence in supratentorial brain tumors2020

    • Author(s)
      Daisuke Kawauchi
    • Organizer
      第79回日本癌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24687
  • [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制2008

    • Author(s)
      川内大輔
    • Organizer
      Neuro2008
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-20700282
  • [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制2008

    • Author(s)
      川内大輔
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制2008

    • Author(s)
      川内大輔, 斎藤哲一郎
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-20240029
  • [Presentation] 小脳顆粒細胞の分化におけるホメオボックス遺伝子Mbh1の機能2007

    • Author(s)
      川内大輔
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-18700307
  • 1.  岩崎 真樹 (00420018)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  SAITO Tetsuichiro (00202078)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 3.  MUROYAMA Yuko (20422248)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  丸山 玲緒 (60607985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  上阪 直史 (70597624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  飯島 圭哉 (10751878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  三輪 秀樹 (80468488)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  CHAPMAN OWEN
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  ANRAKU Yasutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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