Matsuura Yoshiyuki 松浦能行

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MATSUURA Yoshiyuki 松浦能行

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Researcher Number	10402413
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 国際医療福祉大学, 薬学部, 教授 2016 – 2020: 名古屋大学, 理学研究科, 准教授 2011 – 2015: 名古屋大学, 理学(系)研究科(研究院), 准教授 2010 – 2012: 名古屋大学, 理学研究科, 准教授 2009: Nagoya University, 名古屋大学・理学研究科, 准教授 … More 2008: Nagoya University, 大学院・理学研究科, 准教授 2007 – 2008: Nagoya University, 理学研究科, 准教授 2006: 名古屋大学, 理学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 43020:Structural biochemistry-related / Biological Sciences / Biophysics
Keywords	Principal Investigator X線結晶解析 / 構造生物学 / 核移行 / 核輸送 / がん / シグナル伝達 / CRM1 / 核外輸送 / 細胞内輸送 / チロシンキナーゼ … More / 核膜孔複合体 / 核膜孔 / 細胞周期 / インポーティン / 蛋白質相互作用 / 反応速度論 / 転写制御 / アクチン動態 / 天然変性蛋白質 / 蛋白質動態 / 蛋白質動熊 / 細胞生物学 / 核外輸送受容体 Less

Research Projects
(9 results)
Research Products
(25 results)

がんシグナル分子PKM2の核移行制御機構の構造基盤Principal Investigator
- Principal Investigator
  
  松浦能行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  International University of Health and Welfare
Structural basis for nuclear import of cancer-promoting signaling moleculesPrincipal Investigator
- Principal Investigator
  
  Yoshiyuki Matsuura
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  International University of Health and Welfare
  Nagoya University
Structural basis for activation of the oncogenic nonreceptor tyrosine kinase FerPrincipal Investigator
- Principal Investigator
  
  Matsuura Yoshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
CＲＭ１による核外輸送：メカニズムから病態までの構造基盤Principal Investigator
- Principal Investigator
  
  松浦能行
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Cell-cycle dependent regulatory mechanism of nuclear import and its physiological significancePrincipal Investigator
- Principal Investigator
  
  Matsuura Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
Nuclear export mediated by CRM1: from X-ray structures to mechanism in living cellsPrincipal Investigator
- Principal Investigator
  
  MATSUURA Yoshiyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
細胞骨格関連遺伝子群転写調節因子MALがアクチン動態のセンサーとして機能する機構Principal Investigator
- Principal Investigator
  
  松浦能行
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
核外輸送受容体CRM1のX線結晶解析Principal Investigator
- Principal Investigator
  
  松浦能行
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
Molecular mechanism of nuclear export: variations on a themePrincipal Investigator
- Principal Investigator
  
  MATSUURA Yoshiyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University

All 2023 2015 2014 2013 2012 2011 2010 2008 Other

All Journal Article Presentation

[Journal Article] Structures of importin-α bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1α2023
- Author(s)
  Matsuura Yoshiyuki、Miyawaki Kazuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 652 Pages: 1-5
- DOI
  10.1016/j.bbrc.2023.02.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06511
[Journal Article] Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal2023
- Author(s)
  Matsuura Yoshiyuki
- Journal Title
  
  Data in Brief
  
  Volume: 47 Pages: 108988-108988
- DOI
  10.1016/j.dib.2023.108988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06104
[Journal Article] CRM1核外輸送複合体の形成と解体の構造基盤の解明と創薬への応用2015
- Author(s)
  小山昌子、松浦能行
- Journal Title
  
  生化学
  
  Volume: 87 Pages: 41-48
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25121713
[Journal Article] Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p2015
- Author(s)
  Kobayashi, J., Hirano, H., Matsuura, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 463 Issue: 3 Pages: 309-314
- DOI
  10.1016/j.bbrc.2015.05.060
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440019
[Journal Article] Structural insights into how Yrb2p accelerates the assembly of the Xpo1p nuclear export complex2014
- Author(s)
  Masako Koyama, Natsuki Shirai, and Yoshiyuki Matsuura
- Journal Title
  
  Cell Reports
  
  Volume: 9 Issue: 3 Pages: 983-995
- DOI
  10.1016/j.celrep.2014.09.052
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J30003, KAKENHI-PUBLICLY-25121713
[Journal Article] A 2.1-angstrom-resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition2013
- Author(s)
  Saito, N.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 425 Issue: 2 Pages: 350-364
- DOI
  10.1016/j.jmb.2012.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770110
[Journal Article] Mechanistic insights from the recent structures of the CRM1 nuclear export complex and its disassembly intermediate2012
- Author(s)
  Masako Koyama
- Journal Title
  
  BIOPHYSICS
  
  Volume: 8 Issue: 0 Pages: 145-150
- DOI
  10.2142/biophysics.8.145
- NAID
  130003310839
- ISSN
  1349-2942
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J30003, KAKENHI-PROJECT-23770110
[Journal Article] CRM1による核外輸送機構の構造基盤2011
- Author(s)
  小山昌子、松浦能行
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 834-838
- NAID
  10029737810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770110
[Journal Article] 核-細胞質間高分子輸送の構造生物学2011
- Author(s)
  松浦能行
- Journal Title
  
  生物物理
  
  Volume: 51 Pages: 208-213
- NAID
  10029482414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770110
[Journal Article] An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.2010
- Author(s)
  Koyama, M., Matsuura, Y.
- Journal Title
  
  EMBO J. 29
  
  Pages: 2002-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18687010
[Presentation] 出芽酵母のRan結合蛋白質Yrb2pがXpo1p (CRM1)による核外輸送を促進する機構の構造基盤2014
- Author(s)
  小山昌子、白井菜月、松浦能行
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25121713
[Presentation] 出芽酵母の核局在型Ran結合蛋白質Yrb2pが核外輸送受容体CRM1への積み荷積載反応をスピードアップする機構の構造基盤2014
- Author(s)
  小山昌子、白井菜月、松浦能行
- Organizer
  第32回染色体ワークショップ•第13回核ダイナミクス研究会
- Place of Presentation
  広島
- Year and Date
  2014-12-16
- Data Source
  KAKENHI-PUBLICLY-25121713
[Presentation] 核内のRan 結合蛋白質 Yrb2 が CRM1 による核外輸送を触媒的に促進する機構の構造基盤2012
- Author(s)
  小山昌子、白井菜月、松浦能行
- Organizer
  第85回日本生化学大会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] Kinetic and X-ray crystallographic studies of assembly/disassembly of the CRM1 nuclear export complex2012
- Author(s)
  Koyama, M., Shirai, N., Matsuura, Y
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学(愛知県)
- Year and Date
  2012-09-23
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] Structural insights into the function of Yrb2, a cofactor that facilitates CRM1-mediated nuclear export2011
- Author(s)
  Masako Koyama, Natuki Shirai, Yoshiyuki Matsuura
- Organizer
  American Society for Cell Biology meeting
- Place of Presentation
  デンバー、米国
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] Structural insights into the function of Yrb2, a cofactor that facilitates CRM1-mediated nuclear export2011
- Author(s)
  Koyama, M., Shirai, N., Matsuura, Y
- Organizer
  American Society for Cell Biology meeting
- Place of Presentation
  デンバー(米国)
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] CRM1による核外輸送機構の構造基盤2011
- Author(s)
  小山昌子、齊藤なつみ、松浦能行
- Organizer
  第11回日本蛋白質科学会
- Place of Presentation
  ホテル阪急エキスポパーク(大阪府)
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] CRM1による核外輸送機構の構造基盤2011
- Author(s)
  小山昌子、齊藤なつみ、松浦能行
- Organizer
  第１１回　日本蛋白質科学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23770110
[Presentation] Structural basis for CRM1-mediated nuclear export2010
- Author(s)
  Yoshiyuki Matsuura
- Organizer
  GCOE/構造生物学研究センター国際シンポジウムProtein dynamics : from molecules to assembly
- Place of Presentation
  名古屋大学
- Year and Date
  2010-11-24
- Data Source
  KAKENHI-PROJECT-21770109
[Presentation] 核・細胞質間輸送の構造生物学2010
- Author(s)
  松浦能行
- Organizer
  生物物理の未来研究会
- Place of Presentation
  名古屋大学
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21770109
[Presentation] NES/RanGTP結合に伴うCRM1構造変化のFRETによる検出2008
- Author(s)
  齊藤なつみ、小山昌子、松浦能行
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18687010
[Presentation] NES/RanGTP結合に伴うCRM1構造変化のFRETによる検出2008
- Author(s)
  齊藤なつみ、小山昌子、松浦能行
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18687010
[Presentation] CRM1核外輸送複合体の形成と解体の構造基盤
- Author(s)
  松浦能行
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121713
[Presentation] 核内のRan結合蛋白質Yrb2がCRM1による核外輸送を促進する機構
- Author(s)
  小山昌子、白井菜月、松浦能行
- Organizer
  第３１回染色体ワークショップ・第１２回核ダイナミクス研究会
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PUBLICLY-25121713
[Presentation] ヌクレオポリンNup53pがKap121pによる核移行を制御する機構の構造基盤
- Author(s)
  小林純也、松浦能行
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25440019

Matsuura Yoshiyuki 松浦 能行

MATSUURA Yoshiyuki 松浦 能行

Research Projects

Research Products

がんシグナル分子PKM2の核移行制御機構の構造基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for nuclear import of cancer-promoting signaling moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis for activation of the oncogenic nonreceptor tyrosine kinase FerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CＲＭ１による核外輸送：メカニズムから病態までの構造基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell-cycle dependent regulatory mechanism of nuclear import and its physiological significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nuclear export mediated by CRM1: from X-ray structures to mechanism in living cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞骨格関連遺伝子群転写調節因子MALがアクチン動態のセンサーとして機能する機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核外輸送受容体CRM1のX線結晶解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of nuclear export: variations on a themePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structures of importin-α bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1α2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRM1核外輸送複合体の形成と解体の構造基盤の解明と創薬への応用2015

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insights into how Yrb2p accelerates the assembly of the Xpo1p nuclear export complex2014

Author(s)

Journal Title

Matsuura Yoshiyuki 松浦能行

MATSUURA Yoshiyuki 松浦能行