Oshima Naoki 大嶋直樹

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OSHIMA Naoki 大嶋直樹

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Researcher Number	10403461
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 島根大学, 学術研究院医学・看護学系, 講師 2019: 島根大学, 医学部, 特別協力研究員 2013 – 2017: 島根大学, 医学部, 助教 2005 – 2006: 島根大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Laboratory medicine
Keywords	Principal Investigator アレルギー / 好酸球性食道炎 / 腸管オルガノイド / 好酸球性胃腸炎 / 経皮感作 / 好酸球 / 自然リンパ球 / NH細胞 / ILC2 / IL-33 … More Except Principal Investigator … More Tollip / A20 / MyD88 / 好酸球性食道炎 / Ahr / Clec4a4 / 制御性好酸球 / 好酸球性胃腸炎 / ファーバースコープ / ラマン分光法 / 医療ラマン / 新規診断法 / 内視鏡 / エオシノフィルペルオキシダーゼ / ラマンスペクトル / IRAK-M / Toll-like receptor / negative feedback system / innate immunity / ネガティブフィードバック調整 / RAK-M / ネガティブフィードバック / Toll受容体 / 自然免疫 / サイトカイン / 逆流性食道炎 / 食道 / リンパ球 / ヒト / マウス / 好酸球 / プロトンポンプ阻害薬 / アレルギー / 胃酸 / 食道炎 Less

気相液相界面培養腸管疑似モデルを用いたLeaky gutと好酸球性胃腸炎の関連の解明Principal Investigator
- Principal Investigator
  
  大嶋直樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
A study regarding a novel anti-inflammatory eosinophil subset on pathogenesis of eosiophilic gastroenteritis
- Principal Investigator
  
  石原俊治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
腸粘膜の透過性制御に着目したヒト腸管疑似モデルによる好酸球性胃腸炎の病態解明Principal Investigator
- Principal Investigator
  
  大嶋直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
Mechanism of eosinophilic esophagitis focusing on the immune response of the esophagus-skin interface via percutaneous sensitisation.Principal Investigator
- Principal Investigator
  
  Oshima Naoki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
The development of a Raman spectroscopic technique to diagnose Eosinophil Esophagitis non-bioptically
- Principal Investigator
  
  Yamamoto Tatsuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shimane University
Essential role of interleuikin-33-induced innate lymphoid cells in development of eosinophilic esophagitis in micePrincipal Investigator
- Principal Investigator
  
  Oshima Naoki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shimane University
Effect of gastric acid on the eosinophilic esophagitis
- Principal Investigator
  
  Kinoshita Yoshikazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shimane University
Role of negative regulators for Toll-like receptor-dependent signaling in gut innate immune system
- Principal Investigator
  
  ISHIHARA Shunji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shimane University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 好酸球性食道疾患診療ガイド（木下芳一編）2014
- Author(s)
  大嶋　直樹　他
- Total Pages
  103
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-26870378
[Book] 小腸疾患の臨床－最近の進歩（田尻久雄　編）：好酸球性胃腸炎2013
- Author(s)
  大嶋直樹、古田賢司、石原俊治、木下芳一
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-25460928
[Journal Article] Gastric Metastasis from Salivary Duct Carcinoma Mimicking Scirrhous Gastric Cancer2024
- Author(s)
  Kishimoto Kenichi、Shibagaki Kotaro、Araki Asuka、Murakami Kotaro、Takahashi Yusuke、Kotani Satoshi、Oka Akihiko、Yazaki Tomotaka、Fukuba Nobuhiko、Mishima Yoshiyuki、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Kadota Kyuichi、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 63 Issue: 3 Pages: 373-378
- DOI
  10.2169/internalmedicine.1965-23
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08542
[Journal Article] Predictive Factors for Efficacy of Oral Tacrolimus Induction Therapy in Moderate to Severe Ulcerative Colitis Patients: Large Multicenter Retrospective Cohort Study2023
- Author(s)
  Oshima Naoki、Hiraoka Sakiko、Hayashi Ryohei、Takahashi Sakuma、Ishii Manabu、Hashimoto Shinichi、Yashima Kazuo、Igawa Shoko、Inokuchi Toshihiro、Ueno Yoshitaka、Inaba Tomoki、Matsumoto Hiroshi、Kawashima Kousaku、Takami Taro、Isomoto Hajime、Shiotani Akiko、Tanaka Shinji、Ishihara Shunji
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: in press Issue: 7 Pages: 1087-1093
- DOI
  10.1093/ibd/izad150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08542
[Journal Article] Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-na?ve patients2023
- Author(s)
  Shibagaki K、Ishimura N、Oshima N、et al
- Journal Title
  
  Gastric Cancer
  
  Volume: 26 Issue: 6 Pages: 1002-1011
- DOI
  10.1007/s10120-023-01420-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08542
[Journal Article] Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -na?ve patients: a multicenter retrospective analysis2023
- Author(s)
  Kotani Satoshi、Ishimura Norihisa、Ishihara Shunji、et al
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 59 Issue: 1 Pages: 1-10
- DOI
  10.1007/s00535-023-02050-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08056, KAKENHI-PROJECT-22K08542
[Journal Article] Development of In-situ Raman Diagnosis Technique of Eosinophil Esophagitis2023
- Author(s)
  Riki　Zakaria,　Bibin.B.　Andria,　Takumu　Watanabe, AnisaMaryani, Pradjna N.Paramitha, Yasmi P.Kuntana, Yukako Kusaka, Hemanth Noothalapati, Keita Iwasaki, Naoki Oshima, Kosuke Hashimoto, Hiroko Matsuyoshi, Shunji Ishihara, Tatsuyuki Yamamoto, Hidetoshi Sato
- Journal Title
  
  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
  
  Volume: 285 Pages: 121804-121804
- DOI
  10.1016/j.saa.2022.121804
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04486, KAKENHI-PROJECT-21K18081, KAKENHI-PROJECT-22K08542
[Journal Article] Heterotopic Gastric Mucosa in Middle Esophagus Complicated with Esophageal Ulcers2022
- Author(s)
  Kishimoto Kenichi、Shibagaki Kotaro、Nonomura Saya、Sumi Shohei、Fukuda Naoki、Takahashi Yusuke、Kotani Satoshi、Okimoto Eiko、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 18 Pages: 2735-2740
- DOI
  10.2169/internalmedicine.8705-21
- NAID
  130008164558
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-09-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] Low Fecal Calprotectin Predicts Histological Healing in Patients with Ulcerative Colitis with Endoscopic Remission and Leads to Prolonged Clinical Remission2022
- Author(s)
  Kawashima Kousaku、Oshima Naoki、Kishimoto Kenichi、Kataoka Masatoshi、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Kazumori Hideaki、Ishikawa Noriyoshi、Araki Asuka、Ishihara Shunji
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 29 Issue: 3 Pages: 359-366
- DOI
  10.1093/ibd/izac095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07961, KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients2022
- Author(s)
  Cha Na、Oshima Naoki、Kishimoto Kenichi、Kotani Satoshi、Okimoto Eiko、Yazaki Tomotaka、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Shibagaki Kotaro、Tobita Hiroshi、Kawashima Kousaku、Ishimura Norihisa、Ishihara Shunji
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 70 Issue: 3 Pages: 297-303
- DOI
  10.3164/jcbn.21-139
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07961, KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] The Simultaneous Onset of Pancreatitis and Colitis as Immune-related Adverse Events in a Patient Receiving Nivolumab Treatment for Renal Cell Carcinoma2022
- Author(s)
  Yazaki Tomotaka、Moriyama Ichiro、Tobita Hiroshi、Sonoyama Hiroki、Okimoto Eiko、Oka Akihiko、Mishima Yoshiyuki、Oshima Naoki、Shibagaki Kotaro、Kawashima Kousaku、Ishimura Norihisa、Nagami Taichi、Maruyama Riruke、Shiina Hiroaki、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 10 Pages: 1485-1490
- DOI
  10.2169/internalmedicine.7911-21
- NAID
  130008114221
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-05-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn's Disease2021
- Author(s)
  Kishimoto Kenichi、Kawashima Kousaku、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Oshima Naoki、Ishimura Norihisa、Ishikawa Noriyoshi、Maruyama Riruke、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 3 Pages: 385-389
- DOI
  10.2169/internalmedicine.5340-20
- NAID
  130007979732
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971, KAKENHI-PROJECT-19K08907
[Journal Article] Primary Extragastrointestinal Stromal Tumor of Greater Omentum with Intraperitoneal Bleeding2021
- Author(s)
  Kataoka Masatoshi、Saitoh Tsukasa、Kawashima Kousaku、Yazaki Tomotaka、Sonoyama Hiroki、Okimoto Eiko、Oka Akihiko、Mishima Yoshiyuki、Mishiro Tsuyoshi、Oshima Naoki、Shibagaki Kotaro、Tobita Hiroshi、Moriyama Ichiro、Ishimura Norihisa、Nagase Mamiko、Hirahara Noriyuki、Tajima Yoshitsugu、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 21 Pages: 3413-3419
- DOI
  10.2169/internalmedicine.6519-20
- NAID
  130008110287
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08907, KAKENHI-PROJECT-21K08753
[Journal Article] Intestinal-type gastric dysplasia in Helicobacter pylori-na?ve patients2021
- Author(s)
  Shibagaki Kotaro、Itawaki Ayako、Miyaoka Yoichi、Kishimoto Kenichi、Takahashi Yusuke、Kotani Satoshi、Mishiro Tsuyoshi、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Onuma Hideyuki、Nagasaki Makoto、Nagase Mamiko、Araki Asuka、Kadota Kyuichi、Kushima Ryoji、Ishihara Shunji
- Journal Title
  
  Virchows Archiv
  
  Volume: 480 Issue: 4 Pages: 783-792
- DOI
  10.1007/s00428-021-03237-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08907
[Journal Article] Differential gene expression analysis of dasatinib-induced colitis in a patient with chronic myeloid leukemia followed for 3?years: a case report2021
- Author(s)
  Oshima Naoki、Mishima Yoshiyuki、Shibagaki Kotaro、Kawashima Kousaku、Ishimura Norihisa、Ikejiri Fumiyoshi、Onishi Chie、Okada Takahiro、Inoue Masaya、Moriyama Ichiro、Suzumiya Junji、Kinoshita Yoshikazu、Ishihara Shunji
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1 Pages: 19-19
- DOI
  10.1186/s12876-020-01584-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971, KAKENHI-PROJECT-19K08907
[Journal Article] Comparison of dapagliflozin and teneligliptin in nonalcoholic fatty liver disease patients without type 2 diabetes mellitus: a prospective randomized study2021
- Author(s)
  Tobita Hiroshi、Yazaki Tomotaka、Kataoka Masatoshi、Kotani Satoshi、Oka Akihiko、Mishiro Tsuyoshi、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Naora Kohji、Sato Shuichi、Ishihara Shunji
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 68 Issue: 2 Pages: 173-180
- DOI
  10.3164/jcbn.20-129
- NAID
  130007993437
- ISSN
  0912-0009, 1880-5086
- Year and Date
  2021-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08907
[Journal Article] 【何をしている好酸球?好酸球性消化管疾患のメカニズム】好酸球性胃腸炎の病態・診断・治療2020
- Author(s)
  大嶋　直樹，石原　俊治
- Journal Title
  
  消化器病サイエンス
  
  Volume: 4 Pages: 99-102
- Data Source
  KAKENHI-PROJECT-19K08907
[Journal Article] Comorbid irritable bowel syndrome symptoms and headache have greater association with anxiety than depression2020
- Author(s)
  Kawashima Kousaku、Fukuba Nobuhiko、Uemura Yusuke、Ota Kuniko、Kazumori Hideaki、Sonoyama Hiroki、Oka Akihiko、Tada Yasumasa、Mishima Yoshiyuki、Oshima Naoki、Yuki Takafumi、Katsube Tomoko、Kinoshita Yoshikazu、Ishihara Shunji
- Journal Title
  
  Medicine
  
  Volume: 99 Issue: 47 Pages: e23059-e23059
- DOI
  10.1097/md.0000000000023059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08907, KAKENHI-PROJECT-17K09383
[Journal Article] Prevalence of functional dyspepsia-like symptoms in ulcerative colitis patients in clinical remission and overlap with irritable bowel syndrome-like symptoms2020
- Author(s)
  Kotani Satoshi、Fukuba Nobuhiko、Kawashima Kousaku、Mishima Yoshiyuki、Sonoyama Hiroki、Okimoto Eiko、Tada Yasumasa、Oka Akihiko、Tamagawa Yuji、Oshima Naoki、Mishiro Tsuyoshi、Tobita Hiroshi、Shibagaki Kotaro、Moriyama Ichiro、Ishimura Norihisa、Kushiyama Yoshinori、Fujishiro Hirofumi、Ishihara Shunji
- Journal Title
  
  Scandinavian Journal of Gastroenterology
  
  Volume: 55 Issue: 5 Pages: 560-564
- DOI
  10.1080/00365521.2020.1761998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08907, KAKENHI-PROJECT-19K23945, KAKENHI-PROJECT-17K09383
[Journal Article] 【炎症性腸疾患の新規治療とその適応】炎症性腸疾患における新規治療の現状2020
- Author(s)
  石原　俊治，三島　義之，岡　　明彦，大嶋　直樹，川島　耕作
- Journal Title
  
  消化器・肝臓内科
  
  Volume: 8 Pages: 219-227
- Data Source
  KAKENHI-PROJECT-19K08907
[Journal Article] Prospective multicenter study of the esophageal triamcinolone acetonide‐filling method in patients with subcircumferential esophageal endoscopic submucosal dissection2020
- Author(s)
  Shibagaki Kotaro、Yuki Takafumi、Taniguchi Hideaki、Aimi Masahito、Miyaoka Yoichi、Yuki Mika、Ishimura Norihisa、Oshima Naoki、Mishiro Tsuyoshi、Tamagawa Yuji、Mikami Hironobu、Izumi Daisuke、Yamashita Noritsugu、Sato Shuichi、Ishihara Shunji、Kinoshita Yoshikazu
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 32 Issue: 3 Pages: 355-363
- DOI
  10.1111/den.13496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08907, KAKENHI-PROJECT-19K23945
[Journal Article] Epidermal differentiation complex protein involucrin is down-regulated in eosinophilic esophagitis.2017
- Author(s)
  Oshima N, Ishihara S, Ishimura N, Kinoshita Y.
- Journal Title
  
  Esophagus
  
  Volume: 14（3） Pages: 171-177
- NAID
  40021166323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870378
[Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia.2017
- Author(s)
  Okimoto E, Ishimura N, Oshima N, Ishihara S, Kinoshita Y.
- Journal Title
  
  Dig Endosc
  
  Volume: 29(1) Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870378
[Journal Article] Specific locations of linear furrows in patients with esophageal eosinophilia2017
- Author(s)
  Okimoto E, Ishimura N, Okada M, Izumi D, Mikami H, Aimi M, Tanimura T, Mishiro T, Oshima N, Ishikawa N, Ishihara S, Adachi K, Maruyama R, Kinoshita Y
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 29 Issue: 1 Pages: 49-56
- DOI
  10.1111/den.12706
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04763, KAKENHI-PROJECT-26460937, KAKENHI-PROJECT-26870378, KAKENHI-PROJECT-16K09282
[Journal Article] Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.2017
- Author(s)
  Jiao D, Ishimura N, Oshima N, Ishihara S, Kinoshita Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 52（2） Pages: 203-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870378
[Journal Article] Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy2016
- Author(s)
  Hemanth Noothalapati, Suguru Uemura, Naoki Ohshima, Yoshikazu Kinoshita, Masahiro, Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
- Journal Title
  
  Vibrational Spectroscopy
  
  Volume: 85 Pages: 7-10
- DOI
  10.1016/j.vibspec.2016.03.016
- NAID
  120005898770
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763, KAKENHI-PROJECT-25460928, KAKENHI-PROJECT-26650133, KAKENHI-PROJECT-15K21441
[Journal Article] Similarifies and Differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis-Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients-2016
- Author(s)
  Jiao DJ, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Ishihara S, Kinoshita Y
- Journal Title
  
  J. Gastrienterol
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460928
[Journal Article] Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.2016
- Author(s)
  Kinoshita Y, Ishimura N, Oshima N, Mikami H, Okimoto E, Jiao DJ, Ishihara S.
- Journal Title
  
  Digestion
  
  Volume: 93 Issue: 1 Pages: 7-12
- DOI
  10.1159/000441668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460937, KAKENHI-PROJECT-25460928, KAKENHI-PROJECT-15H04763, KAKENHI-PROJECT-26460970, KAKENHI-PROJECT-26870378
[Journal Article] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.2016
- Author(s)
  Jiao D, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Izumi D, Okada M, Ishihara S, Kinoshita Y.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 52 Issue: 2 Pages: 203-210
- DOI
  10.1007/s00535-016-1213-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460937, KAKENHI-PROJECT-15H04763, KAKENHI-PROJECT-16K09282
[Journal Article] 好酸球性胃腸炎2015
- Author(s)
  大嶋直樹，石原俊治，木下芳一
- Journal Title
  
  診断と治療
  
  Volume: 103 Pages: 665-669
- Data Source
  KAKENHI-PROJECT-25460928
[Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations2015
- Author(s)
  Ishimura N, Shimura S, Jiao DJ, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
- Journal Title
  
  J. Gastroenterol Hepatol.
  
  Volume: 30 Pages: 71-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations.2015
- Author(s)
  Ishimura N, Shimura S, Jiao D, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: Suppl 1 Issue: S1 Pages: 1-7
- DOI
  10.1111/jgh.12746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460937, KAKENHI-PROJECT-25460928
[Journal Article] 好酸球性消化管障害―好酸球性食道炎と好酸球性胃腸炎―2015
- Author(s)
  大嶋直樹，木下芳一
- Journal Title
  
  アレルギーの臨床
  
  Volume: 35 Pages: 742-746
- Data Source
  KAKENHI-PROJECT-25460928
[Journal Article] 好酸球性消化管障害－好酸球性食道炎と好酸球性胃腸炎－2015
- Author(s)
  大嶋直樹，木下芳一
- Journal Title
  
  アレルギーの臨床
  
  Volume: 35 Pages: 742-746
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] Circumferential distribution and location of Mallory-Weiss tears: recent trends2015
- Author(s)
  Okada M, Ishimura N, Shimura S, Mikami H, Okimoto E, Aimi M, Uno G, Oshima N, Yuki T, Ishihara S, Kinoshita Y.
- Journal Title
  
  Endoscopy International Open
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] 臓器病変を伴う好酸球増多症　好酸球性胃腸炎2015
- Author(s)
  大嶋直樹、木下芳一
- Journal Title
  
  診断と治療
  
  Volume: 103 Pages: 665-669
- Data Source
  KAKENHI-PROJECT-26870378
[Journal Article] 好酸球性胃腸炎2015
- Author(s)
  大嶋直樹，石原俊治，木下芳一
- Journal Title
  
  診断と治療
  
  Volume: 103 Pages: 665-669
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers2015
- Author(s)
  Ishimura N, Mori M, Mikami H, Shimura S, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 15 Pages: 117-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries.2015
- Author(s)
  Kinoshita Y, Ishimura N, Oshima N, Ishihara S
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 21 Issue: 27 Pages: 8433-8440
- DOI
  10.3748/wjg.v21.i27.8433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460937, KAKENHI-PROJECT-25460928
[Journal Article] 好酸球性消化管障害－好酸球性食道炎と好酸球性胃腸炎－2015
- Author(s)
  大嶋直樹、木下芳一
- Journal Title
  
  アレルギーの臨床
  
  Volume: 35 Pages: 100-105
- Data Source
  KAKENHI-PROJECT-26870378
[Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries2015
- Author(s)
  Kinoshita Y, Ishimura N, Oshima N, Ishihara S.
- Journal Title
  
  World J Gastroenterology
  
  Volume: 21 Pages: 8433-8440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04763
[Journal Article] Pathophysiology of Barrett's esophagus-associated neoplasia: circumferential spatial predilection2014
- Author(s)
  shimura N, Okada M, Mikami H, Okimoto E, Fukuda N, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
- Journal Title
  
  Digestion
  
  Volume: 89 Issue: 4 Pages: 291-298
- DOI
  10.1159/000365123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460928, KAKENHI-PROJECT-26460937
[Journal Article] Apoptotic cells ameliorate chronic intestinal inflammation by enhancing regulatory B cell function2014
- Author(s)
  Ansary Md. Mu, Ishihara S, Oka A, Kusunoki R, Oshima N, Yuki T, Kawashima K, Maegawa H, Kashiwagi N, Kinoshita Y
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 20 Issue: 12 Pages: 2308-2320
- DOI
  10.1097/mib.0000000000000240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460928, KAKENHI-PROJECT-26460970
[Journal Article] 好酸球性消化管疾患の診断基準2013
- Author(s)
  木下芳一、大嶋直樹、石村典久、相見正史、石原俊治
- Journal Title
  
  胃と腸
  
  Volume: 48 Pages: 1853-1858
- Data Source
  KAKENHI-PROJECT-25460928
[Journal Article] 好酸球性消化管障害の診断と治療2013
- Author(s)
  木下芳一、大嶋直樹、石村典久、石原俊治
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 110 Pages: 953-964
- NAID
  10031177022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460928
[Presentation] IPMN術後に残膵癌、多発肝転移をきたした一例2023
- Author(s)
  原　　拓史　　福庭　暢彦　　岸本　健一　　兒玉　康秀　　尾上　正樹　　大嶋　直樹　　川島　耕作　　柴垣広太郎　　石村　典久　　石原　俊治　　古田晃一朗
- Organizer
  第131回日本消化器内視鏡学会中国支部例会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] 胆管空腸吻合部狭窄に対するBAE-ERCP下治療後無再発期間に関するCOX比例ハザードモデル解析2023
- Author(s)
  尾上　正樹　　福庭　暢彦　　兒玉　康秀　　古谷　聡史　　園山　浩紀　　岡　　明彦　　三島　義之　　大嶋　直樹　　柴垣広太郎　　森山　一郎　　川島　耕作　　石村　典久　　石原　俊治
- Organizer
  第106回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] 胃転移を来したT細胞リンパ腫の2例～内視鏡所見の検討～2023
- Author(s)
  大屋　　聡　　三島　義之　　田中　晋作　　片岡　祐俊　　尾上　正樹　　岡　　明彦　　柴垣広太郎　　大嶋　直樹　　川島　耕作　　石村　典久　　石原　俊治
- Organizer
  第131回日本消化器内視鏡学会中国支部例会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] 胃切除後症例における経皮内視鏡的胃瘻・十二指腸瘻造設術の成績2023
- Author(s)
  川島　耕作　　大西　浩二　　尾上　正樹　　岸本　健一　　高橋　佑典　　古谷　聡史　　福庭　暢彦　　大嶋　直樹　　石村　典久　　石原　俊治
- Organizer
  第27回PEG・在宅医療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] 難治性潰瘍性大腸炎に対する経口タクロリムス療法のベストユースを再考する―中四国地区多施設共同研究の結果を踏まえて―2023
- Author(s)
  大嶋　直樹　　平岡佐規子　　林　　亮平　　高橋　索真　　石井　　学　　橋本　真一　　八島　一夫　　井川　翔子　　井口　俊博　　上野　義隆　　稲葉　知己　　松本　啓志　　川島　耕作　　高見　太郎　　磯本　　一　　塩谷　昭子　　田中　信治　　石原　俊治
- Organizer
  第20回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] microRNAを用いた好酸球性食道炎の新規バイオマーカーの探索2022
- Author(s)
  大嶋　直樹　　石村　典久　　石原　俊治
- Organizer
  第108回日本消化器病学会総会(東京）
- Data Source
  KAKENHI-PROJECT-19K08907
[Presentation] microRNAを用いた好酸球性食道炎の新規バイオマーカーの探索2022
- Author(s)
  大嶋　直樹　　石村　典久　　石原　俊治
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K08542
[Presentation] 好酸球性食道炎の治療後経過に関する検討2021
- Author(s)
  石村　典久，沖本　英子，三代　　剛，大嶋　直樹，川島　耕作，石原　俊治
- Organizer
  第17回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-19K08907
[Presentation] microRNAの網羅的解析を用いた好酸球性食道炎のバイオマーカーの探索2019
- Author(s)
  大嶋直樹、石村典久、石原俊治
- Organizer
  第97回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-19K08907
[Presentation] Essential role of interleuikin-33-induced innate lymphoid cells in development of eosinophilic esophagitis in mice2017
- Author(s)
  Naoki Oshima, Shunji Ishihara, Kousaku Kawashima, Hiroki Sonoyama, Noritsugu Yamashita, Nobuhiko Fukuba, Yoshiyuki Mishima, Norihisa Ishimura, Ichiro Moriyama, Yoshikazu Kinoshita
- Organizer
  UEG Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870378
[Presentation] Similarities and differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients2016
- Author(s)
  Jiao DJ, Ishimura N, Okada M, Mikami H, Izumi D, Okimoto E, Oshima N, Ishihara S, Kinoshita Y
- Organizer
  Asian Pacific Digestive Week 2016
- Place of Presentation
  神戸コンベンションセンター（神戸）
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Detection of Eosinophils on the Tissue of Esophagus by a Newly Developed Fiber Raman Spectrophotometer2016
- Author(s)
  T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando, H. Hamaguchi
- Organizer
  Fourth Taiwan International Symposium on Raman Spectroscopy
- Place of Presentation
  台北（台湾）
- Year and Date
  2016-06-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Epidermaldifferentiation complex protein involucrin is down-regukated in eosinophikic esophagitis2016
- Author(s)
  Oshima N, Ishihara S, Fukuba N, Kawashima K, Ishimura N, Kinoshita Y
- Organizer
  Asian Pacific Digestive Week 2016
- Place of Presentation
  神戸コンベンションセンター（神戸）
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Development of a non-bioptic diagnostic method for eosinophilic esophagitis using Raman spectroscopy2016
- Author(s)
  Suguru Uemura, Hemanth Noothalapati, Naoki Ohshima, Masahiro Ando, Hiro-o Hamaguchi, Yoshikazu Kinoshita and Tatsuyuki Yamamoto
- Organizer
  Japan Taiwan Medical Spectroscopy International Symposium
- Place of Presentation
  淡路夢舞台国際会議場(淡路）
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Sustained acid suppression by potassium-competitive acid blocker (P-CAB) -possible treatment candidate for patients with eosinophilic esophagitis2016
- Author(s)
  Ishimura N, Okada M, mikami H, Izumi D, Okimoto E, Mishiro T, Oshima N, Ishihara S, Kinoshita Y
- Organizer
  Asian Pacific Digestive Week 2016
- Place of Presentation
  神戸コンベンションセンター（神戸）
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Detection of Eosinophils for the development of a new Raman diagnostic technique for Eosinophilic Esophagitis2016
- Author(s)
  Tatsuyuki Yamamoto, Suguru Uemura, Hemanth Noothalapati, Naoki Oshima, Yoshikazu Kinoshita, Masahiro Ando, Hiro-o Hamaguchi
- Organizer
  The 6th Biomedilca Molecular Imaging
- Place of Presentation
  宜蘭（台湾）
- Year and Date
  2016-11-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] 好酸球を可視化する～ラマン分光法を用いた好酸球性食道炎の診断～2015
- Author(s)
  大嶋直樹，石村典久，木下芳一
- Organizer
  第89回日本消化器内視鏡学会総会
- Place of Presentation
  名古屋国際会議場：名古屋
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25460928
[Presentation] ラマン分光法を用いた好酸球性食道炎の非生検的診断の試み2015
- Author(s)
  上村魁，ヘマンス・ヌータラパティ，大嶋直樹，安藤正浩，浜口宏夫，木下芳一，山本達之
- Organizer
  第13回医用分光学研究会年会
- Place of Presentation
  ホテルグランドヒル市ヶ谷（東京）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] New development of a Raman diagnosis for Eosinophil Esophagitis2015
- Author(s)
  T. Yamamoto, S. Uemura, H. Noothalapati, N. Oshima, Y. Kinoshita, M. Ando and H. Hamaguchi
- Organizer
  Biomedical Molecular Imaging 2015
- Place of Presentation
  Xitou(台湾）
- Year and Date
  2015-11-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] ワークショップ：内視鏡を用いた分子生物学的手法による病態解明；好酸球を可視化する～ラマン分光法を用いた好酸球性食道炎の診断～2015
- Author(s)
  大嶋直樹，石村典久，木下芳一
- Organizer
  第89回日本消化器内視鏡学会総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy2015
- Author(s)
  T. Yamamoto, H. Noothalapati, S. Uemura, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
- Organizer
  ICAVS 2015
- Place of Presentation
  ウィーン（オーストリア）
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Development of new medical diagnostic techniques by Raman spectroscopy2015
- Author(s)
  T. Yamamoto, S. Uemura, H. Noothalapati, N. Ohshima, Y. Kinoshita, M. Ando, and H. Hamaguchi
- Organizer
  Third Taiwan International Raman Spectroscopy
- Place of Presentation
  日月潭（台湾）
- Year and Date
  2015-06-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] Development of a Raman diagnosis for eosinophilic esophagitis2015
- Author(s)
  S. Uemura, H.Noothalapati, N. Ohshima, M. Ando, H. Hamaguchi, Y. Kinoshita, and T. Yamamoto
- Organizer
  Third Taiwan International Raman Spectroscopy
- Place of Presentation
  日月潭（台湾）
- Year and Date
  2015-06-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04763
[Presentation] IL-33を標的とした好酸球性食道炎の病態機序の解明
- Author(s)
  大嶋直樹、石村典久、木下芳一
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26870378
[Presentation] 好酸球性食道炎の病態形成にIL-33は関与するのか？
- Author(s)
  大嶋直樹、石原俊治、木下芳一
- Organizer
  第51回日本消化器免疫学会総会
- Place of Presentation
  京都大学医学部芝蘭会館
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26870378

1. ISHIHARA Shunji (80263531)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. Kinoshita Yoshikazu (30243306)

# of Collaborated Projects: 3 results

# of Collaborated Products: 37 results
3. Yamamoto Tatsuyuki (60230570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. NOOTHALAPATI Hemanth (30748025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
5. モハマドルミ (00379687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三島義之 (30397864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 岡明彦 (80600600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ISHIMURA Norihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 川島耕作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 佐藤英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Naoki 大嶋 直樹

OSHIMA Naoki 大嶋 直樹

Research Projects

Research Products

Co-Researchers

気相液相界面培養腸管疑似モデルを用いたLeaky gutと好酸球性胃腸炎の関連の解明Principal Investigator

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A study regarding a novel anti-inflammatory eosinophil subset on pathogenesis of eosiophilic gastroenteritis

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腸粘膜の透過性制御に着目したヒト腸管疑似モデルによる好酸球性胃腸炎の病態解明Principal Investigator

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Mechanism of eosinophilic esophagitis focusing on the immune response of the esophagus-skin interface via percutaneous sensitisation.Principal Investigator

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The development of a Raman spectroscopic technique to diagnose Eosinophil Esophagitis non-bioptically

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Essential role of interleuikin-33-induced innate lymphoid cells in development of eosinophilic esophagitis in micePrincipal Investigator

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Effect of gastric acid on the eosinophilic esophagitis

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Role of negative regulators for Toll-like receptor-dependent signaling in gut innate immune system

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[Book] 好酸球性食道疾患診療ガイド（木下芳一編）2014

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[Book] 小腸疾患の臨床－最近の進歩（田尻久雄 編）：好酸球性胃腸炎2013

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[Journal Article] Gastric Metastasis from Salivary Duct Carcinoma Mimicking Scirrhous Gastric Cancer2024

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[Journal Article] Predictive Factors for Efficacy of Oral Tacrolimus Induction Therapy in Moderate to Severe Ulcerative Colitis Patients: Large Multicenter Retrospective Cohort Study2023

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[Journal Article] Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-na?ve patients2023

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Oshima Naoki 大嶋直樹

OSHIMA Naoki 大嶋直樹

[Book] 小腸疾患の臨床－最近の進歩（田尻久雄　編）：好酸球性胃腸炎2013

[Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn's Disease2021