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Ayame Hiromi  菖蒲 裕美

ORCIDConnect your ORCID iD *help
… Alternative Names

HIYOSHI Hiromi  日吉 裕美

日吉 裕美  ヒヨシ ヒロミ

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Researcher Number 10406530
Other IDs
Affiliation (Current) 2025: 公益財団法人日本小動物医療センター(臨床研究部), 臨床研究部, 研究員
Affiliation (based on the past Project Information) *help 2025: 公益財団法人日本小動物医療センター(臨床研究部), 臨床研究部, 研究員
2016 – 2022: 名古屋市立大学, 大学院医学研究科, 助教
2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教
2013 – 2014: 筑波大学, 生命環境系, 助教
2006: 埼玉医科大学, 医学部, 研究員
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 42020:Veterinary medical science-related
Except Principal Investigator
Gastroenterology / Biological Sciences
Keywords
Principal Investigator
細胞周期 / アルギニンメチル化酵素 / 脳腫瘍 / ダイオキシン受容体 / AhR / 乳がん
Except Principal Investigator
PD-L1 / Cullin3 / CUL3 / CUL3 … More / BTB蛋白 / 胃がん / Cullin-3 / ユビキチン / PD-L1/PD-1 / 胃癌 / シグナル伝達 / 癌 / 細胞内膜輸送 / Cullin 3 / 消化器がん / ANKFY1 / 細胞内膜輸送メカニズム / 蛋白質 / 遺伝子 / 核酸 / 発現抑制 / 酵素 Less
  • Research Projects

    (6 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (11 People)
  •  ドラッグリポジショニングによる犬のリンパ腫の新たな治療法の開発Principal Investigator

    • Principal Investigator
      菖蒲 裕美
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Japan Small Animal Medical Center
  •  Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy

    • Principal Investigator
      Joh Takashi
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  Membrane trafficking of PD-L1 which is regulated by CUL3-BTBP

    • Principal Investigator
      Tanida Satoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  The role of protein arginine methyltransferase (PRMT) in brain tumorPrincipal Investigator

    • Principal Investigator
      Hiyoshi Hiromi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagoya City University
  •  AhR signaling suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP.Principal Investigator

    • Principal Investigator
      HIYOSHI Hiromi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tsukuba
  •  ヒストンアセチラーゼ阻害を介したRNA依存性転写抑制機構の解析

    • Principal Investigator
      黒川 理樹
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Saitama Medical University

All 2017 2016 2014 2013

All Journal Article

  • [Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017

    • Author(s)
      Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 2 Pages: 208-215

    • DOI

      10.1111/cas.13133

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
  • [Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017

    • Author(s)
      Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
    • Journal Title

      Biolology Open

      Volume: 6 Pages: 1707-1719

    • DOI

      10.1242/bio.029579

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
  • [Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016

    • Author(s)
      Kurozumi S, Yamaguchi Y, Hayashi S, Hiyoshi H, Suda T, Matsumoto H, Takei H, Horiguchi J, Oyama T, Takeyoshi I, Kurosumi M
    • Journal Title

      Cancer Med

      Volume: 5(8) Issue: 8 Pages: 1873-1882

    • DOI

      10.1002/cam4.780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461373, KAKENHI-PROJECT-26461939, KAKENHI-PROJECT-15K10082, KAKENHI-PROJECT-15K18858
  • [Journal Article] Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity.2014

    • Author(s)
      Oie S, Matsuzaki K, Yokoyama W, Tokunaga S, Waku T, Han SI, Iwasaki N, Mikogai A, Yasu zawa-Tanaka K, Kishimoto H, H iyoshi H, Nakajima Y, Araki T, Kimura K, Yanagisawa J, Murayama A.
    • Journal Title

      Cell Report

      Volume: 7(3) Issue: 3 Pages: 807-820

    • DOI

      10.1016/j.celrep.2014.03.038

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-11J40085, KAKENHI-PROJECT-12J00646, KAKENHI-PROJECT-25893022
  • [Journal Article] CHIP acts as a capacitor of phenotypic heterogeneity in breast cancer cells2014

    • Author(s)
      Tsuchiya M, Nakajima Y, Waku T, Hiyoshi H, Morishita T, Furumai R, Hayashi Y, Kishimoto H, Kimura K, Yanagisawa J.
    • Journal Title

      Oncogene

      Volume: なし Issue: 35 Pages: 1-8

    • DOI

      10.1038/onc.2014.387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J00646, KAKENHI-PROJECT-12J00947, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-15K18858
  • [Journal Article] 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP2014

    • Author(s)
      Hiromi Hiyoshi, Natsuka Goto, Mai Tsuchiya, Keisuke Iida, Yuka Nakajima, Naoya Hirata, Yasunari Kanda, Kazuo Nagasawa and Junn Yanagisawa
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 7095-7095

    • DOI

      10.1038/srep07095

    • NAID

      120007136531

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23105013, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26670041, KAKENHI-PROJECT-26860077
  • [Journal Article] Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transfoming Growth Factor-beta Signaling via Estrogen Receptor α2014

    • Author(s)
      Natsuka Goto, Hiromi Hiyoshi, Ichiaki Ito, Keisuke Iida, Yuka Nakajima, Kazuo Nagasawa and Junn Yanagisawa
    • Journal Title

      Journal of Cancer

      Volume: 5 Issue: 5 Pages: 336-343

    • DOI

      10.7150/jca.7202

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23105013, KAKENHI-PROJECT-23310158, KAKENHI-PROJECT-24651258, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26860077
  • [Journal Article] Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer.2013

    • Author(s)
      Hiyoshi H, Johnsen JI, Andang M, Uhlen P.
    • Journal Title

      Br. J. Cancer

      Volume: 108 Issue: 10 Pages: 2191-2191

    • DOI

      10.1038/bjc.2013.235

    • Open Access
    • Data Source
      KAKENHI-PROJECT-25893022
  • 1.  Joh Takashi (30231369)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  東山 繁樹 (60202272)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  Tanida Satoshi (30528782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  黒川 理樹 (70170107)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  荒井 重紀 (10383259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  徳澤 佳美 (20406531)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  前川 大志 (10771917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  久保田 英嗣 (30405188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  Sakaue Tomohisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  林 慎一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  長澤 和夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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