Ayame Hiromi 菖蒲裕美

… Alternative Names

HIYOSHI Hiromi 日吉裕美

日吉裕美ヒヨシヒロミ

Less

Researcher Number	10406530
Other IDs
Affiliation (Current)	2025: 公益財団法人日本小動物医療センター(臨床研究部), 臨床研究部, 研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人日本小動物医療センター(臨床研究部), 臨床研究部, 研究員 2016 – 2022: 名古屋市立大学, 大学院医学研究科, 助教 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教 2013 – 2014: 筑波大学, 生命環境系, 助教 2006: 埼玉医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 42020:Veterinary medical science-related Except Principal Investigator Gastroenterology / Biological Sciences
Keywords	Principal Investigator 細胞周期 / アルギニンメチル化酵素 / 脳腫瘍 / ダイオキシン受容体 / AhR / 乳がん Except Principal Investigator PD-L1 / Cullin3 / CUL３ / CUL3 … More / BTB蛋白 / 胃がん / Cullin-3 / ユビキチン / PD-L1/PD-1 / 胃癌 / シグナル伝達 / 癌 / 細胞内膜輸送 / Cullin 3 / 消化器がん / ANKFY1 / 細胞内膜輸送メカニズム / 蛋白質 / 遺伝子 / 核酸 / 発現抑制 / 酵素 Less

ドラッグリポジショニングによる犬のリンパ腫の新たな治療法の開発Principal Investigator
- Principal Investigator
  
  菖蒲裕美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Japan Small Animal Medical Center
Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy
- Principal Investigator
  
  Joh Takashi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Membrane trafficking of PD-L1 which is regulated by CUL3-BTBP
- Principal Investigator
  
  Tanida Satoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
The role of protein arginine methyltransferase (PRMT) in brain tumorPrincipal Investigator
- Principal Investigator
  
  Hiyoshi Hiromi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
AhR signaling suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP.Principal Investigator
- Principal Investigator
  
  HIYOSHI Hiromi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tsukuba
ヒストンアセチラーゼ阻害を介したRNA依存性転写抑制機構の解析
- Principal Investigator
  
  黒川理樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Saitama Medical University

All 2017 2016 2014 2013

All Journal Article

[Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017
- Author(s)
  Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.13133
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
[Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017
- Author(s)
  Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
- Journal Title
  
  Biolology Open
  
  Volume: 6 Pages: 1707-1719
- DOI
  10.1242/bio.029579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
[Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016
- Author(s)
  Kurozumi S, Yamaguchi Y, Hayashi S, Hiyoshi H, Suda T, Matsumoto H, Takei H, Horiguchi J, Oyama T, Takeyoshi I, Kurosumi M
- Journal Title
  
  Cancer Med
  
  Volume: 5(8) Issue: 8 Pages: 1873-1882
- DOI
  10.1002/cam4.780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461373, KAKENHI-PROJECT-26461939, KAKENHI-PROJECT-15K10082, KAKENHI-PROJECT-15K18858
[Journal Article] Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity.2014
- Author(s)
  Oie S, Matsuzaki K, Yokoyama W, Tokunaga S, Waku T, Han SI, Iwasaki N, Mikogai A, Yasu zawa-Tanaka K, Kishimoto H, H iyoshi H, Nakajima Y, Araki T, Kimura K, Yanagisawa J, Murayama A.
- Journal Title
  
  Cell Report
  
  Volume: 7(3) Issue: 3 Pages: 807-820
- DOI
  10.1016/j.celrep.2014.03.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J40085, KAKENHI-PROJECT-12J00646, KAKENHI-PROJECT-25893022
[Journal Article] CHIP acts as a capacitor of phenotypic heterogeneity in breast cancer cells2014
- Author(s)
  Tsuchiya M, Nakajima Y, Waku T, Hiyoshi H, Morishita T, Furumai R, Hayashi Y, Kishimoto H, Kimura K, Yanagisawa J.
- Journal Title
  
  Oncogene
  
  Volume: なし Issue: 35 Pages: 1-8
- DOI
  10.1038/onc.2014.387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00646, KAKENHI-PROJECT-12J00947, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-15K18858
[Journal Article] 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP2014
- Author(s)
  Hiromi Hiyoshi, Natsuka Goto, Mai Tsuchiya, Keisuke Iida, Yuka Nakajima, Naoya Hirata, Yasunari Kanda, Kazuo Nagasawa and Junn Yanagisawa
- Journal Title
  
  Sci. Rep.
  
  Volume: 4 Issue: 1 Pages: 7095-7095
- DOI
  10.1038/srep07095
- NAID
  120007136531
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23105013, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26670041, KAKENHI-PROJECT-26860077
[Journal Article] Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transfoming Growth Factor-beta Signaling via Estrogen Receptor α2014
- Author(s)
  Natsuka Goto, Hiromi Hiyoshi, Ichiaki Ito, Keisuke Iida, Yuka Nakajima, Kazuo Nagasawa and Junn Yanagisawa
- Journal Title
  
  Journal of Cancer
  
  Volume: 5 Issue: 5 Pages: 336-343
- DOI
  10.7150/jca.7202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23105013, KAKENHI-PROJECT-23310158, KAKENHI-PROJECT-24651258, KAKENHI-PROJECT-25893022, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26860077
[Journal Article] Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer.2013
- Author(s)
  Hiyoshi H, Johnsen JI, Andang M, Uhlen P.
- Journal Title
  
  Br. J. Cancer
  
  Volume: 108 Issue: 10 Pages: 2191-2191
- DOI
  10.1038/bjc.2013.235
- Open Access
- Data Source
  KAKENHI-PROJECT-25893022

1. Joh Takashi (30231369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 東山繁樹 (60202272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Tanida Satoshi (30528782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 黒川理樹 (70170107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 荒井重紀 (10383259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 徳澤佳美 (20406531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 前川大志 (10771917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 久保田英嗣 (30405188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Sakaue Tomohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 林慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 長澤和夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ayame Hiromi 菖蒲 裕美

HIYOSHI Hiromi 日吉 裕美

日吉 裕美 ヒヨシ ヒロミ

Research Projects

Research Products

Co-Researchers

ドラッグリポジショニングによる犬のリンパ腫の新たな治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Membrane trafficking of PD-L1 which is regulated by CUL3-BTBP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of protein arginine methyltransferase (PRMT) in brain tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AhR signaling suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒストンアセチラーゼ阻害を介したRNA依存性転写抑制機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CHIP acts as a capacitor of phenotypic heterogeneity in breast cancer cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transfoming Growth Factor-beta Signaling via Estrogen Receptor α2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer.2013

Author(s)

Ayame Hiromi 菖蒲裕美

HIYOSHI Hiromi 日吉裕美

日吉裕美ヒヨシヒロミ