Kawai Nobuyuki 河井伸之

… Alternative Names

KAWAI Nobuyuki 河井伸之

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Researcher Number	10411034
Affiliation (Current)	2025: 武庫川女子大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2014 – 2016: 武庫川女子大学, 薬学部, 講師 2008 – 2011: Kyoto Pharmaceutical University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Chemical pharmacy
Keywords	Principal Investigator 触媒 / 有機化学 / 薬学 / 合成化学 / 不斉転写 / テトラドロイソキノリン / 形式合成 / Schulzeine / benzo[a]quinolizidine環 / シュルゼインのベンゾキノリジン骨格 … More / 過塩素酸触媒 / 光学活性1位置換テトラヒドロイソキノリン / 1,3-不斉転写 / アルカロイド合成 / 過塩素酸 / 1位置換テトラヒドロイソキノリン / 分子内不斉転写 / ルイス酸 / 癌 Less

Synthesis of 1-substituted tetrahydroisoquinoline alkaloid utilizing intramolecular chirality transfer reactionPrincipal Investigator
- Principal Investigator
  
  Kawai Nobuyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Mukogawa Women's University
Development of direct allylation of amine catalyzed by Lewis acidPrincipal Investigator
- Principal Investigator
  
  KAWAI Nobuyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Development of efficient synthetic method for the natural product possessing sequential chiral quaternary carbons.Principal Investigator
- Principal Investigator
  
  KAWAI Nobuyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University

All 2015 2012 2011 2010 2009 2008 2001 Other

All Journal Article Presentation

[Journal Article] Synthesis of the Core Tricyclic Ring Domain of (–)-Schulzeine B2015
- Author(s)
  Naoyuki Hoshiya, Kenta Noda, Yuji Mihara, Nobuyuki Kawai, Jun’ichi Uenishi
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 80 Issue: 15 Pages: 7790-7796
- DOI
  10.1021/acs.joc.5b01173
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460020
[Journal Article] Synthesis of optically pure (R)- and (S)-tetrahydroisoquinoline-1- and -3-carboxylic acids2015
- Author(s)
  Kurata, Kaoruko; Inoue, Kumiko; Nishimura, Kazuhiko; Hoshiya, Naoyuki; Kawai, Nobuyuki; Uenishi, Junichi
- Journal Title
  
  Synthesis
  
  Volume: 47 Issue: 09 Pages: 1238-1244
- DOI
  10.1055/s-0034-1380289
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590034, KAKENHI-PROJECT-26460020
[Journal Article] Determination of the absolute structure of (+)-akaterpin2012
- Author(s)
  H. Hosoi, N. Kawai, H. Hagiwara, T. Suzuki, A. Nakazaki, K. Takao, K. Umezawa, S. Kobayashi
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: Vol.60, No.1 Pages: 137-143
- NAID
  130001852337
- URL
  https://www.jstage.jst.go.jp/article/cpb/60/1/60_1_137/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790023
[Journal Article] Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC2011
- Author(s)
  H. Hosoi, N. Kawai, H. Hagiwara, T. Suzuki, A. Nakazaki, K. Takao, K. Umezawa, S.Kobayashi
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Issue: 38 Pages: 4961-4964
- DOI
  10.1016/j.tetlet.2011.07.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390004, KAKENHI-PROJECT-22790023
[Journal Article] Stereoselective synthesis of tetrahydroiso-quinoline alkaloids :(-)-trolline,(+)-crispin A,(+)-oleracein E2011
- Author(s)
  N. Kawai, M. Matsuda, J. Uenishi
- Journal Title
  
  Tetrahedron
  
  Volume: Vol.67, No.45 Issue: 45 Pages: 8648-8653
- DOI
  10.1016/j.tet.2011.09.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790023
[Journal Article] Pd^<II>-catalyzed cascade reaction with 1,3-chirality transfer ; stereoselective synthesis of chiral nonracemic 2,2'-THF-THF ring units2011
- Author(s)
  Jun'ichi Uenishi, Yuhei Fujikura, Nobuyuki Kawai
- Journal Title
  
  Org.Lett.
  
  Volume: 13 Issue: 9 Pages: 2350-2353
- DOI
  10.1021/ol2005984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590030, KAKENHI-PROJECT-22790023
[Journal Article] Synthesis of chiral 1-substituted tetrahydroisoquinolines by the intramolecular 1, 3-chirality transfer reaction catalyzed by Bi(OTf)_32011
- Author(s)
  N. Kawai, M. Matsuda, J. Uenishi
- Journal Title
  
  J. Org. Chem
  
  Volume: Vol.76, No.7 Issue: 7 Pages: 2102-2114
- DOI
  10.1021/jo102452d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790023
[Journal Article] Synthesis of Chiral 1-Substituted Tetrahydroisoquinolines by the Intramolecular 1,3-Chirality Transfer Reaction Catalyzed by Bi(OTf)_32011
- Author(s)
  Nobuyuki Kawai
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 76 Pages: 2102-2114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790023
[Journal Article] An efficient synthesis of 2- and 2, 6- substituted piperidines using Pd^<II>-Catalyzed 1, 3-chirality transfer reaction2009
- Author(s)
  Sudhir M. Hande, Nobuyuki Kawai and Jun'ichi Uenishi
- Journal Title
  
  Journal of Organic Chemistry 74
  
  Pages: 244-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Journal Article] Lewis acid-catalyzed intramolecular amination via 1,3-chirality transfer2009
- Author(s)
  Nobuyuki Kawai, Ryuzou Abe, Jun'ichi Uenishi
- Journal Title
  
  Tetrahedron Letters 50
  
  Pages: 6580-6583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Journal Article] An efficient Synthesis of 2 - and 2, 6-Substituted Piperidines Using PdII-Catalyzed 1, 3-Chirality Transfer Reactions.2009
- Author(s)
  Sudhir M. Hande, Nobuyuki Kawai, Jun'ichi Uenishi
- Journal Title
  
  J. Org. Chem. 74
  
  Pages: 244-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Journal Article] Lewis acid-catalyzed intramolecular amination via 1, 3-chirality transfer2009
- Author(s)
  Nobuyuki Kawai, Ryuzou Abe, Jun'ichi Uenishi
- Journal Title
  
  Tetrahedron Letters 50
  
  Pages: 6580-6583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Journal Article] Stereochemistry and Mechanistic Study of Intramolecular Pd II-Catalyzed Oxypalladation and 1, 3-Chirality Transfer Reactions.2008
- Author(s)
  Jun'ichi Uenishi, Yogesh S. Vikhe, Nobuyuki Kawai
- Journal Title
  
  Chem. Asian J. 3
  
  Pages: 473-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Journal Article] Stereochemistry and Mechanistic Study of Intramolecular Pd^<II>-Catalyzed Oxypalladation and 1, 3-Chirality Transfer Reactions2008
- Author(s)
  Jun'ichi Uenishi, Yogesh S. Vikhe, Nobuyuki Kawai
- Journal Title
  
  Chemistry - An Asian Journal 3
  
  Pages: 473-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] スルホン酸エステル類を有機触媒とする環化反応のメカニズム2011
- Author(s)
  河井伸之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] Syhtesis of chiral 1-substituted tetrahydroisoquinoline by cyclization with neutral organocatalyst2011
- Author(s)
  Nobuyuki Kawai, Koichi Ishibashi, Jun'ichi Uenishi
- Organizer
  第2回プロセス化学国際シンポジウム
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2011-08-10
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] Neutral organocatalysts promoting dehydrative cyclization with 1, 3-chiralty transfer2011
- Author(s)
  Nobuyuki Kawai
- Organizer
  AIMECS11 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] Synthesis of chiral 1-substituted tetrahydroisoquinoline by cyclization with neutral organocatalyst2011
- Author(s)
  Nobuyuki Kawai
- Organizer
  第2回プロセス化学国際シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] スルホン酸エステルを触媒とする1, 3-不斉転写反応とテトラヒドロイソキノリンアルカイドの合成2011
- Author(s)
  河井伸之
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 分子内1, 3-不斉転写反応を誘起する有機スルホン酸エステル触媒2011
- Author(s)
  河井伸之
- Organizer
  第61回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 1, 3-Chirality Transfer on Lewis Acids Catalyzed Intramolecular Amino Substitution.2010
- Author(s)
  Nobuyuki Kawai, Mika Matsuda, Ryuzou Abe, Jun-ichi Uenishi
- Organizer
  The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 6,7-位に酸素官能基を有する光学活性テトラヒドロイソキノリン環形成と関連するアルカロイドの不斉合成2010
- Author(s)
  河井伸之
- Organizer
  第40回複素環化学討論会
- Place of Presentation
  仙台(日本)
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 光学活性テトラヒドロイソキノリン類の合成2010
- Author(s)
  河井伸之
- Organizer
  第37回有機反応懇談会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 2価Pd触媒によるドミノ型環化反応2010
- Author(s)
  藤倉悠平, 河井伸之, 上西潤一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 光学活性テトラヒドロイソキノリン誘導体の新規合成法の開発2010
- Author(s)
  松田望花, 阿部隆三, 河井伸之, 上西潤一
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 触媒的分子内1, 3-不斉転写反応による窒素環化合物の合成2010
- Author(s)
  河井伸之, 阿部隆三, 松田望花, 上西潤一
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 光学活性1位置換テトラヒドロイソキノリン類の新規合成2010
- Author(s)
  河井伸之
- Organizer
  第60回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] Bi(OTf)3を触媒とする光学活性テトラヒドロイソキノリン誘導体の合成2010
- Author(s)
  松田望花, 阿部隆三, 河井伸之, 上西潤一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Bi(OTf)_3を触媒とする光学活性テトラヒドロイソキノリン誘導体の合成2010
- Author(s)
  河井伸之
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 2位2'位で連結された光学活性THF, THP環化合物の合成2010
- Author(s)
  藤倉悠平, 河井伸之, 上西潤一
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Catalytic intramolecular 1, 3-chirality transfer reaction to form azaheterocycles2010
- Author(s)
  Nobuyuki Kawai
- Organizer
  The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790023
[Presentation] 分子内環化によるシクロペンタン環の立体選択的合成法の研究2010
- Author(s)
  畑中惇志., 河井伸之., 上西潤一
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都(日本)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] ビスマストリフラートを触媒としたキラルなアリルコールへの立体選択的分子内直接アミノ置換反応2009
- Author(s)
  阿部隆三, 松田望花, 河井伸之, 上西潤一
- Organizer
  第36回有機反応懇談会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 1, 3-Chirality Transfer on Lewis Acids Catalyzed Intramolecular Amino Substitution.2009
- Author(s)
  Nobuyuki Kawai, Ryuzou Abe, Mika Matsuda, Sudhir Mahadeo Hande, Jun-ichi Uenishi
- Organizer
  11th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 1, 3-不斉転写を伴う触媒的環化反応による光学活性な1位置換テトラヒドロイソキノリンの合成研究2009
- Author(s)
  河井伸之, 阿部隆三, 松田望花, 上西潤一
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] ルイス酸触媒によるキラルな2級アリルアルコールへの窒素求核剤の分子内SN2'反応2009
- Author(s)
  河井伸之, 阿部隆三, 松田望花, Sudhir Mahadeo Hande, 上西潤一
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Asymmetric synthesis of (+)- and (-)-coniine2008
- Author(s)
  Sudhir M. Hande、河井伸之、上西潤一
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Stereochemistry and Mechanistic Study of Intramolecular Pd^<II>-Catalyzed Oxypalladation and 1, 3-Chirality Transfer Reactions2008
- Author(s)
  Yogesh S. Vikhe, Nobuyuki Kawai, Jun'ichi Uenishi
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  京都(日本)
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Total synthesis of (-)-zampanolide.2008
- Author(s)
  Takuya Iwamoto, Nobuyuki Kawai, Jun' ichi Uenishi
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] Stereochemistry and mechanistic study of intramolecular PdII-catalyzed oxypalladation and 1, 3-chirality-transfer reaction.2008
- Author(s)
  Yogesh S. Vikhe, Nobuyuki Kawai, Jun' ichi Uenishi
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 分子内環化によるシクロペンタン環の合成2001
- Author(s)
  畑中惇志, 河井伸之, 上西潤一
- Organizer
  難病克服を目指した分子基盤創薬科学の開拓成果発表会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790020
[Presentation] 光学活性1-アルケニルテトラヒドロイソキノリンから有用アミノ化合物への変換
- Author(s)
  野田健太、倉田薫子、三原裕二、西村和晃、河井伸之、星谷尚亨、上西潤一
- Organizer
  第44回複素環化学討論会
- Place of Presentation
  札幌市民ホール（北海道・札幌市）
- Year and Date
  2014-09-10 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-26460020

1. 小林進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 鈴木孝洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 上西潤一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kawai Nobuyuki 河井 伸之

KAWAI Nobuyuki 河井 伸之

Research Projects

Research Products

Co-Researchers

Synthesis of 1-substituted tetrahydroisoquinoline alkaloid utilizing intramolecular chirality transfer reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of direct allylation of amine catalyzed by Lewis acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of efficient synthetic method for the natural product possessing sequential chiral quaternary carbons.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of the Core Tricyclic Ring Domain of (&#8211;)-Schulzeine B2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of optically pure (R)- and (S)-tetrahydroisoquinoline-1- and -3-carboxylic acids2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Determination of the absolute structure of (+)-akaterpin2012

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stereoselective synthesis of tetrahydroiso-quinoline alkaloids :(-)-trolline,(+)-crispin A,(+)-oleracein E2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pd^<II>-catalyzed cascade reaction with 1,3-chirality transfer ; stereoselective synthesis of chiral nonracemic 2,2'-THF-THF ring units2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of chiral 1-substituted tetrahydroisoquinolines by the intramolecular 1, 3-chirality transfer reaction catalyzed by Bi(OTf)_32011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Chiral 1-Substituted Tetrahydroisoquinolines by the Intramolecular 1,3-Chirality Transfer Reaction Catalyzed by Bi(OTf)_32011

Author(s)

Journal Title

Data Source

[Journal Article] An efficient synthesis of 2- and 2, 6- substituted piperidines using Pd^<II>-Catalyzed 1, 3-chirality transfer reaction2009

Author(s)

Journal Title

Data Source

[Journal Article] Lewis acid-catalyzed intramolecular amination via 1,3-chirality transfer2009

Author(s)

Journal Title

Data Source

[Journal Article] An efficient Synthesis of 2 - and 2, 6-Substituted Piperidines Using PdII-Catalyzed 1, 3-Chirality Transfer Reactions.2009

Author(s)

Journal Title

Data Source

[Journal Article] Lewis acid-catalyzed intramolecular amination via 1, 3-chirality transfer2009

Author(s)

Journal Title

Data Source

[Journal Article] Stereochemistry and Mechanistic Study of Intramolecular Pd II-Catalyzed Oxypalladation and 1, 3-Chirality Transfer Reactions.2008

Kawai Nobuyuki 河井伸之

KAWAI Nobuyuki 河井伸之

[Journal Article] Synthesis of the Core Tricyclic Ring Domain of (–)-Schulzeine B2015