Kuboyama Tomoharu 久保山友晴

… Alternative Names

久保山友晴クボヤマトモハル

KUBOYAMA Tomoharu 久保山友晴

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Researcher Number	10415151
Other IDs	https://orcid.org/0000-0003-3037-9974
Affiliation (Current)	2025: 第一薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 第一薬科大学, 薬学部, 教授 2020 – 2023: 第一薬科大学, 薬学部, 准教授 2019: 富山大学, 学術研究部薬学・和漢系, 助教 2018: 富山大学, 和漢医薬学総合研究所, 助教 2015 – 2016: 富山大学, 和漢医薬学総合研究所, 助教 … More 2011 – 2013: 富山大学, 和漢医薬学総合研究所, 助教 2008 – 2009: The Institute of Physical and Chemical Research, 神経成長機構研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 神経成長機構研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Basic Section 52010:General internal medicine-related / Basic Section 51030:Pathophysiologic neuroscience-related / Neuroscience in general / Neuroscience in general Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / Biological Sciences / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 軸索 / dystrophic endball / 軸索再生 / パキシリン / プロテインキナーゼA / コンドロイチン硫酸プロテオグリカン / 食品 / 記憶 / 不安障害 / 生薬 … More / 不安症 / 記憶改善 / M2マイクログリア / M2 / 記憶障害 / 軸索変性 / アミロイドβ / HDAC3 / マイクログリア / アルツハイマー病 / 細胞接着班 / p21-activated kinase / プロテオグリカン / 脊髄損傷 / 細胞接着 / Lpaxillin / paxillin / 細胞接着斑 … More Except Principal Investigator マイクログリア / 脊髄損傷 / 遺伝系統 / 神経疾患 / 偽遺伝子 / 抗炎症作用成分 / M2 / M1 / 大黄 / Rheum / 介在ニューロン / 皮質脊髄路 / 軸索 / 骨格筋細胞 / 生薬 / 運動ニューロン / 軸索修復 / 骨格筋萎縮 / 硫酸化構造 / 軸索伸長 / パキシリン / 軸索再生 / dystrophic endball / コンドロイチン硫酸プロテオグリカン / Ca2+ / 糖鎖 / カルシウム / cAMP / 成長円錐 / 軸索ガイダンス / ケラタン硫酸 / コンドロイチン硫酸 / 国際情報交換 / Western blotting / Vimentin / デノソミン / DARTS法 / IGF1受容体 / vimentin / アストロサイト / 軸索伸展 Less

Development of functional foods with nootropic effects through the construction of neuronal networksPrincipal Investigator
- Principal Investigator
  
  久保山友晴
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Recovery from refractory anxiety by reconstruction of neuronal networksPrincipal Investigator
- Principal Investigator
  
  久保山友晴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Development of high value-added Rhubarb effective for neurological disorders
- Principal Investigator
  
  小松かつ子
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
Development of therapeutic strategy for Alzheimer's disease via M2 microgliaPrincipal Investigator
- Principal Investigator
  
  Kuboyama Tomoharu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
  University of Toyama
Traditional medicine-based drug development-creation of new paradigm-
- Principal Investigator
  
  Tohda Chihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  University of Toyama
Recovery from spinal cord injury in the chronic phase -the mechanism of denosomin, a novel compound with multiactivities-
- Principal Investigator
  
  TOHDA Chihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Toyama
Axonal regeneration via regulation of point contactsPrincipal Investigator
- Principal Investigator
  
  KUBOYAMA TOMOHARU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  University of Toyama
Analyses of the functional domains in sugar chains using neuronal growth cones
- Principal Investigator
  
  TOJIMA Takuro
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycanPrincipal Investigator
- Principal Investigator
  
  KUBOYAMA Tomoharu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2009 Other

All Journal Article Presentation Patent

[Journal Article] Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia2023
- Author(s)
  Kuboyama Tomoharu、Hotta Kenichiro、Asanuma Mai、Ge Yue-Wei、Toume Kazufumi、Yamazaki Takuma、Komatsu Katsuko
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 77 Issue: 4 Pages: 699-711
- DOI
  10.1007/s11418-023-01710-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06626, KAKENHI-PROJECT-22K07460
[Journal Article] Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix2021
- Author(s)
  Kuboyama Tomoharu、Kominato Seiya、Nagumo Misaki、Tohda Chihiro
- Journal Title
  
  Phytomedicine
  
  Volume: 82 Pages: 153452-153452
- DOI
  10.1016/j.phymed.2020.153452
- NAID
  130008001435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03558, KAKENHI-PROJECT-18K07389
[Journal Article] Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease2020
- Author(s)
  Kuboyama Tomoharu、Yang Ximeng、Tohda Chihiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 13 Pages: 4665-4665
- DOI
  10.3390/ijms21134665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03558, KAKENHI-PROJECT-18K07389
[Journal Article] Development of New Therapies for Neurodegenerative Diseases <i>via</i> Axonal Growth2019
- Author(s)
  Kuboyama Tomoharu
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 11 Pages: 1385-1390
- DOI
  10.1248/yakushi.19-00147
- NAID
  130007740057
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-11-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07389
[Journal Article] Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression2019
- Author(s)
  Yang Zhiyou、Kuboyama Tomoharu、Tohda Chihiro
- Journal Title
  
  Phytotherapy Research
  
  Volume: in press Issue: 4 Pages: 1-8
- DOI
  10.1002/ptr.6305
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07389, KAKENHI-PROJECT-17H03558
[Journal Article] Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons2018
- Author(s)
  Kuboyama Tomoharu
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 140 Issue: 140 Pages: 140-140
- DOI
  10.3791/58229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07389
[Journal Article] The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury.2016
- Author(s)
  Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 6:326 Pages: 1-10
- DOI
  10.3389/fphar.2015.00326
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670044, KAKENHI-PROJECT-16H05276
[Journal Article] Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study.2015
- Author(s)
  Watari H, Shigyo M, Tanabe N, Tohda M, Cho KH, Kyung PS, Jung WS, Shimada Y, Shibahara N, Kuboyama T, Tohda C.
- Journal Title
  
  Phytother Res.
  
  Volume: 29 Issue: 3 Pages: 351-356
- DOI
  10.1002/ptr.5250
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] Active constituents from Drynaria fortune Rhizomes on the attenuation of Aβ25-35-induced axonal atrophy.2015
- Author(s)
  Yang Z, Kuboyama T, Kazuma K, Konno K, Tohda C.
- Journal Title
  
  J Natural Products
  
  Volume: 78(9) Issue: 9 Pages: 2297-2300
- DOI
  10.1021/acs.jnatprod.5b00290
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670044, KAKENHI-PROJECT-15H05268
[Journal Article] Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth.2015
- Author(s)
  Shigyo M, Kuboyama T, Sawai Y, Tada-Umezaki M, Tohda C.
- Journal Title
  
  Scientific Reports
  
  Volume: 5:12055. Issue: 1 Pages: 1-13
- DOI
  10.1038/srep12055
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage.2015
- Author(s)
  Kuboyama T, Lee YA, Nishiko H, Tohda C.
- Journal Title
  
  Neurobiol Aging
  
  Volume: ? Issue: 5 Pages: 1808-1819
- DOI
  10.1016/j.neurobiolaging.2015.02.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice.2014
- Author(s)
  Shigyo M, Tanabe N, Kuboyama T, Choi SH, Tohda C.
- Journal Title
  
  BMC Res Notes
  
  Volume: 7 Issue: 1 Pages: 332-332
- DOI
  10.1186/1756-0500-7-332
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases2014
- Author(s)
  Kuboyama T, Tohda C, Komatsu K
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 37(6) Pages: 892-897
- NAID
  130004147346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.2014
- Author(s)
  Kuboyama T, Tohda C, Komatsu K.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 37
- NAID
  130004147346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] 伝統薬物研究が薬理学にもたらす新しい視点2014
- Author(s)
  東田千尋, 久保山友晴
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 Pages: 73-77
- NAID
  130003391427
- URL
  http://plaza.umin.ac.jp/JPS1927/fpj/issue/TOC14-143(2)/14-143-2.htm
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] 伝統薬物研究が薬理学にもたらす新しい視点．2014
- Author(s)
  東田千尋、久保山友晴、
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 Pages: 73-77
- NAID
  130003391427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] 伝統薬物研究が薬理学にもたらす新しい視点．2014
- Author(s)
  東田千尋、久保山友晴
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 Pages: 73-77
- NAID
  130003391427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice2014
- Author(s)
  Shigyo M, Tanabe N, Kuboyama T, Choi S-H, Tohda C
- Journal Title
  
  BMC Res Notes
  
  Volume: 7(1) Pages: 332-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Effects of Ashwagandha (roots of Withania somnifera Dunal) on neurodegenerative diseases2014
- Author(s)
  Kuboyama T, Tohda C, Komatsu K
- Journal Title
  
  Biol Pharm Bull
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Effects of Ashwagandha (roots of Withania somnifera Dunal) on neurodegenerative diseases.2014
- Author(s)
  Kuboyama T., Tohda C., Komatsu K.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 37 Pages: 892-897
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670044
[Journal Article] New perspective in pharmacology brought by studying traditional medicine2014
- Author(s)
  Tohda C, Kuboyama T
- Journal Title
  
  Nihon Yakurigaku Zasshi
  
  Volume: 143(2) Pages: 73-77
- NAID
  130003391427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Effects of Ashwagandha (roots of Withania somnifera Dunal) on neurodegenerative diseases.2014
- Author(s)
  Kuboyama T., Tohda C., Komatsu K.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 37(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration2013
- Author(s)
  Tomoharu Kuboyama, Xueting Luo, Kevin Park, Murray G. Blackmore, Takuro Tojima, Chihiro Tohda, John L. Bixby, Vance P. Lemmon, Hiroyuki Kamiguchi
- Journal Title
  
  Experimental Neurology
  
  Volume: 248 Pages: 157-169
- DOI
  10.1016/j.expneurol.2013.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23110005, KAKENHI-PROJECT-23500439, KAKENHI-PROJECT-23700376, KAKENHI-PROJECT-24300137, KAKENHI-PROJECT-24500393
[Journal Article] A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin.2013
- Author(s)
  Teshigawara K, Kuboyama T, Shigyo M, Nagata A, Sugimoto K, Matsuya Y, Tohda C.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 168 Issue: 4 Pages: 903-919
- DOI
  10.1111/j.1476-5381.2012.02211.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790246, KAKENHI-PROJECT-23500439, KAKENHI-PROJECT-23700376, KAKENHI-PROJECT-24406005
[Journal Article] Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice.2012
- Author(s)
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T.
- Journal Title
  
  Sci. Rep.,
  
  Volume: 2 Issue: 1 Pages: 535-535
- DOI
  10.1038/srep00535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439, KAKENHI-PROJECT-23700376, KAKENHI-PROJECT-24406005
[Journal Article] Screening of fractions from some Chinese herbs for spinal cord injury2012
- Author(s)
  Wang X-H, Zhu H, Konno K, Tohda C, Kazuma K, Kuboyama T, Miyanaga S
- Journal Title
  
  Chinese Journal of Experimental Traditional Medical Formulae
  
  Volume: 18(12) Pages: 246-248
- URL
  http://en.cnki.com.cn/Article_en/CJFDTotal-ZSFX201212072.htm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Screening on functions from some Chinese herbs for spinal cord injury2012
- Author(s)
  Wang XH, Zhu H, Konno K, Tohda C, Kazuma K, Kuboyama T, Miyanaga S
- Journal Title
  
  Chinese Journal of Experimental Traditional Medical Formulae
  
  Volume: 18(12) Pages: 246-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Screening of fractions from some Chinese herbs for spinal cord injury.2012
- Author(s)
  Wang X-H, Zhu H, Konno K, Tohda C, Kazuma K, Kuboyama T, Miyanaga S.
- Journal Title
  
  Chinese Journal of Experimental Traditional Medical Formulae
  
  Volume: 18 Pages: 246-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Screening on functions from some Chinese herbs for spinal cord injury.2012
- Author(s)
  Wang XH, Zhu H, Konno K, Tohda C, Kazuma K, Kuboyama T, Miyanaga S
- Journal Title
  
  Chinese Journal of Experimental Traditional Medical Formulae
  
  Volume: 18 Pages: 246-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD2011
- Author(s)
  Tohda C, Nakada R, Urano T, Okonogi A, Kuboyama T
- Journal Title
  
  Int. J. Neurosci
  
  Volume: 121(12) Issue: 12 Pages: 641-648
- DOI
  10.3109/00207454.2011.602809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439, KAKENHI-PROJECT-23700376
[Journal Article] Kamikihi-to (KKT) rescues axonal and synaptic2011
- Author(s)
  Tohda C, Nakada R, Urano T, Okonogi A, Kuboyama T.
- Journal Title
  
  Int. J. Neurosci.
  
  Volume: 121 Pages: 641-648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Current and future therapeutic strategies2011
- Author(s)
  Tohda C., Kuboyama T.
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 132 Pages: 57-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500439
[Journal Article] Current and future therapeutic strategies for functional repair of spinal cord injury.2011
- Author(s)
  Tohda C, Kuboyama T.
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 132 Pages: 57-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700376
[Journal Article] Current and future therapeutic strategies for functional repair of spinal cord injury2011
- Author(s)
  Tohda C
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 132 Issue: 1 Pages: 57-71
- DOI
  10.1016/j.pharmthera.2011.05.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23110005, KAKENHI-PROJECT-23500439, KAKENHI-PROJECT-23700376
[Patent] 神経回路網の再構築・賦活用医薬または食品　国内出願番号：2015
- Inventor(s)
  東田千尋、久保山友晴、楊志友
- Industrial Property Rights Holder
  レジリオ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-130692
- Filing Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26670044
[Patent] 脊髄損傷慢性期の機能改善剤2014
- Inventor(s)
  東田千尋、久保山友晴、田辺紀生
- Industrial Property Rights Holder
  国立大学法人富山大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-157268
- Filing Date
  2014-08-01
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 長野県栽培Rheum属植物由来根のマイクログリアM2化に着目した品質評価.2023
- Author(s)
  久保山友晴，堀田健一郎，浅沼舞，當銘一文，山嵜琢磨，小松かつ子.
- Organizer
  第40回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07460
[Presentation] Mechanisms of sibiricose A5, a constituent of Polygalae Radix, for recovery of memory in Alzheimer’s disease model mice.2023
- Author(s)
  Kuboyama T, Arake Y, Tsutsumi T, Nagumo M, Kominato S, Tohda C.
- Organizer
  第66回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-22K07460
[Presentation] 遠志成分sibiricose A5の抗アルツハイマー病作用とその作用機序の解明.2023
- Author(s)
  久保山友晴、荒毛優太、塘健太、南雲美咲、小湊誠也、東田千尋.
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-22K07460
[Presentation] 長野県栽培Rheum属植物由来根茎のマイクログリアM2化に着目した品質評価2022
- Author(s)
  久保山友晴，堀田健一郎，浅沼舞，當銘一文，山嵜琢磨，小松かつ子
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-21K06628
[Presentation] アルツハイマー病モデルマウスにおいて、HDAC3阻害はマイクログリアから分泌されるIGFBP6を介して変性軸索を正常化させ、記憶回復作用を示す2022
- Author(s)
  久保山友晴、岡本陽里、東田千尋
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-22K07460
[Presentation] マイクログリアM2化活性に着目した長野県産大黄の品質評価2022
- Author(s)
  久保山友晴，堀田健一郎，浅沼舞，當銘一文，山嵜琢磨，小松かつ子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06628
[Presentation] アミロイドβによる軸索変性に着目したアルツハイマー病予防・治療法の開発2020
- Author(s)
  久保山友晴、楊熙蒙、東田千尋
- Organizer
  第37回和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] HDAC3 inhibition ameliorates memory function via M2 microglia in a transgenic mouse model of Alzheimer’s disease.2019
- Author(s)
  Kuboyama T, Tohda C.
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] 神経変性疾患の根本治療を目指した和漢薬研究2019
- Author(s)
  久保山友晴
- Organizer
  第36回和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] 軸索伸長を基盤とした神経変性疾患治療法の開発2018
- Author(s)
  久保山友晴
- Organizer
  日本薬学会北陸支部第130回例会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] アルツハイマー病の予防と治療を目指した和漢薬研究2018
- Author(s)
  久保山友晴
- Organizer
  第35回和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] マイクログリアの善玉化によるアルツハイマー病治療法の開発.2018
- Author(s)
  久保山友晴
- Organizer
  Toyama Academic GALA 2018
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] HDAC3 inhibition ameliorates memory function via regulating microglial phenotype in Alzheimer’s disease model mice.2018
- Author(s)
  Kuboyama T, Tohda C.
- Organizer
  第61回日本神経化学会大会・第40回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-18K07389
[Presentation] マイクログリアの良性化活性を有する生薬の探索.2016
- Author(s)
  小湊誠也、久保山友晴、東田千尋
- Organizer
  日本薬学会北陸支部会128回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 骨格筋を活性化することにより慢性期脊髄損傷を改善する薬物の研究．2016
- Author(s)
  小谷篤、田辺紀生、久保山友晴、東田千尋
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Diosgeninによるアルツハイマー病の記憶回復にHSC70の減少が関与する．2016
- Author(s)
  楊熙蒙、久保山友晴、東田千尋
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 急性期および慢性期脊髄損傷における運動機能へのmatrineの作用．2016
- Author(s)
  田辺紀生、久保山友晴、東田千尋
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 生薬エキス投与後に脳内で検出される成分の同定とそのアルツハイマー病改善メカニズムの解析.2016
- Author(s)
  東田千尋,、楊志友、久保山友晴
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2016-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Reduction of HSC70 relates to diosgenin-induced memory improvement in a mouse model of Alzheimer’s disease.2016
- Author(s)
  Yang X, Kuboyama T, Tohda C.
- Organizer
  Society for Neuroscience 46th Annual Meeting (Neuroscience 2016)
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Naringenin restores axonal degeneration and memory deficits in a mouse model of Alzheimer’s disease.2016
- Author(s)
  Yang Z, Kuboyama T, Tohda C.
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Approach to identify anti-Alzheimer’s disease compounds that are delivered into the brain after administration of traditional medicine.2016
- Author(s)
  Yang Z, Kuboyama T, Tohda C.
- Organizer
  Society for Neuroscience 46th Annual Meeting (Neuroscience 2016)
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Matrine facilitates axonal growth and improves motor function in spinal cord injury in acute and chronic phases.2016
- Author(s)
  Tanabe N, Kuboyama T, Tohda C.
- Organizer
  Society for Neuroscience 46th Annual Meeting (Neuroscience 2016)
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Extracellular neuroleukin improves hindlimb motor dysfunction of spinal cord injury.2016
- Author(s)
  Tanie Y, Tanabe N, Kuboyama T, Tohda C.
- Organizer
  Society for Neuroscience 46th Annual Meeting (Neuroscience 2016)
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 細胞外neuroleukinは脊髄損傷の運動機能障害を回復させる．2016
- Author(s)
  谷江良崇、田辺紀生、久保山友晴、東田千尋
- Organizer
  第59回日本神経化学会大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] アルツハイマー病治療を目指した伝統薬物研究.2016
- Author(s)
  久保山友晴、楊志友、東田千尋
- Organizer
  日本薬学会北陸支部会128回例会
- Place of Presentation
  金沢
- Invited
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 伝統薬物研究が拓く認知症の根本治療戦略．2015
- Author(s)
  東田千尋、渡り英俊、久保山友晴
- Organizer
  医療薬学フォーラム2015 第23回クリニカルファーマシーシンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Extracellular virnentin interacts with insulin-like growth factor l receptor to promote axonal growth.2015
- Author(s)
  Shigyo M. Kuboyama T. Sawai Y, Tada-Umezaki M, Tohda C.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Crude drug-derived brain-active constituents for improvement of Alzheimer’s disease.2015
- Author(s)
  Yang Z, Kuboyama T, Tohda C.
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Brain-Active Herbal Metabolites for the Treatment of Alzheimer’s Disease.2015
- Author(s)
  Yang Z, Kuboyama T, Tohda C.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Immediate or delayed administrations of matrine improve motor dysfunction in spinal cord injured mice.2015
- Author(s)
  Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] A novel compound, denosomin, ameliorates motor function in spinal cord injured mice via axonal growth associated with astrocyte-secreted vimentin.2015
- Author(s)
  Kuboyama T., Shigyo M., Tohda C.
- Organizer
  JMSA New York Life Science Forum 2015
- Place of Presentation
  New York, USA
- Year and Date
  2015-04-12
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Diosgeninによるアルツハイマー病の記憶回復に関わるシグナル分子の探索.2015
- Author(s)
  楊熙蒙、久保山友晴、東田千尋.
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 細胞外vimentinによる軸索伸展作用メカニズムの解明．2015
- Author(s)
  執行美智子、久保山友晴、梅嵜雅人、沢井裕佑、東田千尋
- Organizer
  日本薬学会北陸支部第127回例会
- Place of Presentation
  東京
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] The mechanism of Denosomin in astrocytes leading to release of axonal growth factors.2015
- Author(s)
  Tanie Y, Shigyo M, Tanabe N, Kuboyama T, Tohda C.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Diosgenin decreases the expression of HSC70 and improves memory function in Alzheier’s disease model mice.2015
- Author(s)
  Yang X, Kuboyama T, Tohda C.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] The recovery of motor function by a crude drug and its active constituent in spinal cord injured mice2014
- Author(s)
  Tanabe N., Kuboyama T., Kazuma K., Konnno K., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 日本および韓国で用いられている加味帰脾湯の記憶増強作用の比較2014
- Author(s)
  渡り英俊、執行美智子、田辺紀生、東田道久、 Ki-Ho Cho、島田豊、柴原直利、久保山友晴、東田千尋
- Organizer
  第31回和漢医薬学学会学術大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced growth cone collapse, axonal atrophy and memory impairment2014
- Author(s)
  Kuboyama T., Lee Y., Nishiko H., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Improvement of motor dysfunction in acute and chronic phases in spinal cord injury mice by a crude drug-derived compound2014
- Author(s)
  Tanabe N., Kuboyama T., Kazuma K., Konnno K., Tohda C.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] DR-induced cognitive enhancement in Alzheimer's disease model mice, 5XFAD, and underlying mechanisms2014
- Author(s)
  Yang Z., Kuboyama T., Tohda C.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Extracellular vimentin facilitates axonal growth by interacting with IGF1R2014
- Author(s)
  Shigyo M., Kuboyama T., Chihiro T.
- Organizer
  第57回日本神経化学大会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Extracellular vimentin promotes axonal growth via IGF1R2014
- Author(s)
  Shigyo M., Kuboyama T., Tohda C.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice2014
- Author(s)
  Shigyo M., Tanabe N., Kuboyama T., Coi S.-H., Chihiro T.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] DR improves memory impairment in Alzheimer's disease model mice, 5XFAD, and attenuates amyloid β-induced axonal atrophy2014
- Author(s)
  Yang Z., Kuboyama T., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Clathrin-mediated endocytosis is a key target for amyloid β-induced axonal degeneration and memory impairment2014
- Author(s)
  Kuboyama T., Lee Y., Nishiko H., Tohda C.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] A novel compound, Denosomin, promotes axonal growth via astrocytes secreting vimentin after spinal cord injury2013
- Author(s)
  Shigyo M, Teshigawara K, Kuboyama T, Nagata A, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Endocytosis-mediated axonal growth cone degeneration induced by amyloid β2013
- Author(s)
  Kuboyama T, Nishiko H, Tohda C
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer's disease model 5XFAD mice2013
- Author(s)
  Tohda C, Urano T, Umezaki M, Kuboyama T
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Investigation of crude drugs effective for spinal cord injured mice2013
- Author(s)
  Tanabe N, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Tohda C
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Ashwagandha成分Sominoneの誘導体Denosominのアストロサイトを介した脊髄損傷改善作用．2013
- Author(s)
  執行美智子、久保山友晴、東田千尋.
- Organizer
  第30回和漢医薬学会学術大会,
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 脊髄損傷の運動機能改善効果を持つ漢方生薬の研究2013
- Author(s)
  田辺紀生, 久保山友晴, 数馬恒平, 紺野勝弘, 東田千尋
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Investigation of crude drugs effective for spinal cord injured mice.2013
- Author(s)
  Tanabe N, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Tohda C
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 脊髄損傷後の機能回復に低分子量タンパク質Racが関与する．2013
- Author(s)
  甲田将章、上山健彦、執行美智子、久保山友晴、東田千尋、齋藤尚亮、甲村英二.
- Organizer
  日本脳神経外科学会　第72回学術総会,
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 脊髄損傷後の機能回復に低分子量タンパク質Racが関与する2013
- Author(s)
  甲田将章、上山健彦、執行美智子、久保山友晴、東田千尋、齋藤尚亮、甲村英二
- Organizer
  日本脳神経外科学会　第72回学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] A novel compound, Denosomin, promotes axonal growth via astrocytes secreting vimentin after spinal cord injury．2013
- Author(s)
  Shigyo M, Teshigawara K, Kuboyama T, Nagata A, Sugimoto K, Matsuya Y, Tohda C.
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice．2013
- Author(s)
  Tohda C, Urano T, Umezaki M, Kuboyama T.
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Ashwagandha成分 Sominoneの誘導体Denosominのアストロサイトを介した脊髄損傷改善作用2013
- Author(s)
  執行美智子、久保山友晴、東田千尋
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 脊髄損傷後の機能回復に低分子量タンパク質Rac が関与する2013
- Author(s)
  甲田将章, 上山健彦, 執行美智子, 久保山友晴, 東田千尋, 齋藤尚亮, 甲村英二
- Organizer
  日本脳神経外科学会第72回学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 新規化合物 denosominはアストロサイトからの vimentin放出を促進して脊髄損傷マウスの運動機能を回復させる2013
- Author(s)
  久保山友晴、執行美智子、東田千尋
- Organizer
  平成25年度神経糖鎖生物学夏の斑会議
- Place of Presentation
  守山、滋賀
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice2013
- Author(s)
  Tohda C, Urano T, Umezaki M, Kuboyama T
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] A novel compound, Denosomin, promotes axonal growth via astrocytes secreting vimentin after spinal cord injury2013
- Author(s)
  Shigyo M, Teshigawara K, Kuboyama T, Nagata A, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Endocytosis-mediated axonal growth cone degeneration induced by amyloid β.2013
- Author(s)
  Kuboyama T, Nishiko H, Tohda C.
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Investigation of crude drugs effective for spinal cord injured mice2013
- Author(s)
  Tanabe N, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Tohda C
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Diosgenin is an exogenous activator of 1, 25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer's disease model 5XFAD mice2013
- Author(s)
  Tohda C, Urano T, Umezaki M, Kuboyama T
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Investigation of crude drugs effective for spinal cord injured mice．2013
- Author(s)
  Tanabe N, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Tohda C.
- Organizer
  Neuro 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 脊髄損傷後の機能回復に低分子量タンパク質Racが関与する2013
- Author(s)
  甲田将章、上山健彦、執行美智子、久保山友晴、東田千尋、齋藤尚亮、甲村英二
- Organizer
  日本脳神経外科学会第72回学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Ashwagandha 成分Sominone の誘導体Denosomin のアストロサイトを介した脊髄損傷改善作用2013
- Author(s)
  執行美智子, 久保山友晴, 東田千尋
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Endocytosis-mediated axonal growth cone degeneration induced by amyloid β2013
- Author(s)
  Kuboyama T, Nishiko H, Tohda C
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 新規化合物denosomin はアストロサイトからのvimentin 放出を促進して脊髄損傷マウスの運動機能を改善させる2013
- Author(s)
  久保山友晴, 執行美智子, 東田千尋
- Organizer
  平成25年度神経糖鎖生物学夏の班会議
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 脊髄損傷の運動機能改善効果を持つ漢方生薬の研究2013
- Author(s)
  田辺紀生、久保山友晴、数馬恒平、紺野勝弘、東田千尋
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Ashwagandha成分Sominoneの誘導体Denosominのアストロサイトを介した脊髄損傷改善作用2013
- Author(s)
  執行美智子、久保山友晴、東田千尋
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 新規化合物denosominはアストロサイトからのvimentin放出を促進して脊髄損傷マウスの運動機能を改善させる．2013
- Author(s)
  久保山友晴、執行美智子、東田千尋.
- Organizer
  平成25年度神経糖鎖生物学夏の班会議
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] A novel compound, Denosomin induces vimentin-secretion from astrocytes, resulting in promotion of axon elongation.2012
- Author(s)
  Kuboyama T, Teshigawara K, Shigyo M, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Denosomin improves SCI via axonal growth by increasing astrocyte-secreted vimentin2012
- Author(s)
  Shigyo M, Kuboyama T, Teshigawara K, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 阻害性プロテオグリカンによる軸索再生阻害機構の解明2012
- Author(s)
  久保山友晴、Vance Lemmon、Jerry Silver、東田千尋、上口裕之
- Organizer
  2012年度　包括脳ネットワーク夏のワークショップ
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer's disease model 5XFAD mice2012
- Author(s)
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T
- Organizer
  Neuroscience2012
- Place of Presentation
  New Orleans, LA, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] A novel compound, Denosomin induces vimentin-secretion from astrocytes, resulting in promotion of axon elongation2012
- Author(s)
  Kuboyama T, Teshigawara K, Shigyo M, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience2012
- Place of Presentation
  New Orleans, LA, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 阻害性プロテオグリカンによる軸索再生阻害機構の解明2012
- Author(s)
  久保山友晴, Vance Lemmon, Jerry Silver, 東田千尋, 上口裕之
- Organizer
  2012年度包括脳ネットワーク夏のワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] コンドロイチン硫酸プロテオグリカン濃度勾配による軸索再生阻害のシグナル伝達機構2012
- Author(s)
  久保山友晴
- Organizer
  第2回「神経糖鎖生物学」領域会議
- Place of Presentation
  淡路、兵庫
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] コンドロイチン硫酸プロテオグリカン濃度勾配による軸索再生阻害のシグナル伝達機構2012
- Author(s)
  久保山友晴
- Organizer
  第2回「神経糖鎖生物学」領域会議
- Place of Presentation
  淡路市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Novel mechanism of functional recovery from spinal cord injury.2012
- Author(s)
  Tohda C., Kuboyama T., Teshigawara K., Shigyo M.
- Organizer
  14th International Congress of Histochemistry and Cytochemistry
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] A novel compound, denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin2012
- Author(s)
  Kuboyama T
- Organizer
  1st Joint Symposium Between Natural Products Research Institute, College of Pharmacy, Seoul National University and Institute of Natural Medicine, University of Toyama
- Place of Presentation
  Toyama
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Diosgenin is an exogenous activator of 1,25D_3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer's disease model 5XFAD mice2012
- Author(s)
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Novel mechanism of functional recovery from spinal cord injury2012
- Author(s)
  Tohda C, Kuboyama T, Teshigawara K, Shigyo M
- Organizer
  14th International Congress of Histochemistry and Cytochemistry
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] A novel compound, denosomin ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin2012
- Author(s)
  Kuboyama T
- Organizer
  1st Joint Symposium Between Natural Products Research Institute, College of Pharmacy, Seoul National University and Institute of Natural Medicine, University of Toyama
- Place of Presentation
  富山市
- Invited
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] A novel compound, Denosomin induces vimentin-secretion from astrocytes, resulting in promotion of axon elongation2012
- Author(s)
  Kuboyama T, Teshigawara K, Shigyo M, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice2012
- Author(s)
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T
- Organizer
  Neuroscience2012
- Place of Presentation
  New Orleans, LA, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice.2012
- Author(s)
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Denosomin improves SCI via axonal growth by increasing astrocyte-secreted vimentin2012
- Author(s)
  Shigyo M, Kuboyama T, Teshigawara K, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience2012
- Place of Presentation
  New Orleans, LA, U.S.A.
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Denosomin improves SCI via axonal growth by increasing astrocyte-secreted vimentin.2012
- Author(s)
  Shigyo M, Kuboyama T, Teshigawara K, Sugimoto K, Matsuya Y, Tohda C
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 阻害性プロテオグリカンによる軸索再生阻害機構の解明．2012
- Author(s)
  久保山友晴、Vance Lemmon、Jerry Silver、東田千尋、上口裕之
- Organizer
  2012年度包括脳ネットワーク夏のワークショップ.
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 阻害性プロテオグリカンによる軸索再生阻害機構の解明2012
- Author(s)
  久保山友晴、Vance Lemmon、Jerry Silver、東田千尋、上口裕之
- Organizer
  2012年度包括脳ネットワーク夏のワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Novel mechanism of functional recovery from spinal cord injury2012
- Author(s)
  Tohda C, Kuboyama T, Teshigawara K, Shigyo M
- Organizer
  14th International Congress of Histochemistry and Cytochemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Novel mechanism of functional recovery from spinal cord injury2012
- Author(s)
  Tohda C, Kuboyama T, Teshigawara K, Shigyo M
- Organizer
  4th International Congress of Histochemistry and Cytochemistry
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Searching for natural medicines that improve spinal cord injury2011
- Author(s)
  Wang XH, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Satake M, Tohda C
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] アルツハイマー病モデルマウスの記憶障害と軸索変性に対する加味帰脾湯の改善作用2011
- Author(s)
  中田理恵, 久保山友晴, 東田千尋
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] コンドロイチン硫酸プロテオグリカンによる軸索再生阻害のシグナル伝達機構2011
- Author(s)
  久保山友晴
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PLANNED-23110005
[Presentation] 脊髄損傷の運動機能回復に関与するDenosomin の軸索伸展作用2011
- Author(s)
  執行美智子, 長田愛子, 勅使川原匡, 久保山友晴, 松谷裕二, 東田千尋
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] 1-deoxy-nor-sominone (Denosomin) improves hindlimb dysfunction in spinal cord injury and promotes neurite outgrowth through astroglia-mediated signaling2011
- Author(s)
  Teshigawara K, Kuboyama T, Matsuya Y, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀、石川
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 脊髄損傷の運動機能回復に関与するDenosominの軸索伸展作用．2011
- Author(s)
  執行美智子，長田愛子，勅使川原匡，久保山友晴，松谷裕二，東田千尋
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] コンドロイチン硫酸プロテオグリカンによる軸索再生阻害のシグナル伝達機構2011
- Author(s)
  久保山友晴, Jerry Silver, 東田千尋, 上口裕之
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] コンドロイチン硫酸プロテオグリカンによる軸索再生阻害のシグナル伝達機構2011
- Author(s)
  久保山友晴
- Organizer
  軸索再生連絡会議
- Place of Presentation
  和光、埼玉
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 1-deoxy-nor-sominone (Denosomin) improves hindlimb dysfunction in spinal cord injury and promotes neurite outgrowth through astroglia-mediated signalling2011
- Author(s)
  Teshigawara K, Kuboyama T, Matsuya Y, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Signal transduction underlying chondroitin sulfate proteoglycan-mediated inhibition of axon regeneration2011
- Author(s)
  Kuboyama T, Silver J, Tohda C, Kamiguchi H
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀、石川
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 新規化合物1-deoxy-nor-sominone (Denosomin)2011
- Author(s)
  勅使川原匡，久保山友晴，松谷裕二，東田千尋
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Denosomin enhances axonal regrowth associated with motor function recovery in spinal cord injury2011
- Author(s)
  Shigyo M, Nagata A, Teshigawara K, Kuboyama T, Matsuya Y, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀、石川
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Searching for natural medicines that improve2011
- Author(s)
  Xiaohua Wang, Tomoharu Kuboyama, et al
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Kamikihi-to improves memory impairment and axon degeneration in a mouse model of Alzheimer’s disease, 5XFAD2011
- Author(s)
  Nakada R, Kuboyama T, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] 新規化合物1-deoxy-nor-sominone (Denosomin)によるアストロサイトを介した脊髄損傷の改善作用2011
- Author(s)
  勅使川原匡, 久保山友晴, 松谷裕二, 東田千尋
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] アルツハイマー病モデルマウスの記憶障害と軸索変性に対する加味帰脾湯の改善作用．2011
- Author(s)
  中田理恵、久保山友晴、東田千尋
- Organizer
  東田千尋会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] Denosomin enhances axonal regrowth associated with motor function recovery in spinal cord injury2011
- Author(s)
  Shigyo M, Nagata A, Teshigawara K, Kuboyama T, Matsuya Y, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Kamikihi-to improves memory impairment and axon degeneration in a mouse model of Alzheimer's disease 5XFAD2011
- Author(s)
  Nakada R, Kuboyama T, Tohda C
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀、石川
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Signal transduction underlying chondroitin sulfate proteoglycan-mediated inhibition of axon regeneration2011
- Author(s)
  Kuboyama T, Silver J, Tohda C, Kamiguchi H
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀市
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] Searching for natural medicines that improve spinal cord injury2011
- Author(s)
  Wang X, Kuboyama T, Miyanaga S, Kazuma K, Konno K, Satake M, Tohda C
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23700376
[Presentation] コンドロイチン硫酸プロテオグリカンによる軸索再生阻害のシグナル伝達機構．2011
- Author(s)
  久保山友晴，Jerry Silver，東田千尋, 上口裕之
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-23500439
[Presentation] パキシリンのリン酸化による軸索再生の制御2009
- Author(s)
  久保山友晴
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-19700301
[Presentation] パキシリンのリン酸化による軸索再生の制御2009
- Author(s)
  久保山友晴、Jerry Silver、上口裕之
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19700301
[Presentation] DR improves memory impairment in Alzheimer’s disease model mice, 5xFAD, and attenuates amyloid-induced axonal atrophy.
- Author(s)
  Yang Z., Kuboyama T., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 細胞外vimentinはIGF1Rを介して軸索伸展を促進する．
- Author(s)
  執行美智子、久保山友晴、東田千尋、
- Organizer
  第36回日本生物学的・精神医学会第57回日本神経化学会大会合同年会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 急性期および慢性期脊髄損傷において運動機能改善を促す生薬とその活性成分の研究．
- Author(s)
  田辺紀生、久保山友晴、数馬恒平、紺野勝弘、東田千尋、
- Organizer
  第13回次世代を担う若手ファーマバイオフォーラム2014.
- Place of Presentation
  富山
- Year and Date
  2014-09-20 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] The recovery of motor function by a crude drug and its active constituent in spinal cord injured mice.
- Author(s)
  Tanabe N., Kuboyama T., Kazuma K., Konno K., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Improvement of motor dysfunction in acute and chronic phases in spinal cord injury mice by a crude drug-derived compound.
- Author(s)
  Tanabe N., Kuboyama T., Kazuma K., Konno K., Tohda C.
- Organizer
  Society for Neuroscience 44th Annual Meeting (Neuroscience 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] New reliable scoring system, Toyama Mouse Score, to evaluate locomotor function following spinal cord injury in mice.
- Author(s)
  Shigyo M., Tanabe N., Kuboyama T., Choi S-H., Tohda C.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] 日本および韓国で用いられている加味帰脾湯の記憶増強作用の比較．
- Author(s)
  19)渡り英俊、執行美智子、田辺紀生、東田道久、Ki-Ho Cho、嶋田豊、柴原直利、久保山友晴、東田千尋、
- Organizer
  第31回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Extracellular vimentin promotes axonal growth via IGF1R.
- Author(s)
  Shigyo M., Kuboyama T., Tohda C.
- Organizer
  第13回次世代を担う若手ファーマバイオフォーラム2014.
- Place of Presentation
  富山
- Year and Date
  2014-09-20 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced growth cone collapse, axonal atrophy and memory impairment
- Author(s)
  Kuboyama T., Lee Y-A., Nishiko H., Tohda C. .
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] DR-induced cognitive enhancement in Alzheimer’s disease model mice, 5xFAD, and underlying mechanisms.
- Author(s)
  Yang Z., Kuboyama T., Tohda C.
- Organizer
  Society for Neuroscience 44th Annual Meeting (Neuroscience 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Extracellular vimentin promotes axonal growth via IGF1R.
- Author(s)
  Shigyo M., Kuboyama T., Tohda C.
- Organizer
  Society for Neuroscience 44th Annual Meeting (Neuroscience 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670044
[Presentation] Clathrin-mediated endocytosis is a key target for amyloid β-induced axonal degeneration and memory impairment.
- Author(s)
  Kuboyama T., Lee Y-A., Nishiko H., Tohda C.
- Organizer
  Society for Neuroscience 44th Annual Meeting (Neuroscience 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670044

1. TOHDA Chihiro (10272931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 92 results
2. 當銘一文 (80563981)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 森永紀 (60465771)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MATSUYA Yuji (50255858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. TESHIGAWARA Kiyoshi (40403737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
6. TOJIMA Takuro (00373332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KAMIGUCHI Hiroyuki (10233933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 紺野勝弘 (40215471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 数馬恒平 (70552446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小松かつ子 (50225570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 浅沼舞 (50852224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 小川鶴洋 (40781646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 楊熙蒙 (80818922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAZUMA Kohei

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Kuboyama Tomoharu 久保山 友晴

久保山 友晴 クボヤマ トモハル

KUBOYAMA Tomoharu 久保山 友晴

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Development of functional foods with nootropic effects through the construction of neuronal networksPrincipal Investigator

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Recovery from refractory anxiety by reconstruction of neuronal networksPrincipal Investigator

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Development of high value-added Rhubarb effective for neurological disorders

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Development of therapeutic strategy for Alzheimer's disease via M2 microgliaPrincipal Investigator

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Traditional medicine-based drug development-creation of new paradigm-

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Recovery from spinal cord injury in the chronic phase -the mechanism of denosomin, a novel compound with multiactivities-

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Axonal regeneration via regulation of point contactsPrincipal Investigator

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Analyses of the functional domains in sugar chains using neuronal growth cones

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A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycanPrincipal Investigator

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[Journal Article] Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia2023

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[Journal Article] Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix2021

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[Journal Article] Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease2020

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[Journal Article] Development of New Therapies for Neurodegenerative Diseases <i>via</i> Axonal Growth2019

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Kuboyama Tomoharu 久保山友晴

久保山友晴クボヤマトモハル

KUBOYAMA Tomoharu 久保山友晴